Infertility

Blasts? Hatching?

I am reading up on folks' experiences/ET's, etc. With my retrieval date rapidly approaching, I'm just wondering if there's a quick 101 summary somewhere on here that will tell me what "blasts, etc. mean.  My RE is fantastic, but doesn't spend a huge amount of time breaking all of this down for me and I really want to understand what I should be listening/watching for as good signs, etc., as we move forward...
38. DH 40. TTC since 2005.
Earlier m/c. DX (finally) 10/10: abnormal acrosome.
ICSI #1 3dt 11/20/11 HPT BFP 11/30 Our beautiful daughters were born July 28, 2012.

Image and video hosting by TinyPic ** All welcome. **

Re: Blasts? Hatching?

  • The advanced fertility website has a comprehensive review of embryo development, including grading. However many clinics have their own grading scale so don't be surprised if yours is not the same. GL
    +++
  • Blastocysts or "blasts" are embryos at the state of development that occurs ~5 days after fertilization. At this point they are usually ~100 cells. People talk a lot about blasts with regard to transferring embryos 5 days after fertilization (the alternative is transferring embryos 3 days after fertilization when they are roughly 8 cells). Hatching is sometimes  talked about in the context of assisted hatching, which is an IVF micromanipulation procedure in which a hole is made in the outer layer of the embryo, the zona pellucida, to assist in the hatching of the embryo and subsequent  implantation. You will also hear people talk about hatching blastocysts, which are blastocysts in the final stage of development as they hatch from the zona pellucida, the outer shell of the embryo. Hope this helps a little.

     This site is an amazing summary of IVF procedures, terms etc: https://www.advancedfertility.com/

    IUIs #1-3 (1x unmedicated, 2x Clomid) = 2 BFNs, 1 m/c at 7w3d
    IUIs #4-6 (injects) = 3 BFNs
    IVF #1 = BFN
    FET #1 = BFN
    FET #2 = BFN
    IVF #2 = BFP, b/g twins lost at 20w due to partial abruption/PPROM
    IVF #3 = c/p 5w2d
    Long-shot Clomid/Prednisone cycle before next IVF = BFP, our beautiful, healthy girl born 6/26/13!
    ~~
    TTC again March 2014
    FET #3 - May/June 2014
    -
    all embryos arrested before xfer - back to the drawing board...
    IVF #4 - July/August 2014 
    beta 1 (11dp3dt) 220, beta 2 (13dp3dt) 671, beta 3 (19dp3dt) 10762
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  • As always, a million thanks!!
    38. DH 40. TTC since 2005.
    Earlier m/c. DX (finally) 10/10: abnormal acrosome.
    ICSI #1 3dt 11/20/11 HPT BFP 11/30 Our beautiful daughters were born July 28, 2012.

    Image and video hosting by TinyPic ** All welcome. **
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