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Any IVF gals not using heparin or lovenox

winofairywinofairy
in Infertility Veterans

I was diagnosed with MTHFR-- homozygous A1298C last August.  My old RE had me take a special MTHFR tablet that he had compounded specially at a local pharmacy.  It's high in b6, b12, and folic acid.  Then my new IVF RE added an additional 4mg of folic acid each day.

I was just speaking with my IVF nurse about whether or not I will need to be on heparin or lovenox and she said the doctor said no because my homocysteine levels were normal.  This worries me because when I had my D&C last April there was a VERY visible clot in the tissue.

Are any of you IVF ladies not taking heparin or lovenox? 

Should I demand to take it even if my homocysteine levels are normal?

BabyFruit Ticker

06.10.12 +HPT 06.12.12 Beta #1 = 2,770 06.14.12 Beta #2 = 6,300
1st U/S 06.18.12 2nd U/S 06.25.12
09.24.12 It's a Boy!! ---> Jacob Owen

Our IF Journey Began: October 2009
**8 Failed IUI's, 1 Blighted Ovum, & 1 Failed IVF**
Dx: MFI, DOR w/MTHFR Homozygous A1298C & Hypothyroidism
03.2012 Lab Results: FSH 6.83 AMH 0.67 TSH 3.8 E2 17
SA 156 million 93% motility 3% morphology

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**~PAIF/SAIF Always Welcome~**
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Re: Any IVF gals not using heparin or lovenox

  • LaLe09LaLe09 member
    I have two copies of MTHFR. I've talked to 4 RE's about this. None of whom recommend lovenox/heparin. I see alot of ladies on these boards who do take it for MTHFR, so i'm really not sure what to think about it all. There does not seem to be an agreed upon consensus in the medical community on how to treat MTHFR- other than high doses of Folic acid/Vit B6.

    DH: Severe MFI/Azoo Me: Compound heterozygous MTHFR
    IVF #1= m/c- methotrexate @6w2d
    FET #1= BFN
    IVF #2= m/c- D&C @8w5d
    IVF #3= Beta #1 9dp5dt= 252, Beta #2 11dp5dt= 417, Beta #3 17dp5dt= 4,952
    US #2 @ 7w2d= twins, baby B measuring behind
    US #3 @ 8w5d= Baby A doing well, no HR in baby B
    *S/PAIF always welcome* BabyFetus Ticker
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  • SweetDahliaSweetDahlia

    I have a blood clotting issue and saw a Hemotologist. She and the RE thought I just needed an asprin and a scrip folic acid. I have had two losses, both went down the same way to the day. :< But I didn't get the RPL testing till after 2.

    IVF 2 failed, and I am not sure about 3 yet. When/If I am supposed to be monitored extra close.

    PAIF and SAIF Always Welcome!
    TTC since 2007
    6 IUIs, 3 IVFs, and 2 m/c :< PCOS, Blood Clotting Disorder & MFI
    IVF #2 Aug 2011 is a BFN:<
    IVF #3 March 2012 is a BFN
    Not sure what to do now. Sad and lost.
    Lilypie Angel and Memorial tickers Lilypie Angel and Memorial tickers
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  • naybirdnaybird
    Ask to see a hematologist if you are having concerns. They know much more about blood problems than your RE.

    I have very specific blood disorders and am monitored monthly by my hema.

    Good luck!
    Renee- 37 DH - Chad - 39
    2/06 - surprise pregnancy - twins
    3/06 - m/c 1st baby at 6 weeks 
    5/06 -2nd baby had no heartbeat at 14 wks.
    D&E - Bled out. Blood transfusions. Week in ICU - Cheated Death!
    Diagnosis: Blood clotting and bleeding disorder, immune issues, & cervical stenosis
    5/10 - 1st IVF cycle - BFN
    FET - 10/12/10 - BFN
    1/11 - IVF with PGD - BFN
    IVF - May - BFN
    6/11 New RE - fingers crossed!
    9/11 - IVF - 4 transferred
    10/13 - BFP!!
    It's a boy! Clint Michael, Due in June!!!

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  • mdluv21mdluv21

    I have other blood clotting issues in addition to MTHFR but I was heparin with my first pregnancy and my MFM took me off at 11 weeks because of spotting/bleeding.  I think it was a huge mistake.  When I met with them for my pre-conception visit, I told them when/if i get pregnant again going off lovenox will not be an option.

    I also take folgard and a prescription prenatal that has a ton of extra folic acid.

