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Lupron injections

tiffanyw1783tiffanyw1783 member
in Infertility
Has anyone had issues with injection site stinging after Lupron shot? Tonight is my second dose of Lupron. I give them in my belly. Last night I felt nothing, tonight I had a burning and stinging sensation for about 3-4 min after the injection and the skin is red around where I gave the injection?

TTC for 8 years.
Started in 2008 with timed intercourse, ovulation testing, no official monitoring.
OB-GYN recommended Clomid and timed intercourse, attempted for 6 straight months.
First surgery June 2009 (OB-GYN): diagnosed with stage 4 endometriosis and large hydrosalpinx on right tube.
Second surgery (July 2009, RE performed this): Right tube had to be removed, lots of adhesions removed.
Attempted "trying on our own" as per RE recommendations, unsuccessful 5-6 months.
HSG performed December 2009: left tube open.
February 2010: started Femara and timed intercourse, attempted 6 months, no BFPs.
Took a break for a while.
January 2011: started IUI process, ovaries never properly responded to medications, 6 failed attempts, never actually completed an IUI.
Took 2012-2014 off due to depression and frustration (side note: did complete grad school to become a nurse practitioner- great distraction).
2015: started seeing RE again, went through tons of testing and HSG, left tube now blocked, only option is IVF.
September 2015: Started first official IVF cycle, cancelled in October due to large cyst on left ovary.
October 2015: started on birth control for 2 months.
December 2015: attempted to start another IVF cycle, cysts on both ovaries on initial ultrasound, left was huge, cancelled to aspirated cyst.
January 2016: Cyst back, surgery for ex-lap, cyst and adhesions removed.
March 2016: Attempted second IVF cycle, estrogen way too high, cyst back, cancelled again.
April 2016: Third attempted IVF cycle, 7 eggs retrieved, 2 mature (but not great) embryos made to fresh transfer, neither implanted.
May-Sept 2016: Break to regain sanity.
Sept-Oct 2016: Attempted fourth IVF cycle, very successful, cyst still on left but we ignored. 7 mature "great looking" eggs retrieved, 4 mature embryos made it to day 5 transfer. Transfer aborted due to large amount of endometriosis fluid in uterus.
FET of 2 embryos completed on 12/12/16.
12/22/16 1st Beta 179 BFP!!!
12/24/16 2nd Beta 449!!
EDD 8/30/17 with two girls!!!!!

Audrey (4lb 8oz) and Olivia (6lb 6oz) born 8/10/17!!

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Re: Lupron injections

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    sberriessberries member
    That is normal. I also used to get that with Lupron sometimes. Sounds like it isn't lasting very long so it's probably just the medicine seeping into your skin.
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    JamieH2000JamieH2000 member
    That happened to me too! Some days it was way worse than others. After like 12 days of lurpon i ended up with some nice bruises on my tummy. Hang in there.. it will be worth it if it works :)

    History in Spoiler

    Age: 32 (same with DH). Together since 2006, Married June 2013 and TTC since August 2015
    Diagnosis: Mild Endo, DOR (AMH of 1.5), Poor Quality Eggs/embryos, Displaced Window of Implantation (ERA Post Receptive)
    March-May 2016: 1 TI and 2 IUIs- BFN 
    June 2016- Laproscopy- found/removed mild endo and confirmed only 1 normal healthy ovary.
    August 2016- IVF #1 with Antagonist Protocol- Cancelled (2 lead follies), converted to IUI- BFN
    Oct-Nov 2016- IVF #2 with Estrogen Priming Micro Lupron Protocol, 2 eggs retrieved, day 3 transfer of 1- BFN
    January 2017- New RE, IVF#3 with Estrogen Priming Antagonist Protocol, 12 eggs, 8 mature, 6 fertilized, 2 day 5 early blasts transferred (none to freeze :(), BFN
    May 2017- Sept 2017- Starting Donor Egg process! Waiting for donor to be available... and then she is pregnant at baseline :(
    Oct 2017- Donor #2: 25R, 22M,18F, 12 blasts frozen! Fresh transfer cancelled due to thin lining with fluid :(
    Nov 2017- Hysterscopy to remove polyp
    Dec 2017- DE FET #1 on 12/8 on 2 perfect blasts- BFN and devastated
    Jan-Mar 2018- ERA #1- Post receptive by 24 hours, ERA #2 RECEPTIVE with 4 days of Progesterone
    Apr 2018- DE FET cancelled for lining issues :(
    Jun 2018- DE FET #2 of two 1AA blasts- first BFP ever! Beta 10dp5dt- 378, Beta 14dp5dt- 2840, Beta 16dp5dt- 4035, beta 18dp5dt- 10916. Due on 2/20 with one baby after a vanishing twin
    Baby Born born early @ 33.5 weeks due to Pre-e
    Back for # 2!
    Report Reply
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    tiffanyw1783tiffanyw1783 member
    Ok! That makes me feel a lot better!! Thank you! I hope it works!!

