Infertility Veterans

Depot Lupron prior to FET/IVF

Any experiences to share? I'm particularly interested in anyone's FET protocol, specific start days and meds, but IVF protocols are also very welcome.

Our proposed is: 3 months of lupron by dint of a single 11.25 mg Depot Lupron injection starting cd21. Around the 2.5 month mark of this, move to daily Lupron injections as one would in a regular medicated FET. 

Thanks !!! 

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Re: Depot Lupron prior to FET/IVF

  • xoxox
    I am AMA and all tests on H came back normal
    3 failed IVF with OE and 2 failed frozen DE cycles
    Last fresh hail mary DE cycle starting Feb 2013
    PAIF/SAIF always welcome
  • Thanks Reb. I'm thinking we need to hit some breezy spot with an open bar.
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  • Just want to chime in to wish you all the best. Good luck!
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  • Hugs E.  I'm not sure I know anything about Lupron depot...but I think this was echloe's fet protocol.  
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  • I am of no help, but just wanted to pop in and tell you that I have everything in me crossed for you! Sending tons and tons of good luck!

    Pregnancy Ticker
  • Sorry, no experience with it, but I wanted to wish you luck.
    TTC #1 since June 2010
    Me: 36, DH: 42
    Dx: DOR and MFI

    DH: low count + very low motility; hormones all normal; Sperm DNA Frag. test = poor to fair; male karyotyping normal
    Me: FSH 13.4 + AMH 0.26 + hypothyroidism; Scratch the hypothyrodism (?); Blood clotting and immune panel all negative; endometrial biopsy normal

    IVF #1 (MDLF - Jul/Aug 2011): BFN (9R, 5M, 3F with ICSI, 3dt of 1 10-cell grade 2, no frosties)
    IVF #2 (EP-antagonist - Sep/Oct 2011): BFN (6R, 4M, 3F w/ ICSI, 3dt of 1 6-cell, 1 7-cell, grade 4s, no frosties)
    DE IVF #1 (shared cycle - June 2012): c/p (6R, 6F w/ICSI, 3dt 1 8-cell grade A- and 1 7-cell grade A-; no frosties)
    DE IVF #2 (shared cycle with new donor - Nov/Dec/ 2012): - BFP!!!!! 12/14/12. U/S on 12/27 shows twins!!!!!

    SAIFW/PAIFW
  • I did Lupron Depot for several months before my last 2 cycles, the same once a month shot you are doing. Then at some point (don't remember exactly when) I switched to daily Lupron. I never had a period before starting the cycle. Then after a couple weeks I added in Delestrogen. These were for fresh cycles though, not FET.

    GL!

    Dx: High FSH, stage IV endo, homozygous C677T MTHFR and PAI-1
    Early loss 10/08
    Lap 1/09
    IVF #1 "natural IVF" - 1 egg retrieved, missed m/c
    Tried several mini-stim cycles with no response
    Switched clinics - dx'd as carrier for Fragile X
    IVF #2 MDL protocol Jan/Feb converted to IUI, BFN
    IVF #2 take 2: Antagonist, one embie, BFN
    IVF #3: Antagonist, no fertilization
    One last ditch effort at OE IVF (antagonist with Clomid) cancelled
    DE cycle #1 Jan/Feb 2011, BFP, ectopic
    DE cycle #2 June/July 2011 - BFP
    10/28/11 Baby girl lost at 17 weeks due to pre-term labor. We love and miss you.
    DE cycle #3 June/July 2012 - BFP, twins, both heartbeats stopped, D&C
    2 frosties but don't know what's next
    FET Dec 2012: BFP! Praying this one sticks for the long haul!
  • Absolutely no help but want to send you tons of well wishes and luck!
    TTC 1/2010 DH Dx - Azoospermia 2/2011
    Hysteroscopy 3/2011 2 Polyps removed 4/2011
    DH on Clomid / Arimidex to address hormonal issues - Sperm found July 2011!
    IVF #1 September 2011 - ER 9/8/2011- 8R, 5M - icsi - 1 made it to transfer - BFFN :-(
    IVF #2 Lucky November 2011 - ER 11/25/2011 - 15 eggs!, 13 mature, 10 fertilized with isci - 7 made it to transfer! Transferred 1 - 8 cell and 2 - 7 cell. BFP!!!!
    1st U/S - Twins! 2nd U/S - 3 heartbeats!!! - HOLY COW!!!
    Prayers for our take home babies!
    2 babies born on 3/27/12 and lost. Last baby born on 3/29/12 and lost at 20 weeks.
    My angels grew wings shortly after birth.
    Ahava Raisel, Matisyahu Nissim & Zev Chaim - Mommy and Daddy will always love you.
    IVF #3 July 2012 - ER 7/17/2012 - 10 R. 5 F. 4 made it to ET
    Transferred 2 on 7/20/2012 no snow babies :-(
    Beta on 7/31/2012 = BFMFN
    A miracle gift expected to come to us through adoption around 9/2012
    Baby girl adopted - Birth Mother changed her mind and took the baby back
    IVF #4 October 2012 - New RE. Doing PGD Testing. 8 R, 7F, 2 made it to 5 day blast for PDG testing. Both Normal (Thank you G-d!!!) 1 boy and 1 girl
    transferred one beautiful 5day blast (girl)
    Please G-d the almighty one - let this be our take home baby!
    Beta #1 158, Beta #2 318, 1 Absolutely magnificent HB at 175! Thank you G-d!!!
    Baby Girl born August 5th. Thank you G-d for our precious miracle.
    AMA. PAIF & SAIF always welcome - I need all the prayers I can get!

