MALE KARYOTYPING??

jamielynnohio

RE wants DH to have karyotype test. Getting ready to hit DR Google- but personally what do you know? I don't know anything about it to even know what to ask you ladies about it. Has your DH had it done? What was the outcome? Is there a solution?

TIA 

vanessagorc

My DH has had about a million tests.  do u know the specific name of the test?  Or is this it?

jamielynnohio

vanessagorc:

My DH has had about a million tests.  do u know the specific name of the test?  Or is this it?

I think that's it. It's what's on the order...it's listed under genetic testing. 

07may07

It is just a blood test on his DNA to see if there are any abnormalities which can be passed down to the children.  Both MH and I had it done as part of our RPL testing.

Both of our tests were normal.  

Good luck!

vanessagorc

07may07:

It is just a blood test on his DNA to see if there are any abnormalities which can be passed down to the children.  Both MH and I had it done as part of our RPL testing.

Both of our tests were normal.  

Good luck!

Ah yes we did exactly this...

Did they suggest testing the sperm?  That's totally different.

jamielynnohio

vanessagorc:

07may07:

It is just a blood test on his DNA to see if there are any abnormalities which can be passed down to the children.  Both MH and I had it done as part of our RPL testing.

Both of our tests were normal.  

Good luck!

Ah yes we did exactly this...

Did they suggest testing the sperm?  That's totally different.

no... just blood drawl. Should I ask about the sperm test. They said sperm looked good???

vanessagorc

jamielynnohio:

vanessagorc:

07may07:

It is just a blood test on his DNA to see if there are any abnormalities which can be passed down to the children.  Both MH and I had it done as part of our RPL testing.

Both of our tests were normal.  

Good luck!

Ah yes we did exactly this...

Did they suggest testing the sperm?  That's totally different.

no... just blood drawl. Should I ask about the sperm test. They said sperm looked good???

It depends on how large of a factor they think sperm/mfi is playing into the equation. 

They can only see if sperm is moving, and is the right shape.  If they want to know if it is actually "normal", they need to test it.  Like by doing an SCSA.

jamielynnohio

vanessagorc:

jamielynnohio:

vanessagorc:

07may07:

It is just a blood test on his DNA to see if there are any abnormalities which can be passed down to the children.  Both MH and I had it done as part of our RPL testing.

Both of our tests were normal.  

Good luck!

Ah yes we did exactly this...

Did they suggest testing the sperm?  That's totally different.

no... just blood drawl. Should I ask about the sperm test. They said sperm looked good???

It depends on how large of a factor they think sperm/mfi is playing into the equation. 

They can only see if sperm is moving, and is the right shape.  If they want to know if it is actually "normal", they need to test it.  Like by doing an SCSA.

thnx V! I guess maybe we'll see how this comes out and go to that text next. They think it's mostly egg, but this RE that I had my WTF (diff than my usual RE- another in the practice. the one who took care of me this entire last cycle) has some suspicion that it could be both egg and sperm issue  I love this RE and if we eeeeevvvvvvver cycle again- I want him as my RE. I trust and love him so much.  

amy1004

As part of our azoo dx, we had karyotyping done on dh. It was mostly to determine if there was a y chromosome microdeletion. I imagine that your re is trying to check everything. I think the frag test on the sperm should also be done. I would rather have every test under the sun rather than wonder "what if?". Good luck Hun, I think of you often and hope that you are doing well.

jamielynnohio

amy1004:

As part of our azoo dx, we had karyotyping done on dh. It was mostly to determine if there was a y chromosome microdeletion. I imagine that your re is trying to check everything. I think the frag test on the sperm should also be done. I would rather have every test under the sun rather than wonder "what if?". Good luck Hun, I think of you often and hope that you are doing well.

Amy- you're a doll! Thnx so much!! Trying to move forward. I thought the wtf would give me more closure than it did oh well, It's a process. 

I'll tell my hubs about you ladies answers and go from there  

abvernon

No answer to your question. However I am glad to "see" you on the board as I have been thinking of you.

 

jamielynnohio

abvernon:

No answer to your question. However I am glad to "see" you on the board as I have been thinking of you.

 

awe thanks, I pop on and comment on threads but never really start any of my own... I think of you all often! xoxo 

labbylover03

Hey girl!  Good to "see" you! 

We had karyotyping done on both my DH and myself after our late first tri loss in May 2010.  It's a test that looks at all 46 chromosomes (23 pairs) for any genetic issues.  Mine came back "normal female"....unfortunately, this is how we discovered my DH's balanced translocation.  For him, they were able to see that a small piece of one of his #6 chromosomes and a small piece of one of his #8 chromosomes had broken off and basically "swapped" places.  So he has a BT with chromosomes 6 & 8.  He is completely normal b/c he's not missing any genetic material.  The problem lies in his fertility and when he sends one set (23) of chromosomes in his sperm to meet my set (23) with my egg.  What happens is our embryo will either be balanced (like DH), completely normal, or unbalanced.  After talking with a geneticist, our embryos would statistically be unbalanced 80-90% of the time....thus resulting in m/c.  Unfortunately, with our two pgd cycles, this was true....1 out 18 tested "normal"....or 94% were abnormal.   This is why we've moved onto donor sperm.  For me, it's a very tough dx as not many people have this....like 1 out of 600 or something like that.   

