Infertility

mosaic embryos

Has anybody had any experience in transferring a mosaic embryo? I was set for an FET today with our last remaining PGS normal embryo but it did not survive the thaw. The embryologist reminded me that I had one mosaic embryo left from an egg retrieval and couple years ago. I am waiting on a call back from a genetics counselor but am curious if anybody had any experience with this. I read that the success rate is much lower. 

Me 35, DH 37

Unexplained infertility and TTC since December 2014

February 2016 - May 2016: 3 IUI's -- all BFN

August 2016: IVF #1 (Lupron, Gonal F and Menopur) -- 12 retrieved, 9 fertilized, 3 frozen and 1 x day 5 hatching blast transferred -- BFN. Sent remaining 3 embryos for PGS testing -- 2 didn't survive thaw, 1 was abnormal.

February 2017: IVF #2 (Gonal F, Menopur, and Ganirelix) -- 12 retrieved, 6 fertilized, 3 sent for PGS testing and all were abnormal

March 2018: IVF #3 (Menopur, Follistim, Ganirelix and HGH) -- 14 retrieved, 12 fertilized, 4 sent for PGS testing, and 3 were PGS normal

May 2018: FET #1 -- BFN

August 2018: FET #2 -- BFP!!! healthy baby girl born May 2019!!

July 2020: FET #3 -- embyro did not survive thaw

September 2020 - IVF #4 (Menopur, Follistim, Ganirelix and HGH) -- 1 PGS normal

October 2020 - FET #4 -- BFN

January 2021 - IVF #5 (Menopur, Follistim, Ganirelix and HGH)  -- 2 PGS normal

February 2021 - FET #5 - BFP!!! Due 11/6/2021



Re: mosaic embryos

  • I transferred 4 abnormal embryos (2 at a time). We ended up with no mosaics, but apparently the % of rating of what is mosaic is dependent upon the lab that grades them. For my clinic the number was pretty low (meaning it barely had to have any mosaicism before they code it abnormal. I did get pregnant with one of them, but ended up being a chemical. There is certainly a chance of it working though based on the fact that PGS only tests 1 cell from the very outer layer which is NOT where the baby forms. That is what forms the placenta which can certainly still maintain a healthy pregnancy. If the egg is has a good cell mass, likely you could get lucky! Good luck!
    Me: 45yo, DH: 47yo
    3 Daughters (singleton @27yo, ID  Di/Di Twins @34yo)
    Protein S Deficiency (Blood Clotting Disorder), MTHFR & VIT D issue 
    5 MC's:  Blighted Ovum-D&C @ 9wks;  Natural MC @ 7wks; Blighted Ovum-D&C @ 9wks; MC boy-D&C @ 9wks & Chem PG in 2019
    Tubes were tied after my Twins (and now I am old). Remarried and want to give my DH a baby!

    IVF#1 OE June 2019 - ER 6/15/19, 24R, 21M, 20F, 7 6DBlasts Frozen for PGS Testing,
    RESULTS of PGS 4 abnormal girls,  2 abnormal boys, 1 indeterminate girl
    FET#1 OE August 23, 2019 (transferring 1 indeterminate girl & 1 abnormal boy) - BFN
    IVF#2 November 15, 2019 - ER 9R, 9M, 6F, 2 5dBlasts (fresh transfer) and 1 6DBlast frozen for PGS Testing,
    FRESH Transfer: November 20, 2019, 2 5-day blasts transferred!! 
    BFP 8dp5dt on 11/27 - 12/2 on FRER, BETA #1 12/2 - 11.93. BETA #2 12/4: 4.41 ~CHEMICAL PG
    ******************Starting Donor Process
    June 2020: Egg Donor Cycle and Fresh Transfer of 1 embryo in Czech Republic - CANCELLED DUE TO COVID19
    October 2020.  Split Cycle at UFC with a friend (Andrea) I met on the Bump who was also supposed to go to Prague too  
    DE Retrieval 9/26/2020, 26R, 24M, 12 split Cycle, 9 Fertilized + 1 "questionable", PRAYING FOR AT LEAST 5 BLASTS
    10/1/2020: 4 5DBlasts (AA, BB, BC, BC), 10/2/2020: 3 6DBlasts (BB, BB, BC) FOR A TOTAL OF: 7 BLASTS!! THANK YOU GOD!!
    PGS RESULTS: 5 NORMALS! DAY 5: AA BOY, BB GIRL, BC BOY / DAY 6: BB GIRL, BC GIRL
    DE FET October 29, 2020 - CANCELED DUE TO FLUID IN LINING
    DE FET November 16th, 2020 (transferring an PGS normal Hatching AA Boy)
  • Not exactly sure what they are considering mosaic, but we transferred an embryo that was classified as "only 85% confidence on chromosome 22" and am currently 10 weeks pregnant.
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  • @teamginger13 Reading your post- I’m so happy to hear you had a normal healthy baby girls after a number of “abnormally” tested embryos. I just found out that my first 5 embryos may also all be abnormal, 4 are, 1 was inconclusive so will be retested. I am a bit deflated.... But I’m also a few years older. Hoping this last one may be viable. If not, another ER process will start.
    Me: 39   SO: 34
    TTC #1 since 2019
    Dx: DOR

    IVF Journey:
    EF #1: 10/18; 6R FROZEN
    ER #1: 11/8/20; 7R. (Folded in Frozen from 2018)
                13R/9M/8F/5Emb; PGS: 5Abn
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