Letrozole and Estradiol? — The Bump
Infertility

Letrozole and Estradiol?

Hi All-
Wondering if anyone has taken Letrozole and Estradiol together? Did it help thicken your lining and get mature follies at the same time? Thanks for any info! 

Me: 37 DH: 32 TTGP Since 2014 INFERTILITY INFO (Medicated, IUI's, IVF/FET) IN SPOILER
October 2014-April 2015: Without Medication or Doctor Guidance No Periods/No O BFN 
Medicated April-December 2015: Clomid (didn't work) and so we tried Femera/Letrozole. Progesterone Met 1000 Not diagnosed PCOS but treating the same. Anovulatory. TI No US No O BFN 

- TW - 
IUI"S 
January 2016-October 2016: Letrozole 2.5mg-7.5 mg, Pregyl or Ovideral Trigger Shot.
9 cycles of IUI
(7 Cancelled due to no mature follicles) (2 attempted IUI's with mature follicles)  

IUI # 2 June 2016 and July 2016:  Met 1000, Estrogen (21 days), Progesterone (5 days) Femera 5m 6/28/16 Ultrasound CD14 = 25 follie. Pregnyl Trigger CD14 IUI 7/13 1stBeta (DPO 15): 7.6 (Surprise BFP...but Low #'s) 2ndBeta (DPO 17): 18 3rdBeta (DPO 19) 52.8 Progesterone Prescribed (spotting) 4thBeta (DPO 26) 6.9 Chemical Pregnancy BFN

IVF and FET (diagnosed with PCOS) 204 pounds at start of IVF
IVF # 1 October and November 2016: CCRM - Minneapolis 10/14 Consult and CD 3 testing, 10/14 started (OCP Antagonist - BCP) BCP, 10/21 1 day work up, Doxycycline 100mg 10 days, 10/24 stop bcp, Bloodwork US 10/29, 10/30-11/8 Stims 2 vials of Menopur, Dexamethasone, 225 of Gonal-F daily (dropped to 120). CCRM Vitamin Cocktail (like 20 of them), Monitoring (11/2, 11/4, 11/5, 11/6, 11/7, 11/8), Retrieval 11/10 (38 eggs, 30 mature, 16 fertilized ICSI), 11/16 8 Blasts 11/30 CCS testing results 3 Normal 5aa's (2 boys and 1 girl) 1 Unknown 4 Abnormal (All girls) 


Fet #1 January 2017: CCRM - Minneapolis bcp/lupron/suppository/p4 in oil QOD AF 12/7, 12/8 start meds. 1/3 lining and blood work check 14/15 mm, BW check 1/6. 1/9 transfer with acupuncture 1 CCS/PGS Normal 5aa hatching Progesterone around 26ish? Lower estrogen level 207 (wanted above 300 but over 200 was acceptable), started 1 estrace, progesterone in oil every other day, vivelle dot patches 4 every other day, 3x estrodiol daily, vitamin cocktail. POAS: - 4dp5dt and 5dp5dt, 6dp5dt frer very very very faint line. 7dp5dt and 8dp5dt + on Accuclear. 8dp5dt pregnant on a clear blue easy digital. 214 pounds at FET
1/18 #1 Beta 91.1
1/20 #2 Beta 215.9
2/3 6 week US 2 sacs? Twins? but only 1 heartbeat/pole good heartbeat Stopped taking baby asprin Added in DHEA Veg Vitamin (also got the report that they transferred a girl 5aa eggo) 
2/10 7 week US 2 sacs (likely vanishing twin) only 1 heartbeat/pole etc good heartbeat 137
2/24 9 week US 1 eggo sac good heart beat 182 1 very small fluid sac (shrinking) 
2/24 9 week 2 days start weening. Graduated from RE (CCRM is now starting weening as soon as 8.5 weeks)
3/7 10 Weeks 5 days  weened completely of FET meds A1C 5.3% (Normal)
3/9 11 Weeks 1 day my progesterone level was 15 and my estrogen level was 881 (I freaked out!)
3/16 12 Weeks 1 day baby heard on doppler 164 HB
4/14 16 week 2 days Ultrasound baby is looking good with all good numbers sized 17 weeks. Also got to hear her on the doppler for a few mins too. 

5/5 19 Weeks 2 days going in for "20" week anatomy ultrasound got measurements but need to come back as wasn't able to get all the measurements
MEASUREMENTS BPD 4.6 cm 19 weeks 6 days* (78%) HC 17.0 cm 19 weeks 4 days* (70%) AC 14.5 cm 19 weeks 4 days* (69%) Femur 3.1 cm 19 weeks 6 days* (63%) Humerus 3.1 cm 20 weeks 2 days (84%) Cerebellum 2.0 cm 19 weeks 5 days
CisternaMagna 6.2 mm Nuchal Fold 4.5 mm
HC/AC 1.17 FL/AC 0.22 FL/BPD 0.68 EFW (Ac/Fl/Hc) 309 grams - 0 lbs 11 oz
THE AVERAGE GESTATIONAL AGE is 19 weeks 5 days +/- 10 days.

