Trouble TTC

PCOS and Metformin

I am newly diagnosed with PCOS and had a few questions for you ladies who have it also. My doctor had mentioned possibly starting Metformin when he called to give me my results, and I was curious to hear how your experience with that medication has been.

I do have insulin resistance and some liver problems (very high ALT levels and NAFLD). My follow-up appointment to discuss treatment options isn't for 3 weeks, so I have been trying to read up on everything so I can be better prepared / more knowledgeable about what to expect when I go in. 

TIA for your comments / sharing your experience.

Re: PCOS and Metformin

  • I have PCOS and take Metformin.  My experience has been pretty good so far.  I have some digestive issues when I eat carb heavy meals but otherwise no problem whatsoever.  I would avoid reading about people's experiences too much because I honestly put off taking mine because of things I read online and I regret putting it off for as long as I did. Good luck! 

    Me 36 DH 34 - Married May 2010
    DX: PCOS/Unexplained Infertility/MTHFR Mutation
    TTC since December 2014
    Fresh Transfer: Gonal, Menopur, Cetrotide. ~ Chemical Pregnancy :(  
    FET #1: 1st Beta- 3,792~ 2nd Beta- 4,227~ BFP ~ Miscarriage at 8 weeks :( 
    FET #2: 1st Beta 207~2nd Beta 235~ BFP~ Miscarriage at 6 weeks :(
    FET #3: 1st Beta 18~ 2nd Beta 44~BFP~ Miscarriage 5 weeks :(
    FET #4: 1st Beta 50~ 2nd Beta 97.7~ Miscarriage 6 weeks 5 days :(
    FET#5: 1st Beta 29~ 2nd Beta 109~ 3rd Beta 227~ 4th Beta 661~ Miscarriage 5 weeks 3 days 
    Miracle Natural BFP Estimated Due Date June 2019~ God is good 
    2 snow babies 






  • Hi! I have not been diagnosed with PCOS but i do take metformin for type 2 diabetes....like world traveler if I eat too many carbs or too much sugar it does cause me digestive issues...also I had some initial digestive issues when I first got on it...but otherwise no other issues...good luck! 
    Me: 36 years old   DH: 42 years old
    Married: 05.2012  
    TW:
    TTC #1 Since April 2016
    HSG/FSH/AMH/E2/SA all normal DX: unexplained IF

    spontaneous BFP 01/01/2017-  Alexander was born sleeping 04/13/2017 at 19w1d  ic/chorio
    September 2017 HSG #2 & Gonal-F/Femara/Ovidrel/IUI #1 = ep (Salpingectomy of left fallopian tube)
    spontaneous BFP 01/02/2018  EDD Aug 30th  It's a GIRL!
    Cerclage placed on 03/02BabyFruit Ticker  Cerclage removal 08/02
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  • echo+novemberecho+november member
    edited July 2016
    Sorry for your new diagnosis. I just got the PCOS diagnosis but my doctor didn't prescribe metformin so I'm not much help.

    Worldtravler0522 regarding fear of side effects. The benefit of the rx will likely outweigh any down side. Good luck with your new treatment!

    Edit: some of my text got cut off.
    Me: 33
    Married in 2014
    TTC for 10 months--No response to Clomid 50, 100, 150
    June 2016--PCOS dx
    July 2016--7.5 mg Letrozole--Ovidrel 7/6--TI--BFP

     

  • My experience with Metformin has been pretty good. I started out taking one pill at dinner time (750mg) for one week and then increased to two pills.  If I eat a lot of carbs, I do have some digestive issues the next morning. Overall, it has taught me to eat better and I have actually lost weight since starting it!  
    About me:
    TTC#1: October 2015
    dx: PCOS & MFI
    IUI #1 w/Femara + Ovidrel June 2016 ~ BFP
    July 2016: Blighted Ovum
    IUI #2 w/Femara + Ovidrel September 2016 ~BFN
    IUI #3 w/Femara + Ovidrel October 2016 ~BFN
    IUI #4 w/Femara + Ovidrel November 2016 ~BFN
    IVF with ICSI January 2017 ~BFN
    FET February 2017 ~BFN
    IVF with ICSI March 2017 ~BFP--Twins Due 12/8/17
    Team Blue X 2!
  • @worldtraveler0522 I definitely won't let it scare me off! I know everyone may react differently to medication. 

    @beary67 That's great that it helped you lose weight. I'm hoping for a similar effect if that is the med my doctor recommends at our next appointment. Did you have trouble trying to lose weight prior to taking Metformin? I have tried all sorts of healthy diets exercise routines previously and just can't lose weight. I understand that is an unfortunate side effect to PCOS.
  • I have PCOS, and am currently taking Metformin. 
    I have had some digestive issues, at the start of taking it, but they have resolved now for the most part. 



