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Fert Report: Day 1

RosyGlowRosyGlow member
in Infertility

Well, out of 29 retrieved, 12 were mature, and 11 fertilized. 

On the one hand, I'm thrilled that we had a high fertilization rate. On the other, I'm so confused as to why SO MANY were not mature. Is 1/3 maturity rate normal? Seriously?!? 

Since about 50% of them will have my "bad" gene, and it's likely that another 23% might have anueploidy issues. Although, the 23% aneuploidy is out of the number we send off for testing, and it may overlap with some of the unhealthy embryos affected by the gene, right? Frankly, I don't want to have 10 children, so we would be thrilled with not having too many "extras" anyway. I only need one healthy baby for starters, but with high numbers yesterday, I got my hopes up that we might avoid having to do a fresh cycle more than once. It's just such a delicate, fragile, frightening process. 

I'll admit - at first, I cried. Now I'm so worried about these embryos growing in the lab - I'm so scared that more will arrest before Sunday. I'm praying for miraculous growing rates, but I'm also trying to be realistic. We may lose more along the way, right? 

Help me stay positive? Prayers for my little growers would be much appreciated. 

| Married since 2008 | DH and I: Both 30 | Me: Endometriosis and Carrier of an X-Linked Dominant Genetic Disorder | DH: Low Morph | Planning IVF with PGD and PGS in 2013 | Freeze-All IVF #1: March 2013 ER 3/26. 29R, 12M, 11F. 4 5AA frozen blasts. Freeze-All IVF#2: May 2013 ER 5/15. 31R, 21M, 20F. 6 5AA frozen blasts. Our PGD probe was completed in late June (total of 20 weeks to develop). PGD and PGS Results came on 6/19: 3 healthy embryos (normal chromosomes and unaffected by my family's genetic disorder). FET #1: July 2013 Natural Cycle - Cancelled due to insufficient lining (only got to 7.5mm). FET #1.2: August 2013 - Medicated Cycle with Lupron & Estrogen Patches to build up lining. Single embryo transfer was 8/23. Beta #1: 240! Beta #2: 578! U/S on 9/19 at 6w4d: We saw the heart beating at 131bpm. Second U/S on 10/4 at 8w5d: We saw the heart beating at 178bpm. EDD 5/11/2014
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PAIF/SAIF/Everyone Welcome! 


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Re: Fert Report: Day 1

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    HappyWifeMrsKHappyWifeMrsK

    Hi RosyGlow!   Nice fert rate indeed! 

    It is disappointing of course to find out that they were not all mature :(

    I'm sure the 23% will overlap with some of the other embryos that pgd will rule out.  Still, 11 fertilize

    Me 27 DH 33 dx MFI
    1st cycle of IVF w/ ICSI = started bcp's 8/2/12, lupron 8/22/12, stims 9/7/12,ER 9.20.12 ET 9/23/12 3dt 1 6A and 1 4B; Positive HPT 10/2/12, BFP Beta 10/3/12: 38!, 2nd Beta 10/5/12 28 :( worst phone call ever. 3rd beta 10/9/10 2.9...
    IVF #2 w/ ICSI = bcp 3/1, ER/ET planned for the week of 4/8
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    sorrellam30sorrellam30 member
    Praying and rooting for you!

     


    imageimageimageimage

     
     

    *******siggy/ticker warning***** 

     Me(31). DH (31)

    DH SA normal count and motility, 1% morphology
    Me .72 AMH, Fragile X premutation carrier
    IVF #1 (6/12/13) BFN

    IVF #2 (8/16/13) BFN

    FET 10/4/13 Chemical

    IVF #3 MC 5 weeks 5 days

    IVF #4 DE 11/7 BFP, edd 7/28/15

    All Welcome

    BabyFruit Ticker

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    txcavtxcav member

    **Warning BFP in Siggy**

     

     

