Many BFN's, time to consider ERA? — The Bump
Infertility

Many BFN's, time to consider ERA?

**Trigger Warning** 

Like many us on this board, DH and I have been trying to conceive for years. I've been through IUI's, multiple IVF's/FET's.... All BFN. After my 2nd failed FET, my RE suggested I do Endometrial Receptivity Array (ERA) testing. I've included an article written by my RE explaining the ERA. http://www.fertilityplanit.com/era-test-finds-25-of-ivf-frozen-transfers-occur-on-wrong-day/

So back in June I prepped, as if for a transfer. On day 5 of PIO, I went to the RE for an outpatient procedure. The whole thing took about 15 min. Basically they took a large scrapping for my uterine lining. For those that have had a scratch, it was very much like that but a little longer and slightly more painful. I rested for about 10 min afterwards and then went home. Pretty simple. 

Two weeks later the results from the ERA arrived and I was told that I am a day 6 transfer not day 5. This means my body is most receptive to implantation after an additional day of PIO. I was skeptical that this would really make a difference. I know many of you can appreciate this, because you've all been through something similar. Anyway, I went in for a transfer on August 14th. 

Yesterday, I went for my blood test. After leaving the office, I cried the whole way to work. I was so sure it hadn't worked again. When the office called with results, I let it go to voicemail. I just couldn't hear that bad news again. So when I finally did listen to the voicemail, I was in shock. I dropped my phone because I was shaking so much. I had to listen to the message 3 times to get through it and finally be able to call them back. I finally had my BFP. 

Now I know this is just the beginning. The logical side of me says that I could have a chemical, miscarry etc. But HELL, I'm pregnant. MY BODY CAN ACTUALLY GET PREGNANT. I took 3 home tests today, for the first time, just so I could see the words pregnant; see that double line. 

I guess my whole point is that I'm not skeptical anymore. All of my embryos where the same quality, I didn't change my regimen for this transfer and I even kept drinking coffee throughout (I hadn't previously). I really do believe the science of the ERA is what helped me this time. I can't predict my future, but I know that I would definitely recommend this test to anyone with multiple failed transfers.

A few facts: it's not cheap about $1300. My insurance covered the RE side of it, but not the lab testing (it was sent out of the practice). OOP I paid about $800. The procedure is quick, but fairly painful. I went by myself, and while I was ok during, on the drive home I had some decent cramping and was wishing DH had been there to drive. It's a lot of prep for something minor, just to wait and then prep again. But after alllll the other waiting, it wasn't too bad. Plus the little break in btwn trying was really refreshing. 
*TW* Pregnancy/Loss Mentioned
Me: 37 /PCOS DH: 37/no issues TTC: 7/13
Started with RE 12/14; 3 failed rounds of clomid, started letrozole
IUI #1 & #2- BFN
IVF #1 - 9/15 Cancelled Day 9
IVF #2- started stims 10/24  ER- 11/15 6 eggs- 5 fertilized/ 1 frozen
FET #1 -1 embryo-12/9/15- BFN
IVF #3- started stims 1/22/16  ER- 2/8 33 eggs(!)- 21 mature, all 21 fertilized - 6 snowflakes!
FET #2- 2 embryos- April 4th-BFN
ERA-June 8- results show need 12 addt'l hours of PIO
FET #3-  2 embryos transferred August 14,2016  BFP! on 8/24! Beta #1-22  Beta #2-83 Beta #3-368 
Confirmed singleton-Heartbeat on 9/19-160bpm! EDD: May 1, 2017, It's a girl!!
Pre-term labor/loss-stillborn at 18w. 
FET #4- 1 embryo-Aug 12th-BFP on 8/23 Beta #1-112 Beta #2-298 Beta #3-1010
Confirmed Identicals!- Heartbeats seen on 9/8  Miscarriage on 9/18
FET #5- 1 embryo- 1/12/18-BFN
Lots of testing and finally determined I have elevated natural killer cells. Will begin prednisone and IVL treatment before next round.
IVF#4- April 2018 8 eggs, 7 fertilized/3 frozen
FET #6- 1 embryo- 6/11/18- BFP on 6/21 Beta #1-446, Beta #2-1841 
Confirmed singleton- 6/29/18 HB-157 EDD: February 22, 2019. It's a Boy!



