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Falling AMH-how does this even happen

MandaS08MandaS08 member
in Infertility Veterans

Last summer my AMH was 1.1 and I was diagnosed with DOR.  In December it was 1.0.  We just re-drew and its now down to a .29.

How does it decrease so much so quickly?!  At this poing I'm wondering if there even is a point to doing another IVF cycle.

TTC since 5/2010
DX with Diminished Ovarian Reserve - AMH of 1.1 - 7/2011; AMH of .42 8/2012BFP 9/1/10-M/C confirmed 9/8/10-Methotrexate 10/6/10
IUI #1 (w/clomid)-9/5/11-BFN ; IUI #2 (w/clomid)-10/5/11 - BFP - 11/1/12-No sac seen; 11/2/11 and 11/9/11-Methotrexate 
IVF #1- ER 2/2; ET 2/5;-Two 8 cell embryos transfered = BFFN
Surprise BFP - 5/7/12
U/S on 6/8/12 - H/B at 128 BPM; U/S on 6/14/12 @ 9wks-No H/B-D&C on 6/17/12
IVF 2.0- ER 10/17; ET 10/20-One 12 cell, one 10 cell and one 8 cell embryo transfered
BFP!   11/16/12 U/S- Two nuggets with perfect heartbeats! EDD 7/10/13

 

5/31/2013- My miracles arrived at 34w2d!  Welcome to the world Harper and Nolan!Lilypie First Birthday tickers

My Blog- http://waitingonaangel.wordpress.com/

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Re: Falling AMH-how does this even happen

  • jlcrane78jlcrane78 member
    Being DOR is the biggest thorn in my side. I'm out of cycles, though, so even if mine fell it wouldn't matter. I'm sorry hun.
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  • Mrs.McIrishMrs.McIrish member

    It just does with DOR.  My dropped from 0.92 in 1/11 to 0.3 in Sept. 11.  It's probaby undetectable now.. 

    But even though they say that the number doesn't fluctuate, it can.   Mine went up from the 0.3 in Sept 11 to 0.37 in Dec. 11.   

    Sorry you got these results but your AFC is more important imo. Some RE's don't even use AMH as it is still deemd "experimental".

    TTC #1 since 8/1/10; Me:41 and BRCA1+, DH:46
    DOR (FSH 24.3)/ terrible egg quality ; homozygous MTHFR c677t
    5 IUI's: 2/11 to 6/11 and 1/12= BFN
    OE IVF#1-4 8/11-6/12= all BFN
    DE IVF#1 11/12 bad embryos= BFN
    DE IVF #2 2/13 BFP/Beta hell: m/c 5w6d
    CFNBC 7 months, not doing well; decided on guarantee program at RBA w/frozen DE
    DE IVF #3 1/14  ET 4BB; BFP;M/C 5w1d, incomplete m/c; MVA extraction in ER 7w1d

    DE FET#1 ET 3/1714; BFP, beta 1 3/27= 197, beta 2 3/31= 1586, beta 3 4/7= 13879!!
    First u/s= Twins with HBs at 6w2d! We are Team Pink x 2!!

