XP: Adding MTHFR to the diagnosis — The Bump
Secondary IF

XP: Adding MTHFR to the diagnosis

I don't know how these blood tests weren't done before by the first RE, but I just got an email from the current RE's nurse saying this last round of testing shows I'm compound heterozygous for MTHFR.  Yay.  Let's just add that to my LPD, low AMH and the fact that I'm AMA.  I'm seriously starting to feel like everything is wrong with me.  It's getting depressing. I'll start adding baby aspirin today and we'll do lovenox starting at transfer for the IVF cycle in January.

The farther along we go down this path, the more I think DD truly is a miracle.  With all that I feel is stacked against us now, how in the world did we conceive her on our own and carry that pregnancy through with no problem?  So very blessed to have her.  

TTC #1 since 6/08. Cycle #6 - BFP 12/22/08, EDD 9/3/09, DD 8/14/09 at 37w1d
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TTC #2 since 6/11
me=36 - low AMH, DH=38
BFP #2 - 8/31/11, EDD 5/10/12, M/C 9/23/11
BFP #3 - 3/4/12, EDD 11/14/12, CP 3/11/12
BFP #4 - 5/9/12, EDD 1/19/13, CP 5/11/12
BFP #5 - 8/22/12, EDD 5/5/13, CP 8/24/12
IVF#1 - January 2013 - EPP/Antagonist - 7R, 3M, 2F, 3dt of 2 8-cell embies
BFP #6 - 2/3/13, EDD 10/15/13, DS 9/18/13 at 36w1d
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Re: XP: Adding MTHFR to the diagnosis

  • Did your RE add teh baby aspirin and lovenox due to the MTHFR?  My friend just got diagnosed with this too.  I don't think our (we go to the same RE) has said they will do anything extra.  They also have MFI too.  Just curious.

    I think the same thing about my DS.  He was conceived first month on Clomid lowest dosage.  How in the world? He is so perfect and smart!  Yet now we are in the middle of IVF...???  Crazy.

    GL!  

    TTC#1: 14 months on our own (did HSG, b/w, SA);
    BFP on Cycle 14--TWINS! Identical twin boys stillborn at 19wks(1/9/10)
    3 break cycles; took clomid 50mg, BFP #2 Beta #1 35, Beta #2 338!!! Owen was born 2/11/11! 
    TTC#2: 4 cycles on clomid: BFNs
    BFP #3: Cycle #5 100mg clomid; beta #1 21; beta #2 6=CP 
    Cycle #6 break cycle TTC no meds=BFN
    Cycle #7: 150 clomid+ovidril+IUI=BFN (switched to RE)
    Cycle #8: follistem+ovidril+TI=BFN
    Cycle #9 Forced break due to cyst
    Cycle #10 follistem+ovidril+TI=BFN
    Cycle #11 follistem+ovidril+TI=BFN
    Cycle#12 Forced break due to cyst, went on BCP; did repeat HSG, Saline U/S
    Cycle #13 IVF: Follistim/Menapur ER 11-30 11 eggs, 5 mature, 4 fertilized and 3dt on 12-3; BFN
    Cycle #14: IVF#2 lupron/follistim/menopur ER 1-22, 19 eggs, 14 fertilized, 5dt on 1-27, BFP!! beta 1: 63, beta 2: 119; EDD 10-15-13; 1 frozen embie
    Miracle Surprise BFP, EDD 10-1-15; saw HB great Betas, 11weeks lost baby MC at home
    Moved forward with FET transfered solo frostie on 6-4-15, beta 1: 315, beta 2: 738, u/s showed one baby on track EDD 2-21-16
  • image jeannaqueena:

    Did your RE add teh baby aspirin and lovenox due to the MTHFR?  My friend just got diagnosed with this too.  I don't think our (we go to the same RE) has said they will do anything extra.  They also have MFI too.  Just curious.

    I think the same thing about my DS.  He was conceived first month on Clomid lowest dosage.  How in the world? He is so perfect and smart!  Yet now we are in the middle of IVF...???  Crazy.

    GL!  

    Well, the RE originally said it didn't require any additional treatment, but I asked about the baby aspirin and lovenox. The response back from the nurse was that baby aspirin couldn't hurt now and that we would start lovenox at transfer. Not sure if they're adding the lovenox just for my peace of mind since I asked about it or if they would've done it anyway and I just didn't know about it yet since we're so far from being at that point yet? I guess better to be safe than sorry.
    TTC #1 since 6/08. Cycle #6 - BFP 12/22/08, EDD 9/3/09, DD 8/14/09 at 37w1d
    Baby Birthday Ticker Ticker
    TTC #2 since 6/11
    me=36 - low AMH, DH=38
    BFP #2 - 8/31/11, EDD 5/10/12, M/C 9/23/11
    BFP #3 - 3/4/12, EDD 11/14/12, CP 3/11/12
    BFP #4 - 5/9/12, EDD 1/19/13, CP 5/11/12
    BFP #5 - 8/22/12, EDD 5/5/13, CP 8/24/12
    IVF#1 - January 2013 - EPP/Antagonist - 7R, 3M, 2F, 3dt of 2 8-cell embies
    BFP #6 - 2/3/13, EDD 10/15/13, DS 9/18/13 at 36w1d
    Lilypie First Birthday tickers
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  • Compound heterozygous is probably not as significant as homozygous.  Honestly, I think baby aspirin is totally harmless and probably helpful for lots of us.  Lovenox may be helpful too, esp if you have any other coagulation issue.  

    Did they check your homocysteine level?

    Are you taking L-methylfolate or high dose folic acid?

    If not, you should ask your doctor about these things.   

    TTC #1 12/2009
    BFP #1 1/2010, M/C 6 weeks
    BFP #2 6/2010, DD lost to congenital heart disease, we are heartbroken.

    TTC #2 4/2011, diagnosed MTHFR, FVL
    Four natural cycles BFN; Clomid IUI BFN; Follistim IUI BFN;
    1/2012 IVF #1 BFN
    4/2012 FET BFP #3
    5/2012 7w1d u/s: anembryonic demise; M/C @ 8w.
    6/2012 found Stage II/III endo on laparoscopy, removed w/ laser.
    8/2012 IVF #2 epic fail: no viable embryos.

    Vacation, break, second opinions, on to new RE.
    1/2013 Surprise chemical pregnancy BFP #4 (break cycle), IVF #3 postponed.
    2/2013 TI w/ hormonal support, prednisone, aspirin, Lovenox, acupuncture gave us a miracle BFP #5!
    Heartbeat on U/S at 6w1d! Baby,please stay!!
    Our miracle baby boy arrived 10/2013!  We are so in love!!

    10/2014 Surprise BFP #6
    Our second daughter arrived in May 2015!  We are so grateful!  

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