#5 - bummer (long)
Well with a heavy heart I write this. Today I had a d&c to complete my 5th m/c, this was my first ivf cycle and I felt so good about everything. I had been going in twice a week for bloodwork and u/s to check everything and we were right on track. Growing great, wonderful heartbeat and then Wednesday when we went into the office at 8w3d our lo no longer had a heartbeat. I was in a state of shock...how could this happen again? My levels were all good, we had beautiful embryos that we transferred and even did pgd testing to make sure they were genetically well off. All of my m/c have been unexplained-everything checks out with both myself and my husband.
We are going to take a break for a little bit before doing a FET (we have 6 frosties in waiting for us). My RE suggested that next time we will do the same thing but add in lovenox, I don't have any clotting problems but he said we are treating an unknown and we should throw the kitchen sink at this next one. One of his associates suggested taking steroids during the first trimester as well. Has anyone done this? I'm not sure of the purpose for the steroid. Also, he wants to do a neupogen wash before the transfer to help with implantation. Has anyone done this and had success with it? I'm pretty much willing to try anything....I don't know how many more losses I can take. My fertility clinic has 10 physicians in it and they get together for round table discussions for certain pts and I was informed today that they are going to be discussing my case so maybe they can come up with a miracle for me.
Any and all advice would be greatly appreciated...I just wish my babies would stick. For lack of better wording I feel like my body is rejecting all of my embryos and I'm beginning to wonder if I will ever successfully carry a baby.
Re: #5 - bummer (long)
Me: 29 ovulatory disorder
DH: 30 MFI - low everything
IUI #1: 11/5/12 BFN
December IUI cancelled due to cyst
IUI #2: 1/8/13 BFN
IVF in April 2013 transferred one beautiful blast on 4/13
Beta #1 4/22: BFP!! 33 Beta #2 54 Beta #3 70 Beta #4 83 Beta #5 105. Possible ectopic, MTX and M/C 5w4d
FET 6/21 - Beta #1: 79 BFP!! Beta #2: 253 U/S 7/12: saw the sac! U/S #2 7/19 great heartbeat of 127!! U/S #3 heartbeat of 154! U/S #4 graduated to OB
EDD 3/9/14
Me: 32 H: 31
IVF #1 October 2013 Antagonistic Protocol with ICSI ER 10/31/13 (18R 16M 11F- 6 blasts to freeze)
ET delayed due to OHSS
FET scheduled for July 8. Delayed due to a crazy high TSH (it had been under control for YEARS!)
FET #1 8/5/14 sET BFN
What testing have you had done? Recurrent loss testing? Immune testing?
3/22 ER: 25R, 20M, 15F. 9 genetically normal, and 3 survived to Day 5
3/27 ET: transferred 1 embryo, beta 9dp5dt=163, 12dp5dt=639
4/25 1st ultrasound at 7 weeks = identical twins with heartbeats?!!!
О Привязать! Z!
I've had the whole gauntlet of testing. My RE specializes in genetic disorders so those have all been cleared some immune testing have been done but kind of inconclusive results. So its sort of like we are trying to treat the unknowns that wouldn't hur
My BLOG: www.ivfbabyquest.wordpress.com -Update - old blog.
PAIF/SAIF Welcome!
Me: 42, Hubby: 35, TTC since Jan 2010. Dx: DOR due to advanced maternal age. Also: Hypothyroidism (100mcg Levothyroxin). Positive for MTHFR (hetero-C677T), Factor V Leiden, and Fragile X (on DH side). Taking pre-natal vitamins.
First natural PG 9/27/11; mc: 1/20/12
First RE visit: 8/8/12, Saline Sonogram: 8/28/12, IVF injection class: 10/11/12, add FaBB Tab for FVL, +Vitamin D.
IVF #1: 10/17/12 Baseline: FSH- 9.4, E2- 24, LH- 3.7, Prog- 0.3 The u/s showed 6 follicles in my right & 9 in my left. Rx: 150 Bravelle & 150 Menopur SQ nightly. 10/21/12: Add Ganirelix SQ every morning.
ER 10/28/12: 13 Retreived. 7 Mature. 6 Fertilized. 5 Made it to PGS. ET 11/2/12: CANCELED. All 5 came back from PGS as having "severe abnormalities."
IVF #2: 1/7/13 Baseline: FSH- 8.8, 4 follicles in my right & 6 in my left. Rx: 150 Bravelle & 150 Menopur SQ nightly. 1/11/13: Add Ganirelix SQ every morning. hCG Trigger 1/16/13
ER 1/18/13: 9 Retrieved. 5 Mature. 5 Fertilized. 2 Made it to PGS. ET 1/23/13: CANCELED. All embryos (he even sent the ones not growing) came back from PGS as having "multiple severe abnormalities."
