Infertility

IVF Vet ?: Menopur Burn

This is a question for all you IVF vets out there. I did my first Menopur shot last night and MAN did that thing burn. The whole time I was injecting it I was hissing through my teeth because of the burning sensation. I also bled quite a bit and have a nice lil bruise today.

Any tips to decrease the burning sensation? Should I wait a few minutes to inject it after mixing, ice the area, pinch the skin more, or am I grasping at straws and just have to deal with the pain? If I can do anything to help a little bit with the pain, I'm all for it!!

TIA! 

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Re: IVF Vet ?: Menopur Burn

  • When I did my injection, it didn't hardly burn at all. I did do that one first, before my Follistim, to get it out of the way first and I went REALLY slow. Like I counted to 15 or 20 during the injection itself. I never iced for any of my injections.

    Good luck! I hope you can figure out a way that's less painful!
    Me: 37, DH: 35 :: TCC since 2/11 SA: Perfect! CD3  HSG = Blocked Right Tube
    April- Femara 2.5mg + Trigger + IUI = BFN   May- Femara 5mg = CX - No Response on Left = BFN
    June- Femara 7.5mg + Trigger + IUI = BFN  August- Lap & Hysteroscopy = Blocked & Partially Blocked Tubes
    September- Femara 5mg = CX - No Response on Left = BFN  October- 100mg Clomid + Trigger + TI = BFN
    IVF # 1: Stims 11/30 ER 12/12/12! (10R, 10M, 8F, 2T, 6 F) :: Beta #1- 176  c/p @ 4w4d
    FET #1 February 26th :: Lost 4 to Thaw, Transferred 2 = BFFN
    IVF # 2 Stims 5/10 ER 5/21 (15R, 13M, 13F, 2T, 7F- 6d3 & 1d5) :: Beta # 1- 15 c/p @ 4w
    FET #2 Cancelled, Right Tube Developed a Hydro  8/28 Hydro & Scar Tissue Removed  Cleared for FET
    FET #2.2 Scheduled for September 20th
    2 Thawed, 2 Transferred! Beta #1- 96, Beta #2 906! :: EDD June 10th
    2015- 2 failed FET. We are done
    SURPRISE! BFP 8/8/16   EDD 4/1/17

     
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  • I actually never felt a burn with Menopur (but I did with my trigger shot).  I would ice the area first.  Also, I did all my injections in my thigh, which was less painful overall for me.

    My TTC Journey:
    Dx: Hypothalamic amenorrhea / mild PCOS (Pretty much a hormone/ovulatory disorder)
    Progesterone to induce period w/ the goal of Clomid - never got period (September 2011). Referred to RE.
    Femera - never responded to the meds (December 2011)
    Clomid with TI - BFN (February 2012)
    Injectables (Menopur) - hyperstimulated/canceled (March 2012)
    Injectables #2 (Menopur) with TI- BFN (May 2012)
    IVF - OHSS (transfer canceled), but 11 frozen! (June 1012)
    FET - 1 transferred on 8/09/12. Beta#1 (11dp5dt): 350.3; Beta#2: 365; Beta#3: 157. Biochemical pregnancy.
    FET # 2 - 1 transferred on 11/01/12. Beta#1 (11dp5dt): 337; Beta#2: 769. BFP!!! 1st ultrasound 11/28/12 showed heartbeat, but measuring 5 days behind. 2nd ultrasound 12/05/12 - miscarriage.
    FET # 3 - 1 transferred on 1/24/13. Beta#1 (11dp5dt): BFN.
    FET # 4 - 2 transferred on 3/21/13.  Bet #1 (11dp5dt): 660; Beta#2: 1,300.  Miscarried at home @ 6 weeks.

    FET # 5 - 2 transferred on 7/12/13.  Beta #1 (10dp6dt): BFN.
    Attempted an IUI in late August 2013, but didn't respond well.
    IVF #2 with PGS - Stims started 10/28 with retrieval on 11/11.  Of 14 mature eggs, 10 fertilized, 4 made it to Day 5 & 1 made it to Day 6. We did PGS on the Day 5 embryos, and 3 of 4 were normal. Had ET on 11/17. Beta #1 (8dp6dt): 203. Beta #2 (10dp6dt): 618. We since had two ultrasounds & on 12/19, our RE released us to the OB.  On 1/02/14, we had our first ultrasound with the OB where we heard the heartbeat.  We are so thankful for the blessing & crossing every finger & toe for a healthy & successful pregnancy.

