IVF with PGD to prevent future losses? — The Bump
TTC After a Loss

IVF with PGD to prevent future losses?

chloe97chloe97
2500 Comments 500 Love Its Fourth Anniversary First Answer
member
edited May 2016 in TTC After a Loss
Hi all:

Im officially back from N'16. I won't go in to the full story which I posted on the MC/L board if anyone wants to read it. I hate to be back here or that any of us are here, but I'm happy to know that this board is here. 

I'm having a D&E next week, but I'm off for the next week or so and doing some thinking about our next steps. 

I'm turning 37 next month and will have had 2 late 1st tri losses due to chromosomal abnormalities. The 1st of unknown origin, the 2nd because of triploidy, which strangely has no relation to AMA. Because it will have been a year of TTC by the time we are ready to start TTC again and because we want 2 children and because we can't handle another loss emotionally, we are strongly considering skipping right to IVF with PGD. My body seems to gets pregnant every time I have unprotected during my ovulation period. This makes me think I'm one of those awesome "superfertile women" that accepts every fertilized egg instead of rejecting the bad ones. The worst part is these pregnancies last for a long time and so I'm losing my precious fertility time.

Am I being crazy? Should I hold off and wait for my body to recover, make sure I'm taking my Coq-10 and hope for the best when it's time to TTC? I'm just wondering if anyone else who has had multiple losses had considered it? I have great IF coverage and H's parents have offered to pay for anything that stops us from going through this again. 
Age 39, H 38

Married 8/15

Pregnancy #1, MMC, D&C November/December 2015
Pregnancy #2, Dx with Triploidy at 12 weeks, MMC, D&C May 2016
Pregnancy #3 BFP 10/20/2016- EDD 7/01/2017
DD was born on June 26, 2017
Pregnancy #4 CP 4/2018
Pregnancy #5 BFP 9/13/2018, EDD= 5/27/2019

Re: IVF with PGD to prevent future losses?

  • I have had a lot of these same thoughts and I'm only 30. Since my RPL panel is normal, it makes me more worried that either DH or I are contributing poorly genetics-wise. (I also get pregnant easily, which actually increases the anxiety at times I think.)

    I would suggest looking into an RE if you can. I would suggest getting an RPL panel if possible, and consider tests for DOR and SA. I would think that at the very least, an RE would request these tests first so that simpler things are ruled out before you skip to such an extreme therapy. That being said, if finances aren't an issue, it may be something to consider sooner rather than later. 

    I guess my overall thoughts point to consulting with an RE when you can. They can answer all of your questions. Sending lots of love. I admire your strength through this process and your perseverance through this awful situation. 
  • BornReadyBornReady
    1000 Comments 500 Love Its Third Anniversary Photogenic
    member
    edited May 2016
    Sorry you're dealing with this. I had my IVF consult this past week and will begin cycling soon. We are choosing PGS testing as well, which adds another 4-6 weeks into the cycle. Our timeline will be to do stims and egg retrieval, but not a fresh transfer due to PGS. After AF for that cycle I will do birth control to put me on hold until the tested embryos are back and then cycle again to get my body ready for a FET. I was kind of bummed at the long process, but happy that we will only be implanting healthy embryos.

    The PGS testing is obviously out of pocket and depends on your embryo yield. We were told about $4800 for 4-5 eggs. Who knows how accurate that is though. 

    If I remember correctly you already had a RE consult right? Hopefully you can get back on soon and develop a plan. I don't think you are crazy at all to want to prevent this as much as possible. And if money is no object, I think IVF is the way to go. 

    IVF with ICSI is the recommended treatment for our infertility, so it is completely covered by our insurance, thanks goodness. We were told it offered us at our age, early-mid 30's , 65-80% chance of live birth. Which is awesome compared to the 5% we were told for IUI.

    i wish you luck. The pressure of time lost is such a mind-f*ck and a huge contribution to my grief as well. 

    Feel free to ask anything, I'm definitely not an expert, but I'm in the midst of it.
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  • edited May 2016
    I'm so sorry that you're having to go through all of this.

    IVF will only be successful if you have good eggs. Of course quality is difficult to assess until retrieval, but my RE has methods by which he feels he can establish an educated guess on that and I bring this up because it may be something you can discuss with your RE before making that decision. With two chromosomal losses, DOR may be something you're dealing with... And a DOR dx doesn't necessarily prevent you from IVF, but there may be ways you can try and help boost quality as much as possible before you go for retrieval.

