Endometrial Function Test through Yale University — The Bump
Infertility

Endometrial Function Test through Yale University

Hello All.  Long story short, after 6 failed transfers (details in my signature), my RE is recommending that we do an Endometrial Function Test through Yale University.  We have already done an ERA, but sounds like this is different in that it tests the endometrium for various issues and markers which could be preventing implantation.  Has anyone heard of this or done this test?  Google searching is giving me some information, but not a ton.  I am just curious as to if anyone found this test and the results useful, and if so, how did the results alter your treatment?

Thanks in advance!
- August 2013 - December 2013 3 rounds Clomid 
- February 2014 - DH diagnosed with bilateral absence of vasdeferens, so on to IVF with ICSI.
- November 2014 - First IVF round/retrieval.  From that we ended up with 12, day 3 embryos.  Fresh transfer - chemical pregnancy
- February 2015 - 1st FET - BFN
- Dec 2015 - 2nd FET  - BFN
- Dec 2016 - 3rd FET - Added endo scratch, endometrial HCG, and resistant uterine protocol - BFN 
- Dec 2017 - Intra uterine scope and biopsy - Found nothing that could be causing us not to concieve
- Jan 2018 - ERA- Found I was post receptive and we needed 12 less hours of progesterone before transfer
- February 2018 - 4th FET - because of needing to mimic ERA cycle, had to thaw all 4 remaining embryos to day 5.  In that process 3 of the embryos arrested and the remaining embryo was very poor quality.  We weren't too surprised when that also ended in a BFN. 
- July 2018 - Full IVF round with PGS testing.  18 retrieved, 12 mature, 5 made it to day 5 testing day, 2 Normal.
-October 2018 - 5th FET with a good quality PGS normal embryo with altered ERA transfer timing - BFN

July IVF 2018 Link - https://docs.google.com/spreadsheets/d/1DfZXNH1ydA731CAEia7ySoE5SYlJkyFlYTQa7MW8gzc/edit?usp=sharing


Re: Endometrial Function Test through Yale University

  • So we have decided to move forward with this test.  Since I didn't have a lot of luck finding people with experience as to what this test entails and what the results might mean, I think I will post some information here as I get it.  Hopefully it might help someone else in the future who is looking for information.

    A fellow Bumpie on the July IVF thread found me a really good article that explains the test in a way I could understand:

    https://news.yale.edu/2003/07/14/newly-invented-endometrial-function-test-eft-solves-puzzle-unexplained-infertility-yale-r

    I also found some information on Yale's website:

    https://medicine.yale.edu/obgyn/kliman/infertility/eft/

    The video on their website was pretty cheesy but could be helpful.
    - August 2013 - December 2013 3 rounds Clomid 
    - February 2014 - DH diagnosed with bilateral absence of vasdeferens, so on to IVF with ICSI.
    - November 2014 - First IVF round/retrieval.  From that we ended up with 12, day 3 embryos.  Fresh transfer - chemical pregnancy
    - February 2015 - 1st FET - BFN
    - Dec 2015 - 2nd FET  - BFN
    - Dec 2016 - 3rd FET - Added endo scratch, endometrial HCG, and resistant uterine protocol - BFN 
    - Dec 2017 - Intra uterine scope and biopsy - Found nothing that could be causing us not to concieve
    - Jan 2018 - ERA- Found I was post receptive and we needed 12 less hours of progesterone before transfer
    - February 2018 - 4th FET - because of needing to mimic ERA cycle, had to thaw all 4 remaining embryos to day 5.  In that process 3 of the embryos arrested and the remaining embryo was very poor quality.  We weren't too surprised when that also ended in a BFN. 
    - July 2018 - Full IVF round with PGS testing.  18 retrieved, 12 mature, 5 made it to day 5 testing day, 2 Normal.
    -October 2018 - 5th FET with a good quality PGS normal embryo with altered ERA transfer timing - BFN

    July IVF 2018 Link - https://docs.google.com/spreadsheets/d/1DfZXNH1ydA731CAEia7ySoE5SYlJkyFlYTQa7MW8gzc/edit?usp=sharing


    suzycupcake
  • We received our protocol/schedule for the Endometrial Function Test.  Basically we will do a Mock FET cycle but instead of the transfer, they will do two biopsies on cycle days 15 and 24.  

    Here is a break down of the schedule:

    Pre Procedure Month
    - Cycle day 21:  Start Lupron 20 units nightly

    Procedure Month

    - Cycle day 1-2: check estrogen levels

    - Cycle day 3: start vaginal Estrace 2mg once daily, lower Lupron dose to 10 units nightly

    - Cycle day 6: US Check

    - Cycle day 7: Increase Estrace to 2 mg twice daily

    - Cycle day 10: US Check

    - Cycle day 11: depending on previous US, may increase Estrace dose

    - Cycle day 13: US Check.  If lining adequate, start progesterone vaginally.  Only one dose today, 25 mg in evening.