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  • No suggestions, it just burns. I always try to do it quick, while most time swearing. Good luck!!!
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  • I so feel your Menopur pain! It burns like hell for me every single night! It is just awful and never has gotten better for me. I mix the Follistim and Menopur, and I can seriously feel the second the Follistim is done going in and the Menopur starts. I would definitely suggest icing for at least 5 minutes (or until numb). I have been bleeding and bruising every night. It all just SUCKS!!! I start swearing at MH's sperm as he injects me every night. Somehow, you will make it through, I promise!!! :) Oh, and I also lay a heating pad on my tummy after the burn for a few minutes. That really soothes it. I know some think that could be harmful, but all of my docs have said it was completely safe. 
             

            

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     Me (34)- no issues found MH (36)- MFI due to Vericocele. Straight to IVF w/ICSI 9/12, Antagonist. 9R, 7M, 5F = BFN c/p,  New RE for IVF #2- 1/13., Long Lupron. ER on 1/22 -10R, 9M, 9F. Transfer on hold due to overstimming. FET in Feb. 2 frozen blasts. Another BFN & another c/p. RPL testing all negative besides MTHFR gene, vericocle repair surgery 4/12/13-Bilateral Grade 3 Vericocele found & fixed, IVF #3 with PGS  4/13- 11R, 9M, 9F. Transferred 2 normal=BFN, 3 normal on ice. CCRM-here we come! ODWU-All test results normal. EPP in August. 21R, 20M, 19F. 12 blasts biopsied & frozen for CCS testing. Results showed 11 normal! FET Oct. 30. 2 5d 4AA blasts transferred. First ever BFP!!! Beta 1=216, Beta 2=870 1st U/S=It's TWINS!!! It's a BOY and a GIRL!! Everyone Welcome!!! 
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  • Hi! I started Menopur on Monday morning - before work crazy! Anyway I lay with an ice pack the entire time DH is mixing and trying to play the part of every doctor he has seen on tv. The ice really seems to help as well as I pinch my own skin up right before the injection and I squeeze pretty hard - seems to take my mind off of it, oh and i sing or start rambling about what i am going to do that day. i am a huge baby when it comes to injections. I hope that helps! Oh and buy some cute band-aides - those help too if only to make you smile. GL!

  • Menopur burned for me as well. I alternated injecting it relative fast (for less burning time) and injecting slowly (for less intense burning over a long time). You could ice it before hand but for me that did absolutely nothing.
  • There doesnt seem to be a lot of rhyme or reason to my menopur burn, but I do notice it helps to inject slowly and make sure it's mixed really well.
    "Everything will be alright in the end. So if it's not alright, it is not yet the end."
    Me:29 DH:29  TTC since 1/11 Dx: unexplained IF/early DOR/immune issues 
    Feb'12- July'12-testing(all clear minus slight arcuate ute), 3 IUI with clomid all BFN
    8/30IVF#1 Antagonist protocol- ER 9/11-8R, 7M, 5F. 
    ET 9/14 2 embies transferred. 1 10cell Grade 4, 1 8cell Grade 4. No frosties. BFN
    IVF#2 Antagonist protocol plus baby aspirin- ER 12/5-16R, 12M, 8F!
    ET 12/10 5dt! 1 fully expanded blast & 1 early blast. No frosties. BFN
    3/13 hysteroscopy & polypectomy, Consulted w Dr. Kwak-Kim.  
    DX: High NK cells, cytokines, DHEAs& PAI1;  hypothyroid, +APA, restricted bloodflow
    7/13 IVF#3 Long lupron protocol with PIO, Crinone, Prometrium, and vivelle
    (plus synthroid, metformin, baby asa, metanx, PNV, Vit E, D, calcium, fish oil, CoQ10, IVIg infusions and lovenox per Dr. Kwak-kim)
    ER 7/19 14R, 11M, 9F(4 natural fert, 5 with ICSI)
    ET 5dt 7/24 2 fully expanded blasts.  SURPRISE 3 FROSTIES!!!
    Beta #1 8/2 335!!!! Beta #2 829!!!  1st u/s 8/14 showed TWINS!!!!!
    11/11: TEAM PURPLE!!!!!
    3/21/14-L&W born at 37w via csection

