Zofran? — The Bump
Pregnant after IF

Zofran?

Good morning,

Well not for me I guess...I am about at the end of my rope with this morning sickness. I knew to expect this but it is all day, every day and seems to be getting worse. I've been taking 50 mg of B6 in the morning and that helped me stop throwing up but the nausea is still really intense. I try to eat every couple of hours and that does help some but the menu of things I can tolerate shrinks a little more each day. At this point it's down to bagels and grilled cheese sandwiches. RE said he would prescribe me Zofran when I saw him on Thurs and I said I would wait it out because I really didn't want to take anything if I didn't have to. Well, now that I've done nothing but lay on the couch for the past 3 days feeling absolutely miserable, I think I have to.

How many of you take this for morning sickness and did you find it helped your nausea? Is there anything else out there I should ask about? TIA!
TTC since June 2011
DX: DH (30) severe MFI, severely low count & low motility
Me (32): all clear
Appt with Urologist 5/21/12: exam, ultrasound, bloodwork all normal.
Testicular Biopsy with TESE on 6/8/12. good sperm found! (left side only) froze sperm, failed thaw test :(
Orientation for IVF/ICSI on 6/13/12. Waiting for the green light following biopsy results...results show adequate sperm production both sides.
2nd SA 6/18/12: sample is "adequate for ICSI"
Plan: IVF/ICSI July 2012!
ER: 7/26/12. 15 eggs retrieved, all mature.
TESE/TESA/aspiration from epididymis, no motile sperm found :(
froze all eggs, the saga of praying for good sperm continues.
8/3/12: 2nd opinion from MFI uro on biopsy slides. Suspects "partial late maturation arrest."
Plan: more SAs, third biopsy/TESE with frozen back-up either from DH or DS.
SA 8/17/12: Zero sperm
SA 8/23/12: Zero sperm
9/26/12: SPERM FOUND! 15 eggs thawed, 12 survived and were ICSI'd, only 3 fertilized normally. Refrozen as embies and will thaw in Nov. Please survive and grow!
All 3 survived the thaw on 11/15/12!
FET 11/17/12: transferred 2, one 4B, one 4C. Beta 11/30:BFFN
moving on to DS
DIUI#1 2/18/13,50mg Clomid cd 3-7, Ovidrel trigger, Beta 3/4/13: BFN.
DIUI#2 3/19/13, 50 mg Clomid cd 3-7, Ovidrel trigger, Beta #1 (14dpiui) 4/2/13: BFP!!!! 150. Beta #2 4/4/13: 420 Beta #3 4/8/13: 2691. Beta #4 4/15/13: 15,086
1st u/s 4/8/13 shows one gestational sac
2nd u/s 4/15/13 shows yolk sac, fetal pole and early heartbeat
3rd u/s 4/25/13: measuring right on track. Heart rate 148 bpm
A/S 7/22/13: IT'S A BOY!!
PAIF/SAIF Always Welcome
[IMG]http://i49.tinypic.com/2qmon5u.jpg[/IMG] [IMG]http://i225.photobucket.com/albums/dd243/laurakat24/turkeybaster-1.jpg"[/IMG]Image and video hosting by TinyPic
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Re: Zofran?

  • It's a mircale drug. I've had it at the hospital when I've had really bad stomach flu, it works wonders.

    My nausea has been so-so this time around, some good days, some bad days, and for the most part I'm working through it, but I have to fly next week for a work trip and I get nauseated anyway on planes, so I asked for prescription, and only plan to take it when I'm flying. I can't imagine anything worse than up-chucking on a plane in a suit.

    I say if you need it, take it. I am still working full time so if it gets really bad to where I can't work, I really will have to think about taking it more often.

    **Warning: Losses and living child mentioned**
    BFP#1 1/31/12, EDD 10/6/12 Harrison Gray born sleeping @ 18w6d. You changed our lives little guy.
    BFP#2 EDD 10/29/13, C/P 2/25/13, Bye little Ish, we barely got to know you.
    BFP#3 EDD 12/21/13, Baby Boots born 11/23/13 My rainbow baby!
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  • It's seriously my miracle drug. I had it in my IV line last week when I had to go and get fluids due to dehyrdation.

    My nausea has been prettty bad all day and every day. I also just got diagnosed with Hyperemesis which is no fun at all.  I would defineately call your doc and see if they can call it in.


