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IF Testing & Treatment w/o 1.24

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Re: IF Testing & Treatment w/o 1.24

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    oh no @fantasyflyte!! i'm so sorry this whole thing has proven so very very stressful. what a mess. for whatever it is worth, though, if you're able to get the IUI by sunday morning this is still very much within the window of catching that egg. As I recall from back in the day when i was obsessively reading articles about IUI timing, a 36-42 hour window is not uncommon. but definitely have sex too. and hopefully the roads will be open and you'll be able to sneak in tomorrow!
    History
    I am doing this on my own. Left ovary and fallopian tube removed due to cyst/necrosis just after birth. Right ovary and tube still purport to function.
    Began TTC in Aug '18 @ age 35
    5 or 6 (or 7?!) cycles using frozen donor sperm, ICI. All BFN
    Mar-Jun '19 IUIs, all BFN
    Began process of referral for RE in spring of '19, blood tests confirm low AMH (.54) but all else is good.
    May '19 HSG shows open tube, but ultrasound suggests fibroids
    MRI in June '19 confirms two large fibroids, one growing through wall of uterus
    In June '19 I move from California to Oregon, disrupting my insurance, referrals, etc. 5 months spent piecing it all back together.
    Nov. '19 attempted myomectomy (vaginal approach) failed. 2nd surgery using laparoscopic method in Jan '20 is successful.
    April '20 --> June '20, natural IUIs, all BFN.
    July? saline ultrasound and bubble test demonstrate open tube
    July '20 clomid cycle cancelled for thin lining
    Aug-Oct, 3 femara cycles, all BFN
    RE referral. While waiting to set up an appointment Nov-Jan,I continue with natural cycles and ICI, using a known donor, BFN...
    Jan '21 more bloodwork, AMH is worse (.30), FSH high albeit not catastrophic at 13.2. hysteroscopy all good. "looks cozy!" says the RE.
    Feb '21, injectables (menopur, novarel), iui, BFN (doc said the frozen donor sperm sample had the "best numbers she'd ever seen!")
    Mar '21, injectables, iui cancelled due to lack of follicles, converted to at home-insem. BFN
    May '21, first IVF round cancelled due to cyst.
    July '21 IVF: standard antagonist. 225menupur/225gonal-f/cetrotide/5000u trigger, AFC 7; 6 days of stims. 8 eggs retrieved, 7 mature, 5 fertilize, 4 made it to blast. 3 are 4AB, 1 is 4BB. PGT-A results all abnormal.
    Oct '21 somewhat improved AMH (.51) and significantly improved FSH (8.9). Maybe it's all the pills I swallow.
    Dec -21, standard antagonist. 225menupur/225gonal-f/cetrotide/5000u trigger, AFC 5; 11 days of stims. retrieval yields 5, 4M, 2 reach day-6 blast (4AB & 4BB). 1 low-level mosaic (chr. 3 deletion), 1 complex abnormal.
    Feb '22 FET (low-level mosaic): CP.
    May '22 egg retrieval, lupron flare protocol. HGH priming for 1 month before stims; md lupron 20/20u daily; menopur 225, follistim 225, 10k trigger after 8 days of stims; AFC 10; 13 retrieved; 10 mature; 8 fertilized. All frozen at 2PN for later thaw, grow, and biopsy.
    July '22 egg retrieval same protocol: 9 days of stims; AFC 8; 10 retrieved, 8 mature, 4 fertilized and frozen.
    Sept '22 ER same protocol: AFC 10; 12 retrieved, 11 mature, 11 fertilized.
    From the 3 retrievals, 7 survived to day 5-6 blastocyst, from which I have 2 normal embryos!
    Jan 20, Fully medicated FET, baby aspirin, dexamethasone, acupuncture, and as much woo as I can stand (which isn't very much). BFN.
    July 23, Natural FET + baby aspirin. BFN.
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    bows22bows22 member
    edited January 2022
    @fantasyflyte at my clinic the IUI would be Sunday, they only count a positive/peak with FMU so tomorrow morning would be the one that counts, and they would schedule it for the next day. So don’t stress! But yes have sex tonight!
