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Leuprolide acetate

msldyc23msldyc23 member
in Infertility

I’ve been taking leuprolide acetate daily since 9/11 and my cycle should have started last week. 

How long did you take leuprolide acetate before your period started? 

Should I be concerned? 

37F, DH36
Low AMH, Mild Adenomyosis, Breast Cancer Survivor
IVF#1 10/24/18 ER 15R, 10M, 7F, 2 BLAST, 1 D5: BB boy (PGT)
FET#1 12/08/20 cancelled due to lining

FET#2 February 2021 BFN

IVF#2-4 2021 Antagonist Protocol cancelled, poor responder and high estrogen 

IVF#5 December 2021 Micro Dose Lupron Protocol, 7ER, 2M, 2F, 2BLAST, 2PGT, abnormal

IVF#6 January 2022 Micro Dose Lupron Protocol, cancelled, poor responder


  


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    inthewoods23inthewoods23 member
    Have you stopped taking the leuprolide acetate? As long as you are taking it, it will prevent you from ovulating so your next cycle will not start until you stop taking it.

    In my experience, depending on how many days I was on it, it has taken between 40-50 days from the last day of the leuprolide acetate just to ovulate. I've heard it can take up to 6 months for your cycle to return (more likely when it's the depot lupron than the daily injection).
    *TW* History:
    Me: 34 DH: 36 | Together since 2007 | Married July 2016

    TTC #1 since 7.2017
    Dx: low morph (1%), ANA positive, low decidualization score, high TSH and testosterone, histone antibodies

    IUI #1-3 | all BFN
    IVF #1 | 6.11.19 | 24R, 17M, 15F, 6B, PGT-A tested - 5 normal, 3 girls & 2 boys
    FET #1 | 9.10.19 | BFN "I know you, but we've never met. I'm with you, but I don't know your name"
    RPL, Receptiva, & ERA testing | all normal/negative, recommended going on gluten and dairy free diet for next FET
    FET #2 | 3.31.20 | Opted to cancelled due to pandemic, continued diet and tried naturally over the summer
    2nd Opinion with another RE | 8.20.20 | Not immune to measles (received 1 dose); SA results similar to 2 years ago; decided to move forward with FET #2 redo at start of next cycle
    Surprise natural BFP! | 9.22.20 | MC 10.23.20 at 8 weeks
    TTCAL naturally | starting 11.22.20

    Initial consultation with Reproductive Immunologist | 9.14.21
    Decidualization score biopsy | 10.1.21 | abnormal - low score of 1; endometrial scratch recommended and progesterone supplementation
    Saline sono | 10.15.21 | normal
    Bloodwork | 10.21.21 | high TSH, high testosterone, positive for anti-nuclear antibodies and histone antibodies, high protein S, multiple genetic mutations
    BFP! | 11.3.21 | EDD 7.14.22 B) | biopsy provided same effect as endometrial scratch; added supplemental progesterone and estrogen, prednisone, levothyroxine, and MTX Support to maintain pregnancy
    DS born 7.19.22 after induction


    TTC #2 begins 6.2023
    Consultation with RI | 6.6.23
    Saline sono, endometritis biopsy, skin & eye check | all normal
    Labs | high TSH, Factor XIII mutation, high %CD56
    Follow up | 8.8.23 | prescribed metformin, prednisone, plaquenil, and levothyroxine
    Repeat labs after 3 weeks on meds
    Follow up | 11.9.23 | Green light!, increase in prednisone, added lovenox
    Repeat labs in 8 weeks
    Follow up | 1.16.24 | Green light continues
    TTC put on pause
    Report Reply
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    msldyc23msldyc23 member
    @inthewoods23

    Im going to call the Dr. tomorrow b/c she said I should take it up until my cycle start. My cycle should have started last week..

    I thought it was suppose to be a 14 day kit but I have been taking it well over 14 days now.

    I’m just curious if anyone else has had to take this 14 day kit longer.

    37F, DH36
    Low AMH, Mild Adenomyosis, Breast Cancer Survivor
    IVF#1 10/24/18 ER 15R, 10M, 7F, 2 BLAST, 1 D5: BB boy (PGT)
    FET#1 12/08/20 cancelled due to lining

    FET#2 February 2021 BFN

    IVF#2-4 2021 Antagonist Protocol cancelled, poor responder and high estrogen 

    IVF#5 December 2021 Micro Dose Lupron Protocol, 7ER, 2M, 2F, 2BLAST, 2PGT, abnormal

    IVF#6 January 2022 Micro Dose Lupron Protocol, cancelled, poor responder


      


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    inthewoods23inthewoods23 member
    It lasts 14 days if you're injecting 20 units a day. For my egg retrieval and FETs I was doing 10 units a day most of the time. This allowed the vial to last about 28 days
    *TW* History:
    Me: 34 DH: 36 | Together since 2007 | Married July 2016

    TTC #1 since 7.2017
    Dx: low morph (1%), ANA positive, low decidualization score, high TSH and testosterone, histone antibodies

    IUI #1-3 | all BFN
    IVF #1 | 6.11.19 | 24R, 17M, 15F, 6B, PGT-A tested - 5 normal, 3 girls & 2 boys
    FET #1 | 9.10.19 | BFN "I know you, but we've never met. I'm with you, but I don't know your name"
    RPL, Receptiva, & ERA testing | all normal/negative, recommended going on gluten and dairy free diet for next FET
    FET #2 | 3.31.20 | Opted to cancelled due to pandemic, continued diet and tried naturally over the summer
    2nd Opinion with another RE | 8.20.20 | Not immune to measles (received 1 dose); SA results similar to 2 years ago; decided to move forward with FET #2 redo at start of next cycle
    Surprise natural BFP! | 9.22.20 | MC 10.23.20 at 8 weeks
    TTCAL naturally | starting 11.22.20

    Initial consultation with Reproductive Immunologist | 9.14.21
    Decidualization score biopsy | 10.1.21 | abnormal - low score of 1; endometrial scratch recommended and progesterone supplementation
    Saline sono | 10.15.21 | normal
    Bloodwork | 10.21.21 | high TSH, high testosterone, positive for anti-nuclear antibodies and histone antibodies, high protein S, multiple genetic mutations
    BFP! | 11.3.21 | EDD 7.14.22 B) | biopsy provided same effect as endometrial scratch; added supplemental progesterone and estrogen, prednisone, levothyroxine, and MTX Support to maintain pregnancy
    DS born 7.19.22 after induction


    TTC #2 begins 6.2023
    Consultation with RI | 6.6.23
    Saline sono, endometritis biopsy, skin & eye check | all normal
    Labs | high TSH, Factor XIII mutation, high %CD56
    Follow up | 8.8.23 | prescribed metformin, prednisone, plaquenil, and levothyroxine
    Repeat labs after 3 weeks on meds
    Follow up | 11.9.23 | Green light!, increase in prednisone, added lovenox
    Repeat labs in 8 weeks
    Follow up | 1.16.24 | Green light continues
    TTC put on pause
    Report Reply
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