6/9 24 Weeks 2 days Glucose Test 1 hour (Failed) 190
6/16 25 Weeks 2 days Ultrasound and 1st Baby Shower 
6/20 25 Weeks 6 days Glucose Test 3 Hours (Failed) 95 (95), 183 (180), 213 (155), 198 (140) etc
6/21 26 Weeks Recommended to a perintologist
6/22 26 Weeks 1 day start monitoring blood sugar levels 
6/30 27 Weeks 2 day A1 (blood sugar test ordered)

7/5 28 Weeks Echo and 3d Ultrasound
AMNIOTIC FLUID Q1: 2.6 Q2: 3.2 Q3: 4.8 Q4: 5.6 AFI Total = 16.3 cm Amniotic Fluid: Normal 
MEASUREMENTS BPD 7.2 cm 28 weeks 5 days* (60%) HC 26.4 cm 28 weeks 4 days* (48%) AC 23.3 cm 27 weeks 4 days* (36%) Femur 5.2 cm 28 weeks 0 days* (36%) Humerus 4.8 cm 28 weeks 0 days (49%)
HC/AC 1.13 FL/AC 0.23 FL/BPD 0.73 Ceph Index 0.77 EFW (Ac/Fl/Hc) 1142 grams - 2 lbs 8 oz (37%)
THE AVERAGE GESTATIONAL AGE is 28 weeks 1 day +/- 14 days.

7/10 28 Weeks 5 days Dietitian Appt and Lactatcian Consultant and A1 blood draw 5.4% (normal) 218.5 pounds
7/20 30 Weeks GD consult. 6 Lantus at 7pm daily. Novolog 1 unit for every 15 gm carbohydrate if consumed more than 30 gm at brkfst or 60 gm at lunch or supper 215.6 pounds
7/20 30 Weeks Transferred care to OB due to high risk. 216 pounds

8/2 32 Weeks Ultrasound (not cooperative and still breech) and then weekly NST's
MEASUREMENTS BPD 8.0 cm 32 weeks 2 days* (44%) HC 29.2 cm 31 weeks 6 days* (22%) AC 26.9 cm 31 weeks 0 days* (24%)  Femur 6.3 cm 32 weeks 2 days* (57%) Humerus 5.7 cm 32 weeks 6 days (71%)
HC/AC 1.08 FL/AC 0.23 FL/BPD 0.78 Ceph Index 0.78 EFW (Ac/Fl/Hc) 1808 grams - 3 lbs 15 oz (29%)
THE AVERAGE GESTATIONAL AGE is 31 weeks 6 days +/- 18 days.
AMNIOTIC FLUID Q1: 3.4 Q2: 2.9 Q3: 2.9 Q4: 4.4 AFI Total = 13.6 cm Amniotic Fluid: Normal

8/8 32w6d upped to 1:10 for dinner 
8/11 Baby Shower
8/13 Baby Shower
8/16 34 weeks NST good reading Upped to 8 at bed for fasting and 1:7 for dinner 
8/18 Dr Appt

8/24 35 weeks 1 day (was suppose to be scheduled for 36 weeks) Weeks Ultrasound/GD Dr Appt/OB Appt 
Frank Breech
MEASUREMENTS BPD 8.9 cm 35 weeks 6 days* (67%) HC 31.7 cm 35 weeks 1 day * (35%) AC 30.2 cm 34 weeks 2 days* (33%) Femur 6.9 cm 34 weeks 6 days* (57%) Humerus 6.0 cm 34 weeks 6 days (64%)
HC/AC 1.05 FL/AC 0.23 FL/BPD 0.78 Ceph Index 0.80 EFW (Ac/Fl/Hc) 2494 grams - 5 lbs 8 oz (39%)
THE AVERAGE GESTATIONAL AGE is 35 weeks 1 day +/- 21 days.
AMNIOTIC FLUID Q1: 3.3 Q2: 3.8 Q3: 2.4 Q4: 3.8 AFI Total = 13.4 cm Amniotic Fluid: Normal

8/31 36 Weeks
9/7 37 Weeks
9/10 Water broke...I got it tested at the emergency room it it showed it was negative. More water breaking and didn't go to the dr.
9/11 37 weeks 4 days Called the Dr and got retested for water breaking...
10:30pmish Baby Girl Born via Emergency C Section (Frank Breech Baby) 6lbs 3oz  -
9/13 Dropped to 5 pounds 10oz and had jaundice 
9/13 38 weeks

9/22 39 Weeks 2 days C Section Scheduled for 10am (arrive at 8am) Equinox/Solstice
EDD 9/27

Re: Letrozole and Estradiol?

  • Hi @BecauseLove! I took letrozole and estradiol for all 3 of my IUIs. Unfortunately, they were all unsuccessful. I did, however, have 1 or 2 mature follicles each time and my lining was nice and thick. Vaginal estradiol is the way to go... for me at least. I ended up moving on to IVF/FET and I've never seen my lining so thick (from the vaginal estradiol)! I hope you get your happy ending soon!
    *TW - Pregnancy mentioned*
    Me: 28 DH: 33, Married May 2014
    3 failed IUIs Dec '15 - Feb '16
    IVF April/May 2016 - 1 failed fresh transfer. 11 snow angels.
    1st FET 7/29/16 = BFP
    Lawson arrived on 4/24/2017 at 7lbs 15oz, 21 1/2 inches long!
    Surprise pregnancy!! Baby #2 due 10/11/18 <3
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