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    @fantasyflyte Ugh, so sorry for the added stress levels. You have good calming advice from Optimist and Bows. Hope you’re able to get the IUI tomorrow if that makes you feel better. If not, Sunday should be good too. 
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    Thanks guys. I'm thinking about asking when I call tomorrow if we can do an ultrasound Sunday morning to see if I've already ovulated or not and do the IUI if I haven't? Or maybe just IUI and hope. We'll figure it out, it's just frustrating. Especially at the end of an already bad day.
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    @fantasyflyte there is some evidence to suggest that if ovulation has recently occurred, an IUI may be even more likely to succeed than just prior to ovulation. Just so long as its not too long after ovulation. I'm not sure how well an ultrasound tech can guess re: # of hours post-O you might be.
    There are also studies that suggest that an IUI pretty much anytime after LH surge is detected and up to 42 hours afterwards all work approximately as well. I've been where you are, and I know how tempting it can be to try to manage the timing on the IUI because it's basically the only aspect of this you can attempt to control. But try to trust that if you're within that broad window, you're pretty likely to put sperm and egg into contact with one another.
    History
    I am doing this on my own. Left ovary and fallopian tube removed due to cyst/necrosis just after birth. Right ovary and tube still purport to function.
    Began TTC in Aug '18 @ age 35
    5 or 6 (or 7?!) cycles using frozen donor sperm, ICI. All BFN
    Mar-Jun '19 IUIs, all BFN
    Began process of referral for RE in spring of '19, blood tests confirm low AMH (.54) but all else is good.
    May '19 HSG shows open tube, but ultrasound suggests fibroids
    MRI in June '19 confirms two large fibroids, one growing through wall of uterus
    In June '19 I move from California to Oregon, disrupting my insurance, referrals, etc. 5 months spent piecing it all back together.
    Nov. '19 attempted myomectomy (vaginal approach) failed. 2nd surgery using laparoscopic method in Jan '20 is successful.
    April '20 --> June '20, natural IUIs, all BFN.
    July? saline ultrasound and bubble test demonstrate open tube
    July '20 clomid cycle cancelled for thin lining
    Aug-Oct, 3 femara cycles, all BFN
    RE referral. While waiting to set up an appointment Nov-Jan,I continue with natural cycles and ICI, using a known donor, BFN...
    Jan '21 more bloodwork, AMH is worse (.30), FSH high albeit not catastrophic at 13.2. hysteroscopy all good. "looks cozy!" says the RE.
    Feb '21, injectables (menopur, novarel), iui, BFN (doc said the frozen donor sperm sample had the "best numbers she'd ever seen!")
    Mar '21, injectables, iui cancelled due to lack of follicles, converted to at home-insem. BFN
    May '21, first IVF round cancelled due to cyst.
    July '21 IVF: standard antagonist. 225menupur/225gonal-f/cetrotide/5000u trigger, AFC 7; 6 days of stims. 8 eggs retrieved, 7 mature, 5 fertilize, 4 made it to blast. 3 are 4AB, 1 is 4BB. PGT-A results all abnormal.
    Oct '21 somewhat improved AMH (.51) and significantly improved FSH (8.9). Maybe it's all the pills I swallow.
    Dec -21, standard antagonist. 225menupur/225gonal-f/cetrotide/5000u trigger, AFC 5; 11 days of stims. retrieval yields 5, 4M, 2 reach day-6 blast (4AB & 4BB). 1 low-level mosaic (chr. 3 deletion), 1 complex abnormal.
    Feb '22 FET (low-level mosaic): CP.
    May '22 egg retrieval, lupron flare protocol. HGH priming for 1 month before stims; md lupron 20/20u daily; menopur 225, follistim 225, 10k trigger after 8 days of stims; AFC 10; 13 retrieved; 10 mature; 8 fertilized. All frozen at 2PN for later thaw, grow, and biopsy.
    July '22 egg retrieval same protocol: 9 days of stims; AFC 8; 10 retrieved, 8 mature, 4 fertilized and frozen.
    Sept '22 ER same protocol: AFC 10; 12 retrieved, 11 mature, 11 fertilized.
    From the 3 retrievals, 7 survived to day 5-6 blastocyst, from which I have 2 normal embryos!
