Infertility

Newb Intro

Hi ladies,

I'm Alicia. I'm 36, been married for 6 years and TTC for 5.  After too many months of being too afraid of getting bad news and telling myself that it'd just take one more month, I finally talked to GYN in September.  HSG showed no blockages and all my bloodwork was normal except for a slightly elevated DHEA-S, but a TVUS showed no cysts, so no PCOS.  

After an agonizing month of waiting, my first RE appointment is tomorrow.  I'm trying not to worry too much about it, but honestly worrying is kind of what I do best, except maybe denial and magical thinking.  Any advice about what I can expect?  Thanks!
Me 36, DH 48
Married since 9/9/12
TTC since 9/13
DX: Unexplained infertility 11/18
IUI #1: Jan 19, BFN
IUI #2: Feb 19, TBD

Re: Newb Intro

  • @Noodle9912 sorry that you’re finding yourself here. I can tell you about my experience in the work up process if that helps.. they took my hx, did day 3 FSH, AMH, and an ultrasound to count follicles. That was pretty much it (besides the hsg). They’ll likely do a sperm analysis on your partner too. All in all, the work up didn’t include too much. 

    They tend to start us unexplained ppl w clomid and IUI, which apparently does not have a great success rate. And if that doesn’t work after a few tries, then IVF. 
  • Thanks @somewhereinnyc that helps me stress less!
    Me 36, DH 48
    Married since 9/9/12
    TTC since 9/13
    DX: Unexplained infertility 11/18
    IUI #1: Jan 19, BFN
    IUI #2: Feb 19, TBD
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  • @Noodle9912 sorry to see you here. Our first RE appointment was going over our medical history and looking at the testing we already had completed (we had already done an HSG and SA). They basically told us they want me to call them on CD1 to schedule a baseline blood work and ultrasound to find any underlining issues. Sometimes those tests will give you a diagnosis, sometimes not (unexplained). From there they'll will give you your options. My RE for unexplained likes to try 3 IUIs before moving into IVF.

    Don't be afraid to ask them any questions!
    *TW* History:
    Me: 34 DH: 36 | Together since 2007 | Married July 2016

    TTC #1 since 7.2017
    Dx: low morph (1%), ANA positive, low decidualization score, high TSH and testosterone, histone antibodies

    IUI #1-3 all BFN
    IVF #1 | 6.11.19 | 24R, 17M, 15F, 6B, PGT-A tested - 5 normal, 3 girls & 2 boys
    FET #1 | 9.10.19 | BFN "I know you, but we've never met. I'm with you, but I don't know your name"
    RPL, Receptiva, & ERA testing | all normal/negative, recommended going on gluten and dairy free diet for next FET
    FET #2 | 3.31.20 | Opted to cancelled due to pandemic, continued diet and tried naturally over the summer
    2nd Opinion with another RE | 8.20.20 | Not immune to measles (received 1 dose); SA results similar to 2 years ago; decided to move forward with FET #2 redo at start of next cycle
    Surprise natural BFP! | 9.22.20 | MC 10.23.20 at 8 weeks
    TTCAL naturally | starting 11.22.20

    Initial consultation with Reproductive Immunologist | 9.14.21
    Decidualization score biopsy | 10.1.21 | abnormal - low score of 1; endometrial scratch recommended and progesterone supplementation
    Saline sono | 10.15.21 | normal
    Bloodwork | 10.21.21 high TSH, high testosterone, positive for anti-nuclear antibodies and histone antibodies, high protein S, multiple genetic mutations
    BFP! | 11.3.21 | EDD 7.14.22 B) | biopsy provided same effect as endometrial scratch; added supplemental progesterone and estrogen, prednisone, levothyroxine, and MTX Support to maintain pregnancy
    DS born 7.19.22 after induction