  • @Kay6519 after stopping BC, I went from 135lbs to 170lbs in just a few months and I could not lose the weight. I had a personal trainer and a nutritionist I was working with, and at most, I lost 5lbs over 2 months of working my butt off. I still had to work to lose weight while on Metformin, but the weight came of much easier for me since I've been on the medicine. 
    About me:
    TTC#1: October 2015
    dx: PCOS & MFI
    IUI #1 w/Femara + Ovidrel June 2016 ~ BFP
    July 2016: Blighted Ovum
    IUI #2 w/Femara + Ovidrel September 2016 ~BFN
    IUI #3 w/Femara + Ovidrel October 2016 ~BFN
    IUI #4 w/Femara + Ovidrel November 2016 ~BFN
    IVF with ICSI January 2017 ~BFN
    FET February 2017 ~BFN
    IVF with ICSI March 2017 ~BFP--Twins Due 12/8/17
    Team Blue X 2!
  • Like previous posters I lost weight while taking Metformin.  To date I think I've lost 50 pounds. Good luck! 

    Me 36 DH 34 - Married May 2010
    DX: PCOS/Unexplained Infertility/MTHFR Mutation
    TTC since December 2014
    Fresh Transfer: Gonal, Menopur, Cetrotide. ~ Chemical Pregnancy :(  
    FET #1: 1st Beta- 3,792~ 2nd Beta- 4,227~ BFP ~ Miscarriage at 8 weeks :( 
    FET #2: 1st Beta 207~2nd Beta 235~ BFP~ Miscarriage at 6 weeks :(
    FET #3: 1st Beta 18~ 2nd Beta 44~BFP~ Miscarriage 5 weeks :(
    FET #4: 1st Beta 50~ 2nd Beta 97.7~ Miscarriage 6 weeks 5 days :(
    FET#5: 1st Beta 29~ 2nd Beta 109~ 3rd Beta 227~ 4th Beta 661~ Miscarriage 5 weeks 3 days 
    Miracle Natural BFP Estimated Due Date June 2019~ God is good 
    2 snow babies 






  • I LOVE my metformin!!!! Had a little digestive issues right at first, but resolved in a week. (Don't trust a fart!!) Haha

    Trigger warning


    me: 28 dh: 34
    married since October 2015-started trying immediately
    dx: PCOS, anovulatory
    rx: provera metformin progesterone
    *TW*
    BFP August 2016- early mc- Enoch Matthis
    1 clomid cycle (March 2017)
    BFP March 2017  ~  EDD December 13, 2017
    di/di TWINS!!!!! vanishing twin- Hannah Jordan
    DS-Nov 23, 2017- emergency induction-- Pre-eclampsia
    *End TW*
    BFP Sept.2019


  • @mrswifeytoad haha don't trust a fart!! Ain't that the truth!

    I had to ask for controlled release metformin and even with that I've only manage to get up to 1000mg.  It makes me crazy nauseous.
    DX PCOS + mild male factor
    TTC since Dec. 2015
    Current Treatment: Metformin, Provera, Letrozole, Trigger, IUI
    Past Treatment: Clomid + Metformin x 3 BFN
    Letrozole 5 mg + Trigger shot + IUI = BFP!
    Beta confirmed 8/22
    EDD 5/1/17
  • I was dx with PCOS and was given the RX metformin 500 mg 3 times a day. I started with 500 mg for a week and then each week I increases my dose.
    Once I hit the 3x daily my stomach just couldn't handle it. So I was taken back down to 500 mg  twice daily and it's much more managable.

    It has helped me reduce my intake of carbs/sugars because the digestive issues following are not fun. That being said I've been on it for 3 months now, and most digestive issues are no longer a problem and I am down almost 10 pounds. Good luck! :) 
  • I am not diagnosed but had some symptoms of PCOS but not enough...they decided to give me Met anyways. I already have kinda a irb stuff but it made it hyper sensitive like I am always aware where a bathroom is sorta thing.  I haven't lost any weight on it. I have stopped taking it twice while ttc...1 time we didn't have mature follies so I went back on it. The other time we ended up with a CP. 
    Me: 37 DH: 32 TTGP Since 2014 INFERTILITY INFO (Medicated, IUI's, IVF/FET) IN SPOILER
    October 2014-April 2015: Without Medication or Doctor Guidance No Periods/No O BFN 
    Medicated April-December 2015: Clomid (didn't work) and so we tried Femera/Letrozole. Progesterone Met 1000 Not diagnosed PCOS but treating the same. Anovulatory. TI No US No O BFN 