    Jan 20, Fully medicated FET, baby aspirin, dexamethasone, acupuncture, and as much woo as I can stand (which isn't very much). BFN.
    July 23, Natural FET + baby aspirin. BFN.
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    here's an article. before reading this, remember to keep in your mind that according to the way most clinics do things and how they did things in this study, your "peak" reading would be this morning (saturday), since they instruct women to only test for their LH surge once each morning. so... taking that under consideration, this study indicates for women who have received their positive first-thing-in-the-morning opk, an IUI +/- 24 hours after that (so sunday morning for you) is better than 2 days later (monday morning). but even 2 days later, there are still a significant # of women who get pregnant.
    History
    I am doing this on my own. Left ovary and fallopian tube removed due to cyst/necrosis just after birth. Right ovary and tube still purport to function.
    Began TTC in Aug '18 @ age 35
    5 or 6 (or 7?!) cycles using frozen donor sperm, ICI. All BFN
    Mar-Jun '19 IUIs, all BFN
    Began process of referral for RE in spring of '19, blood tests confirm low AMH (.54) but all else is good.
    May '19 HSG shows open tube, but ultrasound suggests fibroids
    MRI in June '19 confirms two large fibroids, one growing through wall of uterus
    In June '19 I move from California to Oregon, disrupting my insurance, referrals, etc. 5 months spent piecing it all back together.
    Nov. '19 attempted myomectomy (vaginal approach) failed. 2nd surgery using laparoscopic method in Jan '20 is successful.
    April '20 --> June '20, natural IUIs, all BFN.
    July? saline ultrasound and bubble test demonstrate open tube
    July '20 clomid cycle cancelled for thin lining
    Aug-Oct, 3 femara cycles, all BFN
    RE referral. While waiting to set up an appointment Nov-Jan,I continue with natural cycles and ICI, using a known donor, BFN...
    Jan '21 more bloodwork, AMH is worse (.30), FSH high albeit not catastrophic at 13.2. hysteroscopy all good. "looks cozy!" says the RE.
    Feb '21, injectables (menopur, novarel), iui, BFN (doc said the frozen donor sperm sample had the "best numbers she'd ever seen!")
    Mar '21, injectables, iui cancelled due to lack of follicles, converted to at home-insem. BFN
    May '21, first IVF round cancelled due to cyst.
    July '21 IVF: standard antagonist. 225menupur/225gonal-f/cetrotide/5000u trigger, AFC 7; 6 days of stims. 8 eggs retrieved, 7 mature, 5 fertilize, 4 made it to blast. 3 are 4AB, 1 is 4BB. PGT-A results all abnormal.
    Oct '21 somewhat improved AMH (.51) and significantly improved FSH (8.9). Maybe it's all the pills I swallow.
    Dec -21, standard antagonist. 225menupur/225gonal-f/cetrotide/5000u trigger, AFC 5; 11 days of stims. retrieval yields 5, 4M, 2 reach day-6 blast (4AB & 4BB). 1 low-level mosaic (chr. 3 deletion), 1 complex abnormal.
    Feb '22 FET (low-level mosaic): CP.
    May '22 egg retrieval, lupron flare protocol. HGH priming for 1 month before stims; md lupron 20/20u daily; menopur 225, follistim 225, 10k trigger after 8 days of stims; AFC 10; 13 retrieved; 10 mature; 8 fertilized. All frozen at 2PN for later thaw, grow, and biopsy.
    July '22 egg retrieval same protocol: 9 days of stims; AFC 8; 10 retrieved, 8 mature, 4 fertilized and frozen.
    Sept '22 ER same protocol: AFC 10; 12 retrieved, 11 mature, 11 fertilized.
    From the 3 retrievals, 7 survived to day 5-6 blastocyst, from which I have 2 normal embryos!
    Jan 20, Fully medicated FET, baby aspirin, dexamethasone, acupuncture, and as much woo as I can stand (which isn't very much). BFN.
    July 23, Natural FET + baby aspirin. BFN.
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    fantasyflytefantasyflyte member
    edited January 2022
    @optimistgardener thank you! I tried googling some last night but got confused lol.

    My nurse emailed me back today and said that for best timing, they'd say to have sex today and tomorrow, but she's going to ask the doctor if we should still do an IUI tomorrow and email me back.

