Pregnant after IF

Ongoing soreness from PIO injection site, after stopping injections

Has anyone experienced this?

All my PIO shots went to the same area on both sides of my hips/backside.  We had the nurse draw circles for us.  

They got way sore during the injections, and I had constant knots under my skin.  Now, the knots have healed, but the skin there still feels weird.  A little sore, a little numb.  Definitely different.

Is this common?  If you're experienced it, does it go away?  I've been off the injections for about 4 weeks.
Me- 39 (turning 40 in April), TTC for the first time ever (since Jan 2015), low ovarian reserve
Married 3/14/14 to my wonderful wife, but her sperm count is rather low
TTC with frozen donor sperm and science

7 IUIs, 7 BFNs.
2 IVF attempts, both cancelled and converted to IUI, both BFNs.
Decided that my tired old ovaries are ready to retire.
Next step- reciprocal IVF, using my wife's eggs, my uterus!  
fresh 5 day transfer (2 embryos) 4/17/17- BFP! 
Identical twins "due" 1/2/17 (but anticipated arrival sometime December)

Re: Ongoing soreness from PIO injection site, after stopping injections

  • I've been finished with my injections for 11.5 weeks and I still have a slight soreness and numbing sensation.  The numbness actually runs down my legs a little.  It has gotten better as time has gone on.  I was also on delestrogen every third night.  I've just thought it was normal since I had so many injections in a 10ish week period.  Interested in what others have to say.. 
    TTC since:  1/2015
    11/16:  IVF #1.  BFN
    2/23/17:  FET with a BFP on 3/8/17.
    EDD: 11/11/17 with a baby GIRL!

  • I had the same thing happen after I stopped PIO shots for awhile. For weeks it continued to be sore/numb in the same area as where the needle went and even shot down my leg at times. I mentioned it to my doctor and they believed it was actually my sciatic nerve being pressed on early on in my pregnancy from the changes happening in my body, not from the PIO shots.
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  • Yup. I've been off injections for over 10 weeks now and I still have little sore spots. I'm thinking it must be scar tissue or something. It's not bothersome unless I press directly on them. But yea, youre not alone!
    Me: 32, Hubs: 36
    Married: September 2013
    TTC since April 2014, Dx: MFI
    DH started Clomid Oct 2015
    April-June 2016- 3 IUIs: All BFN
    July 2016- IVF #1: 16 eggs ->1 PGS-normal embryo
    Sept 2016- single FET #1: BFN
    Nov 2016- IVF #2 16 eggs -> 3 PGS-normal embryos
    Jan 2017- single FET #2: BFN
    Feb 2017- endometrial scratch
    March 2017- FET #3 (double transfer): BFP!
       Beta #1: 386 (9dp5dt), Beta #2: 1,960 (12dp5dt)
       Pregnant with: Triplets Twins Singleton
       It's a GIRL! :)
       EDD: November 16, 2017
       Dx w/ preeclampsia: Updated delivery date: 10/4/17
    <3 Hazel Summerlyn <3
    Find me on the IG

    BabyFruit Ticker
  • I've had lower back pain where those shots were since I went off the PIO. The numbness is also present but has migrated some to my hips also. I'm attributing it to both the PIO and the pregnancy. Hips spreading/nerves moving etc plus sleeping on my sides exclusively at this point.
  • I get some phantom PIO pains every now and then, but they aren't too bad.
    Me: 31 PCOS + Homozygous A1298C MTHFR DH: 32 A-OK!
    December 2015-IVF 24 eggs retrieved, 16 mature, 14 fertilized with ICSI, 9 frozen blastocysts
    January 2016-FET #1-BFP!
    February 2016-MC @ 7w3d
    April 2016-Hysterscopy and D&C
    May 2016-September 2016-Prepare to move to Qatar and TTC is on hold
    October 2016-Natural BFP & MC @ 6w
    December 2016-Natural CP
    April 2017-FET #2-BFP-It's TWINS!
    Follow our journey
  • This is very common. My RE nurse told me that there can be mild nerve damage that takes a long time to heal. While the soreness went away after a few months, I still have slight numbness/itching sensations in those areas to this day!
    *** Trigger Warnings ***

    TTC #1 since March 2011
    Dx = Unexplained IF
    1 medicated TI cycle & 4 clomid IUIs = all BFNs
    June 2013 IVF #1 = 6 frosties + BFP!
    DS1 born 2/14

    TTC #2 since December 2014
    May 2015 unassisted BFP ended in m/c at 7wks
    April 2016 FET #1 = BFN
    June 2016 FET #2 = c/p
    August 2016 FET #3 = BFP!
    DS2 born 4/17
  • @KLake42 I was doing PIO for about 1.5 months. Last shot was on March 7th. The numbness started few days before my last shot and 4.5 months later I still have numbness in both upper outer thighs! (I didn't do the shots on my thighs. But I guess the nerve in the butt goes to the thighs)  It is much better now than 4.5 months ago. But it is still there. 

