A few MFI questions

tptbabe

So we got back DH's latest SA results and the first one wasn't a fluke. (It actually got worse) So now we're dealing with a whole new ballgame! (pun intended)

The RE set up a bunch of testing for DH, including an sonogram, bloodwork to check for Y-Chromosome deletion, CFTR mutation, FSH, TSH, prolactin, and testosterone. The first two I'm going to have to google, but thought maybe somebody here might be able to give me a little more information on as well?

So, on to the questions! She reccomended a supplement called "Coast MFS". Has anyones DH tried this? Is it really worth it? Did it do anything for you?

Next (DH had this question, and it's possibly a little TMI) for the sonogram, how does it work? We know they're doing it on the testicles, so obviously it's not going to be any fun for him. (Yes, I'm aware that we go through worse, but this is new for him) Also, he's wondering if they have to shave to do the sono? Like, he keeps it neat, but would hair affect it? (Told you it was TMI!)

So that's where we are now. She's saying that with the numbers the way they are now, if there's nothing we can find to fix, then we're looking at IVF/ICSI. She wouldn't even consider IUI because of the low numbers on everything and the high level of antibodies. We should have his testing done by the end of this cycle, so at least I know that we'll know soon I guess?

kaf7

Sorry you're in the MFI boat. It is a tough one.

 I can only answer your first questions about Y chromosome microdeletion and CFTR.

There are mild forms of cystic fibrosis (people normally think of this as a lung disease and gut disease) that can cause infertility, particularly male factor. That's why they will check for that and rule it in or out. It is also important if you move on to do IVF/ICSI to check whether he is a carrier (which wouldn't affect his sperm, but if you are both carriers can increase the likelihood that you would have a child with cystic fibrosis).

The Y microdeletion is sometimes found in otherwise healthy men with male factor infertility. It means that a tiny piece of the genetic material on the chromosome that makes him a man is missing. I don't think they fully understand what it does/responsible for (or at least I don't!) but it can help your RE with deciding whether certain therapies to improve SA's are going to be useful.

I don't know about Coast MFS or the sonogram. I very much doubt he would have to shave.

tptbabe

Thank you so much! Google was being absolutely no help with those two. I'm wondering if the Y chromosome thing might be a factor in his case, since his cousin has Turners Syndrome? (I have no idea if it's a genetic thing, but it's something to think about!)

kaf7

You're right that Turners is genetic but a totally different genetic thing (different chromosome that is affected).

 Glad I could help and I hope things go smoothly and the SA improves.

tptbabe

That's true, I was just thinking chromosomal defects in general. Fortunately until now, I haven't really had to know a whole heck of alot about this!

I am going to have so many more questions as this goes on... Thanks for the well-wishes

Pnut30

Hi!

My DH has had all of those tests.... The sonogram was embarassing for him but not painful or anything... It really was just like it sounds, an ultrasound of the scrotum.  I felt awful for him because they just sent him to a radiology lab where I am sure they don't do that type of ultrasound everyday.... I did not go but I just imagined the awkardness between him and the "young girl" he described when she realized what he was there for.  But he said everything went fine, I think they put a sheet over them so that only the actual scrotum is showing to the tech..I don't remember anything about hair though.... I would think it wouldn't matter and if it did they would tell you. 

The other tests are just more blood work... The Y-Chromosome deletion checks for chromosomal defects that are causing the MFI.

The hardest part about all of these tests is waiting for the results!!!! It should take a few weeks depending on the lab to get the results...

Good Luck!!