hey all, I am moving on to letrozole (femera) next cycle due to funky visual side effects and inconsistant responses to Clomid. What is the difference betweeen the two meds and can one expect to respond better to letrozole than Clomid? Are the chances per month of getting PG about the same? Any info/advice would help!


TTC since 1/10 DX PCOS
Early 2010: 3 rounds of Clomid 50mg, 100mg, & 150mg. responded to first cycle, but all BFN
summer 2010: break
10/10: 100 mg Clomid cancelled due to no response
11/10: RE consult: begin Metformin 1500 mg + I month BCPs
12/10: 100 mg Clomid + Hcg + TI + progesterone = BFN
1/11: 5 mg Femera + Hcg + IUI + progesterone = BFP!!!
2/21/11: beta # 1 116 2/23: beta # 2 57 =2/25 m/c
3/2011: break cycle
3/30/11: surprise BFP! beta #1 =36 beta #2 4/1/11= 87 beta #3 4/5/11= 701
4/20/11: US hb found @ 6w2d
Re: Clomid vs. Letrozole success?
I wish I had some answers for you. I'm hoping to try femara for TTC#2 in a couple of months. I didn't respond at all to clomid -- no ovulation -- and I can't afford injectables this time around, so I have big hopes for femara.
I'm sure I've heard here that femara often works when clomid doesn't. Hopefully someone with experience will chime in.
Good luck!
I don't really have answers for you but I'm sort of in the same boat. I'll be trying Letrozole next cycle. DS was conceived on a break cycle after injects, I did 4 rounds of clomid and never responded.
While TTC#2 I've been TTC since September 2009, at first was just on Met (PCOS), have done 3 rounds of clomid, I responded but was not successful. I'm going to try 2 rounds of Letrozole before moving on to injects.
TTC #2 with PCOS since September 2009
BFP, Femara 7.5mg, Ovidrel, IUI. Beta #1 17dpIUI -495 Beta #2 19dpIUI-1031
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Caroline is a letrozole baby...I tried 5 rounds of clomid with no success.
Good luck!