Infertility
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First round of clomid

Hi ladies!
   Started my first round of clomid: 50mg CD5-9.  A little nervous about all of the side effects I have been reading. Would love some feedback from you gals who have used clomid.

<3

Re: First round of clomid

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    liljoy-2liljoy-2 member
    edited February 2017
    Hi and sorry you have to be here, but you are in the right place :) Clomid has been used extensively throughout the years and most women do relatively well on it. However, it is considered a harsh drug by some REs. I was ok-ish on this dose (a bit of grogginess) until I had what I can describe as eye floaters which developed at the end of the tx and afterwards (I still have them from time to time). At that point we decided clomid is no longer in my future, as vision side effects are a show-stopper. But it's supposed to be rare so don't worry too much, the doc know what they are doing and it's only for a few days anyway. 
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    I remember doing 100mg and it dried out the hoo-ha which made sexy time shockingly uncomfortable lol. I switched to femera after that and never had the issue again :).
    Me 35, Him 40
    TTC June 2013
    Lap, HSG, Hysteroscopy
    High FSH/ Low AMH
    Endo Mild/ Moderate
    History w/Clomid/Femera/Progesterone
    IVF #1 cancelled poor responder
    IVF #2 two good eggs/ froze both on day 3 rather then lose before blast
    Awaiting sonohystogram to determine if minor surgery needed before FET


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    This is my first clomid month too, 50mg CD 4-8.  I had awful headaches for the first 2-3 days, butvthey went away. Really no other issues. Follicle check on CD 12 showed 6 potentials on my R side (nothing on my L). I go in tomorrow to see what matured. 
    ~Mom to an amazing Jan 2011 boy~
    ~EDD Nov 18, 2017 with my IUI success story~

    [spoiler]
    BabyFruit Ticker[/spoiler]

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    I did 5 cycles with Clomid 50mg. The main side effect for me was hot flashes. 
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    My first round of clomid 50 I had horrible headaches the entire time. When I upped my dose to 75 for the next round I didn't have any problems what so ever. Everyone tends to react a little different. 
    BFP #1: 1.22.16                 MMC: 2.29.16 ( tetrasomy 11, partial deletion 1, XXX) D&C: 3.2.16
    BFP #2: 4.14.16                 CP: 4.17.16
    BFP #3: 6.10.2016             CP: 6.17.16
    RE appt: 6.27.2016- saline sono all clear
    Progenity: + carrier Tay-Sachs, Gaucher's, hemachromatosis. DH: carrier Alpha 1 anti-trypsin
    PCOS, hypothyroid, MTHFR, hx of LEEP in 2006
    Clomid + TI Cycle #1: 50mg Trigger 8.24.2016- BFN
    Clomid 75mg + IUI#1 9.25.2016- BFP #4 10/6
    Beta #1 15   Beta #2 38    Beta #3- 71     beta #4 171   Beta # 5- 21  Natural MC 10/21
    HSG- clear
    IVF Jan 2017
    Egg Retrieval 1.22.17: 32 eggs retrieved,29 mature, 24 fertilized, 14 to blastocyst for biopsy
    PGS results: 4 PGS normal 2 XX, 2 XY
    FET: 3.13.2017 for 2 PGS embryos
    Beta#1: 3.24.2017......... 78; Beta # 2 241; Beta #3 4198
    Baby BOY due 11.29.2017






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    I took Clomid several cycles before I started IVF and was lucky to not have any side effects. Everyone is different. GL and welcome!
    History and blog link in spoiler
    2016 - dx with super low ovarian reserve; failed cycle with clomid, failed IUI, 
    2017 - egg retrieval #1 - 3 eggs, 0 embryos appropriate for transfer; ER #2 2 eggs, 0 embryos on day 3; ER #3 1 egg 0 embryos
    moved to donor egg in summer 2017; 35 eggs retrieved; 19 fertilized; 9 total embryos
    Fresh transfer Dec 2017= BFP!  baby boy born 8/22/18

    May 2019 - surprise natural pregnancy ended in MC
    Nov 2019 FET; MC at 9 weeks
    May 2020 FET; BFN
    July 2020 FET; CP treated with methotrexate
    Oct 2020 BFP! 

    Take a look at my blog


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    Ah, that sounds harsh! lol Glad you got something better :)
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    @pawcall I go in as well on CD 12 - hoping for good news! Send baby dust too you! :)


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    laurad75 said:
    I took Clomid several cycles before I started IVF and was lucky to not have any side effects. Everyone is different. GL and welcome!
    How many cycles did you do? My Dr. said he is only comfortable with doing this for 3 cycles and if we unsuccessful we will be referred to another Dr. and do the IVF. I have read online so many mixed things. I guess all Dr.'s are different.. 
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    We did 3 cycles of clomid, besides major bloating I felt fine thankfully. We went to a specialist after that where they actually wanted 3 more cycles of clomid but we opted to do IVF, so some will do a lot of rounds of it-? Good luck to you!
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    My first RE was only comfortable doing 3 rounds of clomid as well, but that was because of my history. 
    BFP #1: 1.22.16                 MMC: 2.29.16 ( tetrasomy 11, partial deletion 1, XXX) D&C: 3.2.16
    BFP #2: 4.14.16                 CP: 4.17.16
    BFP #3: 6.10.2016             CP: 6.17.16
    RE appt: 6.27.2016- saline sono all clear
    Progenity: + carrier Tay-Sachs, Gaucher's, hemachromatosis. DH: carrier Alpha 1 anti-trypsin
    PCOS, hypothyroid, MTHFR, hx of LEEP in 2006
    Clomid + TI Cycle #1: 50mg Trigger 8.24.2016- BFN
    Clomid 75mg + IUI#1 9.25.2016- BFP #4 10/6
    Beta #1 15   Beta #2 38    Beta #3- 71     beta #4 171   Beta # 5- 21  Natural MC 10/21
    HSG- clear
    IVF Jan 2017
    Egg Retrieval 1.22.17: 32 eggs retrieved,29 mature, 24 fertilized, 14 to blastocyst for biopsy
    PGS results: 4 PGS normal 2 XX, 2 XY
    FET: 3.13.2017 for 2 PGS embryos
    Beta#1: 3.24.2017......... 78; Beta # 2 241; Beta #3 4198
    Baby BOY due 11.29.2017






