Lupron to trigger?

jlcrane78

Ok, so I was way off base.  My office is using Lupron to trigger me.  Has anyone else heard of that?  They are using it because we are doing the PGD on our embryos so they'll be vitrified, and they say it essentially "ends my cycle" sooner.  I've never heard of that before. 

wordslikeswords

Hi! I've been lurking a lot on here, but I usually post on 3T so I hope you don't mind if I hop over to respond.

My RE uses a lupron trigger for me. I was told it was to prevent OHSS. I'm not sure about ending the cycle, but I didn't get OHSS, so I don't think it's a bad thing. I've found it to work just fine as a trigger, too.

theworms

Lupron is used to trigger is some cases.

GL cutie

AmberB75

I had a Lupron trigger on both of my IVF cycles.  I was told its used when there is a high risk of OHSS, which was a big concern on both of my cycles.  There is essentially zero risk of OHSS with a Lupron trigger.

Sloane99

I used Lupron to trigger as well, for the exact same reasons, we did PGD on our 3 blasts and I am just beginning the meds for my FET tomorrow.

The Lupron in small doses will trigger just like any other one and you will not be at risk for OHSS, it essentially shuts your body down after ER - meaning that there's no way to do an ET afterwards or anything which is why more don't use it. If you're doing a planned FET then it's good because the RE's can push you a bit more aggressively given there's no OHSS risk. If you have any other questions, let me know!

jlcrane78

Sloane99:

I used Lupron to trigger as well, for the exact same reasons, we did PGD on our 3 blasts and I am just beginning the meds for my FET tomorrow.

The Lupron in small doses will trigger just like any other one and you will not be at risk for OHSS, it essentially shuts your body down after ER - meaning that there's no way to do an ET afterwards or anything which is why more don't use it. If you're doing a planned FET then it's good because the RE's can push you a bit more aggressively given there's no OHSS risk. If you have any other questions, let me know!

Ooh, I'd love to know more about your cycle.  You can send me a PM if you don't want to post here, but I'd like to know how many eggs you had retrieved, how many fertilized, how many embryos made it to PGD testing, and how many were considered normal.  I wish you a ton of luck with your transfer tomorrow!

Sloane99

No problems posting, these boards know way too much about me as it is! Your post caught my eye since I haven't heard of too many of use doing the PGD on 5d and a later FET.

I used Follistim, Menopur and growth hormone in my cycle with Ganirelix as the antagon. I had my ER earlier this month, they got 12 eggs, 8 mature, 7 fertilized (ICSI), on day 3 we had four 8-celled embies, one 6 cell one and three at 5 cells. By day 5 we had three that made it blast and are now frozen. We are still awaiting the PGD results and basically sitting on our phones right now as it should have been a week ago so not sure how many are considered normal.

I'm starting meds for my FET tomorrow, not having my FET. I did breakthrough bleed about 5 days after ER which they attributed to the Lupron trigger, I went on Provera and never got a withdrawal bleed from that, then did a PIO shot and nothing. Finally had an U/S that showed my lining was super thin, so the breakthrough bleed was all the AF I am going to get. My FET cycle consists of 30 days of Lupron, then add in Estrace for 2 weeks, then stop Lupron and add in Progesterone for 5 days, then ET.

It's a long road, especially since my body didn't co-operate, but really, what isn't a long road with IF and when has my body co-operated! We're happy with our decision to do it this way though.

What's your story, why did you guys decide to go this route?

 

Faith722

I did a lupron trigger with my this past cycle.  It was a last minute change b/c my E2 was rising fast.  I was told there's a lower risk of OHSS with a lupron trigger and that's why we used it.

DeputiesWife

I was given 2 triggers this cycle - luporn and HCG - they went with the HCG.

 

Just wanted to wish you luck.  

jlcrane78

Sloane99:

No problems posting, these boards know way too much about me as it is! Your post caught my eye since I haven't heard of too many of use doing the PGD on 5d and a later FET.

