Infertility

Mini IVF

Hey ladies- hope it's ok I started a new thread to ask this question

Can we chat about mini IVF? I'm not there yet, still going to try IUI 2 more times, but, I have been reading up on IVF and saw info about Mini IVF. Anyone do this or talk to their RE about it? 

Thanks! 

Re: Mini IVF

  • I just wanted to at least respond. I have heard of other women doing it, I have no experience with it myself. I guess it is becoming a more common next step, and likely in the future may be the go to process. The philosophy is quality over quantity, and that using your body's natural systems the eggs/embryos is better... I'm not sure if that's just because there's less synthetic hormones or what. I hope someone else can shed some additional light on this for you. Best of luck with the IUIs though. FX you don't even need it ;)
    ---
    Started TTC April 2011
    Me: 32, DH: 32
    Diagnosis: Endometriosis

    • 2012 - 3 Rounds clomid - all BFN
    • 2013 - 1 Fresh IVF with 2 day 3 embryos - BFN
    • 2014 - 1 Frozen IVF with 2 day 5 embryos - BFN
    • Took a long break, continuing trying naturally
    • Feb 2016 - Biopsy = Endo, DH sperm improved from 1% to 6% morphology
    • March 2016 - Fresh IVF cycle with acupuncture & intralipids: 20 eggs retrieved (17 mature), 7 ICSI'd fertilized, 9 naturally fertilized. 16 total embryos!
    • April 8th - 2 embryos (1ICSI and 1 Natural) transferred. (7 blastocysts frozen), April 18th - Beta = BFN
    • Sept 23rd - Lupron Depot Injection for Endo control
    • Nov 15th 2016 - Started daily Lupron Injections for upcoming FET
    • Nov 22 - Baseline US/BW - Intralipid Infusion - Start Meds for FET with immune protocol
    • Dec 16th FET transfer of 3 embryos (1 - AA, 2 - BB)
    • TW below
    • Dec 22nd - first ever bfp (very faint lines FRER & cheapie)
    • Dec 27th Beta = 192, Dec 29th Beta = 379
    • EDD - Sept 5th 2017

    - - -
    I'm a YouTube vlogger who talks about Infertility, IVF and Endometriosis. Check it out here!
    Follow along at http://liv4today.blog
    Instagram @liv4todayvlog 


  • I've wondered about this as well for a while now, the cost effective side gives more opportunity if it ever got there but I've read that the success rates aren't as high?

    I've also found the "effortless IVF" path interesting but I'm not a candidate for that. There's a clinic opening in Alberta soon.

    Me: 37 DH: 37 - Married 10.2015 ❤️ Canadian 
    DX: Endometriosis - Stage 4, DOR, RPL
    TTC #1 07.2015
    03.2016 - Natural BFP - MC 5w4d
    04.2016 - Natural BFP - Chemical
    10.2016 - IUI w/ Injections #1 = IUI Cancelled (cyst/no mature follicle)
    11.2016 - IUI w/ Injections #2 = BFP, EDD 08.2017 - It's a BOY!
    TTC #2 06.2019
    08.2019 - IUI w/ Injections #1 = Chemical
    09.2019 - IUI w/ Injections #2 = BFN
    10.2019 - IUI w/ Injections #3 = BFN
    01.2020 - IUI w/ Injections #4 = BFN
    08.2020 - Natural BFP - MC 9w5d
    11.2020 - IVF Retrieval - 3AB & 4BB
    05.2021 - FET #1 = BFP, EDD 02.2022 - It's a BOY!

           
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  • I've been looking into this as well so I'm joining to see what others say.  We are having a consult with our RE sometime in the next month to go over options and I plan on asking about mini IVF.
    Me: 28 with PCOS
    DH: 30, TTC since May 2015
    Started 2000mg Metformin in 8/2016
    8/2016: Letrozole (4 follies)  BFN
    9/2016: Letrozole (2 follies),  IUI, progesterone, BFN
    10/2016: Letrozole (2 follies),  IUI, progesterone, BFN
    11/2016: Letrozole (2-4 follies), IUI, progesterone, BFN
  • liljoy-2liljoy-2 member
    edited December 2016
    Yes, my first IVF was only with low dose Clomid. my tolerance for hormones is low and I'm afraid of long term effects 


  • I've done two mini IVFs. One was great, 5 days tamoxifen followed by low stims, 21 eggs, 15 mature and fertilized, 6 blasts. Second I used letrozole instead, 16 eggs, 9 mature, 4 fertilized, one blast transfered day 5, BFN. Never tried the clomid mini. Just be careful with it. The letrozole tends to create lead follicles which was disastrous to us. I'm too scared to try the tamoxifen protocol after that because my dr wouldn't say that the drug made the difference.
    It's worth a try and works wonders for some ladies. I'm also looking back into this and more natural IVFs because my eggs seem to get fried in IVF 
  • liljoy-2liljoy-2 member
    edited December 2016
    @kangastein Wow, the number of retrieved mature eggs with your mini-IVF is amazing, my doc had my hopes really down saying max. 4. What was the issue with letrozole? I don't know anything about it. 
    On Clomid I also had one very big and another one small/immature, so it seems I'm prone to this anyway despite RE saying that Clomid is better than letrozole in this respect. 
  • @bestofjoy we're doing IVF out of male factor so all the follicles they saw in my ovaries came out during mild IVF. I actually chose it with no understanding of it, only because it was cheaper. A dr told me that Letrozole really creates lead follicles but maybe when you have four follicles, that all four will be captured in the lead (?). Letrozole wasn't for me, I also had abnormal eggs on it (why 5 didn't fertilize). But but best cycle yet has been on tamoxifen! Even better than the long Lupron! 
  • @bestofjoy consolidating from our other thread, I'm looking at natural IVF because I seem to have quite a few eggs after an IVF cycle and thought maybe we could capture them. My dr thinks we need more quantity than we would get, but I'm worried my problem may be egg quality due to overstimulation and a natural would help. They would do mild drugs also. I'm in the TWW with two day 5 early blasts that we thought we should just put in instead of PGD testing, but if it fails I want a back up.
  • @kangastein Yes, natural IVF makes sense in a lot of cases. Docs are not very eager to do this, only a few clinics do this or advertise it. 
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