    Me (30) my best friend (38)
    TTTC since "Jan 2011"
    RE appt april 2012
    Dx: PCOS and stage 1 endo
    S/A 19 million, 48 motility, 1 morphology
    6.1 progestrone
    HSG: tubes clear
    clomid 50mg + #1 IUI + trigger 6/9/12 BFN 6/18/12 Clomid 150mg +#2 IUI + trigger: 7/9/2012 BFN 7/18/2012 stage 1: endo removed 8/14/12
    Letrozole 2.5mg+estrogen=cycle cancelled for little to no response
    Follistim 75 (10/15-10/19) follistim 67 (10/20-10/21) cycle cancelled due to over response 9 follies and very thin lining
    ~ IVF #1:BC pills started 10/27~
    ~IVF class schedualed for 11/13~
    ~ Lupron starts Thanksgiving day~
    ~Stims start December 1st~
    ~ER: December 12th ~
    ~ET: December 15th~
    19 R. 12. Fertilized with ICSI, 2 transfered
    only 1 made it to freeze!
    Beta #1 12/27/12 (26)
    beta #2 12/29/12 (78.9)
    Beta #3 12/31/12 (149)
    Beta #4 1/4/13 (48)
    C/P on 1/4/13 @ 5 weeks and 2 days
    ~ IVF #2 ~
    ~ BC pills1/15-2/3~
    ~Lupron beings 1/31~
    ~stims start Feb. 9th~
    ~ER 2/21/13~
    ~14 R, 12 fertilized with ICSI~
    ~1 made it to freeze~
    ~Twin Boys Arrived August 31, 2013
    image Anniversary
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    P/SAIF Welcome~ everyone welcome
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  • Thanks so much, ladies. Just paged my RE and he's going to call it in. Something's gotta give, hopefully it helps!
    TTC since June 2011
    DX: DH (30) severe MFI, severely low count & low motility
    Me (32): all clear
    Appt with Urologist 5/21/12: exam, ultrasound, bloodwork all normal.
    Testicular Biopsy with TESE on 6/8/12. good sperm found! (left side only) froze sperm, failed thaw test :(
    Orientation for IVF/ICSI on 6/13/12. Waiting for the green light following biopsy results...results show adequate sperm production both sides.
    2nd SA 6/18/12: sample is "adequate for ICSI"
    Plan: IVF/ICSI July 2012!
    ER: 7/26/12. 15 eggs retrieved, all mature.
    TESE/TESA/aspiration from epididymis, no motile sperm found :(
    froze all eggs, the saga of praying for good sperm continues.
    8/3/12: 2nd opinion from MFI uro on biopsy slides. Suspects "partial late maturation arrest."
    Plan: more SAs, third biopsy/TESE with frozen back-up either from DH or DS.
    SA 8/17/12: Zero sperm
    SA 8/23/12: Zero sperm
    9/26/12: SPERM FOUND! 15 eggs thawed, 12 survived and were ICSI'd, only 3 fertilized normally. Refrozen as embies and will thaw in Nov. Please survive and grow!
    All 3 survived the thaw on 11/15/12!
    FET 11/17/12: transferred 2, one 4B, one 4C. Beta 11/30:BFFN
    moving on to DS
    DIUI#1 2/18/13,50mg Clomid cd 3-7, Ovidrel trigger, Beta 3/4/13: BFN.
    DIUI#2 3/19/13, 50 mg Clomid cd 3-7, Ovidrel trigger, Beta #1 (14dpiui) 4/2/13: BFP!!!! 150. Beta #2 4/4/13: 420 Beta #3 4/8/13: 2691. Beta #4 4/15/13: 15,086
    1st u/s 4/8/13 shows one gestational sac
    2nd u/s 4/15/13 shows yolk sac, fetal pole and early heartbeat
    3rd u/s 4/25/13: measuring right on track. Heart rate 148 bpm
    A/S 7/22/13: IT'S A BOY!!
    PAIF/SAIF Always Welcome
    [IMG]http://i49.tinypic.com/2qmon5u.jpg[/IMG] [IMG]http://i225.photobucket.com/albums/dd243/laurakat24/turkeybaster-1.jpg"[/IMG]Image and video hosting by TinyPic
    BabyFruit Ticker
  • Zofran is my best friend. I only take it on the miserable days, but it works like a charm! Hope you feel better!
  • ***lurker chiming in***

    Zofran is VERY constipating. Make sure you increase your fiber and/or take stool softeners.  Trust me. 