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    @twhip25 I think I did 4 cycles and I asked my doctor if there was any concern on doing too many cycles with clomid and he wasn't concerned at all.  After 3 or 4 without success it would likely be time to move on to a more aggressive approach anyway.  

    Out of curiosity, why would you have to switch doctors?  Who is prescribing the clomid?  
    History and blog link in spoiler
    2016 - dx with super low ovarian reserve; failed cycle with clomid, failed IUI, 
    2017 - egg retrieval #1 - 3 eggs, 0 embryos appropriate for transfer; ER #2 2 eggs, 0 embryos on day 3; ER #3 1 egg 0 embryos
    moved to donor egg in summer 2017; 35 eggs retrieved; 19 fertilized; 9 total embryos
    Fresh transfer Dec 2017= BFP!  baby boy born 8/22/18

    May 2019 - surprise natural pregnancy ended in MC
    Nov 2019 FET; MC at 9 weeks
    May 2020 FET; BFN
    July 2020 FET; CP treated with methotrexate
    Oct 2020 BFP! 

    Take a look at my blog


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    laurad75 said:
    @twhip25 I think I did 4 cycles and I asked my doctor if there was any concern on doing too many cycles with clomid and he wasn't concerned at all.  After 3 or 4 without success it would likely be time to move on to a more aggressive approach anyway.  

    Out of curiosity, why would you have to switch doctors?  Who is prescribing the clomid?  


    Currently I am only seeing my OBGYN - he said after the 3 cycles he would refer me to someone else. I am kind of concerned as too why we would have to switch too.
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    @twhip25 that's how we did it too, 3 rounds with my OB, then she referred us to a specialist. She was comfortable doing that much with my diagnosis (blocked tube) but felt if we weren't pregnant after that, a specialist made more sense. So I think fairly common-? Like the OB can do basics to get you pregnant but after that they specialize more in healthy pregnancies and delivery (how my OB described it :)
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    @twhip25 You would have to switch because an OBGYN doesn't treat infertility.  It's not unusual that an OBGYN will refer you to an RE rather than prescribe any IF meds or treatment since it is not within their specialty.  
    History and blog link in spoiler
    2016 - dx with super low ovarian reserve; failed cycle with clomid, failed IUI, 
    2017 - egg retrieval #1 - 3 eggs, 0 embryos appropriate for transfer; ER #2 2 eggs, 0 embryos on day 3; ER #3 1 egg 0 embryos
    moved to donor egg in summer 2017; 35 eggs retrieved; 19 fertilized; 9 total embryos
    Fresh transfer Dec 2017= BFP!  baby boy born 8/22/18

    May 2019 - surprise natural pregnancy ended in MC
    Nov 2019 FET; MC at 9 weeks
    May 2020 FET; BFN
    July 2020 FET; CP treated with methotrexate
    Oct 2020 BFP! 

    Take a look at my blog


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    I'll just be crossing my fingers, toes, anything else that can be crossed that we don't have to meet with someone else & this works!
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    twhip25 I have been on Clomid twice. Once it thinned my lining too much and when I took estrace it stunted my follicle growth so all 5 growing ones, were too small and we cancelled before IUI. (100 mg x days 3-7).

    Now I'm on it again, 100 mg x days 3-9. I am hungry, have hot flashes and bloating. I haven't read hunger is a symptom so maybe I'm just using it as an excuse!?  Anyone else feel hungry all of the time?!
    TTC History in Spolier:
    Me: 32, DH: 33
    Diagnosis: Me: Unexplained. Him: 1% morphology pre-washed.
    IUI  - CANCELLED Jan IUI - 100 mg Clomid Days 3-7. Cancelled after Estrace stunted follicle growth. BFN 
    IUI #1 - Feb/March, 2017 IUI - IUI+7 days Clomid+HCG trigger shot. March 1st IUI. 3/15 BFN
    IUI # 2 - August, 2017 IUI -  7 days Clomid + HCG trigger shot. IUI on August 12. 8/26 BFN 
    *TW* November 1st, BFP. Ended in MC @ 6 w 3 days. 11/20/17. **Natural Cycle with Acupuncture & Chinese Herbs. 
    IUI #3 Feb 24 2018, IUI + 7 days Clomid + HCG Trigger Shot. Feb 24 IUI. 3/12 BFN
    *TW* 5/10/18 BFP/MC. Natural Cycle. 1st Beta 232, 2nd 850. No Fetal pole seen on U/S, 5/30/18. Medicated MC on 6/23. 
    IVF #1, Stims begin on August 17th. ER, 8/28/18. 32 Eggs Retrieved, 18 mature, 18 Fertilized. 12 Day 5. 6 Blasts Tested Normal with CCS. 
    FET 1, 11/6/19. 1 Embryo Transferred. NEG BETA 11/15
    FET 2, 1/29. 1 Embryo to Transfer. +HPT 2/5. Beta 2/7 = 137, 2nd HCG = 317. MC at 6w4d. No fetal pole seen on U/S


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