     Praying for you and so glad about this update. I feel like I have been a little out of the loop on keeping up with my Ducks the past few days. Eleven is a really great number, I am roo

    image
    Me:31 one blocked tube. DH:37 Perfection.
    March-June 2012: Au Naturale. No Luck
    July-November 2012: Letrazole. No Luck
    December 2012: Au Naturale. No Luck
    January 2013: Menopur & IUI
    IUI on 01-16-13. AF arrived day 11, BFN!!
    BCPs, 10 units Lupron started 2/20, Follistim & Menopur begin 3/2
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    RosyGlowRosyGlow member
    imageHappyWifeMrsK:
    Hi RosyGlow!nbsp;nbsp; Nice fert rate indeed!nbsp; It is disappointing of course to find out that they were not all
    | Married since 2008 | DH and I: Both 30 | Me: Endometriosis and Carrier of an X-Linked Dominant Genetic Disorder | DH: Low Morph | Planning IVF with PGD and PGS in 2013 | Freeze-All IVF #1: March 2013 ER 3/26. 29R, 12M, 11F. 4 5AA frozen blasts. Freeze-All IVF#2: May 2013 ER 5/15. 31R, 21M, 20F. 6 5AA frozen blasts. Our PGD probe was completed in late June (total of 20 weeks to develop). PGD and PGS Results came on 6/19: 3 healthy embryos (normal chromosomes and unaffected by my family's genetic disorder). FET #1: July 2013 Natural Cycle - Cancelled due to insufficient lining (only got to 7.5mm). FET #1.2: August 2013 - Medicated Cycle with Lupron & Estrogen Patches to build up lining. Single embryo transfer was 8/23. Beta #1: 240! Beta #2: 578! U/S on 9/19 at 6w4d: We saw the heart beating at 131bpm. Second U/S on 10/4 at 8w5d: We saw the heart beating at 178bpm. EDD 5/11/2014
    image
    PAIF/SAIF/Everyone Welcome! 


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    Sunny BSunny B member

    You still have some great numbers!!

    And keep your hopes up that you may not have to do another fresh cycle at all!

    All my prayers for you :) It seems like you will be in a good position.

    TTC since May 2012
    Me: 32 H: 31
    DX: MFI-Very Low Count, I have Hashimotos.
    IVF prep September 2013 cancelled due to Ovarian Cyst
    IVF #1 October 2013 Antagonistic Protocol with ICSI  ER 10/31/13 (18R 16M 11F- 6 blasts to freeze)
    ET delayed due to OHSS 
    FET scheduled for July 8. Delayed due to a crazy high TSH (it had been under control for YEARS!)
    FET #1 8/5/14 sET BFN 

    All welcome!
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    JulieannT15JulieannT15 member

    Your numbers are good!  I actually had 37 eggs, only 13 mature, 9 fertilized right away and 4 made it to day 6 and frozen.  I was initially upset with the report of only 9 being fertilized out of 37, but really, you only need a few.  Aga

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    BrideJackie11BrideJackie11 member

    imageRosyGlow:
    imageHappyWife

    <Image and video hosting by TinyPic
    Married June 2011 Dx: anovulatory due to prolactinoma (1.5cmx 1.5cm in 2006)
    April 2012: MRI- questionable cyst 8mg by 12mm in pituitary ; referred to RE by Ob-gyn after amenorrhea x 4+ months, provera ineffective, low estrogen level
    cycle 1: May 2012, clomid 50mg; cycle cancelled, thin lining, no response
    cycle 2: June 2012, femara 5mg; cycle cancelled, no response
    cycle 3: July 2012, femara 7.5mg; cycle cancelled (largest folli on Cd12 & cd 16: 11, lining 4)
    Repeat MRI July 25,2012- Cyst unchanged, likely old infarction.
    Aug. 8: met with RE, move to injectables if HSG and SA normal
    Aug. 23: HSG all clear; DH- perfect
    Switched to a new RE in early Sept. IVF here we come
    Genetic testing reveals: Fragile X- Intermediate risk/grey zone.
    IVF#1: ER 11/30: 14 retrieved, 10 mature, 7 fertilized. E2 prior to trigger 5200. Decision made to freeze 6 embryos and transfer later due to OHSS.
    IVF#1.2/FET #1: estrogen injects start 1/18, FET delayed to try to thicken lining. lining 5.4mm. FET- 2/18- transferred one 3AA expanded blast. BFP 5dp5dt. Beta #1- 2/27 9dp5dt- 102.27 beta #2 3/1: 147 :(, beta #3 3/4: 268 told to stop meds and let nature take its course. requested 4th beta (3/6); Beta hell for 2 months.

    FET # 2: endometrial scratch 5/6, added estrace vaginally and ASA to delestrogen and PIO. June 10- transferred one 4AA hatched embryo, BFP 4dp6dt, Beta 1 (9dp6dt) 187, Beta 2 (11dp6dt): 412; Beta 3 (15dp6dt ): 4452. U/S #1- one beautiful embryo with a heartbeat of 133 at 7 weeks.  8 weeks: heartbeat 156. EDD 2/26/2014: born 2-3-14 induced due to Pre-E and HELLP at 36w5d.