    Lilypie Angel and Memorial tickers
  • No depot experience here either but wanted to wish you lots of luck!!!
    SAIFW
    TTC since 2008 dx PCOS & MFI
    Clomid/Femara no "O"
    IVF #1 BFN
    FET #1 cancelled for biopsy
    FET #1.2 c/p, July 2012 c/p
    IUI #1 & 1.2 canceled
    IVF #2 ER 12/1, Freeze all due to OHSS
    FET #2.1 cancelled due to DVT risk, FET #2.2 Jan 2013
    my blog
    image
  • No experience, but I wanted to wish you lots of luck. Please keep us posted! We're all rooting for you. 
    (Live in Europe) TTC since 1/2010
  • imageMitzi Bishi:
    No experience, but I wanted to wish you lots of luck. Please keep us posted! We're all rooting for you. 

    Ditto! GL!

    Multiple ectopics, 2 failed IVF's
    IVF #1: Did not get to ET, embies all failed PGD (major chromosomal defects)
    IVF #2: We have 2 chromosomally perfect embies as a result of PGD (Boy/Girl) 1 failed the thaw (Girl) Transferred 1, yet ended as a c/p
    Thought it was the end of our TTC Journey 6/20/2012
    SHOCK BFP 9/28/2012: IT'S A BOY! and everything is normal !!!!!!

    Little A born 38w 2d on 05/23/13 and is a true miracle for this IF Vet!
     

    image              

     


  • I was supposed to do this protocol for my upcoming cycle for possible unconfirmed endometriosis. After doing a lot of research I wasn't able to bring myself to do it and face all of those potential side effects. I cried for being selfish and will probably rethink things if this cycle doesn't work. But for now, I feel like I made the right decision. If I had confirmed endo I might be thinking differently, but for us it was a kitchen sink addition to treatment. Anyways, I feel like I am babbling, I think my point is to look into the potential side effects as part of your determination. It may very well be worth it for you, and may be in the future for me as well, but it makes me nervous. GL
    imageimage

    Dx: DH - Azoo, Me - Mild PCOS
    DH - sperm found! Seems to produce only for a few days every 70 days!
    Over 1 million in cryo in 15 vials over 6 samples
    IVF #1 - 1 beautiful expanded blast transferred, 4 snowbabies - beta #1 11/30/11 = BFFN
    FET #1, transfered 2 embies 2/16/12 = BFFN; 1 snowbaby left in cryo
    IVF #2 + CGH = 4 genetically normal embies on ice. FET September 26th
    SAIF/PAIF always welcome

    a special GL and prayers to my IF sister Gregermis

    image
    check out my blog!


  • Well here I am being all doom and gloom negative nancy and I didn't even answer the question you asked, just gave unsolicited advice. anyway, my protocol was to be on day 3 of my cycle I would go in to the RE for the first injection, 30 days later I would go in for second injection. The last week of the second 30 days I Would overlap with the standard lupron injections and then start with the estrogen priming for 2 weeks then do transfer. No bcps and no period although there may have been some break through bleeding. The sooner in the initial cycle you get the first depot shot the less likely you are to get breakthrough bleeding.
    imageimage

    Dx: DH - Azoo, Me - Mild PCOS
    DH - sperm found! Seems to produce only for a few days every 70 days!
    Over 1 million in cryo in 15 vials over 6 samples
    IVF #1 - 1 beautiful expanded blast transferred, 4 snowbabies - beta #1 11/30/11 = BFFN
    FET #1, transfered 2 embies 2/16/12 = BFFN; 1 snowbaby left in cryo
    IVF #2 + CGH = 4 genetically normal embies on ice. FET September 26th
    SAIF/PAIF always welcome

    a special GL and prayers to my IF sister Gregermis

    image
    check out my blog!