    - TW - 
    IUI"S 
    January 2016-October 2016: Letrozole 2.5mg-7.5 mg, Pregyl or Ovideral Trigger Shot.
    9 cycles of IUI
    (7 Cancelled due to no mature follicles) (2 attempted IUI's with mature follicles)  

    IUI # 2 June 2016 and July 2016:  Met 1000, Estrogen (21 days), Progesterone (5 days) Femera 5m 6/28/16 Ultrasound CD14 = 25 follie. Pregnyl Trigger CD14 IUI 7/13 1stBeta (DPO 15): 7.6 (Surprise BFP...but Low #'s) 2ndBeta (DPO 17): 18 3rdBeta (DPO 19) 52.8 Progesterone Prescribed (spotting) 4thBeta (DPO 26) 6.9 Chemical Pregnancy BFN

    IVF and FET (diagnosed with PCOS) 204 pounds at start of IVF
    IVF # 1 October and November 2016: CCRM - Minneapolis 10/14 Consult and CD 3 testing, 10/14 started (OCP Antagonist - BCP) BCP, 10/21 1 day work up, Doxycycline 100mg 10 days, 10/24 stop bcp, Bloodwork US 10/29, 10/30-11/8 Stims 2 vials of Menopur, Dexamethasone, 225 of Gonal-F daily (dropped to 120). CCRM Vitamin Cocktail (like 20 of them), Monitoring (11/2, 11/4, 11/5, 11/6, 11/7, 11/8), Retrieval 11/10 (38 eggs, 30 mature, 16 fertilized ICSI), 11/16 8 Blasts 11/30 CCS testing results 3 Normal 5aa's (2 boys and 1 girl) 1 Unknown 4 Abnormal (All girls) 


    Fet #1 January 2017: CCRM - Minneapolis bcp/lupron/suppository/p4 in oil QOD AF 12/7, 12/8 start meds. 1/3 lining and blood work check 14/15 mm, BW check 1/6. 1/9 transfer with acupuncture 1 CCS/PGS Normal 5aa hatching Progesterone around 26ish? Lower estrogen level 207 (wanted above 300 but over 200 was acceptable), started 1 estrace, progesterone in oil every other day, vivelle dot patches 4 every other day, 3x estrodiol daily, vitamin cocktail. POAS: - 4dp5dt and 5dp5dt, 6dp5dt frer very very very faint line. 7dp5dt and 8dp5dt + on Accuclear. 8dp5dt pregnant on a clear blue easy digital. 214 pounds at FET
    1/18 #1 Beta 91.1
    1/20 #2 Beta 215.9
    2/3 6 week US 2 sacs? Twins? but only 1 heartbeat/pole good heartbeat Stopped taking baby asprin Added in DHEA Veg Vitamin (also got the report that they transferred a girl 5aa eggo) 
    2/10 7 week US 2 sacs (likely vanishing twin) only 1 heartbeat/pole etc good heartbeat 137
    2/24 9 week US 1 eggo sac good heart beat 182 1 very small fluid sac (shrinking) 
    2/24 9 week 2 days start weening. Graduated from RE (CCRM is now starting weening as soon as 8.5 weeks)
    3/7 10 Weeks 5 days  weened completely of FET meds A1C 5.3% (Normal)
    3/9 11 Weeks 1 day my progesterone level was 15 and my estrogen level was 881 (I freaked out!)
    3/16 12 Weeks 1 day baby heard on doppler 164 HB
    4/14 16 week 2 days Ultrasound baby is looking good with all good numbers sized 17 weeks. Also got to hear her on the doppler for a few mins too. 

    5/5 19 Weeks 2 days going in for "20" week anatomy ultrasound got measurements but need to come back as wasn't able to get all the measurements
    MEASUREMENTS BPD 4.6 cm 19 weeks 6 days* (78%) HC 17.0 cm 19 weeks 4 days* (70%) AC 14.5 cm 19 weeks 4 days* (69%) Femur 3.1 cm 19 weeks 6 days* (63%) Humerus 3.1 cm 20 weeks 2 days (84%) Cerebellum 2.0 cm 19 weeks 5 days
    CisternaMagna 6.2 mm Nuchal Fold 4.5 mm
    HC/AC 1.17 FL/AC 0.22 FL/BPD 0.68 EFW (Ac/Fl/Hc) 309 grams - 0 lbs 11 oz
    THE AVERAGE GESTATIONAL AGE is 19 weeks 5 days +/- 10 days.

