Infertility

Non-response to Clomid 100mg & Femara 7.5mg. Injectables even worth trying?

I am 37 years old with PCOS trying for baby #1.  I have lost > 10% of my body weight and I am on Metformin 2000mg/day.  I have been on Clomid 100mg & Femara 7.5mg both alone & combined.  I can't get a follicle to grow larger than 10mm.  I have an consult with my fertility doctor in a couple of weeks to talk about injectables but I am feeling like it might just be a money pit.  Any non-responders to both Clomid & Femara have any luck with injectable drugs?

Re: Non-response to Clomid 100mg & Femara 7.5mg. Injectables even worth trying?

  • Hi, have you checked out soulcysters.net? It’s a message board for ladies with PCOS. I used to hang out in the infertility forum when I was first diagnosed with PCO. There I saw many ladies successfully become pregnant with injectables after numerous failed cycles with clomid or letrozole. So it does happen. I think the TTC buddy forums maybe invisible unless you create an account. 
    Me: 41  DH: 46
    Unexplained infertility/AMA, polycystic ovaries, insulin resistance
    FET#1(July 2017): eSET of first of 4 PGS-normal embryos, DS born 3/30/2018
    FET#2(Oct/Nov 2019): eSET  
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  • Injectables are completely different from the oral meds. They are worth a try!!
    Me: 37 DH: 37 - Married 10.2015 ❤️ Canadian 
    DX: Endometriosis - Stage 4, DOR, RPL
    TTC #1 07.2015
    03.2016 - Natural BFP - MC 5w4d
    04.2016 - Natural BFP - Chemical
    10.2016 - IUI w/ Injections #1 = IUI Cancelled (cyst/no mature follicle)
    11.2016 - IUI w/ Injections #2 = BFP, EDD 08.2017 - It's a BOY!
    TTC #2 06.2019
    08.2019 - IUI w/ Injections #1 = Chemical
    09.2019 - IUI w/ Injections #2 = BFN
    10.2019 - IUI w/ Injections #3 = BFN
    01.2020 - IUI w/ Injections #4 = BFN
    08.2020 - Natural BFP - MC 9w5d
    11.2020 - IVF Retrieval - 3AB & 4BB
    05.2021 - FET #1 = BFP, EDD 02.2022 - It's a BOY!

           
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