Didn't mean to write a book or scare you, just wanted you to know our experience!  Best of luck with everything!  And ditto PP, I think of you often!      

j-bell

My husband just had this test along with the y chromosome microdeletion last month.  It's a blood draw.  The only other thing that pp's haven't mentioned is that it took over 3 weeks to get the results back.  I don't know if that was just our lab but it could be something to ask if you are trying to schedule an upcoming cycle.  Good luck! 

jamielynnohio

labbylover03:

Hey girl!  Good to "see" you! 

We had karyotyping done on both my DH and myself after our late first tri loss in May 2010.  It's a test that looks at all 46 chromosomes (23 pairs) for any genetic issues.  Mine came back "normal female"....unfortunately, this is how we discovered my DH's balanced translocation.  For him, they were able to see that a small piece of one of his #6 chromosomes and a small piece of one of his #8 chromosomes had broken off and basically "swapped" places.  So he has a BT with chromosomes 6 & 8.  He is completely normal b/c he's not missing any genetic material.  The problem lies in his fertility and when he sends one set (23) of chromosomes in his sperm to meet my set (23) with my egg.  What happens is our embryo will either be balanced (like DH), completely normal, or unbalanced.  After talking with a geneticist, our embryos would statistically be unbalanced 80-90% of the time....thus resulting in m/c.  Unfortunately, with our two pgd cycles, this was true....1 out 18 tested "normal"....or 94% were abnormal.   This is why we've moved onto donor sperm.  For me, it's a very tough dx as not many people have this....like 1 out of 600 or something like that.   

Didn't mean to write a book or scare you, just wanted you to know our experience!  Best of luck with everything!  And ditto PP, I think of you often!      

oh wow thank you so very much for all the info. it makes my wtf RE explanation make more sense. I'm super nervous for the testing, well the results really. It's just crazy. I wish we would have done the additional testing that they are suggesting for him and I before our last 2 IVF's  

I think of you too girl. I am always poppin on looking for your posts! xoxo 

ecleptic

As everyone else explained- it's a simple blood draw to find microdeletion or translocation. We actually had male karyotyping done as part of our initial battery of MFI testing because MIL had 7 miscarriages and 2 live births. That combined with the unexplained severe MFI gave us a chance at finding a microdeletion or balanced translocation and we wanted to know before starting IVF. My DH is normal, luckily. Now I'm being karyotyped- but it hasn't come back yet. It's not something that's typically done until you've had losses or repeated implantation failure because it's moderately expensive and takes a while to come back.

There's no treatment for translocation by itself. PGD is done to find the "normal" embryos.

It typically takes 2-4 weeks to come back from the lab. They culture the blood for a week or so (if I recall correctly) and blow up one of the cells which splits out the chromosomes and they spread them out on a kinda spiffy looking slide and make sure everything looks right. With delayed tests like these it's a good idea to be proactive- DH's test took 10 weeks to make it from the lab to the doctor. It got lost at the lab and forgotten by the clinic, and then it was normal so they didn't call to say it was back... and we weren't following up. I'm to call and keep calling if the clinic hasn't called me by next Friday (about 3 weeks) to discuss results so the karyotype doesn't delay our next cycle.

jillmatheny

Like others said, it's a simle blood test to look at the DNA to rule out a balanced translocation, which can cause m/c on both sides.  I had one years ago, and DH had one after our last m/c. Luckily in our case, both came back normal.

kthappy76

It's just a bloodtest.  His came back normal, so it wasn't all that helpful.  It is testing his chromosomes, so there isn't anything you can do to change them, but you could do PGD if he's a carrier for something.  GL!

sweetky_06

j-bell:

My husband just had this test along with the y chromosome microdeletion last month.  It's a blood draw.  The only other thing that pp's haven't mentioned is that it took over 3 weeks to get the results back.  I don't know if that was just our lab but it could be something to ask if you are trying to schedule an upcoming cycle.  Good luck! 

This was the same for us too - RE even warned us it would take several weeks. Our new RE ordered it for both of us as part of his version of the RPL. My first RE actually discouraged us from getting it done when we asked about it! 

stei8086

We both did this after our 2nd failed IVF and DH did the y microdeletion as well. We both came back as normal male/female. It looks like everyone has posted about the process so  won't repeat. I am glad we did it because it ruled out any genetic abnormalities that we would pass down. Also check to see if it is covered by your insurance because I heard it is expensive. Good luck and hope you are doing well!!

jamielynnohio

Wow that is some really great information. Thank you all so very very much! You all are so helpful; I'm grateful. I will take all of this info and share it with DH!

KDR1979

We also both had karyotypes drawn. They came back 46 xx & 46 xy. I thought that it wouldn't show a y chromosome micro deletion though & that was actually an extra chromosome test. We paid ~$550 each for the tests. I asked re if it was worth further investigation of the y chromosome & he said no. He said if there is something like that, our children would either get it or not get it, but pgd couldn't fix it.