    We did have sex last night, and will continue through the weekend if no IUI, so maybe the letrozole will turn out to be the key and trying on our own will do it.

    ETA just for clarity, my RE has you do the CBAD test between 4 and 8 pm, and if it's positive to leave a message on a dedicated voicemail line and just come in the next morning. Maybe they do it that way because they do their IUIs in the morning?
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    aaaaand no IUI this cycle, just intercourse. Imma go cry in the corner for a bit.
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    i'm sorry @fantasyflyte
    History
    I am doing this on my own. Left ovary and fallopian tube removed due to cyst/necrosis just after birth. Right ovary and tube still purport to function.
    Began TTC in Aug '18 @ age 35
    5 or 6 (or 7?!) cycles using frozen donor sperm, ICI. All BFN
    Mar-Jun '19 IUIs, all BFN
    Began process of referral for RE in spring of '19, blood tests confirm low AMH (.54) but all else is good.
    May '19 HSG shows open tube, but ultrasound suggests fibroids
    MRI in June '19 confirms two large fibroids, one growing through wall of uterus
    In June '19 I move from California to Oregon, disrupting my insurance, referrals, etc. 5 months spent piecing it all back together.
    Nov. '19 attempted myomectomy (vaginal approach) failed. 2nd surgery using laparoscopic method in Jan '20 is successful.
    April '20 --> June '20, natural IUIs, all BFN.
    July? saline ultrasound and bubble test demonstrate open tube
    July '20 clomid cycle cancelled for thin lining
    Aug-Oct, 3 femara cycles, all BFN
    RE referral. While waiting to set up an appointment Nov-Jan,I continue with natural cycles and ICI, using a known donor, BFN...
    Jan '21 more bloodwork, AMH is worse (.30), FSH high albeit not catastrophic at 13.2. hysteroscopy all good. "looks cozy!" says the RE.
    Feb '21, injectables (menopur, novarel), iui, BFN (doc said the frozen donor sperm sample had the "best numbers she'd ever seen!")
    Mar '21, injectables, iui cancelled due to lack of follicles, converted to at home-insem. BFN
    May '21, first IVF round cancelled due to cyst.
    July '21 IVF: standard antagonist. 225menupur/225gonal-f/cetrotide/5000u trigger, AFC 7; 6 days of stims. 8 eggs retrieved, 7 mature, 5 fertilize, 4 made it to blast. 3 are 4AB, 1 is 4BB. PGT-A results all abnormal.
    Oct '21 somewhat improved AMH (.51) and significantly improved FSH (8.9). Maybe it's all the pills I swallow.
    Dec -21, standard antagonist. 225menupur/225gonal-f/cetrotide/5000u trigger, AFC 5; 11 days of stims. retrieval yields 5, 4M, 2 reach day-6 blast (4AB & 4BB). 1 low-level mosaic (chr. 3 deletion), 1 complex abnormal.
    Feb '22 FET (low-level mosaic): CP.
    May '22 egg retrieval, lupron flare protocol. HGH priming for 1 month before stims; md lupron 20/20u daily; menopur 225, follistim 225, 10k trigger after 8 days of stims; AFC 10; 13 retrieved; 10 mature; 8 fertilized. All frozen at 2PN for later thaw, grow, and biopsy.
    July '22 egg retrieval same protocol: 9 days of stims; AFC 8; 10 retrieved, 8 mature, 4 fertilized and frozen.
    Sept '22 ER same protocol: AFC 10; 12 retrieved, 11 mature, 11 fertilized.
    From the 3 retrievals, 7 survived to day 5-6 blastocyst, from which I have 2 normal embryos!
    Jan 20, Fully medicated FET, baby aspirin, dexamethasone, acupuncture, and as much woo as I can stand (which isn't very much). BFN.
    July 23, Natural FET + baby aspirin. BFN.
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    Oh @fantasyflyte I’m so sorry, I’ve been lurking and hoping for you. Big creepy internet hug. 
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    @fantasyflyte Oh no😢 I’m so sorry. This is a really rotten turn of events. Two cycles in a row is not fair. Let’s all hope that like you said, the Letrozole does the trick with TI. 