  • *** Lurker *** Ticker Warning *** Baby Mentioned ***  

    I have 2 friends who used depot lupron for 3 months before starting cycle and both had successful cycles.  One has 2 children (both IVF cycles) and other has 1 child (did FET).  One had with 2 kids had severe endo and other with 1 child had endo (medium case).

    Another friend used depot lupron for 2 months before IVF cycle (between medium-severe endo) and got BFN.

    I don't know their exact protocols, though, sorry.

    TTC #1 for over 5 years - too many to count IF treatments (tried everything and anything), repeat miscarriages. Finally, Sticky Success!! B/G Twins arrived 2011. VOTE on my Name List Baby Birthday Ticker Ticker
  • mm29mm29 member

    Edwina,

    I have no experience with depot lupron, but I wanted you to know I wish you the very best with your upcoming cycle! 

    GL and lots of PPV's!!!

    ::: Married June 2003:::
    TTC #1 since: Aug. 2008
    Me: 34, DOR, MTHFR-A1298C (heterozygous), decreased blood flow to uterus, Mild Endo
    DH: 38, Balanced translocation 5&10, unexplained MFI, normal SA and SCSA
    Tx History: IUI 1&2= BFN
    IVF# 1 W/ICSI= BFN
    IVF# 2: cancelled d/t no response
    IVF# 3= 1 egg retrieved=immature/not viable
    IVF# 4= c/p
    ***CCRM ODWU***
    Found DHs BT and Me-decreased blood flow to uterus
    Recommended DE IVF w/PGD, incorporate electro-acupuncture. Decided to cycle locally
    ***New RE***
    DE IVF# 1(cycle #6) w/pgd, (freeze all): 30R, 23M, 15F, slow/poor embryo development, 4 biopsied, 1 Normal "Norm"; DE IVF w/PGD, incorporate electro-acupuncture. 
    IVF# 6: (OE/DS) cancelled
    IVF# 7: (OE/DS) 1R, 1M, 1F, arrested day 5
    Plan-DE IVF# 2 (cycle #8): DE/DS in May 2015


    http://icanhazbabyz.blogspot.com/
    imageimage image 
  • Positively useless as far as helpful insight/experience -- but, I wanted to send some additional support your way. Wishing you all the best with your cycle and sending you a ton of good luck, Edwina!
    TTC since honeymoon in 9/2010
    Me: 39, Dx DOR (FSH = 10.5, AMH = 0.43, best AFC = 10), AMA
    MH: 37, Dx Obstructive Azoospermia, multiple successful sperm retrieval procedures

    1/2012: IVF/ICSI #1 Antagonist = cancelled d/t poor response to max stims
    2/2012: IVF/ICSI #2 MDLF (4R, 4M, 1F) = BFP, saw heartbeat, missed m/c 9w0d, D&E
    8/2012: IVF/ICSI #3 EPP/MDLF (7R, 2M, 1F) = BFN

    12/2012: (New RE) Operative hysteroscopy to remove scar tissue

    1/2013: IVF/ICSI #4 Low-dose stim/Antagonist (AFC=6); ER=1/26 (5R-couldn't access rt ovary, 5M, 4F), ET=1/29 (trans 3) = BFP!; 2/11 beta#1(13dp3dt)=2127, 2/13=3367; twin girls due 10/19/13

    PAIF/SAIF very welcome!

    <a href="http://www.thebump.com/?utm_source=ticker&utm_medium=HTML&utm_campaign=tickers" title="Pregnancy"><img src="http://global.thebump.com/tickers/tt16bf7d.aspx" alt=" BabyFruit Ticker" border="0"  /></a>
  • I don't know about the protocol but I am so rooting for you.  Keep us posted for sure.
  • I did lupron for 3 weeks daily before my IVF.   I've started all my FETs with estrace on CD25 through whenever baseline is.  Lupron made me suuuuuuuuuper sleepy for the first 3-4 days and then I was fine
    TTC #1 Since 4/2010, Cycle 30
    Positive for HLA-B27, I'm a mutant :p
    Testing - Me ok, gluten issue? DH - borderline count, low motility
    4/28/11 IUI#1 = BFP!(5/25), EDD 2/2/12 - m/c 5w3d
    7/3, 7/31, 9/25 - IUI#2-4=BFN
    IVF#1 - 1 blast = BFP!! (12/30), EDD 9/9/12, confirmed c/p 4w2d
    FET#1 3/2/12 - 2 blasts =BFP!! EDD 11/18/12, us#1 = twins! Confirmed m/c 5w6d
    4/20-surprise BFP and another c/p 4w2d
    FET#2 7/16/12 - 2 blasts = BFN
    FET#3 8/20/12 - 1 blast - BFP!! Beta #1-2=177, 354
    1st u/s 5w6d, one beautiful little HB :), 2nd u/s 146bpm
    baby girl born 5/10/13

    TTC#2 since 12/17/2014, Cycle 8
    Repeat Testing...FSH=12, AMH=3.8, AFC=28. 
    IUI#5 5/10/15- c/p?
    IVF#2 8/19/15 - cancelled due to cysts
    IVF#2 take two 10/2015 - 5 blasts frozen
    FET#4 12/11/2015 - BFN - 4 blasts remaining
    FET#5 2/18/16 - BFP!!!  Beta1-3, 126, 250, 745!!