IVF #3: NEW RE! 3/1/13 Baseline: FSH- 9.6, E2- 61, Prog- 0.94, 3 follicles in my right & 4 in my left. Rx: 150 Bravelle& 150 Menopur SQ in PM. 3/7/13: Add Ganirelix SQ in AM. hCG Trigger 3/9/13 SQ.
ER 3/11/13: 6R, 2M, 2F. Day 3: one 8 cell, grade 0. Five day ET 3/16/13: one early blast, grade Fair. 3/24/13 AF came a day before beta. BFN
IVF #4: (Added acupuncture to this cycle.) 3/25/13 WTF & Baseline: FSH-11.8, E2- 56, Prog- 0.84 3/26/13 Start stims. 3/30/13 u/s: 5 follicles in my right & 4 in my left. Rx: 225 Bravelle& 225 Menopur SQ in PM. 3/31/13 Add Ganirelix SQ in AM.hCG Trigger 4/3/13 SQ.
ER 4/5/13: 5R, 3M, 3F naturally. Day 3: two 8 cell, grade 0, one 8 cell, grade 2 (Scale 0-best to 3-worst). Five day ET 4/10/13: two blastocysts (the 3rd stopped growing.) Beta 4/18/13: 2.5 BFFN. RE recommends we stop trying and focus on living childless, due to the extremely poor quality of my eggs.
***Decided to stop trying and live CFNBC. I couldn't adjust. So, six months later...
IVF #5: Changed RE. Going to one of the big name clinics now. OWDU: 10/29/13. Update: HORRIBLE experience. Disgusted and distraught at their complete unprofessionalism and how much money and precious time they cost us. Sickening. Have now changed RE again. New Patient appt. 1/30/14.
BFP! Out of nowhere, I got KU the old fashioned way! POAS 1/26/14 - Positive! FDLM 12/30/13. Beta #1 16dpo= 373. Beta #2 18dpo= 801. EDD 10/6/14
2/4/14 1st U/S revealed a 5wk2day sac but no fetal pole. Started 200mgs of progesterone suppositories daily
2/11/14 2nd U/S revealed a perfect 6wk1day "diamond ring" embryo with a beating heart! 138bpm! Add 1mg folic acid and 40mg Lovenox
2/25/14 3rd U/S: perfect 8w1d embryo, 178bpm. 3/6 start spotting. 3/11 10w1d U/S shows no heartbeat. Scheduling D&C. The Stork has forsaken me again.
IVF #5.2: New in-state RE. Supplement priming for 1.5 cycles prior to start of cycle, including DHEA 50mg (stopped 5/15), CoQ10 200mg 2x/day, L-Arginine- 1000mg 2x/day (stopped 6/5 due to cold sore!), myo-inositol- 2g 2x/day, melatonin- 3mg, and Neevo (prenatal for MTHFR).
5/16/14 Day 2 bw cycle prior: FSH- 12.22, E2- 38.37, Prog- 1.35, LH- 9.46. 6/2/14 Day 19 bw: Prog- 23
6/12/14 Baseline: E2- 122.7, Prog- 0.4. 5 follicles in left, 4 follicles in right. Start stims: 375IU Follistim & 150IU Menopur. 6/19 Increase Follistim to 425IU, Menopur still 150IU. 6/18 add Ganirelix. 6/23 Ovidrel trigger SQ. 6/25 ER: 8R, 8M, 5F naturally. Start Medrol & Doxy. 6/26 Start Endometrin. 7/2 Start Lovenox.
7/8/14 Beta= 137.4 BFP!!! (My first from IVF!) E2- 1109, Prog- >60. Stop CoQ10, myo-inositol, and melatonin. 7/9 2nd Beta= 281.4. TSH- 2.70. Increasing Synthroid to 100mcg daily. 7/24 6w3d u/s measured 6w3d, hb: 121bmp! 8/5 8w1d u/s measured 8w3d, hb: 164bpm! Graduated from RE to OB. Now I just need to find an OB!
EDD 3/18/15!
I just wanted to say that I am so sorry for you and DH. My heart is with the both of you; I hope your docs can figure something out.
~love and light~
DX: Unexplained
BETA #1 59 BETA #2 148 BETA #3 283 BETA #4 2,783! US at 6w2d shows 1 bean measuring right on track! HR 121. US at 8w3d measuring on track HR 177. Released form my RE. EDD 12/28