Infertility

BCP suppressing ovaries during IVF protocol?

A fellow AMA/DOR bumpie shared this piece of info with me so I researched it and found an article that concurred with her statement. If your RE put you on BCP as part of your IVF protocol and found that it suppressed your ovaries, what did they recommend next? 

I have my consult 3/19 and want to gather as much info as possible before then! Thanks for your feedback!
Me: 42, dx: DOR (AFC: 5), low AMH (0.163), blocked tube, fibroid
DH: 44, dx: ED (uses Cialis), low count/motility (17 million/44%)
~Our History~
2012: April married <3 , begin TTC
2013: Jan: BFP #1, mc at 11 weeks (Trisomy 10), D&E :'( ; Nov: HSG=blocked right tube, SHG=polyp, fibroid
2014: April: polypectomy; May-Nov: TTC, Dec.= BPF #2, DS born 8/28/15 via C-section <3
2016: Oct.-Dec.: TTC 
2017: Feb.-Aug: benched due to Zika virus threat (Feb.=trip to Philippines) :( , Sept.-Dec.: TTC
2018: Jan.-Apr.: TTC
          May: IVF #1 w/ ICSI/AH: 6R, 3M, 2F; day 3 transfer of both embies; poor quality (E1=grade 3, E2=grade 4)

May 2018 IVF Spreadsheet:

https://docs.google.com/spreadsheets/d/1E9syRZY17j2PF-UgdBpU70DPPY2EplxXNHw4Trc-G4g/edit?usp=sharing

Re: BCP suppressing ovaries during IVF protocol?

  • Most of us get on BC before starting the cycle. But once on stims there is no BC. I can't imagine being on it before retrieval. 

    Married: 5/09 ~ TTC Since: 10/10 ~ PCOS ~ Progesterone from 10/10 - 2/11 ~ HSG on 3/18 - Clear ~ Started Metformin 1000mg & Clomid 50mg 2/11 ~ Metformin upped to 1500mg 4/6 ~ 6/7 Now going to SG and put on Clomid, Ovidrel, Gonal F, Prometrium, Estrace ~ IUI #1 7/2 = BFP!!!!!! March 6th our little man was born. 

    6/17/13 - Ovidrel, Follistim, Prometrium ~ IUI #1 7/2 = BFP! March 17th our St. Pattys day baby arrived

    10/29/17 - Started process for IVF, got pregnant & miscarried a 2nd time since summer. 2/22 started stims - Menopur, Gonal F, Cetrotide - retrieval 3/6 - , PIO, estrace 3xday - FET 4/18 = Beta 1: 616; Beta 2: 1342 = BFP 

  • I went on BC for 14 days or so before starting my shots, and after stimulation had 36 eggs (32 mature) and 27 fertilized. I wouldn't worry too much about it, they do this with tons of women around the world. (Note: I was on high doses of meds to achieve these #s).

    Best of luck in your upcoming venture!
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  • My last three cycles (4-6) have been natural start microdose lupron.  I’m 40 if you can’t see my signature (I’m almost always on mobile/the app myself).  My first cycle last year I did BCP before, and my second and third cycles were luteal lupron.  My history is in my signature, but we’ve had mixed results both with and without suppression prior to starting stims.  Natural start is a lot quicker though - I did two retrievals last month (and February was short - it’s amazing how quickly that clinic takes my money ;).

    Hard to say because the RE, protocol, and lab changed between cycles 3 & 4 though - with first RE we got 1 normal from 8 blasts to test in 3 cycles, with current we got 6 normals from 14 blasts to test in 3 cycles (also inseminated frozen eggs from right after I turned 35 and that disappointingly yielded only one abnormal blast).