    12/1: met with RE to discuss trying for #2


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    curlylocks3curlylocks3 member
    I'm sorry you didn't have a higher number turn out to be mature but I am hoping the 11 you had fertilize are growing away and the PGD testing goes well!
    image  image
    О Привязать! Z!
    The Science Babies debuted 5/6/14 @ 34 weeks
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    PurpleIris30PurpleIris30 member
    Rosy, do you know the size of all your follicles and E2 at trigger?
    My clinic says that roughly half of day 3 embryos will make it to day 5. Significantly less will make it to be frozen. But keep in mind those are just averages and your quality sh
    Married 8/2008. IVF with PGD March 2013.
    3/22 ER: 25R, 20M, 15F. 9 genetically normal, and 3 survived to Day 5
    3/27 ET: transferred 1 embryo, beta 9dp5dt=163, 12dp5dt=639
    4/25 1st ultrasound at 7 weeks = identical twins with heartbeats?!!!
    PPROM at 31w, delivery at 32 weeks of two beautiful girls
    image
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    PurpleIris30PurpleIris30 member
    Also remember that freezing standards vary a lot by clinic if you are going to compare your results. You are still in this but it is always hard to be disappointed, I know.
    Married 8/2008. IVF with PGD March 2013.
    3/22 ER: 25R, 20M, 15F. 9 genetically normal, and 3 survived to Day 5
    3/27 ET: transferred 1 embryo, beta 9dp5dt=163, 12dp5dt=639
    4/25 1st ultrasound at 7 weeks = identical twins with heartbeats?!!!
    PPROM at 31w, delivery at 32 weeks of two beautiful girls
    image
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    RosyGlowRosyGlow member

    imagePurpleIris30:
    Rosy, do you know the size of all your follicles and E2 at trigger? My clinic says that roughly half of day 3
    | Married since 2008 | DH and I: Both 30 | Me: Endometriosis and Carrier of an X-Linked Dominant Genetic Disorder | DH: Low Morph | Planning IVF with PGD and PGS in 2013 | Freeze-All IVF #1: March 2013 ER 3/26. 29R, 12M, 11F. 4 5AA frozen blasts. Freeze-All IVF#2: May 2013 ER 5/15. 31R, 21M, 20F. 6 5AA frozen blasts. Our PGD probe was completed in late June (total of 20 weeks to develop). PGD and PGS Results came on 6/19: 3 healthy embryos (normal chromosomes and unaffected by my family's genetic disorder). FET #1: July 2013 Natural Cycle - Cancelled due to insufficient lining (only got to 7.5mm). FET #1.2: August 2013 - Medicated Cycle with Lupron & Estrogen Patches to build up lining. Single embryo transfer was 8/23. Beta #1: 240! Beta #2: 578! U/S on 9/19 at 6w4d: We saw the heart beating at 131bpm. Second U/S on 10/4 at 8w5d: We saw the heart beating at 178bpm. EDD 5/11/2014
    image
    PAIF/SAIF/Everyone Welcome! 


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    PurpleIris30PurpleIris30 member
    Hey Rosy, your E2 levels are right in line with the number of mature eggs you ended up with. The rule of thumb is about 200 per mature follicle and your E2 will continue to rise after trigger. Follicles under 15 at trigger likely will not be mature, or a
    Married 8/2008. IVF with PGD March 2013.
    3/22 ER: 25R, 20M, 15F. 9 genetically normal, and 3 survived to Day 5
    3/27 ET: transferred 1 embryo, beta 9dp5dt=163, 12dp5dt=639
    4/25 1st ultrasound at 7 weeks = identical twins with heartbeats?!!!
    PPROM at 31w, delivery at 32 weeks of two beautiful girls
    image
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    PurpleIris30PurpleIris30 member
    I forgot to add that you do not want your follicles to get too large so I do not know if an extra day would have been advised with the size of your follicles. I think when you have a couple over 18, you will likely trigger.
    Married 8/2008. IVF with PGD March 2013.
    3/22 ER: 25R, 20M, 15F. 9 genetically normal, and 3 survived to Day 5
    3/27 ET: transferred 1 embryo, beta 9dp5dt=163, 12dp5dt=639
    4/25 1st ultrasound at 7 weeks = identical twins with heartbeats?!!!
    PPROM at 31w, delivery at 32 weeks of two beautiful girls
    image
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    RosyGlowRosyGlow member