I used Follistim, Menopur and growth hormone in my cycle with Ganirelix as the antagon. I had my ER earlier this month, they got 12 eggs, 8 mature, 7 fertilized (ICSI), on day 3 we had four 8-celled embies, one 6 cell one and three at 5 cells. By day 5 we had three that made it blast and are now frozen. We are still awaiting the PGD results and basically sitting on our phones right now as it should have been a week ago so not sure how many are considered normal.

I'm starting meds for my FET tomorrow, not having my FET. I did breakthrough bleed about 5 days after ER which they attributed to the Lupron trigger, I went on Provera and never got a withdrawal bleed from that, then did a PIO shot and nothing. Finally had an U/S that showed my lining was super thin, so the breakthrough bleed was all the AF I am going to get. My FET cycle consists of 30 days of Lupron, then add in Estrace for 2 weeks, then stop Lupron and add in Progesterone for 5 days, then ET.

It's a long road, especially since my body didn't co-operate, but really, what isn't a long road with IF and when has my body co-operated! We're happy with our decision to do it this way though.

What's your story, why did you guys decide to go this route?

 

We did our first round of IVF thinking we were only MFI.  We retrieved 8 eggs, 6 were mature, and 5 fertilized.  Those 5 were all perfect 8 cells on day 3, but they did not make it to blast by day 5 so my RE office cancelled my transfer.  Their protocol is to see if they make it to blast by day 6 and then vitrify them for a FET the following series.

3 of our embies made it to blast on day 6, so they vitrified them and I began the preparation for my FET.  2 of them survived the thaw perfectly, but the 3rd could have gone either way.  The RE encouraged me to transfer all 3, so that is what we did.  We were devastated to find out on beta day that it was a negative.  We met with the doctor about a month later, and he diagnosed me DOR based on my poor response to stims, a low E2 at trigger, and the fact that my embryos didn't progress to blast by day 5 (not to mention our BFN).  He said they probably didn't take because they were abnormal and strongly recommended us to do PGD during our next cycle.

We definitely don't want to transfer abnormal embryos, so we are following through with his recommendation.  I'd really like a minimum of 6 to send in for biopsy.  We're OOP, and the PGD is definitely not cheap.   It has been mentioned we can do embryo banking if we don't get as many as we'd like, so I am keeping that in the back of my head.  I honestly don't know what would be cheaper...sending what we have if we don't get enough or running through another ER.  Our x3 package wasn't created for situations like this, so I'm sure they will want some additional fees.  

I start stims a week from tomorrow, and I am praying hard we get a lot of embryos the first retrieval around and don't even need to consider a 2nd.  Definitely keep me posted on how things go for you since you are right...we are one of those people in the minority that do this!  Good luck!

Sloane99

Hmmm, this is eerily similar, until about 2 hours ago, we assumed we were MFI as well....turns out every single one of our 7 fertilized were abnormal...different abnormal too, like edward's, tri-13, etc. They don't think I'm DOR based on high E2 levels by ER, but right now I'm just just numb. Guess we're gearing up for round 2 and very definitely will be doing the PGD again. Keep me in the loop, I really hope that you have a great cycle and those ovaries do their job!

jlcrane78

Sloane99:

Hmmm, this is eerily similar, until about 2 hours ago, we assumed we were MFI as well....turns out every single one of our 7 fertilized were abnormal...different abnormal too, like edward's, tri-13, etc. They don't think I'm DOR based on high E2 levels by ER, but right now I'm just just numb. Guess we're gearing up for round 2 and very definitely will be doing the PGD again. Keep me in the loop, I really hope that you have a great cycle and those ovaries do their job!

Oh, Sloane.  I am so sorry hun.  Do they have any kind of information for you, such as additional testing you could do outside of the PGD?  When will you be able to cycle again?  I will be rooting for you as you go through round 2, and I will definitely keep you updated on how things go on my end.  Sending hugs.  

Sloane99

Thank you so much, I saw your post on my IF thread as well.

No information at all, other than he strongly suspects it's not related to the sperm quality, and this is an egg issue  based on the way they were growing and dividing, at a point during their growth where it would have been egg dependent. I've made some lifestyle changes recently as part of gearing up for implantation, and I always thought egg quality was what it was, but now I'm hoping that some of these changes will effect our outcome on IVF 2, supplements, accupuncture, etc. We are cycling again in August.