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PIO vs. Progesterone suppository???

mamabear7mamabear7
in Infertility

We had our IVF teach session yesterday.  The RE wrote the pharmacy order and it included both the progesterone in oil injectable as well as a progesterone suppository.  The nurse told me it wasn't necessary to do both and that the PIO injectable is very painful.  I thought it was strange that she was going against the doctors orders.  Anyways, I'll definitely do both if it will increase my chances of the IVF resulting in a pregnancy.  I see my RE again in a couple weeks so I can ask him, but wanted to get your thoughts.  TIA!

Baby Birthday Ticker Ticker BabyFruit Ticker image Eloise & Grant born 7/3/11
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Re: PIO vs. Progesterone suppository???

  • Dr.LorettaDr.Loretta member
    I have never heard of using both, only one.
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  • CandTCandT
    During my fresh cycle I started with the shots and then switched to the suppositories. For my upcoming frozen cycle I have to do both. Just double check with your RE to see what they are meant for, they may have you switch after a few weeks. Good luck!!
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  • cadencaden member

    My last IVF cycle I did both and I will again for this cycle. Last IVF I alternated - 1 PIO one day and 3 suppositories the next day. This time I will do every other day for PIO and suppositories every day.

    Some REs feel people respond better to one or the other, so including both covers both bases. The shots don't hurt that bad. They look a lot scarier than they really are.

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  • EchloeEchloe
    I take both now and took both with my last cycle.  It doesn't hurt you to take more progesterone. If your doctor suggests both then do it.
    Beautiful Miracle Baby lost at 21 weeks due to pre-term labor and incompetent cervix. FET#1 BFN, FET#2 BFP, early loss. FET#3 BFN. IVF#2 BFFN. FET #4 BFP after removing bilateral hydrosalpinx and 3 months of lupron depot. Sticky Bun is here!! Image and video hosting by TinyPic Baby Birthday Ticker Ticker
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  • melaniescmelaniesc

    I don't think it makes a difference which one you do. My IVF 2 years ago I only did Crinone suppositories and I was fine and had DD.

    Flashforward to now: I'm using same RE to ttc #2 and doing IVF again. The office told me they changed their protocol and that they wanted me to do PIO for at least the days between ER and ET and then switch to crinone. Initially i was ok with this, but once I started all my stims they were so painful and I was having such a hart time that I told RE I was not going to do PIO basically because I was tired of shots, emotionally drained and i'd heard PIO was super painful.

     My RE was totally fine with that and I'm only taking Crinone 2xs a day. I am totally fine with this because as i mentioned earlier i only used Crinone the last time and had DD.

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  • mamabear7mamabear7
    thanks everyone.  I will definitely check with my RE.
    Baby Birthday Ticker Ticker BabyFruit Ticker image Eloise & Grant born 7/3/11
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