    TTC #2 begins 6.2023
    Consultation with RI | 6.6.23
    Saline sono, endometritis biopsy, skin & eye check | all normal
    Labs | high TSH, Factor XIII mutation, high %CD56
    Follow up | 8.8.23 | prescribed metformin, prednisone, plaquenil, and levothyroxine
    Repeat labs after 3 weeks on meds
    Follow up | 11.9.23 | Green light!, increase in prednisone, added lovenox
    Repeat labs in 8 weeks
    Follow up | 1.16.24 | Green light continues
    TTC put on pause indefinitely
  • @inthewoods23 thanks for your kind words. We’ve already done those tests too, and AF is about a week away, so I’m glad I won’t have to wait too long for more answers. Having to wait a month for the appointment was hellish. 
    Me 36, DH 48
    Married since 9/9/12
    TTC since 9/13
    DX: Unexplained infertility 11/18
    IUI #1: Jan 19, BFN
    IUI #2: Feb 19, TBD
  • @Noodle9912 we waited about a month for ours too, but I don't think that was as bad as the wait between the first appointment and when my next cycle came to do the baseline BW and US. Based on where I was in my cycle I thought I would only need to wait 2 weeks but I O'ed a week later than originally predicted so then I ended up waiting 3 weeks! Glad your wait won't be as long as mine!
    *TW* History:
    Me: 34 DH: 36 | Together since 2007 | Married July 2016

    TTC #1 since 7.2017
    Dx: low morph (1%), ANA positive, low decidualization score, high TSH and testosterone, histone antibodies

    IUI #1-3 all BFN
    IVF #1 | 6.11.19 | 24R, 17M, 15F, 6B, PGT-A tested - 5 normal, 3 girls & 2 boys
    FET #1 | 9.10.19 | BFN "I know you, but we've never met. I'm with you, but I don't know your name"
    RPL, Receptiva, & ERA testing | all normal/negative, recommended going on gluten and dairy free diet for next FET
    FET #2 | 3.31.20 | Opted to cancelled due to pandemic, continued diet and tried naturally over the summer
    2nd Opinion with another RE | 8.20.20 | Not immune to measles (received 1 dose); SA results similar to 2 years ago; decided to move forward with FET #2 redo at start of next cycle
    Surprise natural BFP! | 9.22.20 | MC 10.23.20 at 8 weeks
    TTCAL naturally | starting 11.22.20

    Initial consultation with Reproductive Immunologist | 9.14.21
    Decidualization score biopsy | 10.1.21 | abnormal - low score of 1; endometrial scratch recommended and progesterone supplementation
    Saline sono | 10.15.21 | normal
    Bloodwork | 10.21.21 high TSH, high testosterone, positive for anti-nuclear antibodies and histone antibodies, high protein S, multiple genetic mutations
    BFP! | 11.3.21 | EDD 7.14.22 B) | biopsy provided same effect as endometrial scratch; added supplemental progesterone and estrogen, prednisone, levothyroxine, and MTX Support to maintain pregnancy
    DS born 7.19.22 after induction


    TTC #2 begins 6.2023
    Consultation with RI | 6.6.23
    Saline sono, endometritis biopsy, skin & eye check | all normal
    Labs | high TSH, Factor XIII mutation, high %CD56
    Follow up | 8.8.23 | prescribed metformin, prednisone, plaquenil, and levothyroxine
    Repeat labs after 3 weeks on meds
    Follow up | 11.9.23 | Green light!, increase in prednisone, added lovenox
    Repeat labs in 8 weeks
    Follow up | 1.16.24 | Green light continues
    TTC put on pause indefinitely
  • @Noodle9912
    Wow, you could be me! Married 11 years (gah, we were such babies!), TTC for over 6. We also waited a long time to get to the RE and OB/GYN -- kept thinking "maybe next month" for 3+ years. Nothing abnormal on all initial testing -- bloods, HSG, sperm analysis, etc. Another one of ye olde 'unexplained's. 

    There is a fair amount of waiting when you are working with an RE -- whether it's waiting between ultrasounds or cycles, the TWW or just waiting for AF to arrive. Some of the bigger clinics actually have to schedule IVF cycles several months in advance since they are so busy -- imagine that waiting o.o !!! 

    My RE also likes doing 3 IUI's for unexplained and then moving to IVF if no success. He also prefers to do frozen transfers rather than fresh since he thinks it gives the embies a better chance of success (freezing the embryos gives you time to build up your lining and make everything as perfect as possible, including timing). 

    TW
    We found success with our first frozen transfer so there is hope for us unexplaineds! 

    You've found a great community of ladies to help you through the process :smiley:

    ~~ Our Story in Spoiler! TW loss/child~~
    Fall 2012 -- started TTC
    Summer 2015 - no BFP yet, labs normal, referred to RE
    Fall 2015 - Summer 2016 - Further testing all normal. 3 IUI's -- BFN. Recommended move to IVF. Planned cycle for fall 2016.
    September 2016 - Surprise natural BFP. MMC @ 8 weeks. RE expressed confidence that we just needed the 'right' embryo.
    Fall 2016 - Spring 2017 -- Break from TTC
    June 2017 - Started IVF; egg retrieval for freeze all cycle. 9 mature eggs retrieved, 5 fertilized. 2 4BB embies on ice.
    August 2017 - FET transfer both embies. BFP.  Twin pregnancy confirmed by ultrasound. EDD 4/28/18
    September 2017 - Twin B stopped developing; Twin A doing perfectly! Graduated from RE @ 10 weeks
    March 2018 - Baby Girl born via C/S due to pre-eclampsia -- strong and healthy!