    imagePurpleIris30:
    Hey Rosy, your E2 levels are right in line with the number of mature eggs you ended up with. The rule of thumb
    | Married since 2008 | DH and I: Both 30 | Me: Endometriosis and Carrier of an X-Linked Dominant Genetic Disorder | DH: Low Morph | Planning IVF with PGD and PGS in 2013 | Freeze-All IVF #1: March 2013 ER 3/26. 29R, 12M, 11F. 4 5AA frozen blasts. Freeze-All IVF#2: May 2013 ER 5/15. 31R, 21M, 20F. 6 5AA frozen blasts. Our PGD probe was completed in late June (total of 20 weeks to develop). PGD and PGS Results came on 6/19: 3 healthy embryos (normal chromosomes and unaffected by my family's genetic disorder). FET #1: July 2013 Natural Cycle - Cancelled due to insufficient lining (only got to 7.5mm). FET #1.2: August 2013 - Medicated Cycle with Lupron & Estrogen Patches to build up lining. Single embryo transfer was 8/23. Beta #1: 240! Beta #2: 578! U/S on 9/19 at 6w4d: We saw the heart beating at 131bpm. Second U/S on 10/4 at 8w5d: We saw the heart beating at 178bpm. EDD 5/11/2014
    image
    PAIF/SAIF/Everyone Welcome! 


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    PurpleIris30PurpleIris30 member
    I did not post my results. I had 25 eggs retrieved, 20 mature, 15 fertilized and were biopsied on day 3.  This morning we learned 9 of the 15 were unaffected and 4 of those 9 were still progressing. They transferred one and are observing the other 3
    Married 8/2008. IVF with PGD March 2013.
    3/22 ER: 25R, 20M, 15F. 9 genetically normal, and 3 survived to Day 5
    3/27 ET: transferred 1 embryo, beta 9dp5dt=163, 12dp5dt=639
    4/25 1st ultrasound at 7 weeks = identical twins with heartbeats?!!!
    PPROM at 31w, delivery at 32 weeks of two beautiful girls
    image
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    RosyGlowRosyGlow member
    imagePurpleIris30:
    I did not post my results. I had 25 eggs retrieved, 20 mature, 15 fertilized and were biopsied on day 3. nbsp;This mo
    | Married since 2008 | DH and I: Both 30 | Me: Endometriosis and Carrier of an X-Linked Dominant Genetic Disorder | DH: Low Morph | Planning IVF with PGD and PGS in 2013 | Freeze-All IVF #1: March 2013 ER 3/26. 29R, 12M, 11F. 4 5AA frozen blasts. Freeze-All IVF#2: May 2013 ER 5/15. 31R, 21M, 20F. 6 5AA frozen blasts. Our PGD probe was completed in late June (total of 20 weeks to develop). PGD and PGS Results came on 6/19: 3 healthy embryos (normal chromosomes and unaffected by my family's genetic disorder). FET #1: July 2013 Natural Cycle - Cancelled due to insufficient lining (only got to 7.5mm). FET #1.2: August 2013 - Medicated Cycle with Lupron & Estrogen Patches to build up lining. Single embryo transfer was 8/23. Beta #1: 240! Beta #2: 578! U/S on 9/19 at 6w4d: We saw the heart beating at 131bpm. Second U/S on 10/4 at 8w5d: We saw the heart beating at 178bpm. EDD 5/11/2014
    image
    PAIF/SAIF/Everyone Welcome! 


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    shewolf576shewolf576 member
    11 is still good. Stay positive and we will keep you in prayers
    Married since 2004 Primary POF Foster parent but have no had an adoption trying embryo adoption Just want a forever baby RE jacksonville FL FIRM
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    monkandnutmonkandnut member
    I don't have any answers for you - but just wanted to say I'm sending T&P your way!!! Best of luck with everything!!!
    TTC #1 since 02/2011
    Me~35 DH~37
    Dx- Unexplained Infertility
    3/21/12- BFP, 4/9/12- M/C
    8/12- IUI #1- BFN
    9/26 & 9/27-IUI #2- back to back- BFN
    Moved on to RE- 10/18
    11/12- IUI #3- 75iu Follistim and HCG Trigger- BFN
    12/12- IUI #4- Cancelled due to Cyst
    1/13- IUI #4.1- 100iu Follistim and HCG Trigger- BFN
    2/9/13- Started BCP in prep for IVF #1
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