    Good luck!
    About me:
    Married 6/18/16 (Me 42, DH 44), TTC #2
    ***TW***
    Natural BFP 8/10/16 --> mc our NIPT-normal little girl at 11w5d on 10/1/16 :(
    As of 12/2016:  AMH 1.42, FSH 6.1, AFC ~10
    Self-benched Nov-Dec 2016 for
    IVF #1 Jan-Feb 2017 (OCP, testosterone primed antagonist w/HGH - ER 2/2/17 - 12R, 7M ICSI'd, 3F, 0B)
    IVF #2 Mar-Apr 2017 (testosterone primed agonist/luteal lupron w/HGH - ER 4/8/17 - 10R, 8M, 8F, 5B, 1 PGS normal)
    IVF #3 May-Jun 2017 (testosterone primed agonist/luteal lupron w/HGH - ER 6/4/17 - 14R, 5F, 3B, 0 normal)
    **New RE**
    IVF #4 Sept 2017 (natural start microdose lupron flare w/HGH - ER 9/28/17 - 33R, 18F, 10B, 4 PGS normals!)
    FET #1 (medicated) of one PGS normal 4AA XX 11/2/17 - Beta #1 11/11/17 (153), Beta #2 11/13/17 (324), mc at 5w1d on 11/19/17 :(
    IVF #5 Dec 2017 - Insemination of 9 frozen eggs from 2012 (8F, 1B, 0 normal)
    Jan 2018 - Natural cycle ERA (normal/receptive) & stimming for
    IVF #6 Jan-Feb 2018 (natural start microdose lupron flare w/HGH - ER 2/3/18 - 17R, 6M, 4F, 0 blasts)
    IVF #7 Feb 2018 (natural start microdose lupron flare w/HGH - ER 2/26/18 - 19R, 9M, 9F, 4B, 2 PGS normals)
    FET #2 Apr 2018 (natural cycle w/o trigger, w/P4 support) of one PGS normal 4AA- XX 4/5/18 - Beta #1 4/14/18 (67), Beta #2 4/16/18 (231)
    Rainbow baby girl born 12/16/2018 (via c-section, induced at 39 weeks)

    -----
    TFAS!
    FET #3 Dec 2019 (natural cycle w/o trigger, w/P4 support) of one PGS normal 3BB XY 12/16/19 - Beta #1 12/24/19 (139), Beta #2 12/27/19 (482)

    Lilypie Maternity tickers
  • I had my first IVF cancelled because I was on BC for two weeks and it suppressed me. I have lower AMH for my age. My AFC went from 13/14 to 8 at baseline. Then we only got 2 follicles to grow with high stims, so we converted to IUI. My second IVF was estrogen priming and the MDL protocol. It didn't work good for me, but it does for some with low AMH. IVF #3 I did estrogen priming and then max stims (450 follistim and 150 menopur) with antagonist and was able to retrieve 12 eggs, 8 mature. Sometimes its really just a guessing game for the right protocol, but if you have lower AMH/lower AFC, I would advise estrogen priming or natural start vs being on BC. Good luck!
    History in Spoiler