    TTC #2
    January/Feb 2021 - Freeze-all IVF cycle 
    March 2021 - FET of 1 PGS normal female embryo. BFP! Beta #1 156,  #2 472, #3 1241, #4 5268 EDD 12/5/21 - Christmas baby!


    "When all is lost then all is found."


  • Update:

    Officially unexplained infertility.  We're doing 2.5mg of Letrozole on CD3-7 and IUI for 3 cycles, but it might have to wait till next month because if AF comes when I expect, they would be doing the IUI on Christmas. I didn't realize it at the time to ask, but I doubt they would work on Christmas.
    Me 36, DH 48
    Married since 9/9/12
    TTC since 9/13
    DX: Unexplained infertility 11/18
    IUI #1: Jan 19, BFN
    IUI #2: Feb 19, TBD
  • @Noodle9912 I have the same question because if letrozole makes me O earlier than normal then my O date this month would be right around Christmas so I'm not sure if they would do it then! I need to ask my RE when I go in for the baseline stuff in the coming days.
    *TW* History:
    Me: 34 DH: 36 | Together since 2007 | Married July 2016

    TTC #1 since 7.2017
    Dx: low morph (1%), ANA positive, low decidualization score, high TSH and testosterone, histone antibodies

    IUI #1-3 all BFN
    IVF #1 | 6.11.19 | 24R, 17M, 15F, 6B, PGT-A tested - 5 normal, 3 girls & 2 boys
    FET #1 | 9.10.19 | BFN "I know you, but we've never met. I'm with you, but I don't know your name"
    RPL, Receptiva, & ERA testing | all normal/negative, recommended going on gluten and dairy free diet for next FET
    FET #2 | 3.31.20 | Opted to cancelled due to pandemic, continued diet and tried naturally over the summer
    2nd Opinion with another RE | 8.20.20 | Not immune to measles (received 1 dose); SA results similar to 2 years ago; decided to move forward with FET #2 redo at start of next cycle
    Surprise natural BFP! | 9.22.20 | MC 10.23.20 at 8 weeks
    TTCAL naturally | starting 11.22.20

    Initial consultation with Reproductive Immunologist | 9.14.21
    Decidualization score biopsy | 10.1.21 | abnormal - low score of 1; endometrial scratch recommended and progesterone supplementation
    Saline sono | 10.15.21 | normal
    Bloodwork | 10.21.21 high TSH, high testosterone, positive for anti-nuclear antibodies and histone antibodies, high protein S, multiple genetic mutations
    BFP! | 11.3.21 | EDD 7.14.22 B) | biopsy provided same effect as endometrial scratch; added supplemental progesterone and estrogen, prednisone, levothyroxine, and MTX Support to maintain pregnancy
    DS born 7.19.22 after induction


    TTC #2 begins 6.2023
    Consultation with RI | 6.6.23
    Saline sono, endometritis biopsy, skin & eye check | all normal
    Labs | high TSH, Factor XIII mutation, high %CD56
    Follow up | 8.8.23 | prescribed metformin, prednisone, plaquenil, and levothyroxine
    Repeat labs after 3 weeks on meds
    Follow up | 11.9.23 | Green light!, increase in prednisone, added lovenox
    Repeat labs in 8 weeks
    Follow up | 1.16.24 | Green light continues
    TTC put on pause indefinitely
  • Noodle9912Noodle9912 member
    edited December 2018
    @mbradfo2 I'm so happy for you that you have a success story! It gives me hope!

    @inthewoods23 my app just jumped ahead with 3 days with my prediction so now I have no idea what's gonna happen, or at least not what Clue is thinking, but I'm going to try to relax and deal with what comes as it happens instead of trying to plan. Never tried that before, it should be tons of fun ;P

    Me 36, DH 48
    Married since 9/9/12
    TTC since 9/13
    DX: Unexplained infertility 11/18
    IUI #1: Jan 19, BFN
    IUI #2: Feb 19, TBD
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