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Additional Testing? (warning - pic in siggy)

kgs0505kgs0505 member
in Infertility

Hi -

I'm usually on the Adoption board, and occassionally on SAIF.  It's been about 3 years since I last pursued treatments and I have 3 embies on ice I want to use this year so I can close the door on treatments.  However, I want to give them the best chance possible.

My history: me unexplained, DH is perfect.  Testing done - SA, HSG, SHG, Day 3 bloods.  Been off BCPs since we got Married in May 2006.

3 cycles of clomid - unresponsive, 2 IUI/injectibles - BFN, 2 fresh IVFs - BFN, 1 FET - BFN.  NEVER had a positive pregnancy test. 

So what else should I ask for as far as testing?  Have there been any advances for people who seem to not be able to support implantation? 

TIA ladies!

TTC since May 2006. After 3 failed Clomid cycles, 2 failed Injectibles/IUIs, 2 failed IVFs and 1 failed FET, we moved on to adoption! 

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Last ditch FET resulted in BFP, and identical twin girls!

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Re: Additional Testing? (warning - pic in siggy)

  • m&m2006m&m2006 member
    i was unable to support implantation of embryos.  i had a whole immunological work up.  i would maybe look into that next. 
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  • solarflaresolarflare member

    Yes - immunology testing looks at this. It's very expensive for the bloodwork (around $1300) but it will give your doctor the most information. I don't know all of the doctors that specialize in IVF and immunology but mine is one - Dr. Zouves in Foster City, CA. I believe there is one called Dr. Sher on the East Coast but check that on google. Many doctors do not buy the Immunology approach but others embrace it wholeheartedly.

    Good luck with your research. 

    ttc since 2/2010 ~
    me (36): Hypothyroid (on Levothroid), low vit. d, borderline/high fsh (day 3: between 7-10) (day 10: 13 during CCCT), AFC: 14
    dh (31): awesome (minus one sample with agglutination)
    Diagnosis:possible DOR and/or unexplained + elevated NK cells + MTHFR (C677T - one copy)

    MAY 2011 - FEB 2012 - 3 injectable IUI's with numerous cancellations due to high TSH levels
    MAY 2012 - onto IVF/ICSI (Antagonist Protocol) on BCP and Folgard (3 week delay - cyst - boooo) 5/21 start stims 5/30 ER 11R 8M 3F 6/2 3DT of 3 6/12 Beta #1 83 | 6/14 Beta #2 196 | 6/21 Beta #3 3818 | 6/28 Beta #4 22,213 | 7/2 1st U/S - 2 on board! 8/24 CVS reveals that we have a boy AND a girl on board!

    Healthy baby boy and girl born in February, 2013 at 38 weeks and 2 days!


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  • Stace26Stace26
    Your situation sounds a little similar to mine.  We just had an FET after three years without treatment.  We adopted our daughter last year.  You may want to request having a blood clotting disorder ruled out and I know some have been tested for natural killer cells both of which there are treatment for.  I know progesterone support is helpful for implantation.  My RE put me on one PIO daily and Crinone suppositories 2x daily this cycle in hopes that it will help.  Best wishes to you!
    DX: Severe MFI (very low motility) in 2006. 2 IVF's and 1 FET ended in 3 losses. Adopted our baby girl born 10/2/10. FET March 2012= c/p. Officially done with fertIlity treatments. Plan to start adoption process again 2014/2015.
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  • luvbostonluvboston member
    Endometrial biopsy to check for receptivity, immune testing, sonohystergram, pelvic mri
    6 m/c
    Anovulatory cycles, increased Synthroid Diagnosed Sep 2010
    Natural cycle Dec 2010 BFP M/C 6 1/2 Weeks, D&E Jan 2011
    1 Clomid/Ovidrel BFN May 2011
    Natural cycle Aug 2011 BFP M/C 4 Weeks
    1 IUI Sept 2011 BFP M/c 7 weeks
    Provera Dec 2011 BFP M/C 3 Weeks
    DQ ALPHA HLA MATCH, High NK Cells Diagnosed Dec 2011
    IVF March 2012 BFP m/c 4weeks 5 days (IL, Prednisone)
    IVF#2w/DS July 2012 MEGA FAILURE BFN (IL, Dexamethasone)
    Diagnosed No real HLA Match, DQ Beta Triad, High TNF, Low NK Cells
    Oct 2012 Natural Cycle m/c 4wks (Lovenox, Prednisone) 
    Went to Beer Center- high tnf, low lad, implantation failure
    Nov/Dec 2012 LIT Treatment
    Dec 12 Humira
    Jan 2013 BFP
    Humira,LIT,Prednisone, Lovenox, IVIG, Baby Aspirin
    Miracle Born August 2013 Premature

    Yours doesn't have to be a sad story


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    Lilypie - (ugiy)


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  • AngnShaunAngnShaun
    I agree that immune and thrombophilia testing would be the next step.  
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  • kgs0505kgs0505 member
    Thanks ladies! Looks like I have a direction to check out now :)

    TTC since May 2006. After 3 failed Clomid cycles, 2 failed Injectibles/IUIs, 2 failed IVFs and 1 failed FET, we moved on to adoption! 

    image


    Last ditch FET resulted in BFP, and identical twin girls!

    image   
    Report Reply
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