BabyFruit Ticker 
tcolechiaJustTheMama27

Re: Many BFN's, time to consider ERA?

  • I've heard about this and done some research. If my upcoming FET#2 isn't successful, I had already planned on asking my RE about this and if we could try it and see if that is part of my problem.

    Congratulations!!!

    halips
  • @mtpbadger I hope you have success this time around!!  Thank you!
    *TW* Pregnancy/Loss Mentioned
    Me: 37 /PCOS DH: 37/no issues TTC: 7/13
    Started with RE 12/14; 3 failed rounds of clomid, started letrozole
    IUI #1 & #2- BFN
    IVF #1 - 9/15 Cancelled Day 9
    IVF #2- started stims 10/24  ER- 11/15 6 eggs- 5 fertilized/ 1 frozen
    FET #1 -1 embryo-12/9/15- BFN
    IVF #3- started stims 1/22/16  ER- 2/8 33 eggs(!)- 21 mature, all 21 fertilized - 6 snowflakes!
    FET #2- 2 embryos- April 4th-BFN
    ERA-June 8- results show need 12 addt'l hours of PIO
    FET #3-  2 embryos transferred August 14,2016  BFP! on 8/24! Beta #1-22  Beta #2-83 Beta #3-368 
    Confirmed singleton-Heartbeat on 9/19-160bpm! EDD: May 1, 2017, It's a girl!!
    Pre-term labor/loss-stillborn at 18w. 
    FET #4- 1 embryo-Aug 12th-BFP on 8/23 Beta #1-112 Beta #2-298 Beta #3-1010
    Confirmed Identicals!- Heartbeats seen on 9/8  Miscarriage on 9/18
    FET #5- 1 embryo- 1/12/18-BFN
    Lots of testing and finally determined I have elevated natural killer cells. Will begin prednisone and IVL treatment before next round.
    IVF#4- April 2018 8 eggs, 7 fertilized/3 frozen
    FET #6- 1 embryo- 6/11/18- BFP on 6/21 Beta #1-446, Beta #2-1841 
    Confirmed singleton- 6/29/18 HB-157 EDD: February 22, 2019. It's a Boy!



    BabyFruit Ticker 
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  • Very interesting and something to consider. thanks for sharing and congrats on your BFP!!

    One somewhat unrelated question. I noticed in your siggy that your first IVF was cancelled and that your second only got 6 eggs, but for your third, you got 33! Can I ask what they changed for each cycle? I just recently had my first IVF cancelled due to low response of only 2 mature follies (I have borderline DOR, so was told originally to expect only 10-12) and I'm convinced that the birth control suppressed me way too much.

    History in Spoiler

    Age: 30 (same with DH). Together since 2006, Married June 2013 and TTC since August 2015
    Diagnosis: Mild Endo, DOR (AMH of 1.5), Poor Quality Eggs/embryos, Displaced Window of Implantation (ERA Post Receptive)
    March-May 2016: 1 TI and 2 IUIs- BFN 
    June 2016- Laproscopy- found/removed mild endo and confirmed only 1 normal healthy ovary.
    August 2016- IVF #1 with Antagonist Protocol- Cancelled (2 lead follies), converted to IUI- BFN
    Oct-Nov 2016- IVF #2 with Estrogen Priming Micro Lupron Protocol, 2 eggs retrieved, day 3 transfer of 1- BFN
    January 2017- New RE, IVF#3 with Estrogen Priming Antagonist Protocol, 12 eggs, 8 mature, 6 fertilized, 2 day 5 early blasts transferred (none to freeze :(), BFN
    May 2017- Sept 2017- Starting Donor Egg process! Waiting for donor to be available... and then she is pregnant at baseline :(
    Oct 2017- Donor #2: 25R, 22M,18F, 12 blasts frozen! Fresh transfer cancelled due to thin lining with fluid :(
    Nov 2017- Hysterscopy to remove polyp
    Dec 2017- DE FET #1 on 12/8 on 2 perfect blasts- BFN and devastated
    Jan-Mar 2018- ERA #1- Post receptive by 24 hours, ERA #2 RECEPTIVE with 4 days of Progesterone
    Apr 2018- DE FET cancelled for lining issues :(
    Jun 2018- DE FET #2 of two 1AA blasts- first BFP ever! Beta 10dp5dt- 378, Beta 14dp5dt- 2840, Beta 16dp5dt- 4035, beta 18dp5dt- 10916. Due on 2/20 with one baby after a vanishing twin
    halips
  • @JamieH2000  I have PCOS, so a lot of follicles (hopefully with eggs) My first cycle was cancelled due to incorrect dosages of meds and low repsonse. On my 2nd cycle, I had about 30 mature follicles, but my ovaries had shifted position and moved behind part of my bowel. So the RE could only reach a few. With my 3rd cycle, we had the correct dosages down pat, and I did a liquid diet for 3 days before retrieval to ensure no issues. 