    TTC since 07/2009
    Me: PCOS, Blood/Immune Issues DH: Low all 3
    Jun.- Sep. 2010 IUI#1-#3 = BFN
    Oct. 2010 = IVF #1 = B/G Twins (passed away Feb. 2011)
    May 2011 = Myomectomy and trans-abdominal cerclage (TAC)
    Sep. 2011 = Surprise BFP = C/P
    Feb. 2012 = sFET #1 = BFN
    Feb.2012 = Hail Mary IUI #4 = BFN
    April/May 2012 = FET #2 w/our last two embies = BFP (Please let this be it!)
    Beta #1 8dp5/6dt = 234 Beta #2 10dp5/6dt = 695 Beta #3 12dp5/6dt = 1796 Beta #4 17dp5/6dt = 17,888 U/S #1 May 17, 2012 = Twins
    Baby B's heart stop beating at 9 weeks 5 days
    Our little miracle baby is a boy. :)

    Baby Boy Owen and Baby Girl Avery were born too early on Feb. 13, 2011 due to a pedunculated fibroid, incompetent cervix and suspected placental abruption.
    Lilypie Angel and Memorial tickers

    "What the heart has once owned and had, it shall never lose." - Henry Ward Beecher
    SAIF/PAIF Welcome
    Lots of love and luck to my PAIF/3T/IF Veteran ladies, especially my dear friend Zookie. Congrats to Papps, Teach84 and Starbuck on their little ones.
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  • mm29mm29 member

    I have one copy of MTFR.  My RE is only having me take extra folic acid and I take a b-complex vitamin. 

    It would not hurt ask to have your homocycteine levels checked.

     

    ::: Married June 2003:::
    TTC #1 since: Aug. 2008
    Me: 34, DOR, MTHFR-A1298C (heterozygous), decreased blood flow to uterus, Mild Endo
    DH: 38, Balanced translocation 5&10, unexplained MFI, normal SA and SCSA
    Tx History: IUI 1&2= BFN
    IVF# 1 W/ICSI= BFN
    IVF# 2: cancelled d/t no response
    IVF# 3= 1 egg retrieved=immature/not viable
    IVF# 4= c/p
    ***CCRM ODWU***
    Found DHs BT and Me-decreased blood flow to uterus
    Recommended DE IVF w/PGD, incorporate electro-acupuncture. Decided to cycle locally
    ***New RE***
    DE IVF# 1(cycle #6) w/pgd, (freeze all): 30R, 23M, 15F, slow/poor embryo development, 4 biopsied, 1 Normal "Norm"; DE IVF w/PGD, incorporate electro-acupuncture. 
    IVF# 6: (OE/DS) cancelled
    IVF# 7: (OE/DS) 1R, 1M, 1F, arrested day 5
    Plan-DE IVF# 2 (cycle #8): DE/DS in May 2015

    http://icanhazbabyz.blogspot.com/
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  • thewormstheworms member

    it depends on what MHTFR's you have.

    i have the 2 in my sig, i take r/x folic acid for it.  i take lovenox for factor 2 which is a clotting disorder.

    maybe you can compromise and take a baby aspirin as part of protocol.

    GL

    image
    Worrying does not empty tomorrow of its troubles, It empties today of its strength. ~Corrie ten Boom
    Courage doesn't always roar. Sometimes courage is the little voice at the end of the day that says I'll try again tomorrow. ~Mary Anne Radmacher (thank you beadinglady)

    It's been a long journey. TTC since 9/06. multiple IUI's and IVF's and 4 m/c's. IVF#3 = BFP, twins, induced at 34w6d due to baby b passing away (no explanation). Delivered on 35w1d, Baby A - baby girl, and Baby B - baby boy, our little angel.
    MTHFR A1298C & C677T, Immune Issues and Factor II
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  • Holly THHolly TH

    W,

    Is the supplement your doctor compounded have regular synthetic folic acid or L-methylfolate?  Because you are homozygous for the MTHFR polymorphism (the most severe form), you have a very limited ability to metabolize synthetic folic acid.  This puts you at risk for folate deficiency related pregnancy complications.  Active L-methylfolate bypasses the MTHFR polymorphism.  It is 7 times more bioavailable than folic acid.  It increases folate levels and decreases homocysteine levels more effectively than folic acid.  It is something simple and safe you can do while trying to conceive to be sure MTHFR related folate deficiency is not an issue.  

    Married to DH - 1996 DS - 13, DD - 11, DD - 9, DS - 4
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