WTF appt. etc... opinions appreciated (long, sorry)

Sophistikitty

I am trying my best to come to terms with our loss but am really having difficulty figuring out where things went wrong. 

Quick summary: My clinic has a 63% live birth rate for DE in 2011.  Our donor stimmed for 8 days (a little short but RE doesn?t think that is the issue).  Out of the 12 mature eggs retrieved 8 fertilized with ICSI, 4 made it to blast.  The two that were transferred were ?excellent quality? (they do not use a number system) and I was given a 70% pregnancy probability with a 40% chance of twins.  Our donor has had two prior successful pregnancies, two freeze all cycles, and one cycle that resulted in m/c which we were told was due to a sperm issue.

DH has had sperm issues in the past.  When we started this journey many moons ago our dx was male factor as he had 6% morphology.  After consulting urologists and faithfully taking supplements (which he is still on) his SA was brought into normal range.  The last DNA frag test he had was last April but at that point his fragmentation was 22.2%.  Our RE does not seem to think that he is the issue but of course admits that it is possible.  He seems to feel that there is something going on with me.  Right away I pointed to my fibroid and adenomyosis.  Again, like I have been told by several other RE?s, he does not feel the location of the fibroid is a concern and he feels that adenomyosis only contributes to failures when it causes a thin lining ? mine was 13mm at transfer.  He seems to think there is something going on autoimmune wise.  This is where I am getting really perplexed.  I have had NK cell testing, ANA testing, anti-cardiolipin testing, lupus anticoagulant testing etc. and everything came back in the normal range.  Part of me wonders if something went wrong with the cycle that I am just not seeing and pointing to me is the easiest out.  Am I being too cynical?  There were two points in the cycle where my clinic made errors.  The first one was they did not go over the instructions with our donor regarding when she was supposed to stop BCP which resulted in her staying on BCP five days longer than scheduled.  The second mistake (a big one) was by the same nurse who ?forgot? to check off PGS (which we had paid for) on our lab slip.  Maybe we would have some answers had that not happened. 

I guess I just want to know what your thoughts are and what your next steps would be if you were in my position.  We have two frosties and I want to make sure I leave no stone unturned before considering transferring them.

What are the ideal E2 and P4 ranges after a positive beta in a DE or FET cycle?  My E2 was over 2300 at 12dp5dt and then over 2600 15dp5dt.  P4 was 46.  For some reason I feel the E2 was high. 

Thank you for reading if you got through all that!  Hugs to everyone!

Mrs.McIrish

Unfortunately, immune issues are way more complicated than you may realize. The tests you had done are just the beginning. Most can only be dealt with by a reproductive immunoligist-- not just the basic tests that an RE may do. The testing and treatme

DoublePortion

((Hugs)) I hope you find the answers you are looking for!

liz4paws

Oh I wish I had advice for you, but I just don't have enough experience with what you're dealing with. I can tell you that I hope you're able to find answers and big huge hugs to you for your loss. 

BrideJackie11

I too don't have any experience with immunology stuff but wanted to say I am sorry that you are going through this and sorry about your loss.   Since you weren't doing a fresh cycle with stimulating the ovaries, I don't think that your

KarlsSweetie05

*** Lurker *** Ticker Warning ***

Hi just wanted to respond quick and agree with Mrs. McIrish that only an RI (Reproductive Immunologist) will run "full panels" on the various types of autoimmune bloodwork. Much more in depth than an RE woul

PrettyAccountant

Hey Sweetie. I don't have any insight only to say I hope you get some answers. Hugs.

PurpleIris30

I wish I could offer more insight on immune issues. I would be upset that they didn't do PGS when you said you wanted it and had paid for it. Although it might not have changed the outcome, at least you'd have the information to narrow down possible cause

Sophistikitty

PurpleIris30:

I would be upset that they didn't do PGS when you said you wanted it and had paid for it. Although it might not

Edwina.McDunnough

I agree with McIrish. The rub is, those frozen DE embryos are worth their weight in gold to you and it's really hard to convince drs that another bunch of DE cycles, surrogacy, or other forms of repeat bludgeoning are options that you're remotely able to

Edwina.McDunnough

Sophistikitty:

PurpleIris30

Sophistikitty

Edwina.McDunnough:

I agree with McIrish. The rub is, those frozen DE embryos are worth their weight in gold to you and it's reall

Sophistikitty

Edwina.McDunnough:

Sop

luvboston

Do you have any autoimmune diseases? If you do not then there is a low chance that you have an autoimmune issue. What was your ANA?(IE 1.160) There are three main RI's Beer, Braverman and Kwak. Immune treatment is very expensive the testing alone will cos

Edwina.McDunnough

Sophistikitty:

Thank you Edwina.

Sophistikitty

luvboston:

Do you have any autoimmune diseases? If you do not then there is a low chance that you have an autoimmune issue. Wh

Sophistikitty

Edwina.McDunnough:

Sop

Gregermis

I agree with PP, BCPs not an issue... really annoying that they didn't do the PGS though!  Sorry about that.  My only other piece of advice for something to look into is gluten intolerance/celiacs.  Have you been tested for this?  T

Lacyj67

I understand how fustrating all this may be. I have never been tested in depth by a RI but do have a high nk cell count and will be doing my intralipid infusion on Friday. Good luck with how you decide to move forward and hopefully they can figure somethi