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  • image Fordlor:
    lurker chiming inZofran is VERY constipating. Make sure you increase your fiber and/or take stool softeners.nbsp; Trust me.nbsp;


    True, that's the only downfall, but I can handle that better than vomiting all day every day. Drink lots of water!
  • I am glad you are getting it!  The thing is you don't HAVE to take it even if its at your house.  Sometimes just having it in my purse helps me.  Also, as PP said make sure you don't get constipated and beware it might give you a headache.  But really it would be better than ending up in the hospital dehydrated. 
    TTC#1: 14 months on our own (did HSG, b/w, SA);
    BFP on Cycle 14--TWINS! Identical twin boys stillborn at 19wks(1/9/10)
    3 break cycles; took clomid 50mg, BFP #2 Beta #1 35, Beta #2 338!!! Owen was born 2/11/11! 
    TTC#2: 4 cycles on clomid: BFNs
    BFP #3: Cycle #5 100mg clomid; beta #1 21; beta #2 6=CP 
    Cycle #6 break cycle TTC no meds=BFN
    Cycle #7: 150 clomid+ovidril+IUI=BFN (switched to RE)
    Cycle #8: follistem+ovidril+TI=BFN
    Cycle #9 Forced break due to cyst
    Cycle #10 follistem+ovidril+TI=BFN
    Cycle #11 follistem+ovidril+TI=BFN
    Cycle#12 Forced break due to cyst, went on BCP; did repeat HSG, Saline U/S
    Cycle #13 IVF: Follistim/Menapur ER 11-30 11 eggs, 5 mature, 4 fertilized and 3dt on 12-3; BFN
    Cycle #14: IVF#2 lupron/follistim/menopur ER 1-22, 19 eggs, 14 fertilized, 5dt on 1-27, BFP!! beta 1: 63, beta 2: 119; EDD 10-15-13; 1 frozen embie
    Miracle Surprise BFP, EDD 10-1-15; saw HB great Betas, 11weeks lost baby MC at home
    Moved forward with FET transfered solo frostie on 6-4-15, beta 1: 315, beta 2: 738, u/s showed one baby on track EDD 2-21-16
  • Thanks for the tips! I'm already kind of backed up as it is, I've only been going every couple of days so I def needed to know that. I just can't stand feeling so sick every day. I've had to call out of work twice already and I just can't make that a habit. Throwing up at work though is brutal. So I really hope this is the answer! Thanks for the input, ladies
    TTC since June 2011
    DX: DH (30) severe MFI, severely low count & low motility
    Me (32): all clear
    Appt with Urologist 5/21/12: exam, ultrasound, bloodwork all normal.
    Testicular Biopsy with TESE on 6/8/12. good sperm found! (left side only) froze sperm, failed thaw test :(
    Orientation for IVF/ICSI on 6/13/12. Waiting for the green light following biopsy results...results show adequate sperm production both sides.
    2nd SA 6/18/12: sample is "adequate for ICSI"
    Plan: IVF/ICSI July 2012!
    ER: 7/26/12. 15 eggs retrieved, all mature.
    TESE/TESA/aspiration from epididymis, no motile sperm found :(
    froze all eggs, the saga of praying for good sperm continues.
    8/3/12: 2nd opinion from MFI uro on biopsy slides. Suspects "partial late maturation arrest."
    Plan: more SAs, third biopsy/TESE with frozen back-up either from DH or DS.
    SA 8/17/12: Zero sperm
    SA 8/23/12: Zero sperm
    9/26/12: SPERM FOUND! 15 eggs thawed, 12 survived and were ICSI'd, only 3 fertilized normally. Refrozen as embies and will thaw in Nov. Please survive and grow!
    All 3 survived the thaw on 11/15/12!
    FET 11/17/12: transferred 2, one 4B, one 4C. Beta 11/30:BFFN
    moving on to DS
    DIUI#1 2/18/13,50mg Clomid cd 3-7, Ovidrel trigger, Beta 3/4/13: BFN.
    DIUI#2 3/19/13, 50 mg Clomid cd 3-7, Ovidrel trigger, Beta #1 (14dpiui) 4/2/13: BFP!!!! 150. Beta #2 4/4/13: 420 Beta #3 4/8/13: 2691. Beta #4 4/15/13: 15,086
    1st u/s 4/8/13 shows one gestational sac
    2nd u/s 4/15/13 shows yolk sac, fetal pole and early heartbeat
    3rd u/s 4/25/13: measuring right on track. Heart rate 148 bpm
    A/S 7/22/13: IT'S A BOY!!
    PAIF/SAIF Always Welcome
    [IMG]http://i49.tinypic.com/2qmon5u.jpg[/IMG] [IMG]http://i225.photobucket.com/albums/dd243/laurakat24/turkeybaster-1.jpg"[/IMG]Image and video hosting by TinyPic
    BabyFruit Ticker
  • I have been on Zofran since 2 weeks after the ET and the dr also gave me a suppository because I was so miserable.  I still throw up but only 2-3 times a day now, which is a HUGE improvement.  Watch out for the constipation.  Some days I just deal with the vomitting until the constipation gets better and then start taking it again :) 
    Married 12-12-04
    TTC since 07
    me-36 PCOS, Tubal Problems, and polyps removed 7-12
    DH - 36 extremely handsome and no fertility problems
    IUI 8-12 and 9-12 failed
    IVF 12-21-2012 - 2 I think perfect no matter what the dr graded them (2B)embryos transferred Beta on 12-31-12 Positve - Beta is 21
    Beta 2 1-2-13 - 31
    Beta 3 1-4-13 - 53
    Beta 4 1/9 - 212!
    Ultrasound 1/10 - Nothing completely empty uterus Beta 1/14 - 743; Beta 1/17 - 1704 ultrasound shows nothing. Officially a miscarriage. 1/21 Beta 3900 Dr. says it ectopic. Ultrasound shows a miracle heartbeat right in the uterus where it belongs! Dr. says I can be cautiously optomistic!!! Hang in there baby!
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  • I've been taking it since early first tri. First I tried the combo of B6 and Unisom (the over the counter sleep aid). My OB said that combination is really good for morning sickness and I agree. I hate ginger otherwise I'd have tried that as well. Ultimately I settled on B6, Unisome, Zofran, and Phenergan at night. It has been working pretty well for me, especially lately. Now I only throw up 5-6 times a week but I don't feel as nauseous throughout the day.