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    Thanks @optimistgardener @anniemarie887 @keikilove . At least a blizzard is good conditions to roll around in bed for a bit. :grimace:
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    @fantasyflyte I am sorry for a blizzard getting in the way when insurance finally came through! This process requires some many stars to line up just right, it can feel so daunting. FX that this is your cycle anyways! 
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    @fantasyflyte I’m so sorry that this cycle is yet another bust for IUI. Gonna hope and pray that Letrazole is all the help you needed!

    @keikilove I guffawed when I read the bit about your RE having a shock at teaching you something lol. I hope that medication does the trick for your lining!!!! And also… your ovaries are MVPs! Hopefully they can keep bringing that A game for your final final final duo-stim. 🤞🏻🤞🏻🤞🏻🤞🏻🤞🏻🤞🏻🤞🏻🤞🏻🤞🏻
    MY CHART
    TTC History
    TTC#2
    Me: 40.5; MH: 39 | Met 02/2009 | Started Dating 08/2017 | Married 02/02/2020
    TTC #2 ... preparing as of March 2024


    TTC #1
    Me: 36, MH: 34 | Met 02/2009 | Started Dating 08/2017 | Married 02/02/2020
    TTC #1 02/2020 - 07/2022
    2009 | Dx PCOS; likely a misdiagnosis
    07/14/20 | Dx Hashimoto's Thyroditis
    07/21/20 | 1st RE appointment
    07/2120 - 08/20/20 | so much testing; no signs of PCOS
    08/20/20 | Dx Unexplained; AMA
    09/08/20 | IUI #1 Clomid + Trigger + Prometrium | BFN
    09/30/20 | Urology consult; more testing required
    10/2020 | Clomid + OPK + TI + Prometrium | BFN
    10/26/2020 | Starting 2nd IUI cycle, with Letrazole and with a new RE / different clinic
    11/03/2020 | New Dx "poor egg quality"; IUI cancelled in favor of Trigger + TI + Prometrium | BFN
    11/26/2020 | Combo IUI (Clomid + Menopur) + Trigger + Prometrium | BFN
    12/20/2020 | Combo IUI (Clomid + Gonal-F) + Trigger | IUI Cancelled due to thin lining; TI only | BFN
    01/14/2021 | Combo IUI (Letrazole + Menopur) + Trigger | BFN
    02/06/2021 | Switched to a new RE (TEW) ; trying naturally until we complete additional testing 
    03/14/2021 | Hybrid Double IUI, with Zymot (Letrazole, Gonal-F) + Trigger + Endometrin | Ovulated 4 mature eggs but still a BFN ☹️
    04/07/2021 | Natural cycle while we regroup | BFN
    04/09/2021 | Employer announces fertility benefits starting 05/01/2021! | Search for a new doctor who accepts insurance
    05/10/2021 | New RE consult & plan for IVF
    05/13/2021 | Mid-luteal IVF cycle #1 interrupted; had to get cancer genetic screening done to make sure I didn't have the same SDHA gene mutation as MH. 
    06/10/2021 | Aygestin priming IVF cycle #1; opted to Cx after 9 days of stims since only 5-6/12 follicles responded
    07/26/2021 | Attempt #2 at IVF cycle #1 (mid-luteal start): 8 retrieved, 8 MII, 6 fert (1 PN3), 3 Day 5 & 6 blasts: 3AA, 3AA, 6AB; 3 euploid
    08/09/2021 | Rest cycle / unmedicated TTC | Shockingly, a BFP! EDD: 5/25/202 | CP at 4w4d
    09/23/2021 | IVF cycle #2 (mid-luteal start): 14 retrieved, 13 MII, 11 fert, 5 Day 5 & 6 blasts: 2 x 3AA, 2 x 3AB, 3BB; 2 euploid
    11/12/2021 | IVF cycle #3 (mid-luteal start): cancelled due to ovaries being on vacation
    12/20/2021 | Rest cycle / unmedicated TTC + Pregmune Immunology Testing; BFN
    01/22/2022 | Rest cycle / unmedicated TTC + understanding uncovered immunological issues; BFN
    02/18/2022 | Mock transfer cycle! ERA, ReceptivaDx, EMMA/ALICE; start Prednisone to address NK activity
    03/16/2022 | Final, "Hail Mary" super-ovulation + TI cycle before FET; BFP! EDD: 12/21/2022 | MMC 05/08/2022
    05/20/2022 | D&C; recovering... 
