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Difference btw Day 3 and Day 5 transfer?

bluek210bluek210 member
in Infertility

My retrieval is scheduled for Sunday - yay!  

I was wondering if a transfer is "preferred" on Day 3 or Day 5. I can't quite get an answer from my doc - he seems to dodge the question - but he said 65% of their transfers are on Day 3.  Trying to plan, and trying to figure out what to hope for.  Logistically, day 5 would be Friday, which would be ideal! 


Me: 35, DH: 34, Started TTC #1 since November '11
Several Clomid/Femara rounds, then fresh IVF September '12
Fresh IVF #1: chemical pregnancy, FET #1: ectopic, methotrexate
FET #2 resulted in our amazing baby boy Levi, born on 11/3/13 at 8 lbs, 5 oz. He is our everything!
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Re: Difference btw Day 3 and Day 5 transfer?

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    k8teeinTXk8teeinTX member
    At my clinic it really depends on how many embryos you have.  If there aren't many (which there never are for me), then you do a 3dt.  If you have lots, then they continue to watch them past day 3 to see which ones "declare themselves" as the best and then do a 5dt.  The idea is that if you don't have very many embies, they want to transfer the few that you do have back to their "natural environment" on the chance that they do better in your ute than in the dish.  Other RE's only do day 5 transfers because they feel that if the embies can't make it in the dish ("perfect environment"), then they won't make it in the ute either.  All about your RE's perspective I suppose...Good luck!
    ~TTC#1 since 05/10~
    Me (38), DH (43)
    DX: MFI & DOR (FSH=9.9, 7.2, 11.6, 12.3; AMH=.19, .27, .007)
    06/11 IUI#1 (clomid unmonitored)=BFN
    09/11 IVF#1 (long lurpon) converted to IUI#2 due to poor response=BFN
    11/11 IVF#1.2 (MDLF) 5R/5M/4F w/ICSI 3dt of 3=BFN
    1/12 hysteroscopy to remove polyps
    3/12 IVF #2 (MDLF) 7R/5M/5F w/ICSI 3dt of 3=BFP!!! Beta #1 (14dpo)=113, Beta #2 (16 dpo)=385, Beta #3 (23 dpo)=3267, Beta #4 (30 dpo)=15,494 
    first u/s (6 wks, 3 days) reveals possible cervical pregnancy
    confirmed cervical pregnancy with fetal HB (7 wks, 2 days)
    5 days in the hospital to end pregnancy (8 wks, 3 days) and monitor bleeding + MTX injects
    6/1/12 hCG finally at zero!!
    6/21/12 hysteroscopy #2=all clear!
    8/12 IVF#3 (EPP/MDLF) 4R/4F w/ICSI, 3dt of 4=chem pg
    10/12 IVF#4 (MDLF) 10R/9M/7F w/ICSI, 5dt of 2, Beta#1 (14dpo)=193, Beta #2 (16dpo)=741, Beta #3 (19dpo)=3949, Beta #4 (5w5d)=35,000+, Beta #5 (6w5d)=91,000+
    04/13 Hospital bed rest at 24wks due to severe cervical shortening and dilation
    05/13 Home bed rest for remainder of pregnancy
    06/26/13 Baby Boy "O" born via unplanned c-section (failure to progress ironically!) after my water broke 
    ON HIS DUE DATE!!!!
    Lilypie Breastfeeding tickers
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    J&D2007J&D2007 member
    Agree with pp. my RE does "90% 5dt" says the nurse..
    Me: 37, DH: 38: ttc 7 years, dx: unknown
    10/11: after 2 years, saw a RE, FSH 5.4
    11/11: BFP! (surprise after thyroid & normal hsg),
    12/11: missed m/c after 7 week u/s, 1/12: D&C
    6/12 IUI#1-IUI #3: clomid = BFP!, C/P
    IVF #1(10/12) FSH 5.4, AFC: 16 long Lupron, 5R/5M/4F, all 4 made it to 5dt, 1 blast/1-8 cell transferred=BFN
    IVF #2(12/12)AFC 21, MD lupron, 4R/4M/3F, 5dt of 1 blast and 2-8cell. BFN.
    IVF#3(4/13) Natural start antagon protocol, 12R,11F. one PGS normal at day 6 transfer. BFN.
    IVF#4 (11/13) C.CRM (ODW.U normal 8/13 Still no Diagnosis) EPP/antagonist. ER 13R/7M/6F. Only 1 made it to freeze. Abnormal. Looking into options of DE, Fresh vs frozen.
    10/14 new local RE to look into what's next. CD3 FSH 4.7, AMH 0.9. Met with DE agencies and exploring options for feb/march 2015.
    Surprise natural bfp (4 days before donor is signed). Beta #1 at 9dpo: 51.8, 2nd beta: 195 (25 hours doubling) @11dpo. 3rd beta (12/15): 516 (35 hrs doubling) 4th beta(12/17): 895 (58 hours doubling) 5th beta(12/19): 2120. U/S at 5w0d(12/22): one gestational sac with yolk sac. U/S #2 (6w0d)12/29. One little bean measuring 6w0d with HR 124. 3rd u/s(1/4)7w0d: baby measuring 7w2d. HR 134. 3/30: A/S at MFM went great except for low lying placenta. Verifi results are normal! Team Blue! Please send any positive thoughts our way! EDD:8/24/2015
    Baby Will born 8/18. He's perfect.
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    Scoop77Scoop77 member

