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XP from 3T: Genetic testing results are back + a MFI question (long).

DebateThisDebateThis member
in TTC After a Loss

My midwife called me w/ the genetic testing results from the m/c today and it appears the baby had triploidy, which is when the baby has a complete extra set of chromosomes, resulting in 69 chromosomes instead of the normal 46. It's rare (1-2% of pregnancies result in triploidy) and most of the time it's a fluke.

All that being said, I have a question - has anyone else had MFI issues linked to a genetic defect? I've found several studies that seem to indicate that infertile men (specifically those who have motility/morphology issues) have a significantly higher occurrence of babies w/ triploidy due to more of their sperm having duplicated genetic material (two sets of genes in the sperm head rather than the normal one).

We're going to be scheduling a consult with a genetic counselor soon but I was just curious to see if anyone else has come across this. 

TIA.
Six years of infertility and loss, four IUIs, one IVF and one very awesome little boy born via med-free birth 10.24.13.
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Re: XP from 3T: Genetic testing results are back + a MFI question (long).

  • MissuskeekersMissuskeekers member
    My doctor said it was a complete fluke. The only study I found was one that found some reccurance in women but it was a really small study.


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    Married 07/17/2010
    Diagnosed with PCOS 10/20/2010 
    TTC since Oct 2010 
    BFP #1 March 31st 2011 Due December 10 2011 
    Missed m/c discovered June 2nd 2011 at 12w4d
    D&C scheduled June 7th 2011 at 13w2d
    Found out our baby boy had Triploidy XXY through embryopathology
    BFP #2 September 28th 2011 Due June 8th 2012
    Missed m/c discovered November 20th 2011 at 11w2d
    D&C November 29th 2011 at 12w4d
    Found out our baby girl had Monosomy X through embryopathology
    BFP #3 April 24th 2012 Due January 5th 2013
    Betas falling on 04/26/12 Chemical Pregnancy
    RPL testing done, multi nodular goiters on thyroid discovered.

    BFP #4 November 22nd 2012, Due August 5th 2013
    Betas: 17 @ 9dpo, 62 @ 11dpo, 124 @ 12dpo, 321 @ 14dpo 720 @ 16dpo 13,805 @ 23 dpo 
    First ultrasound at 6w3d, hb 122 bpm. 
    Second ultrasound at 7w3d hb 143 bpm 
    Third ultrasound at 10w1d hb 167-170 bpm 
    Forth ultrasound 12w1d hb 167 bpm 
    Graduated rpl program, moving on to regular ob! 
    It's a boy! 

    Little man was born August 1st 2013, 7lbs 8oz and 20.5 inches long



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  • DebateThisDebateThis member

    https://www.biolreprod.org/content/66/6/1781.full.pdf

    ^ This is one of the studies I found. There are a bunch more but this one has the most clear abstract.

    Six years of infertility and loss, four IUIs, one IVF and one very awesome little boy born via med-free birth 10.24.13.
    image
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  • laurenli83laurenli83
    1-2% of pregnancies seems like a high stat.  I am so sorry for your loss. Sometimes it's nice to have answers but doesn't necessarily make it any easier.
    Trouble conceiving in 2009/2010, After 6 failed clomid cycles (3 with IUI), we were successful with our first Gonal/IUI cycle with acupuncture. I had a beautiful son born late 2010. 2012: BFP, twin MC, 10 week wait until beta #s were low enough to cycle, non cancerous mass found and removed in endometrium, another cxl'd cycle, now, about ready to start trying, officially with my RE again. And so the journey continues...
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  • buckeyebaby814buckeyebaby814 member
    I'm sorry to hear about your baby, I'm sure getting answers is 'bittersweet' to some degree.  We're not dealing with MFI so I have no advice, just wanted to wish you luck!

    image image imageimageimage  

    CFNBC after 8 losses and IF || History || My Angel Babies

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