Infertility
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EPP with a higher AFC?

Has anyone here done an EPP (estrogen priming protocol) with a higher AFC (antral follicle count)?

I know EPP is generally used in DOR cases and I have a fairly high AFC (usually around 24) but, in past IVFs, have had egg maturity issues and some egg quality issues. Those 2 reasons are the basis behind the EPP in my case for this next IVF.

So I'm wondering, if anyone had done this protocol with a higher AFC - what were your results at retrieval with count, maturity and fert?

Thanks... and hearts.

BzeetyD = 38, Mr. BzeetyD = 44 together 12/02 married 9/08
TTC #1 since 1/10
DX: Unexplained/??? MFI issues

Our lil' lost sparks:
5w3d loss 7/30/10 - EDD March 2011
8w loss 4/15/11 - EDD November 2011
8w3d loss 8/2/12 - EDD March 2013
4w c/p loss 10/29/12 - EDD July 2013

Long story: trying on our own + testing testing testing with 6 rounds of Clomid, more testing, injectables + TI, laparoscopy - one tube blocked, 2 IUIs with Follistim...BFNs.
RPL testing all normal, Karyotyping normal

Moving on to IVF.

IVF #1 April 2012 = BFN, IVF #2 June 2012 = BFP. U/S 7/23 = saw heartbeat but measuring behind. Follow up U/S on 7/30 - no heartbeat. D&C 8/2. Trisomy 12. IVF #3 Oct 2012 = Chemical Pregnancy

Phone consult with CCRM on 12/12/12 - ODWU 1/4/13 - both tubes clear(!) - AFC 24, AMH 3.2, FSH 9.6, LH 5.4, E2 25. DH has high frag rate but improved!
IVF #4 March 2013 CCRM. EP protocol w/ Menopur, Gonal-F & Dexamethasone. ER 3/29 & IMSI, PICSI. 43R 13M 10F 6blasts bio'd. CCS testing reveals 3 normals!!!
FET 5/31/13 of 1 4AA blast - thawed and expanded. 4dp5dt BFP.
Beta 9dp5dt = 181, 11dp5dt = 427. 1st u/s showed a healthy heartbeat! EDD 2/16/14

After 4 years of hoping and heartbreak, our sweet little bean was born on 2/19/14
We are so in love with her.

"I'm not telling you it's going to be easy, I'm telling you it's going to be worth it."

Everybody is welcome!!!

Re: EPP with a higher AFC?

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    Obviously I have no results yet - but that's what we are doing this cycle.  And pretty much every RE that I talked to about our case suggested we try EPP at this point.  And I definitely don't have DOR - I've gotten between 11 and 23 eggs on each of our IVFs. 

     TTC #1 since 6/09
    Dx: PCOS and MFI
    3 IUIs, 4 IVFs = BFFN
      3rd RE: IVF #5/FET = BFP
    14dp5dt=1170 16dp5dt=2573

    1st u/s=
    TWINS!
    It's a Boy and a Girl!

    Born at 34w3d! 
     

  • Options
    imagehootie123:

    Obviously I have no results yet - but that's what we are doing this cycle.  And pretty much every RE that I talked to about our case suggested we try EPP at this point.  And I definitely don't have DOR - I've gotten between 11 and 23 eggs on each of our IVFs. 

    I'm really rooting for good results from you Hootie! Lead the way this month.

    BzeetyD = 38, Mr. BzeetyD = 44 together 12/02 married 9/08
    TTC #1 since 1/10
    DX: Unexplained/??? MFI issues

    Our lil' lost sparks:
    5w3d loss 7/30/10 - EDD March 2011
    8w loss 4/15/11 - EDD November 2011
    8w3d loss 8/2/12 - EDD March 2013
    4w c/p loss 10/29/12 - EDD July 2013

    Long story: trying on our own + testing testing testing with 6 rounds of Clomid, more testing, injectables + TI, laparoscopy - one tube blocked, 2 IUIs with Follistim...BFNs.
    RPL testing all normal, Karyotyping normal

    Moving on to IVF.

    IVF #1 April 2012 = BFN, IVF #2 June 2012 = BFP. U/S 7/23 = saw heartbeat but measuring behind. Follow up U/S on 7/30 - no heartbeat. D&C 8/2. Trisomy 12. IVF #3 Oct 2012 = Chemical Pregnancy

    Phone consult with CCRM on 12/12/12 - ODWU 1/4/13 - both tubes clear(!) - AFC 24, AMH 3.2, FSH 9.6, LH 5.4, E2 25. DH has high frag rate but improved!
    IVF #4 March 2013 CCRM. EP protocol w/ Menopur, Gonal-F & Dexamethasone. ER 3/29 & IMSI, PICSI. 43R 13M 10F 6blasts bio'd. CCS testing reveals 3 normals!!!
    FET 5/31/13 of 1 4AA blast - thawed and expanded. 4dp5dt BFP.
    Beta 9dp5dt = 181, 11dp5dt = 427. 1st u/s showed a healthy heartbeat! EDD 2/16/14

    After 4 years of hoping and heartbreak, our sweet little bean was born on 2/19/14
    We are so in love with her.