    I think it's mostly a matter of what your RE prefers. Here's one opinion from a Texas fertility clinic doctor.

    Link if that doesn't work: https://www.txfertility.com/embryo-transfer-day-3-or-day-5.php

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    k8teeinTXk8teeinTX member
    imageScoop77:

    I think it's mostly a matter of what your RE prefers. Here's one opinion from a Texas fertility clinic doctor.

    Link if that doesn't work: https://www.txfertility.com/embryo-transfer-day-3-or-day-5.php

    Ha, ha!  That's my former RE!!  I now see one of his partners in the same clinic, but you can see where I got my answer from...

    ~TTC#1 since 05/10~
    Me (38), DH (43)
    DX: MFI & DOR (FSH=9.9, 7.2, 11.6, 12.3; AMH=.19, .27, .007)
    06/11 IUI#1 (clomid unmonitored)=BFN
    09/11 IVF#1 (long lurpon) converted to IUI#2 due to poor response=BFN
    11/11 IVF#1.2 (MDLF) 5R/5M/4F w/ICSI 3dt of 3=BFN
    1/12 hysteroscopy to remove polyps
    3/12 IVF #2 (MDLF) 7R/5M/5F w/ICSI 3dt of 3=BFP!!! Beta #1 (14dpo)=113, Beta #2 (16 dpo)=385, Beta #3 (23 dpo)=3267, Beta #4 (30 dpo)=15,494 
    first u/s (6 wks, 3 days) reveals possible cervical pregnancy
    confirmed cervical pregnancy with fetal HB (7 wks, 2 days)
    5 days in the hospital to end pregnancy (8 wks, 3 days) and monitor bleeding + MTX injects
    6/1/12 hCG finally at zero!!
    6/21/12 hysteroscopy #2=all clear!
    8/12 IVF#3 (EPP/MDLF) 4R/4F w/ICSI, 3dt of 4=chem pg
    10/12 IVF#4 (MDLF) 10R/9M/7F w/ICSI, 5dt of 2, Beta#1 (14dpo)=193, Beta #2 (16dpo)=741, Beta #3 (19dpo)=3949, Beta #4 (5w5d)=35,000+, Beta #5 (6w5d)=91,000+
    04/13 Hospital bed rest at 24wks due to severe cervical shortening and dilation
    05/13 Home bed rest for remainder of pregnancy
    06/26/13 Baby Boy "O" born via unplanned c-section (failure to progress ironically!) after my water broke 
    ON HIS DUE DATE!!!!
    Lilypie Breastfeeding tickers
    Report Reply
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    brachatziporabrachatzipora member

    It really depends on your doctor and their thoughts.  There are positives and negatives to both... you can lose some embryos by Day 5 that would have made it on Day 3.  But you get a better picture by Day 5 and can do a blastocyst transfer.  There is a lower risk of identical multiples (an embryo dividing) at blastocyst stage, but you run the risk of only have one to implant if you wait.

