I was on letrozole 2 pills cd 5-9 and had an ultrasound cd 18 which showed one 12mm follicle. I went back to doctor on cd 22 and had zero follicles (other than small ones) and he said the lining was thin. He said I didn't ovulate based on the lining and no fluid showing ovulation (plus I didn't feel that I did). He told me to take 3 pills of letrozole starting on cd 22 for 5 days and to return on Jan 15. Is there any harm in not waiting for af and starting mid-cycle like that?
TTC #2 since 2009 Have PCOS two close calls with letrozole and hcg trigger. Hoping 3rd time does the trick...

Re: mid cycle meds???
From what I understand, if your lining is thin enough and there are no follicles you can start meds again. Did he say to start on CD22 or does he mean to count the day you start as CD5 since you did not get AF?
I started a round of injectibles last month without having AF. My lining was thin and I had no follicles. We just started over as CD1 the day I had my US.
Pregnant with Letrazole (Femara) on the first cycle with DD after TTC 2+ years
TTC#2 with Letrazole (Femara) since January 2012
BFP 06.29.12 EDD 03.11.13 natural m/c 07.13.12
BFP 09.22.12 EDD 05.31.13 natural m/c 10.07.12
CP 11.09.12
BFP 01.01.13 EDD 09.15.13 d&c 01.24.13
BFP 03.26.13 EDD 12.04.13
<a href="http://www.thebump.com/?utm_source=ticker&utm_medium=HTML&utm_campaign=tickers" title="Pregnancy"><img src="http://global.thebump.com/tickers/tt1d0e64" alt=" Pregnancy Ticker" border="0" /></a>
TTC #2 since 2009 Have PCOS two close calls with letrozole and hcg trigger. Hoping 3rd time does the trick...
Pregnant with Letrazole (Femara) on the first cycle with DD after TTC 2+ years
TTC#2 with Letrazole (Femara) since January 2012
BFP 06.29.12 EDD 03.11.13 natural m/c 07.13.12
BFP 09.22.12 EDD 05.31.13 natural m/c 10.07.12
CP 11.09.12
BFP 01.01.13 EDD 09.15.13 d&c 01.24.13
BFP 03.26.13 EDD 12.04.13
<a href="http://www.thebump.com/?utm_source=ticker&utm_medium=HTML&utm_campaign=tickers" title="Pregnancy"><img src="http://global.thebump.com/tickers/tt1d0e64" alt=" Pregnancy Ticker" border="0" /></a>
TTC #2 since 2009 Have PCOS two close calls with letrozole and hcg trigger. Hoping 3rd time does the trick...
Pregnant with Letrazole (Femara) on the first cycle with DD after TTC 2+ years
TTC#2 with Letrazole (Femara) since January 2012
BFP 06.29.12 EDD 03.11.13 natural m/c 07.13.12
BFP 09.22.12 EDD 05.31.13 natural m/c 10.07.12
CP 11.09.12
BFP 01.01.13 EDD 09.15.13 d&c 01.24.13
BFP 03.26.13 EDD 12.04.13
<a href="http://www.thebump.com/?utm_source=ticker&utm_medium=HTML&utm_campaign=tickers" title="Pregnancy"><img src="http://global.thebump.com/tickers/tt1d0e64" alt=" Pregnancy Ticker" border="0" /></a>