    "I'm not telling you it's going to be easy, I'm telling you it's going to be worth it."

    Everybody is welcome!!!
  • Loading the player...
  • Options
    imageBzeetyD:
    imagehootie123:

    Obviously I have no results yet - but that's what we are doing this cycle.  And pretty much every RE that I talked to about our case suggested we try EPP at this point.  And I definitely don't have DOR - I've gotten between 11 and 23 eggs on each of our IVFs. 

    I'm really rooting for good results from you Hootie! Lead the way this month.

    Thanks - me too!  I have to say - I am not a fan of the estrogen patches or supps that I am on - I've managed to get to this point without using either of them.   The estrogen patch isn't bad - but my nurse told me to tape it down and the tape bothered me - it itched around the edges until I finally took off the tape and just left the patch as is.  Now I'm 6 days in and I think I need to add a piece of tape again so that I can make it until tomorrow when I am supposed to replace it.   And well the supps are a mess and I had some trouble with them sliding right back out just walking from the bathroom to my bed!

     TTC #1 since 6/09
    Dx: PCOS and MFI
    3 IUIs, 4 IVFs = BFFN
      3rd RE: IVF #5/FET = BFP
    14dp5dt=1170 16dp5dt=2573

    1st u/s=
    TWINS!
    It's a Boy and a Girl!

    Born at 34w3d! 
     

  • Options
    imagehootie123:
    imageBzeetyD:
    imagehootie123:

    Obviously I have no results yet - but that's what we are doing this cycle.  And pretty much every RE that I talked to about our case suggested we try EPP at this point.  And I definitely don't have DOR - I've gotten between 11 and 23 eggs on each of our IVFs. 

    I'm really rooting for good results from you Hootie! Lead the way this month.

    Thanks - me too!  I have to say - I am not a fan of the estrogen patches or supps that I am on - I've managed to get to this point without using either of them.   The estrogen patch isn't bad - but my nurse told me to tape it down and the tape bothered me - it itched around the edges until I finally took off the tape and just left the patch as is.  Now I'm 6 days in and I think I need to add a piece of tape again so that I can make it until tomorrow when I am supposed to replace it.   And well the supps are a mess and I had some trouble with them sliding right back out just walking from the bathroom to my bed!

    Sorry things are getting funky for you. I hope as your stims start, things get better.

    My EPP is different in that I'm using oral estrogen and cetrotide after my LH surge this cycle to keep things quiet (aka not allow my body to recruit any eggs early.) I've read that there are varying EPPs, and I wonder if there's a typical way they're done. Maybe mine is a weirdo.

     

    BzeetyD = 38, Mr. BzeetyD = 44 together 12/02 married 9/08
    TTC #1 since 1/10
    DX: Unexplained/??? MFI issues

    Our lil' lost sparks:
    5w3d loss 7/30/10 - EDD March 2011
    8w loss 4/15/11 - EDD November 2011
    8w3d loss 8/2/12 - EDD March 2013
    4w c/p loss 10/29/12 - EDD July 2013

    Long story: trying on our own + testing testing testing with 6 rounds of Clomid, more testing, injectables + TI, laparoscopy - one tube blocked, 2 IUIs with Follistim...BFNs.
    RPL testing all normal, Karyotyping normal

    Moving on to IVF.

    IVF #1 April 2012 = BFN, IVF #2 June 2012 = BFP. U/S 7/23 = saw heartbeat but measuring behind. Follow up U/S on 7/30 - no heartbeat. D&C 8/2. Trisomy 12. IVF #3 Oct 2012 = Chemical Pregnancy

    Phone consult with CCRM on 12/12/12 - ODWU 1/4/13 - both tubes clear(!) - AFC 24, AMH 3.2, FSH 9.6, LH 5.4, E2 25. DH has high frag rate but improved!
    IVF #4 March 2013 CCRM. EP protocol w/ Menopur, Gonal-F & Dexamethasone. ER 3/29 & IMSI, PICSI. 43R 13M 10F 6blasts bio'd. CCS testing reveals 3 normals!!!
    FET 5/31/13 of 1 4AA blast - thawed and expanded. 4dp5dt BFP.
    Beta 9dp5dt = 181, 11dp5dt = 427. 1st u/s showed a healthy heartbeat! EDD 2/16/14

    After 4 years of hoping and heartbreak, our sweet little bean was born on 2/19/14
    We are so in love with her.

    "I'm not telling you it's going to be easy, I'm telling you it's going to be worth it."

    Everybody is welcome!!!
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