    We chose to do Day 5, but it's very personal and up to you and your doctor. 

    Baking Blog | TTC Blog | Pinterest
    TTC #1 since October 2010 | Began Testing in January 2012
    DH SA - low motility with 0% morph; varicocele (repaired); low T (on Clomid)
    IVF w/ICSI (long Lupron w/ Repronex and Follistim) in September 2012

    imageimage
    Lilypie Pregnancy tickers

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    bluek210bluek210 member

    thanks guys...

    that link is to an article by my actual dr!  I can't believe he didn't refer me to his own article when I asked about it this morning! 


    Me: 35, DH: 34, Started TTC #1 since November '11
    Several Clomid/Femara rounds, then fresh IVF September '12
    Fresh IVF #1: chemical pregnancy, FET #1: ectopic, methotrexate
    FET #2 resulted in our amazing baby boy Levi, born on 11/3/13 at 8 lbs, 5 oz. He is our everything!
    AlternaTickers - Cool, free Web tickers
    Image and video hosting by TinyPic  image   image
    Report Reply
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    k8teeinTXk8teeinTX member
    imagebluek210:

    thanks guys...

    that link is to an article by my actual dr!  I can't believe he didn't refer me to his own article when I asked about it this morning! 

    Too funny!  I guess my answer should have said "at our clinic...".  Sorry that you couldn't get a straight answer from him, but he's just like that sometimes.  I was with him through a very difficult (life and death at certain points) situation, and I found it very difficult to get straight answers.  Ultimately, this is one of the (many) reasons that I switched to another doc there.  Don't get me wrong, though, you are in very capable hands, he's just difficult to communicate with sometimes...Best of luck at your retrieval on Sunday.  Everyone on staff is really wonderful and you will be well taken care of!

    ~TTC#1 since 05/10~
    Me (38), DH (43)
    DX: MFI & DOR (FSH=9.9, 7.2, 11.6, 12.3; AMH=.19, .27, .007)
    06/11 IUI#1 (clomid unmonitored)=BFN
    09/11 IVF#1 (long lurpon) converted to IUI#2 due to poor response=BFN
    11/11 IVF#1.2 (MDLF) 5R/5M/4F w/ICSI 3dt of 3=BFN
    1/12 hysteroscopy to remove polyps
    3/12 IVF #2 (MDLF) 7R/5M/5F w/ICSI 3dt of 3=BFP!!! Beta #1 (14dpo)=113, Beta #2 (16 dpo)=385, Beta #3 (23 dpo)=3267, Beta #4 (30 dpo)=15,494 
    first u/s (6 wks, 3 days) reveals possible cervical pregnancy
    confirmed cervical pregnancy with fetal HB (7 wks, 2 days)
    5 days in the hospital to end pregnancy (8 wks, 3 days) and monitor bleeding + MTX injects
    6/1/12 hCG finally at zero!!
    6/21/12 hysteroscopy #2=all clear!
    8/12 IVF#3 (EPP/MDLF) 4R/4F w/ICSI, 3dt of 4=chem pg
    10/12 IVF#4 (MDLF) 10R/9M/7F w/ICSI, 5dt of 2, Beta#1 (14dpo)=193, Beta #2 (16dpo)=741, Beta #3 (19dpo)=3949, Beta #4 (5w5d)=35,000+, Beta #5 (6w5d)=91,000+
    04/13 Hospital bed rest at 24wks due to severe cervical shortening and dilation
    05/13 Home bed rest for remainder of pregnancy
    06/26/13 Baby Boy "O" born via unplanned c-section (failure to progress ironically!) after my water broke 
    ON HIS DUE DATE!!!!
    Lilypie Breastfeeding tickers
    Report Reply
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