Infertility

Abnormal Semen Analysis. Thoughts?

Hi everyone!

My husband (35) and I (33) are a same-sex male couple about to begin our IVF journey with donor eggs+surrogate. We thought everything would go well and that there wouldn’t be any issues. Unfortunately that isn’t the case as my husband got his results back and he did have an abnormal semen analysis:

Concentration: 114 million (normal > 15 million)
Motile: 74% (normal > 40%)
Normal Morphology: 3% (normal >=4)

Everything else looked normal but those are the three main factors I’ve learned contribute to male fertility and normal morphology being that low definitely sounds like it will be an issue when it comes to fertilizing eggs. I’ve read online a ton of conflicting info and our doctor hasn’t talked to us yet which is making this even harder.

Can anyone help provide any insight for us or share their personal experiences?

Thanks for your help!

Re: Abnormal Semen Analysis. Thoughts?

  • Just wanted to update that we were told that our clinical team isn’t worried about it, (our doc literally signed off on the results the same day we gave the specimen). They’ll be using ICSI (which they made it sound like that was very common to do anyway for their clinic).
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  • I know you have your answer but still wanted to chime in with my personal experience.

    When my husband had his semen analysis, his concentration and motility were normal (although possibly even lower than your husband's), and his morphology was only 1%. My OB stated they consider it a "yellow flag" as they really don't know how many men out there have no issues with conceiving but have extremely low morphology. We did IUIs which were all unsuccessful. When we moved to IVF they also used ICSI for the procedure. This basically takes the issue of low morphology out of the equation since they inject 1 single normal shaped sperm into the egg. For us the majority of the mature eggs did fertilize so I wouldn't worry too much knowing they will be doing ICSI!

    And FWIW, skipping way ahead in my timeline dealing with infertility, we discovered IVF wasn't necessary as we were able to conceive naturally for reasons that IVF wouldn't fix (implantation problem). I will say it may be beneficial for your husband to take a multivitamin prior to your IVF. It really doesn't help with morphology, but it can improve the concentration and motility for healthier sperm.

    Good luck!
    *TW* History:
    Me: 34 DH: 36 | Together since 2007 | Married July 2016

    TTC #1 since 7.2017
    Dx: low morph (1%), ANA positive, low decidualization score, high TSH and testosterone, histone antibodies

    IUI #1-3 all BFN
    IVF #1 | 6.11.19 | 24R, 17M, 15F, 6B, PGT-A tested - 5 normal, 3 girls & 2 boys
    FET #1 | 9.10.19 | BFN "I know you, but we've never met. I'm with you, but I don't know your name"
    RPL, Receptiva, & ERA testing | all normal/negative, recommended going on gluten and dairy free diet for next FET
    FET #2 | 3.31.20 | Opted to cancelled due to pandemic, continued diet and tried naturally over the summer
    2nd Opinion with another RE | 8.20.20 | Not immune to measles (received 1 dose); SA results similar to 2 years ago; decided to move forward with FET #2 redo at start of next cycle
    Surprise natural BFP! | 9.22.20 | MC 10.23.20 at 8 weeks
    TTCAL naturally | starting 11.22.20

    Initial consultation with Reproductive Immunologist | 9.14.21
    Decidualization score biopsy | 10.1.21 | abnormal - low score of 1; endometrial scratch recommended and progesterone supplementation
    Saline sono | 10.15.21 | normal
    Bloodwork | 10.21.21 high TSH, high testosterone, positive for anti-nuclear antibodies and histone antibodies, high protein S, multiple genetic mutations
    BFP! | 11.3.21 | EDD 7.14.22 B) | biopsy provided same effect as endometrial scratch; added supplemental progesterone and estrogen, prednisone, levothyroxine, and MTX Support to maintain pregnancy
    DS born 7.19.22 after induction


    TTC #2 begins 6.2023
    Consultation with RI | 6.6.23
    Saline sono, endometritis biopsy, skin & eye check | all normal
    Labs | high TSH, Factor XIII mutation, high %CD56
    Follow up | 8.8.23 | prescribed metformin, prednisone, plaquenil, and levothyroxine
    Repeat labs after 3 weeks on meds
    Follow up | 11.9.23 | Green light!, increase in prednisone, added lovenox
    Repeat labs in 8 weeks
    Follow up | 1.16.24 | Green light continues
    TTC put on pause indefinitely
  • skier8390skier8390 member
    edited June 2023
    Thanks inthewoods23! That was very reassuring to read and lines up with what our clinical team was saying. We will proceed using his sperm then. My husband has started taking a multivitamin and we’re both trying to eat healthier and exercise (not just for fertility’s sake but also to be healthy parents for our child).
  • Just looking mathematically, I wouldn't be concerned. With their normal ranges, 15 million sperm, with 40% motile and 4% good morphology leaves 240,000 "good" sperm in that sample size. Your concentration and motile percentage is so much higher, even with the slightly lower percentage of good morphology, you actually end up with more than 10 times more "good" sperm overall in that sample size: 115 million x .74 x .03= more than 2.5 million. They might be trying to upsell you on the ICSI (it does cost more). You could look into/consider if rescue ICSI is something you'd prefer. That gives some time for natural fertilization, but then they'll do ICSI if needed for any egg that wasn't fertilized
  • Thanks for the response 00kim00! It helps when you put it in that perspective! I’ll also keep the ICSI cost in mind.
  • In this article, they say morphology is only one of the variables, and the rest of parameters are ok. Good luck with ICSI. 
  • I understand this is a challenging situation. It's important to consult with your fertility specialist for a detailed analysis and personalized guidance. Low morphology might affect fertilization, but there are options like ICSI to address it. Stay hopeful and proactive in seeking professional advice.
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