    Age: 32 (same with DH). Together since 2006, Married June 2013 and TTC since August 2015
    Diagnosis: Mild Endo, DOR (AMH of 1.5), Poor Quality Eggs/embryos, Displaced Window of Implantation (ERA Post Receptive)
    March-May 2016: 1 TI and 2 IUIs- BFN 
    June 2016- Laproscopy- found/removed mild endo and confirmed only 1 normal healthy ovary.
    August 2016- IVF #1 with Antagonist Protocol- Cancelled (2 lead follies), converted to IUI- BFN
    Oct-Nov 2016- IVF #2 with Estrogen Priming Micro Lupron Protocol, 2 eggs retrieved, day 3 transfer of 1- BFN
    January 2017- New RE, IVF#3 with Estrogen Priming Antagonist Protocol, 12 eggs, 8 mature, 6 fertilized, 2 day 5 early blasts transferred (none to freeze :(), BFN
    May 2017- Sept 2017- Starting Donor Egg process! Waiting for donor to be available... and then she is pregnant at baseline :(
    Oct 2017- Donor #2: 25R, 22M,18F, 12 blasts frozen! Fresh transfer cancelled due to thin lining with fluid :(
    Nov 2017- Hysterscopy to remove polyp
    Dec 2017- DE FET #1 on 12/8 on 2 perfect blasts- BFN and devastated
    Jan-Mar 2018- ERA #1- Post receptive by 24 hours, ERA #2 RECEPTIVE with 4 days of Progesterone
    Apr 2018- DE FET cancelled for lining issues :(
    Jun 2018- DE FET #2 of two 1AA blasts- first BFP ever! Beta 10dp5dt- 378, Beta 14dp5dt- 2840, Beta 16dp5dt- 4035, beta 18dp5dt- 10916. Due on 2/20 with one baby after a vanishing twin
    Baby Born born early @ 33.5 weeks due to Pre-e
    Back for # 2!
  • prudence9-2prudence9-2 member
    edited March 2018
    @mich_elle as I told you on the other thread I responded poorly compared to my previous IVF. Both times I was on BCP prior. But the dr thinks that this time it suppressed my ovaries and recommended to maybe stop and do a different protocol without BCP and with Lupron. Not sure of the exact protocol. 
    TTC history in spoiler box:
    Me: 42, single
    Hysteroscopy: 2013
    IUI #1-2: 2013 BFN
    Surgery 10/2015: Planned to start trying again but had a surgery. (Not related to fertility)
    Surgery 5/2016: Planned to start trying again but had another surgery. (Not related to fertility)
    IUI  #3-5 (with Clomid): summer 2016 BFN
    IVF #1: 11/2016. 30R; 21M; 20F; 8B (6 day5 & 2 day6); 4 normal after PGS
    Medicated FET #1: 1/31/2017 transferred 1 embryo 3AA. BFP. Embryo stopped growing at 6w 1d. MUA at 9w 3d.
    Medicated FET #2June 2017 - cancelled...
    Hysteroscopy #2: June 2017
    Medicated FET #2: 8/7/2017 transferred 1 embryo 5BB. BFP. Ended in CP.
    Medicated FET #3: 10/11/2017 transferred 1 embryo 3AA. BFN
    ERA: December 2017 - need an extra 12 hours of PIO
    Medicated FET #4: 1/24/2018 transferred 1 embryo 4AA. BFN
    Out of embryos.  :'(
    IVF #2: 03/2018.

  • I was on the normal protocol of BCP for my first 2 cycles. For my third cycle my RE changed the protocol  -- this time around I was on estrace starting 10 days after ovulation followed by 3 nightly ganirelix injections (then I got AF the following day). I am on day 3 of stims now so I''m not sure it helped but I will say that I had more follicles at my baseline then I did my other 2 IVF cycles. Like PP suggested though, I wouldn't read too much into it. My RE likely just changed mine because we were on our third and final try so we were basically just grasping at straws trying to come up with a different protocol that might work for me. GL!

    Me 35, DH 37

    Unexplained infertility and TTC since December 2014

    February 2016 - May 2016: 3 IUI's -- all BFN

    August 2016: IVF #1 (Lupron, Gonal F and Menopur) -- 12 retrieved, 9 fertilized, 3 frozen and 1 x day 5 hatching blast transferred -- BFN. Sent remaining 3 embryos for PGS testing -- 2 didn't survive thaw, 1 was abnormal.

    February 2017: IVF #2 (Gonal F, Menopur, and Ganirelix) -- 12 retrieved, 6 fertilized, 3 sent for PGS testing and all were abnormal

    March 2018: IVF #3 (Menopur, Follistim, Ganirelix and HGH) -- 14 retrieved, 12 fertilized, 4 sent for PGS testing, and 3 were PGS normal

    May 2018: FET #1 -- BFN

    August 2018: FET #2 -- BFP!!! healthy baby girl born May 2019!!

    July 2020: FET #3 -- embyro did not survive thaw

    September 2020 - IVF #4 (Menopur, Follistim, Ganirelix and HGH) -- 1 PGS normal

    October 2020 - FET #4 -- BFN

    January 2021 - IVF #5 (Menopur, Follistim, Ganirelix and HGH)  -- 2 PGS normal

    February 2021 - FET #5 - BFP!!! Due 11/6/2021



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