    Sorry I couldn't be more helpful. Best of luck to you!
    *TW* Pregnancy/Loss Mentioned
    Me: 37 /PCOS DH: 37/no issues TTC: 7/13
    Started with RE 12/14; 3 failed rounds of clomid, started letrozole
    IUI #1 & #2- BFN
    IVF #1 - 9/15 Cancelled Day 9
    IVF #2- started stims 10/24  ER- 11/15 6 eggs- 5 fertilized/ 1 frozen
    FET #1 -1 embryo-12/9/15- BFN
    IVF #3- started stims 1/22/16  ER- 2/8 33 eggs(!)- 21 mature, all 21 fertilized - 6 snowflakes!
    FET #2- 2 embryos- April 4th-BFN
    ERA-June 8- results show need 12 addt'l hours of PIO
    FET #3-  2 embryos transferred August 14,2016  BFP! on 8/24! Beta #1-22  Beta #2-83 Beta #3-368 
    Confirmed singleton-Heartbeat on 9/19-160bpm! EDD: May 1, 2017, It's a girl!!
    Pre-term labor/loss-stillborn at 18w. 
    FET #4- 1 embryo-Aug 12th-BFP on 8/23 Beta #1-112 Beta #2-298 Beta #3-1010
    Confirmed Identicals!- Heartbeats seen on 9/8  Miscarriage on 9/18
    FET #5- 1 embryo- 1/12/18-BFN
    Lots of testing and finally determined I have elevated natural killer cells. Will begin prednisone and IVL treatment before next round.
    IVF#4- April 2018 8 eggs, 7 fertilized/3 frozen
    FET #6- 1 embryo- 6/11/18- BFP on 6/21 Beta #1-446, Beta #2-1841 
    Confirmed singleton- 6/29/18 HB-157 EDD: February 22, 2019. It's a Boy!



    BabyFruit Ticker 
  • @halips Congrats on your BFP!! That is very interesting and encouraging to hear. We're on a break after failed IVF and since we are paying OOP for everything we're debating when to go back and try again but we'd obviously like to maximize our chances for success. I'm intrigued by this and will definitely ask my RE when we go back. I'd rather pay OOP a little more up front to maximize our chances for success. Thanks so much for sharing!
    Me: 33, Hubby: 36
    TTC since May 2014
    First RE Appt - September 2015
    DX: Hypothyroid, DOR
    IUI w/ Clomid - October 2015 - BFN
    ER - 2/10/16, 2 Day 3 Embryos
    FET - 4/15/16 - BFN
    Summer 2016 - Taking a break to try herbal treatment and acupuncture
    halips
  • such good news, congrats!! amazing how different everybody's body is...thank you for sharing! 
    **TW**
    Me & DH - 31
    TTC since December 2011
    Diagnosis: Unexplained, although mild polycystic ovaries (not syndrome) and irregular cycles
    2013/14: 6 rounds clomid,
    Aug 2015: IVF #1 = Antagonist Cycle: 100 Puregon and Orgalutran
                                     21 eggs collected, only 1 viable embryo, transferred but BFN
    July/Aug 2016: IVF #2 (with acupuncture) = 87.5 Gonal F and Synarel Spray 2xdaily
                                          ER 8/8, transferred 1 day 5 blastocyst 13/8, 2 frosties.
                                          Beta #1 = 85  Beta #2 = 242
                                          EDD 1st May 2017 *Baby Boy*

    halips
  • @halips I'm so happy to hear that things worked out for you!! I will definately be looking into this!! Congrats on the pregnancy!!!!!!!! Couldn't be happier for you!!
    Me 30 || DH 36
    Unexplained Infertility- Postive for MTHFR Gene Mutation

