I think lupron is the easiest too even though it's the same size needle as follistim/menopur/ganirelix. I never really got any reaction or stinging from lupron so I always did those shots myself. I'm so scared of the PIO needles!!!
The PIO needles actually don't hurt going in or anything. They just cause pain afterward - my butt was SO bruised and sore that for the first week it hurt to lie down. And even after I stopped them my butt muscle was sore for weeks. But the shot itself is fine
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Re: Oh - and a good thing about Lupron