    6/9 24 Weeks 2 days Glucose Test 1 hour (Failed) 190
    6/16 25 Weeks 2 days Ultrasound and 1st Baby Shower 
    6/20 25 Weeks 6 days Glucose Test 3 Hours (Failed) 95 (95), 183 (180), 213 (155), 198 (140) etc
    6/21 26 Weeks Recommended to a perintologist
    6/22 26 Weeks 1 day start monitoring blood sugar levels 
    6/30 27 Weeks 2 day A1 (blood sugar test ordered)

    7/5 28 Weeks Echo and 3d Ultrasound
    AMNIOTIC FLUID Q1: 2.6 Q2: 3.2 Q3: 4.8 Q4: 5.6 AFI Total = 16.3 cm Amniotic Fluid: Normal 
    MEASUREMENTS BPD 7.2 cm 28 weeks 5 days* (60%) HC 26.4 cm 28 weeks 4 days* (48%) AC 23.3 cm 27 weeks 4 days* (36%) Femur 5.2 cm 28 weeks 0 days* (36%) Humerus 4.8 cm 28 weeks 0 days (49%)
    HC/AC 1.13 FL/AC 0.23 FL/BPD 0.73 Ceph Index 0.77 EFW (Ac/Fl/Hc) 1142 grams - 2 lbs 8 oz (37%)
    THE AVERAGE GESTATIONAL AGE is 28 weeks 1 day +/- 14 days.

    7/10 28 Weeks 5 days Dietitian Appt and Lactatcian Consultant and A1 blood draw 5.4% (normal) 218.5 pounds
    7/20 30 Weeks GD consult. 6 Lantus at 7pm daily. Novolog 1 unit for every 15 gm carbohydrate if consumed more than 30 gm at brkfst or 60 gm at lunch or supper 215.6 pounds
    7/20 30 Weeks Transferred care to OB due to high risk. 216 pounds

    8/2 32 Weeks Ultrasound (not cooperative and still breech) and then weekly NST's
    MEASUREMENTS BPD 8.0 cm 32 weeks 2 days* (44%) HC 29.2 cm 31 weeks 6 days* (22%) AC 26.9 cm 31 weeks 0 days* (24%)  Femur 6.3 cm 32 weeks 2 days* (57%) Humerus 5.7 cm 32 weeks 6 days (71%)
    HC/AC 1.08 FL/AC 0.23 FL/BPD 0.78 Ceph Index 0.78 EFW (Ac/Fl/Hc) 1808 grams - 3 lbs 15 oz (29%)
    THE AVERAGE GESTATIONAL AGE is 31 weeks 6 days +/- 18 days.
    AMNIOTIC FLUID Q1: 3.4 Q2: 2.9 Q3: 2.9 Q4: 4.4 AFI Total = 13.6 cm Amniotic Fluid: Normal

    8/8 32w6d upped to 1:10 for dinner 
    8/11 Baby Shower
    8/13 Baby Shower
    8/16 34 weeks NST good reading Upped to 8 at bed for fasting and 1:7 for dinner 
    8/18 Dr Appt

    8/24 35 weeks 1 day (was suppose to be scheduled for 36 weeks) Weeks Ultrasound/GD Dr Appt/OB Appt 
    Frank Breech
    MEASUREMENTS BPD 8.9 cm 35 weeks 6 days* (67%) HC 31.7 cm 35 weeks 1 day * (35%) AC 30.2 cm 34 weeks 2 days* (33%) Femur 6.9 cm 34 weeks 6 days* (57%) Humerus 6.0 cm 34 weeks 6 days (64%)
    HC/AC 1.05 FL/AC 0.23 FL/BPD 0.78 Ceph Index 0.80 EFW (Ac/Fl/Hc) 2494 grams - 5 lbs 8 oz (39%)
    THE AVERAGE GESTATIONAL AGE is 35 weeks 1 day +/- 21 days.
    AMNIOTIC FLUID Q1: 3.3 Q2: 3.8 Q3: 2.4 Q4: 3.8 AFI Total = 13.4 cm Amniotic Fluid: Normal

    8/31 36 Weeks
    9/7 37 Weeks
    9/10 Water broke...I got it tested at the emergency room it it showed it was negative. More water breaking and didn't go to the dr.
    9/11 37 weeks 4 days Called the Dr and got retested for water breaking...
    10:30pmish Baby Girl Born via Emergency C Section (Frank Breech Baby) 6lbs 3oz  -
    9/13 Dropped to 5 pounds 10oz and had jaundice 
    9/13 38 weeks

    9/22 39 Weeks 2 days C Section Scheduled for 10am (arrive at 8am) Equinox/Solstice
    EDD 9/27
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