    Natural cycles with 1 miscarriage
    -3 IUI's w/ Clomid= BFN 
    -IVF #1-Follistim and Menopur= BFN
    ***11 Eggs, 10 mature, 8 fertilized, transferred 1 (day 5) 2 made it to freeze
    -FET #1- Transferred 2, day 5 embryos =BFN
    -IVF #2- Follistim and Menopur = BFN
    ***11 retrieved, 8 mature, 6 fertilized, transferred 2 (day 3), 4 made it to freeze (Follistim and Menopur) = BFN
    -FET #2- Transferred 2, day 3 embryos = BFN
    **Changed doctor**
    -IUI #4- natural cycle = BFN
    -IUI #5- Follistim (5 eggs) BFP- lead to Miscarriage  :'(
    -Laproscopic Surgery for Endometriosis, Polyp removal and Cyst removal. 
    -IVF #3- Menopur, Follistim, Lupron, Ganirellex- BFP lead to Eptopic Pregnancy  :'(
    ***11 Eggs retrieved, 10 Mature, 8 fertilized, transferred 3 embryos (day 3), 0 made it to freeze
    -Lapropscopic surgery- Removal of Fallopian Tube
    -IVF #4- Estrogen Priming with Vivelle dot, Menopur, Follistim, Ganirellex- BFP  :)
    ***15 Eggs retreived, 11 mature, 11 fertilized, 2 embryos transferred (day 3), 2 made it to freeze
    Found out I was positive for MTHFR Gene Mutation during TWW of IVF #4

    halips
  • That is so interesting; I have not heard of it before. Super-congrats on your BFP!!!!!!! I hope you have a healthy pregnancy and baby! 
    halips
  • @halips Congrats on your BFP! Thanks for sharing the info about ERA testing. I am going to be researching it a little bit more and ask my RE if I should consider doing it if my upcoming FET cycle ends in a BFN.  

    Me: 29 DH: 35

    TTC since: 12/2013

    Unexplained Infertility- arcuate uterus diagnosed 6/2016 

    MC: 12/25/2014

    3 IUIs with Clomid- BFN- 2016

    Fresh IVF cycle-BFN- 7/2016

    PGS testing- 8/15/2016

    FET- 10/3/16-BFP!!! Beta #1- 736 Beta #2 3,223 Beta #3 22,015


    halips
  • Congrats on your BFP!!!! I'm so happy to have read your story as I'm currently preparing for the same test this month. My RE suggested the ERA after two failed transfers and of course we are willing to try anything at this point. Fingers crossed for a similar result!
    halips
  • @babydep thank you! My fingers are crossed for you! :)
    *TW* Pregnancy/Loss Mentioned
    Me: 37 /PCOS DH: 37/no issues TTC: 7/13
    Started with RE 12/14; 3 failed rounds of clomid, started letrozole
    IUI #1 & #2- BFN
    IVF #1 - 9/15 Cancelled Day 9
    IVF #2- started stims 10/24  ER- 11/15 6 eggs- 5 fertilized/ 1 frozen
    FET #1 -1 embryo-12/9/15- BFN
    IVF #3- started stims 1/22/16  ER- 2/8 33 eggs(!)- 21 mature, all 21 fertilized - 6 snowflakes!
    FET #2- 2 embryos- April 4th-BFN
    ERA-June 8- results show need 12 addt'l hours of PIO
    FET #3-  2 embryos transferred August 14,2016  BFP! on 8/24! Beta #1-22  Beta #2-83 Beta #3-368 
    Confirmed singleton-Heartbeat on 9/19-160bpm! EDD: May 1, 2017, It's a girl!!
    Pre-term labor/loss-stillborn at 18w. 
    FET #4- 1 embryo-Aug 12th-BFP on 8/23 Beta #1-112 Beta #2-298 Beta #3-1010
    Confirmed Identicals!- Heartbeats seen on 9/8  Miscarriage on 9/18
    FET #5- 1 embryo- 1/12/18-BFN
    Lots of testing and finally determined I have elevated natural killer cells. Will begin prednisone and IVL treatment before next round.
    IVF#4- April 2018 8 eggs, 7 fertilized/3 frozen
    FET #6- 1 embryo- 6/11/18- BFP on 6/21 Beta #1-446, Beta #2-1841 
    Confirmed singleton- 6/29/18 HB-157 EDD: February 22, 2019. It's a Boy!



    BabyFruit Ticker 
    Babydep
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