    In about one week I will have to start PIO again in preparation for my next FET and im really afraid it will get much worse. 
    TTC history in spoiler box:
    Me: 42, single
    Hysteroscopy: 2013
    IUI #1-2: 2013 BFN
    Surgery 10/2015: Planned to start trying again but had a surgery. (Not related to fertility)
    Surgery 5/2016: Planned to start trying again but had another surgery. (Not related to fertility)
    IUI  #3-5 (with Clomid): summer 2016 BFN
    IVF #1: 11/2016. 30R; 21M; 20F; 8B (6 day5 & 2 day6); 4 normal after PGS
    Medicated FET #1: 1/31/2017 transferred 1 embryo 3AA. BFP. Embryo stopped growing at 6w 1d. MUA at 9w 3d.
    Medicated FET #2June 2017 - cancelled...
    Hysteroscopy #2: June 2017
    Medicated FET #2: 8/7/2017 transferred 1 embryo 5BB. BFP. Ended in CP.
    Medicated FET #3: 10/11/2017 transferred 1 embryo 3AA. BFN
    ERA: December 2017 - need an extra 12 hours of PIO
    Medicated FET #4: 1/24/2018 transferred 1 embryo 4AA. BFN
    Out of embryos.  :'(
    IVF #2: 03/2018.

  • I had a bit of nerve damage as well from them. My baby is 7 months now and I don't feel anything at all. It did take a good three or four months for it to heal but it did def go away. Just with time. :-) it was a bit scary though. 
  • I'm really glad to hear that I'm not alone in this, and that it eventually heals!  I know there are other areas of the body for IM injections (thighs).  I wonder why REs don't encourage us to mix up the locations a bit more.  Maybe some of us have chubbier thighs (I know I do) so it might not work for everyone.
    Me- 39 (turning 40 in April), TTC for the first time ever (since Jan 2015), low ovarian reserve
    Married 3/14/14 to my wonderful wife, but her sperm count is rather low
    TTC with frozen donor sperm and science

    7 IUIs, 7 BFNs.
    2 IVF attempts, both cancelled and converted to IUI, both BFNs.
    Decided that my tired old ovaries are ready to retire.
    Next step- reciprocal IVF, using my wife's eggs, my uterus!  
    fresh 5 day transfer (2 embryos) 4/17/17- BFP! 
    Identical twins "due" 1/2/17 (but anticipated arrival sometime December)

  • @KLake42 my numbness is in the outter upper thighs. But I actually inject in the butt. 

    Since im doing the injections on my own I first asked if I can do it in the thighs and the nurse at my clinic told me I shouldn't because it's more painful than in the butt. 
    TTC history in spoiler box:
    Me: 42, single
    Hysteroscopy: 2013
    IUI #1-2: 2013 BFN
    Surgery 10/2015: Planned to start trying again but had a surgery. (Not related to fertility)
    Surgery 5/2016: Planned to start trying again but had another surgery. (Not related to fertility)
    IUI  #3-5 (with Clomid): summer 2016 BFN
    IVF #1: 11/2016. 30R; 21M; 20F; 8B (6 day5 & 2 day6); 4 normal after PGS
    Medicated FET #1: 1/31/2017 transferred 1 embryo 3AA. BFP. Embryo stopped growing at 6w 1d. MUA at 9w 3d.
    Medicated FET #2June 2017 - cancelled...
    Hysteroscopy #2: June 2017
    Medicated FET #2: 8/7/2017 transferred 1 embryo 5BB. BFP. Ended in CP.
    Medicated FET #3: 10/11/2017 transferred 1 embryo 3AA. BFN
    ERA: December 2017 - need an extra 12 hours of PIO
    Medicated FET #4: 1/24/2018 transferred 1 embryo 4AA. BFN
    Out of embryos.  :'(
    IVF #2: 03/2018.

  • The butt shots didn't hurt too much at first, but after a few weeks, when everything was sore, I was cussing like crazy every time the needle went back in.
    Me- 39 (turning 40 in April), TTC for the first time ever (since Jan 2015), low ovarian reserve
    Married 3/14/14 to my wonderful wife, but her sperm count is rather low
    TTC with frozen donor sperm and science

    7 IUIs, 7 BFNs.
    2 IVF attempts, both cancelled and converted to IUI, both BFNs.
    Decided that my tired old ovaries are ready to retire.
    Next step- reciprocal IVF, using my wife's eggs, my uterus!  
    fresh 5 day transfer (2 embryos) 4/17/17- BFP! 
    Identical twins "due" 1/2/17 (but anticipated arrival sometime December)

  • @KLake42 for me it depended on the day. Some days didn't hurt at all and some did. Not looking forward to start it again next week. But hope I will keep it up for 3 months this time around :)
    TTC history in spoiler box:
    Me: 42, single
    Hysteroscopy: 2013
    IUI #1-2: 2013 BFN
    Surgery 10/2015: Planned to start trying again but had a surgery. (Not related to fertility)
    Surgery 5/2016: Planned to start trying again but had another surgery. (Not related to fertility)
    IUI  #3-5 (with Clomid): summer 2016 BFN
    IVF #1: 11/2016. 30R; 21M; 20F; 8B (6 day5 & 2 day6); 4 normal after PGS
    Medicated FET #1: 1/31/2017 transferred 1 embryo 3AA. BFP. Embryo stopped growing at 6w 1d. MUA at 9w 3d.
    Medicated FET #2June 2017 - cancelled...
    Hysteroscopy #2: June 2017
    Medicated FET #2: 8/7/2017 transferred 1 embryo 5BB. BFP. Ended in CP.
    Medicated FET #3: 10/11/2017 transferred 1 embryo 3AA. BFN
    ERA: December 2017 - need an extra 12 hours of PIO
    Medicated FET #4: 1/24/2018 transferred 1 embryo 4AA. BFN
    Out of embryos.  :'(
    IVF #2: 03/2018.

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