    TTC for 8 years.
    Started in 2008 with timed intercourse, ovulation testing, no official monitoring.
    OB-GYN recommended Clomid and timed intercourse, attempted for 6 straight months.
    First surgery June 2009 (OB-GYN): diagnosed with stage 4 endometriosis and large hydrosalpinx on right tube.
    Second surgery (July 2009, RE performed this): Right tube had to be removed, lots of adhesions removed.
    Attempted "trying on our own" as per RE recommendations, unsuccessful 5-6 months.
    HSG performed December 2009: left tube open.
    February 2010: started Femara and timed intercourse, attempted 6 months, no BFPs.
    Took a break for a while.
    January 2011: started IUI process, ovaries never properly responded to medications, 6 failed attempts, never actually completed an IUI.
    Took 2012-2014 off due to depression and frustration (side note: did complete grad school to become a nurse practitioner- great distraction).
    2015: started seeing RE again, went through tons of testing and HSG, left tube now blocked, only option is IVF.
    September 2015: Started first official IVF cycle, cancelled in October due to large cyst on left ovary.
    October 2015: started on birth control for 2 months.
    December 2015: attempted to start another IVF cycle, cysts on both ovaries on initial ultrasound, left was huge, cancelled to aspirated cyst.
    January 2016: Cyst back, surgery for ex-lap, cyst and adhesions removed.
    March 2016: Attempted second IVF cycle, estrogen way too high, cyst back, cancelled again.
    April 2016: Third attempted IVF cycle, 7 eggs retrieved, 2 mature (but not great) embryos made to fresh transfer, neither implanted.
    May-Sept 2016: Break to regain sanity.
    Sept-Oct 2016: Attempted fourth IVF cycle, very successful, cyst still on left but we ignored. 7 mature "great looking" eggs retrieved, 4 mature embryos made it to day 5 transfer. Transfer aborted due to large amount of endometriosis fluid in uterus.
    FET of 2 embryos completed on 12/12/16.
    12/22/16 1st Beta 179 BFP!!!
    12/24/16 2nd Beta 449!!
    EDD 8/30/17 with two girls!!!!!

    Audrey (4lb 8oz) and Olivia (6lb 6oz) born 8/10/17!!

    Report Reply
  • Options
    JamieH2000JamieH2000 member
    That happened to me too! Some days it was way worse than others. After like 12 days of lurpon i ended up with some nice bruises on my tummy. Hang in there.. it will be worth it if it works :)

    History in Spoiler

    Age: 32 (same with DH). Together since 2006, Married June 2013 and TTC since August 2015
    Diagnosis: Mild Endo, DOR (AMH of 1.5), Poor Quality Eggs/embryos, Displaced Window of Implantation (ERA Post Receptive)
    March-May 2016: 1 TI and 2 IUIs- BFN 
    June 2016- Laproscopy- found/removed mild endo and confirmed only 1 normal healthy ovary.
    August 2016- IVF #1 with Antagonist Protocol- Cancelled (2 lead follies), converted to IUI- BFN
    Oct-Nov 2016- IVF #2 with Estrogen Priming Micro Lupron Protocol, 2 eggs retrieved, day 3 transfer of 1- BFN
    January 2017- New RE, IVF#3 with Estrogen Priming Antagonist Protocol, 12 eggs, 8 mature, 6 fertilized, 2 day 5 early blasts transferred (none to freeze :(), BFN
    May 2017- Sept 2017- Starting Donor Egg process! Waiting for donor to be available... and then she is pregnant at baseline :(
    Oct 2017- Donor #2: 25R, 22M,18F, 12 blasts frozen! Fresh transfer cancelled due to thin lining with fluid :(
    Nov 2017- Hysterscopy to remove polyp
    Dec 2017- DE FET #1 on 12/8 on 2 perfect blasts- BFN and devastated
    Jan-Mar 2018- ERA #1- Post receptive by 24 hours, ERA #2 RECEPTIVE with 4 days of Progesterone
    Apr 2018- DE FET cancelled for lining issues :(
    Jun 2018- DE FET #2 of two 1AA blasts- first BFP ever! Beta 10dp5dt- 378, Beta 14dp5dt- 2840, Beta 16dp5dt- 4035, beta 18dp5dt- 10916. Due on 2/20 with one baby after a vanishing twin
    Baby Born born early @ 33.5 weeks due to Pre-e
    Back for # 2!
    Report Reply
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