  • I took it and it was a gift from Heaven!!!  I still noticed eating small meals really helped, which was hard to do because i didn't always feel hungry, but sometimes it just meant snacking on a few crackers and drinking water. 

    I say get it!!!!

    ~Jen
    4/12: HSG All Clear
    5-1-12: DX of PCOS
    5-4-12: DH S/A all normal.
    5-16-12: Offically start IUI#1-->Clomid(50mg) + Trigger + IUI + progesterone supplements=BFN
    IUI #2-same treatment-->BFN
    July IUI#3-same treatment--->BFN
    Aug 22, 2012-Laparoscopy Found/Removed extensive endometreosis.
    September 2012-IUI #4-Same treatment as before. BFN
    October 2012-forced break/Surgery to remove abnormal cells in left breast.
    November 2012-First Injects Cycle (IUI #5)! 225IU Follistim CD 3-5, then monitoring appointment. 20+ follier & e2 >2000-Mild OHSS
    December 2012-#2 Injects + IUI#6): Beta 1/18/13-BFN!
    Jan 2013-Starting IVF!!! BC starts Jan 17/Lupron on Feb 13/Stims on Feb 18/ER on March 1 IVF Protocol: Lupron 10 units in am until stimms. Then 5 units of Lurpon in am, 150iu of Follistim and 1 unit of Menopur in pm. Holding dosage throughtout since response has been great. Thought we would be freeze all due to OHSS, but ended up getting more follicles then expected! 14 total!!! 12 mature and 11 fertilized. Dr calls for a 5 day transfer!! :) Will freeze remaining.
    image
    With Love & Strength, Hope Grows!
    WHEN, not IF!!!
  • Thanks! I did get it yesterday and found that it helped a lot. I haven't taken any today, only B6 this morning and I still feel good. It's good to have it though...sure I'm far from out of the woods! :)
    TTC since June 2011
    DX: DH (30) severe MFI, severely low count & low motility
    Me (32): all clear
    Appt with Urologist 5/21/12: exam, ultrasound, bloodwork all normal.
    Testicular Biopsy with TESE on 6/8/12. good sperm found! (left side only) froze sperm, failed thaw test :(
    Orientation for IVF/ICSI on 6/13/12. Waiting for the green light following biopsy results...results show adequate sperm production both sides.
    2nd SA 6/18/12: sample is "adequate for ICSI"
    Plan: IVF/ICSI July 2012!
    ER: 7/26/12. 15 eggs retrieved, all mature.
    TESE/TESA/aspiration from epididymis, no motile sperm found :(
    froze all eggs, the saga of praying for good sperm continues.
    8/3/12: 2nd opinion from MFI uro on biopsy slides. Suspects "partial late maturation arrest."
    Plan: more SAs, third biopsy/TESE with frozen back-up either from DH or DS.
    SA 8/17/12: Zero sperm
    SA 8/23/12: Zero sperm
    9/26/12: SPERM FOUND! 15 eggs thawed, 12 survived and were ICSI'd, only 3 fertilized normally. Refrozen as embies and will thaw in Nov. Please survive and grow!
    All 3 survived the thaw on 11/15/12!
    FET 11/17/12: transferred 2, one 4B, one 4C. Beta 11/30:BFFN
    moving on to DS
    DIUI#1 2/18/13,50mg Clomid cd 3-7, Ovidrel trigger, Beta 3/4/13: BFN.
    DIUI#2 3/19/13, 50 mg Clomid cd 3-7, Ovidrel trigger, Beta #1 (14dpiui) 4/2/13: BFP!!!! 150. Beta #2 4/4/13: 420 Beta #3 4/8/13: 2691. Beta #4 4/15/13: 15,086
    1st u/s 4/8/13 shows one gestational sac
    2nd u/s 4/15/13 shows yolk sac, fetal pole and early heartbeat
    3rd u/s 4/25/13: measuring right on track. Heart rate 148 bpm
    A/S 7/22/13: IT'S A BOY!!
    PAIF/SAIF Always Welcome
    [IMG]http://i49.tinypic.com/2qmon5u.jpg[/IMG] [IMG]http://i225.photobucket.com/albums/dd243/laurakat24/turkeybaster-1.jpg"[/IMG]Image and video hosting by TinyPic
    BabyFruit Ticker
  • I agree that Zofran is great.  My only other info for you is that you can develop a tolerance to Zofran (I did).  So, if you take it for a few weeks and all of a sudden feel like its not working as well as it used to, see if you can get Phenergan.  For me, it worked just as well, and it doesn't make you constipated.  Good luck!
    TTC #1 7/10, Me (31)- Dx DOR (AMH 0.6); DH (30)- normal
    BFP on Cycle #8. Natural M/C at ~8 weeks
    IUI #1 and #2 (8/12, 9/12)- 50 mg Clomid + Ovidrel = BFNs
    IVF #1 (EPP) 13R/10M/9F, 5DT 1-4AA blast, beta #1-148, beta #2-322, 5 frosties! 
     image  image  
    image
  • image baker916:
    I agree that Zofran is great. nbsp;My only other info for you is that you can develop a tolerance to Zofran I did. nbsp;So, if you take it for a few weeks and all of a sudden feel like its not working as well as it used to, see if you can get Phenergan. nbsp;For me, it worked just as well, and it doesn't make you constipated. nbsp;Good luck!


