PGS accuracy? — The Bump
Infertility

PGS accuracy?

What is the accuracy of PGS testing for down syndrome? We used a donor and of 20 eggs retrieved, only 5 made embryos, and of those 5 only 1 tested PGS normal.

now my first beta, only 10 days post transfer, was very high at 617. In the back of my mind I am slightly nervous about down syndrome since that can cause very high betas, and because 19 of 20 eggs were bad. 

Re: PGS accuracy?

  • High HCG is associated with Down’s at 11-14 weeks, I thought, not at such early stage of pregnancy. And I also remember that the serum marker (like HCG) was not a very good marker anyway (too many false positives, I vaguely remember). 
    This is anecdotal but I transferred 1 PGS-normal embryo. I had the nuchal scan at 12 weeks and that came back high risk for Down’s (the measurement was slightly above the cutoff). I did the Harmony test and that came back low risk for Down’s, similar to the PGS result. My son doesn’t have Down’s. 
    Me: 41  DH: 46
    Unexplained infertility/AMA, polycystic ovaries, insulin resistance
    FET#1(July 2017): eSET of first of 4 PGS-normal embryos, DS born 3/30/2018
    FET#2(Oct/Nov 2019): eSET  
    31magnolia
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