    06/21/2022 | Trying naturally until October 2022
    07/21/2022 | BFP! EDD 04/02/2023; 👦🏼 born on 4/5/2023


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    Today is my first ever appointment with a RE. Wish me luck. I'm kinda scared.
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    good luck @deaf_girl! hopefully the appointment goes well, you learn some new things, and you leave with a new confidence that things are going to work out for you!
    History
    I am doing this on my own. Left ovary and fallopian tube removed due to cyst/necrosis just after birth. Right ovary and tube still purport to function.
    Began TTC in Aug '18 @ age 35
    5 or 6 (or 7?!) cycles using frozen donor sperm, ICI. All BFN
    Mar-Jun '19 IUIs, all BFN
    Began process of referral for RE in spring of '19, blood tests confirm low AMH (.54) but all else is good.
    May '19 HSG shows open tube, but ultrasound suggests fibroids
    MRI in June '19 confirms two large fibroids, one growing through wall of uterus
    In June '19 I move from California to Oregon, disrupting my insurance, referrals, etc. 5 months spent piecing it all back together.
    Nov. '19 attempted myomectomy (vaginal approach) failed. 2nd surgery using laparoscopic method in Jan '20 is successful.
    April '20 --> June '20, natural IUIs, all BFN.
    July? saline ultrasound and bubble test demonstrate open tube
    July '20 clomid cycle cancelled for thin lining
    Aug-Oct, 3 femara cycles, all BFN
    RE referral. While waiting to set up an appointment Nov-Jan,I continue with natural cycles and ICI, using a known donor, BFN...
    Jan '21 more bloodwork, AMH is worse (.30), FSH high albeit not catastrophic at 13.2. hysteroscopy all good. "looks cozy!" says the RE.
    Feb '21, injectables (menopur, novarel), iui, BFN (doc said the frozen donor sperm sample had the "best numbers she'd ever seen!")
    Mar '21, injectables, iui cancelled due to lack of follicles, converted to at home-insem. BFN
    May '21, first IVF round cancelled due to cyst.
    July '21 IVF: standard antagonist. 225menupur/225gonal-f/cetrotide/5000u trigger, AFC 7; 6 days of stims. 8 eggs retrieved, 7 mature, 5 fertilize, 4 made it to blast. 3 are 4AB, 1 is 4BB. PGT-A results all abnormal.
    Oct '21 somewhat improved AMH (.51) and significantly improved FSH (8.9). Maybe it's all the pills I swallow.
    Dec -21, standard antagonist. 225menupur/225gonal-f/cetrotide/5000u trigger, AFC 5; 11 days of stims. retrieval yields 5, 4M, 2 reach day-6 blast (4AB & 4BB). 1 low-level mosaic (chr. 3 deletion), 1 complex abnormal.
    Feb '22 FET (low-level mosaic): CP.
    May '22 egg retrieval, lupron flare protocol. HGH priming for 1 month before stims; md lupron 20/20u daily; menopur 225, follistim 225, 10k trigger after 8 days of stims; AFC 10; 13 retrieved; 10 mature; 8 fertilized. All frozen at 2PN for later thaw, grow, and biopsy.
    July '22 egg retrieval same protocol: 9 days of stims; AFC 8; 10 retrieved, 8 mature, 4 fertilized and frozen.
    Sept '22 ER same protocol: AFC 10; 12 retrieved, 11 mature, 11 fertilized.
    From the 3 retrievals, 7 survived to day 5-6 blastocyst, from which I have 2 normal embryos!
    Jan 20, Fully medicated FET, baby aspirin, dexamethasone, acupuncture, and as much woo as I can stand (which isn't very much). BFN.
    July 23, Natural FET + baby aspirin. BFN.
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    @optimistgardener I don't know how I feel right now. The appointment seemed kind of rushed and I didn't get all my questions answered. I'm going to try to message them to them and see how that goes.
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