Infertility

Lead Follicle IVF

Hi everyone,

I am on my second IVF stim cycle. The first cycle was cancelled when I over stimmed and had 50 + large follicles developing. 

This stim I am having very different issues. I Am on stim day 8 and have one lead follicle that is 14mm. All the rest of my follicles are 5mm. The doctor has changed up my med protocol in hopes that some of the small follicles will “catch up” but I do not feel very hopeful. I feel that it is inevitable that this cycle will be cancelled. 

Does anyone have experience with this? Is there any hope? 

Re: Lead Follicle IVF

  • @lmatche was there a lead follicle present before you started the stim medications? I've heard of cycles being cancelled due to one showing up at baseline. Is it possible your new protocol is having the complete opposite effect and only producing 1 follicle? With that big of a difference in sizes, I would expect that they would cancel the cycle again. Don't give up hope though - they will work to find you a protocol that yields better results.
    *TW* History:
    Me: 34 DH: 36 | Together since 2007 | Married July 2016

    TTC #1 since 7.2017
    Dx: low morph (1%), ANA positive, low decidualization score, high TSH and testosterone, histone antibodies

    IUI #1-3 all BFN
    IVF #1 | 6.11.19 | 24R, 17M, 15F, 6B, PGT-A tested - 5 normal, 3 girls & 2 boys
    FET #1 | 9.10.19 | BFN "I know you, but we've never met. I'm with you, but I don't know your name"
    RPL, Receptiva, & ERA testing | all normal/negative, recommended going on gluten and dairy free diet for next FET
    FET #2 | 3.31.20 | Opted to cancelled due to pandemic, continued diet and tried naturally over the summer
    2nd Opinion with another RE | 8.20.20 | Not immune to measles (received 1 dose); SA results similar to 2 years ago; decided to move forward with FET #2 redo at start of next cycle
    Surprise natural BFP! | 9.22.20 | MC 10.23.20 at 8 weeks
    TTCAL naturally | starting 11.22.20

    Initial consultation with Reproductive Immunologist | 9.14.21
    Decidualization score biopsy | 10.1.21 | abnormal - low score of 1; endometrial scratch recommended and progesterone supplementation
    Saline sono | 10.15.21 | normal
    Bloodwork | 10.21.21 high TSH, high testosterone, positive for anti-nuclear antibodies and histone antibodies, high protein S, multiple genetic mutations
    BFP! | 11.3.21 | EDD 7.14.22 B) | biopsy provided same effect as endometrial scratch; added supplemental progesterone and estrogen, prednisone, levothyroxine, and MTX Support to maintain pregnancy
    DS born 7.19.22 after induction


    TTC #2 begins 6.2023
    Consultation with RI | 6.6.23
    Saline sono, endometritis biopsy, skin & eye check | all normal
    Labs | high TSH, Factor XIII mutation, high %CD56
    Follow up | 8.8.23 | prescribed metformin, prednisone, plaquenil, and levothyroxine
    Repeat labs after 3 weeks on meds
    Follow up | 11.9.23 | Green light!, increase in prednisone, added lovenox
    Repeat labs in 8 weeks
    Follow up | 1.16.24 | Green light continues
    TTC put on pause indefinitely
  • FuzzyDustFuzzyDust member
    edited August 2020
    @Imatche, sorry to hear that your cycles keep getting problems.
    I also had a very large number of follicles with my first IVF, but in the end we didn't end up with that many eggs (and I did have bad OHSS afterwards). I do hear stories of people having one very big lead follicle and other catching up in the end, so you still have hope! If it doesn't happen, do you have an option of switching to IUI instead? 
    -----------------------------------------------------------------------------------------------------
    My story in signature spoiler. Children mentioned.
    Me: 37 DH: 45
    I don't produce FSH, so no natural menstrual cycle. DH has reduced morphology.
    Summer 2014 IUI (with first husband): cancelled after almost a month of stims due to too many follicles
    Time off to divorce, get back on my feet, find a new hubby and get married again 💑
    March 2017 IVF#1: ~70 follicles, 13R, 10M, 7F, 3B = 2 PGS Normal (both XY) - no transfer due to ohss
    Sept 2017 FET#1: BFP, Beta#1 (10dpt) - 253, Beta#2 (12dpt) - 528, DS born 05/31/2018 👨‍👩‍👦
    Dec 2019 FET#2: BFN
    Changed clinic, planning March 2020 IVF#2 - postponed due to the pandemic
    April 2020 IVF #2: ~30 follicles, 24R, 12M, 8F, 4B = 2XY & 2XX, all normal  <3
    Sept 2020 FET#3: one XX embryo, BFP, Beta#1 (9dpt) - 161, Beta#2 (11dpt) - 519, Beta#3 (19dpt) - 7174, Due date 05/30/2021
    DD born 05/23/2021 👨‍👩‍👧‍👦 - My family is now complete <3
  • Loading the player...
  • Thanks for the positive vibes. My last monitoring appointment showed some more promise, with 8 follicles gaining quickly in size. I am back for more monitoring today, and am hopeful that things will continue to progress for me. Unfortunately IUI is not an option, as I have a non - functioning uterus. So, I am attempting to make embryos for a surrogacy journey. 
  • Glad to hear the rest are catching up!! Best of luck to you!
    -----------------------------------------------------------------------------------------------------
    My story in signature spoiler. Children mentioned.
    Me: 37 DH: 45
    I don't produce FSH, so no natural menstrual cycle. DH has reduced morphology.
    Summer 2014 IUI (with first husband): cancelled after almost a month of stims due to too many follicles
    Time off to divorce, get back on my feet, find a new hubby and get married again 💑
    March 2017 IVF#1: ~70 follicles, 13R, 10M, 7F, 3B = 2 PGS Normal (both XY) - no transfer due to ohss
    Sept 2017 FET#1: BFP, Beta#1 (10dpt) - 253, Beta#2 (12dpt) - 528, DS born 05/31/2018 👨‍👩‍👦
    Dec 2019 FET#2: BFN
    Changed clinic, planning March 2020 IVF#2 - postponed due to the pandemic
    April 2020 IVF #2: ~30 follicles, 24R, 12M, 8F, 4B = 2XY & 2XX, all normal  <3
    Sept 2020 FET#3: one XX embryo, BFP, Beta#1 (9dpt) - 161, Beta#2 (11dpt) - 519, Beta#3 (19dpt) - 7174, Due date 05/30/2021
    DD born 05/23/2021 👨‍👩‍👧‍👦 - My family is now complete <3
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