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  • Yep, it burns. Ice and pinch is the way I did it.
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    Started TTC June 2011Cycles #1-10 = BFNCycle #11: 100 mg Clomid + TI =BFNReferred to RE March 2012HSG all clear, FSH = 13, Prolactin = 28, S/A = greatApril 2012 MRI to check for brain tumor due to elevated Prolactin = clearJune 2012 Hysteroscopy to remove uterine polyps and partial septateJuly 2012 IUI #1 7/7/12 = BFNAugust 2012 IUI #2.1 Cancelled due to early/missed ovulation = BFNSeptember 2012 Forced break due to one huge cyst October 2012 IUI #2.2 = BFNNovember 2012 Begin BCPs for IVF #1December 2012 IVF #1 = Delayed due to cyst. Start stims 12/22January 2013 ER: 1/2, 14R, 10M, 9FET: 1/7 Transferred 1 "Perfect" blast! 4 frosties!Beta #1: 99 BFP! #2: 227 #3: 584 #4: 3,020Baby Boy born September 25, 2013

    TTC #2
    November 2014 - Begin BCPs
    December 2014 - Start Lupron 12/25
    January 2015 - FET #1

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  • I think I was immune to the true Menopur burn since its nowhere near as the fun of my Lovenox injection, LOL.

    Like pp said inject it really really slow. That did help me out a lot and I never iced any of my shots, I didn't really feel that I needed it but if it helps go for it!

    Hope they get better!

    Me: 33, Endocrine issues & FVL       DH: 32, Nothing 
    NTNP 2009-2012         TTC since 2012:
    • Clomid, 2 IUI cycles, and 5 IVF cycles = BFN
    • FET #1   August 2013 = BFP!     EDD 5/11/14
    • Jack dx at 19w1d with Dandy Walker on 12/16/13
    • Severe Pre-e /HELLP set in Jack born sleeping at 20w1d on 12/23/13
    • FET #2 --July 2014  BFP!  ---  EDD  4/5/15

    Jack has handpicked his sibling up there :)

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  • Ugh yes burned for me too! I tried two mix it and let it sit while I did my other injection (gonal f). I also did ice each time before hand but it is just not fun. Afterwards I rewarded myself with some sweets! Hang in there!
    Me:30 low AMH; DH:30 MFI (count, motility, morphology)
    2 rounds clomid 100 mg -BFN
    IUI#1- 25 mg clomid- July 2012= BFN!
    IUI #2 August = BFN!
    IUI #3 September = BFN!

    IVF #1 November - converted to IUI #4 due to poor response = BFN
    IVF #1.2 February- converted to IUI #5 due to poor response = BFN
    IVF #1.3 April- micro dose Lupron flare with HGH; 14R, 13M, 11F! Transfer of 1 day 5 blast on 4/30, 4 frosties. BFP! Beta #1 9dp5dt= 179; Beta #2 11dp5dt= 442; Beta #3 4106 Stick baby stick!!

    *trying to keep hope*




  • Honestly, nothing ever decresed the burning sensation for me. I tried ice, pinching myself extra hard...mixing the injections...nope...still burned. Sorry:-(

    ~TTC#1 Since July 2011~ 
    Dx: Fibroids & Tubal Infertility
                                                        9/12 -IVF#1 =BFN; 5/14 -IVF#2=BFP:-) EDD 2.19.2015                                                

    S/PAIF Welcome 





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  • Oh yes the lovely burn. For all my cycles and will when I start it tom. I do it slow and alternate sides. I also pinch and put it in a 90 degree angle. I think there is no real way to go around the burning. I was told not to ice, so I never did with any injections. If you are bleeding and bruising prob. putting it in to hard or pressing. Pull back on the plunger more <3
    Married BF 6/29/2002/
    TTC Since Aug 2011/
    ME:34 all clear/DH:41 DX Severe MFI/
    IVF w/ICSI OCT 2012 Stims started 10/8/ER 10/19/12/ET 10/24/Beta#1 11/2=BFN (beta was 1.2)

    IVF 2.0-Baseline 11/7/12 beta 0/All Clear
    Stim start 11/7/12//ER 11/19 11M//10F
    ET 2 embies 11/24//Beta#1 28 Beta #2 23 Beta#3 29
    stop meds Beta#4 37/C/P 5W5D EDD:8/12/13/IVF#3 in Jan

    Ivf 3-frozen 3 poor 3day/fet=bfn

    Ivf#4 New dr. New protocol=beta1 197 beta#2 677 beta#3 1557
     u/s 8/13 =TWINS 2 strong hb
    Due Date 4/4/14

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