    Image and video hosting by TinyPicLilypie Angel and Memorial tickers

    Tons of love and ((hugs)) to my IF sister NMscubagirl


  • No experience with depot Lupron, but I wanted to say that I'm thinking about you. Sounds like you're making progress and that's fantastic.  I owe you an email, big time.  Didn't see your note til after we got back from our vacation last weekend.  Haven't forgotten about you, of course, and I'm sorry I couldn't give you timely advice. Hugs!
    Baby girl Lila born 2013.
    Baby boy Henry born 2015.
    Expecting our capstone baby (boy) early March 2018.
  • I am just curious of what your doc's reasoning for Depot Lupron.  I was going to do the Depot Lupron for a negative beta 3 integrin biopsy, prior to what would be my fourth transfer (2xIVF/ICSI and 1 FET all BFN) - last minute doc decide to scrap the whole plan.  I had been on Lupron daily from 6/1-6/21 (decision to try Depot Lupron was on 6/18 - we were traveling which gave me plenty of time to decide to have the injection or not)  so then dropped the dose down and started lining prep with estrogen and transferred Friday the 13th...in the end I am so glad she scrapped it because I already felt like hell from being in menapause, which the Lupron causes, and I got my bfp in the evening of the 17th...So I guess, my point is - Lupron makes me feel like hell and it isn't always needed.  Sorry if this rambles. 
  • I've never done Depot Lupron, but I just wanted to wish you the very best of luck!!! I hope this is it for you!!!

    Renee- 37 DH - Chad - 39
    2/06 - surprise pregnancy - twins
    3/06 - m/c 1st baby at 6 weeks 
    5/06 -2nd baby had no heartbeat at 14 wks.
    D&E - Bled out. Blood transfusions. Week in ICU - Cheated Death!
    Diagnosis: Blood clotting and bleeding disorder, immune issues, & cervical stenosis
    5/10 - 1st IVF cycle - BFN
    FET - 10/12/10 - BFN
    1/11 - IVF with PGD - BFN
    IVF - May - BFN
    6/11 New RE - fingers crossed!
    9/11 - IVF - 4 transferred
    10/13 - BFP!!
    It's a boy! Clint Michael, Due in June!!!

    image
    Baby Birthday Ticker Ticker





  • Thanks everyone. It's been a particularly rough day (more on that later) and all the support really helps.

    Ambray, it was rec'd based on questionable EFT results which is similar to your biopsy.

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  • Edwina, I have absolutely NO experience with this, but I wanted to wish you luck. 
    imageimage

    TTC#1 since October 2010

    "The jump is so frightening between where I am and where I want to be...because of all I may become I will close my eyes and leap." Mary Anne Radmacher

    Me:35, 5 major abdominal surgeries for Ulcerative colitis, failed j pouch, perm. Ileostomy DX-DOR & Tubal abnormalities/Extensive Adhesions from earlier surgeries.latest fsh -26 :(

    IVF 1- March 2012 Antagonist Protocol; BCP until March 3; AFC this cycle is 10 (Hooray); Start stims on March 9; ER on March 19- 2R; 2T (1 perfect 8 cell, 1 scrappy 3 cell); tubal infection from ER-hospitalized. Doomed! BFN

    Essure Procedure to treat bilateral hydrosalpinx; June 2012, wait 3 months for confirmation test.

    IVF2 (Egg Banking)-letrozole/antagonist cycle; June/July 2012 225iu merional + cetrotide; slow responder, Ovulated before ER. Unbelievable. Canceled remaining cycles with my eggs

    DE IVF in Brno, Czech. Approx. ET on Oct 6 CANCELLED-Essure didn't close both tubes-test again in 3 months

    IVF3-DE IVF ET on Dec 9, 2012 (decided to roll the dice no matter what!)

    2 perfect HB transferred; 8dp5dt beta:36; 10dp5dt beta 15; chemical pregnancy.

    Turning our hearts toward adoption

    DH:36, SA-perfect

    Married since July 11, 2009

    Fur baby Cairn Terrier

    SAIF/PAIF Welcome

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