    Oh good to know! Thanks for the tip!
    TTC since June 2011
    DX: DH (30) severe MFI, severely low count & low motility
    Me (32): all clear
    Appt with Urologist 5/21/12: exam, ultrasound, bloodwork all normal.
    Testicular Biopsy with TESE on 6/8/12. good sperm found! (left side only) froze sperm, failed thaw test :(
    Orientation for IVF/ICSI on 6/13/12. Waiting for the green light following biopsy results...results show adequate sperm production both sides.
    2nd SA 6/18/12: sample is "adequate for ICSI"
    Plan: IVF/ICSI July 2012!
    ER: 7/26/12. 15 eggs retrieved, all mature.
    TESE/TESA/aspiration from epididymis, no motile sperm found :(
    froze all eggs, the saga of praying for good sperm continues.
    8/3/12: 2nd opinion from MFI uro on biopsy slides. Suspects "partial late maturation arrest."
    Plan: more SAs, third biopsy/TESE with frozen back-up either from DH or DS.
    SA 8/17/12: Zero sperm
    SA 8/23/12: Zero sperm
    9/26/12: SPERM FOUND! 15 eggs thawed, 12 survived and were ICSI'd, only 3 fertilized normally. Refrozen as embies and will thaw in Nov. Please survive and grow!
    All 3 survived the thaw on 11/15/12!
    FET 11/17/12: transferred 2, one 4B, one 4C. Beta 11/30:BFFN
    moving on to DS
    DIUI#1 2/18/13,50mg Clomid cd 3-7, Ovidrel trigger, Beta 3/4/13: BFN.
    DIUI#2 3/19/13, 50 mg Clomid cd 3-7, Ovidrel trigger, Beta #1 (14dpiui) 4/2/13: BFP!!!! 150. Beta #2 4/4/13: 420 Beta #3 4/8/13: 2691. Beta #4 4/15/13: 15,086
    1st u/s 4/8/13 shows one gestational sac
    2nd u/s 4/15/13 shows yolk sac, fetal pole and early heartbeat
    3rd u/s 4/25/13: measuring right on track. Heart rate 148 bpm
    A/S 7/22/13: IT'S A BOY!!
    PAIF/SAIF Always Welcome
    [IMG]http://i49.tinypic.com/2qmon5u.jpg[/IMG] [IMG]http://i225.photobucket.com/albums/dd243/laurakat24/turkeybaster-1.jpg"[/IMG]Image and video hosting by TinyPic
    BabyFruit Ticker
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