    K & K born 11/21/14 at 38wks 4 days

    imageimage

    SAIF/PAIF Welcome


    http://waitingforraintostop.wordpress.com

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  • Edwina.McDunnoughEdwina.McDunnough
    Were they done at the same lab? Anyway, it's a number and a guide or estimate; not some be-all, know-all, end-all factor. You need to look at your AFC and all those other things that go into a DOR dx to see the whole picture. In the end, the real deal is how you respond to meds in real life. And even if your OR is declining, your age may still be on your side. Plenty of girls here have super crap OR and get pregnant (and BTW freak out but never come back to share their stories).
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  • AmCheriAmCheri member
    My therapist described it as your fertility falling off a cliff and that's exactly what mine did in the last year. AMH is down, my AFC cut in half. Yes, DOR sucks but for me, the biggest problem is that my body just doesn't respond to stims well at all. Give me 12 days of 600iu Follistim, and I'll show you two deadbeat follies. Sorry for the news. If you respond ok, I see no reason to not try again. 
    Baby girl Lila born 2013.
    Baby boy Henry born 2015.
    Expecting our capstone baby (boy) early March 2018.
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  • lynn0926lynn0926 member
    It def does not hurt to try again. You have been "successful" in the past. Unfortunetly, this happens with DOR. I went from having an AFC of 16 in Jan 2011 to an AFC of 6 by June 2011. After that some months it was 3 others it was 6. Similar thing happened with my younger sister. 
    Pregnancy Ticker
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  • mm29mm29 member

    Mine decreased quickly too!  When first drawn my AMH was 0.5 and 9 months later it was  <0.1.

    I am so sorry you are dealing with this! 

    ::: Married June 2003:::
    TTC #1 since: Aug. 2008
    Me: 34, DOR, MTHFR-A1298C (heterozygous), decreased blood flow to uterus, Mild Endo
    DH: 38, Balanced translocation 5&10, unexplained MFI, normal SA and SCSA
    Tx History: IUI 1&2= BFN
    IVF# 1 W/ICSI= BFN
    IVF# 2: cancelled d/t no response
    IVF# 3= 1 egg retrieved=immature/not viable
    IVF# 4= c/p
    ***CCRM ODWU***
    Found DHs BT and Me-decreased blood flow to uterus
    Recommended DE IVF w/PGD, incorporate electro-acupuncture. Decided to cycle locally
    ***New RE***
    DE IVF# 1(cycle #6) w/pgd, (freeze all): 30R, 23M, 15F, slow/poor embryo development, 4 biopsied, 1 Normal "Norm"; DE IVF w/PGD, incorporate electro-acupuncture. 
    IVF# 6: (OE/DS) cancelled
    IVF# 7: (OE/DS) 1R, 1M, 1F, arrested day 5
    Plan-DE IVF# 2 (cycle #8): DE/DS in May 2015

    http://icanhazbabyz.blogspot.com/
    imageimage image 
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  • joules12joules12 member
    DOR sucks!  So sorry that you're in this situation!
    TTC since honeymoon in 9/2010
    Me: 39, Dx DOR (FSH = 10.5, AMH = 0.43, best AFC = 10), AMA
    MH: 37, Dx Obstructive Azoospermia, multiple successful sperm retrieval procedures

    1/2012: IVF/ICSI #1 Antagonist = cancelled d/t poor response to max stims
    2/2012: IVF/ICSI #2 MDLF (4R, 4M, 1F) = BFP, saw heartbeat, missed m/c 9w0d, D&E
    8/2012: IVF/ICSI #3 EPP/MDLF (7R, 2M, 1F) = BFN

    12/2012: (New RE) Operative hysteroscopy to remove scar tissue

    1/2013: IVF/ICSI #4 Low-dose stim/Antagonist (AFC=6); ER=1/26 (5R-couldn't access rt ovary, 5M, 4F), ET=1/29 (trans 3) = BFP!; 2/11 beta#1(13dp3dt)=2127, 2/13=3367; twin girls due 10/19/13

    PAIF/SAIF very welcome!

    <a href="http://www.thebump.com/?utm_source=ticker&utm_medium=HTML&utm_campaign=tickers" title="Pregnancy"><img src="http://global.thebump.com/tickers/tt16bf7d.aspx" alt=" BabyFruit Ticker" border="0"  /></a>
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  • Delta04Delta04 member
    Yes - your AMH can be very temperamental.  Mine took a nose dive in a relatively short period of time.  As said above, there are many other factors to take into account - including age.  So sorry that you have to deal with this.
    TTC since 3/07. IVF#1 = canceled. IVF#2 = 0% fertilization. IVF#3 = BFN. IVF#4 = c/p.  
    Moving forward with Adoption 2017!
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