    - Cycle day 14: Increase progesterone to 25mg twice a day

    - Cycle day 15: Biopsy

    - Cycle day 16: Increase progesterone to 50 mg twice daily

    - Cycle day 18: Increase Progesterone to 100 mg twice daily

    - Cycle day 23: Increase Progesterone to 200 mg twice daily

    - Cycle day 24: Biopsy

    It sounds like this is Yale's standard protocol for the test.  I will be starting the Lupron on December 14th.  I am looking forward to getting the process started!

    On a side note, my RE also decided that she wants me on long term Prednisone for our next FET.  Since I will be on it for the real FET, I also have to be on it for the testing cycle.  I started with 20 mg daily last Saturday.
    - August 2013 - December 2013 3 rounds Clomid 
    - February 2014 - DH diagnosed with bilateral absence of vasdeferens, so on to IVF with ICSI.
    - November 2014 - First IVF round/retrieval.  From that we ended up with 12, day 3 embryos.  Fresh transfer - chemical pregnancy
    - February 2015 - 1st FET - BFN
    - Dec 2015 - 2nd FET  - BFN
    - Dec 2016 - 3rd FET - Added endo scratch, endometrial HCG, and resistant uterine protocol - BFN 
    - Dec 2017 - Intra uterine scope and biopsy - Found nothing that could be causing us not to concieve
    - Jan 2018 - ERA- Found I was post receptive and we needed 12 less hours of progesterone before transfer
    - February 2018 - 4th FET - because of needing to mimic ERA cycle, had to thaw all 4 remaining embryos to day 5.  In that process 3 of the embryos arrested and the remaining embryo was very poor quality.  We weren't too surprised when that also ended in a BFN. 
    - July 2018 - Full IVF round with PGS testing.  18 retrieved, 12 mature, 5 made it to day 5 testing day, 2 Normal.
    -October 2018 - 5th FET with a good quality PGS normal embryo with altered ERA transfer timing - BFN

    July IVF 2018 Link - https://docs.google.com/spreadsheets/d/1DfZXNH1ydA731CAEia7ySoE5SYlJkyFlYTQa7MW8gzc/edit?usp=sharing


    Kp214
  • @katie35 this information is amazing! I look forward to your updates about this new test. Good luck! 
    katie35
  • We had our first biopsy this morning so I thought I would add in the additional information that I have so far.

    The biopsy itself wasn't bad.  My RE took two biopsies as this is what the RE at Yale recommend her to do.  I was pretty crampy during each but the biopsies/cramping only lasted about 20-30 seconds each.

    I found out today that Yale won't actually start processing the results of the biopsies until they receive both specimens and then they will process them together.  It sounds like it will take at least two weeks from the time they start processing the specimens for me to get any results back. 

    I had to make sure all of my paper was signed today which included Yale's Patient Privacy Agreement and the Financial Agreement.  

    For costs, I confirmed today that for Yale to process the samples, they will charge me $595 per specimen.  In the grand scheme of everything we have done so far, this didn't seem so bad!  So for cost for the entire testing process, I am figuring the following:

    Medications (Estrace, Progesterone Suppositories, Lupron): $110 (after insurance)
    Ultrasounds: 100 (after insurance)x3 = $300
    Biopsy Specimen Processing: 595x2 = $1190
    Biopsy Procedures: Forgot to ask, but I don't remember this being too aweful from my ERA

    - August 2013 - December 2013 3 rounds Clomid 
    - February 2014 - DH diagnosed with bilateral absence of vasdeferens, so on to IVF with ICSI.
    - November 2014 - First IVF round/retrieval.  From that we ended up with 12, day 3 embryos.  Fresh transfer - chemical pregnancy
    - February 2015 - 1st FET - BFN
    - Dec 2015 - 2nd FET  - BFN
    - Dec 2016 - 3rd FET - Added endo scratch, endometrial HCG, and resistant uterine protocol - BFN 
    - Dec 2017 - Intra uterine scope and biopsy - Found nothing that could be causing us not to concieve
    - Jan 2018 - ERA- Found I was post receptive and we needed 12 less hours of progesterone before transfer
    - February 2018 - 4th FET - because of needing to mimic ERA cycle, had to thaw all 4 remaining embryos to day 5.  In that process 3 of the embryos arrested and the remaining embryo was very poor quality.  We weren't too surprised when that also ended in a BFN. 
    - July 2018 - Full IVF round with PGS testing.  18 retrieved, 12 mature, 5 made it to day 5 testing day, 2 Normal.
    -October 2018 - 5th FET with a good quality PGS normal embryo with altered ERA transfer timing - BFN

    July IVF 2018 Link - https://docs.google.com/spreadsheets/d/1DfZXNH1ydA731CAEia7ySoE5SYlJkyFlYTQa7MW8gzc/edit?usp=sharing


  • ninamininami member
    10 Comments Name Dropper Photogenic
    Hi @katie35! Found you on this threat. Great info, sounds like its totally worth it for those of us "unexplained" . Just really feels like its timing issue. Especially from my own experience, since I did implant on my own, just miscarried. Yale is a great place. Got my friend pregnant after years of failure.
Sign In or Register to comment.
Choose Another Board
Search Boards