Infertility

Slow responder on Gonal-F

My baseline E2 was 27 on Thursday last week.  I had been on 10 IU of lupron for 9 days at that point.  I was told to start stims on Saturday night with 225 IU of Gonal-f for 3 nights and then drop to 150 IU on the 4th night  (as well as decrease the lupron to 5 IU). That brings us to today. I went in this morning and my E2 was only 60 and the tech couldn't really see any follicles yet.  My nurse told me to increase back up to 225 IU and come back on Friday.  I asked whether this was normal and she of course said there is no such thing as normal in IF.   I know it's early, but anyone have anything similar on past cycles?  Thanks ladies.

****************SIGGY WARNING****************

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TTC since 2011
DH: 29, Severe MFI; grade III varicocele; surgery postponed till KU
Me: 30, POF/DOR, factor II hetero, MTHFR homo
5 IVF's, LLP, EEP, MDLF all BFN
IVF 6 using DEB USA frozen eggs
developed bilateral PE's from BCP, cancelled/delayed 6 mths, taking lovenox
Feb'15 SURPRISE 1st BFP ever! EDD: 10/10/15, FX
Still have frozen donor eggs on ice
All are welcome!

Re: Slow responder on Gonal-F

  • **ticker warning**

    Do they mean, they couldn't see any follicles starting to respond yet? There are always some follicles, they should have seen some at your baseline.

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  • imageBootsOrHearts:

    **ticker warning**

    Do they mean, they couldn't see any follicles starting to respond yet? There are always some follicles, they should have seen some at your baseline.

     

    Yes, sorry, exactly. 

    ****************SIGGY WARNING****************

    image
    TTC since 2011
    DH: 29, Severe MFI; grade III varicocele; surgery postponed till KU
    Me: 30, POF/DOR, factor II hetero, MTHFR homo
    5 IVF's, LLP, EEP, MDLF all BFN
    IVF 6 using DEB USA frozen eggs
    developed bilateral PE's from BCP, cancelled/delayed 6 mths, taking lovenox
    Feb'15 SURPRISE 1st BFP ever! EDD: 10/10/15, FX
    Still have frozen donor eggs on ice
    All are welcome!
  • htn1763htn1763 member
    I was a slow responder as well (or the Lupron over-suppressed me). I had to increase my gonal-f (and stop Lupron altogether) everytime I went in for a check. I ended up stimming for 14 days.

    Me: 33 DH: 32 SA#1 low count (6mil) SA#2- now in IUI range!(30mil) Dx:MFI
    11/1- IUI#1,12/1- IUI#2, 1/2- IUI#3 all BFFN
    IVF#1. Long Lupron.ER 3/8 10R,4M,5F. ET 3/3-one 1AB, 2 frosties 5dp5dt-BFP!! Beta 3/25-794 Beta 3/27- 1794
    First u/s 4/8 saw hb. 4/22 missed mc 8w3d. d&c 4/26
    FET #1- bcp start 6/9. ET 7/12. 2 perfect blasts.5dpt-BFP!! 
    Beta 7/24 -1,239!! Beta 7/26- 2569 Beta 7/29- 7120.  U/S 8/7 hb 118! U/S 8/14 hb 143! U/S 8/20 hb 170. Graduated!! Stick baby stick! 


  • crpatecrpate member

    Seems like we're in a similar boat. There was no indicator I would respond poorly to the stim meds (gonal f and menopur). 

    My first ivf cycle I had numbers similar to yours. I stimmed the entire 11 days and gonal f was upped to 375. I only had 4 eggs retrieved.

    this cycle I'm doing an antagonist cycle (no lupron) and I have my first check tomorrow. Hopefully this will work better.

    It's not late late for them to grow... Grow follies! Maybe ask if your gonal f could go even higher. 

  • Thanks for the input ladies!  I'm hope they just need a little longer to kickstart into growing.  I will definitely ask about increasing it even more if they don't suggest that. 
    ****************SIGGY WARNING****************

    image
    TTC since 2011
    DH: 29, Severe MFI; grade III varicocele; surgery postponed till KU
    Me: 30, POF/DOR, factor II hetero, MTHFR homo
    5 IVF's, LLP, EEP, MDLF all BFN
    IVF 6 using DEB USA frozen eggs
    developed bilateral PE's from BCP, cancelled/delayed 6 mths, taking lovenox
    Feb'15 SURPRISE 1st BFP ever! EDD: 10/10/15, FX
    Still have frozen donor eggs on ice
    All are welcome!
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