    I totally understand what you're thinking and why... I don't think it's too aggressive or anything like that at all, but I hope your RE will give you a full work up to make sure that whatever route you choose can help you achieve your desired outcomes. 

    You're still in my thoughts. I'm sending you big internet hugs. 

    Me: 40, DH: 35 / Married: 2009; TTC #1: 2013

    2013 - 2015: 5 pregnancies —> 5 miscarriages

    TTCAL with RE (RPL specialist): February 2016

    2016: 3 medicated TI cycles —> 3 medicated IUI cycles: All BFN

    Donor Egg IVF Transfer: May 1, 2017

    May 11, 2017: BFP!! Beta #1: 449.1, Beta #2: 844, Beta #3: 1714

    EDD: 1/17/18, it's a GIRL!  <3 E. L. A. born 12/7/2017








    BornReady
  • I am not in the position you are - but your thought process makes sense. We're each on different paths and so what is right for you may not be right for others - so long as you and DH are on a similar page I think you should trust your gut and your RE.
    ---TW BFP and MC mentioned - scroll down past the Lilo and Stitch gif to avoid ---




    Me: 33 & DH: 33
    Married: 07/2006
    TTC: 10/2015
    BFP #1: 11/2015, MC 12/2015 (7 weeks)
    BFP #2: 06/2016, EDD 2/15/2017



    Pregnancy Ticker






  • roxgibbonsroxgibbons
    500 Love Its 500 Comments Third Anniversary Name Dropper
    member
    edited May 2016
    @chloe97 again I'm so sorry for everything you are going through. As for your question- I don't think your jumping the gun-  like you I'm in the AMA category ( I'll be 38 in July) and AMA makes things tricky as you don't have time to screw around. IVF with PGS sounds like a good option and at minimum getting the RE consult started when you are ready is a good step. Plus the RE will test for DOR and other things so you will have an idea of what you are dealing with. My RE told us he has plenty of patients who skip straight to IVF as they don't want to mess around and just want the best possible outcome. As for the CoQ10 and any other supps it certainly doesn't hurt to do anything you can to help yourself whether you do IVF or continue to try naturally. I went as far as changing personal care products and some cleaning products and getting rid of plastic containers in our house. I figured it can't hurt and hopefully help my eggs.
     ****TW: Pregnancy, loss and children mentioned****
    Me (39) DH (40) 
    From my first marriage DD: 03/04 CP:01/06 DS:12/06 
    DH- no kids
    ******************
    TTC: since 2/15, RE Consult 9/15
    IUI #1 10/15: Letrozole = BFN 
    IUI #2 11/15: Letrozole + trigger = BFN
    1/08/16: Surprise- BFP!!  2/16/16: MMC @10w 2days,  D&C: 2/17/16
    TTCAL: May 2016
    IUI #3 5/27/16: Letrozole+trigger=BFN
    IUI #4 06/24/16: 7.5mg Letrozole+trigger= BFN
    IUI#5 08/24/16 Menopur+trigger = BFN
    IUI #6 09/19/16 5 mg Letrozole +Menopur + Trigger= BFN
    **10/2016: No more medicated cycles, TTCAL on our own**
    12/03/16: BFP!! EDD: 08/12/17 It's a girl!! 
    Eleni was born on 8/14/17!!
    chloe97
  • I'm in a similar boat - I get pregnant easily but can't stay pregnant, and I've had the same thought process as you. And I agree with
    @Wishilivedinflorida. It increases my anxiety to think that I could have four losses in a year at our current rate. That's a lot of heartbreak in a short period of time, and given how long it can drag out, I too feel pressure about "lost time" from a MC.

    My plan is to do the basic RPL testing through my OB first to see if anything is obviously wrong. We're considering setting up a consult with an RE after that to discuss results and any additional testing. I think it makes sense to get all the bloodwork and screening tests done first to know if there is an obvious problem that can be fixed. But otherwise, considering your age and insurance situation, I don't think it's strange at all to consider jumping straight to IVF. It actually seems somewhat common as a treatment for unexplained RPL or chromosomal abnormality RPL, actually. 
    catiecatpchloe97
  • chloe97chloe97
    2500 Comments 500 Love Its Fourth Anniversary First Answer
    member
    Guys, thank you all for giving me your thoughts, it's so helpful to hear from likeminded people that my thought-process isn't overreactive or getting ahead of ourselves. You guys are all seriously the best!!

    We did meet with an RE the day before we found out we were pregnant and so we still need to undergo the standard RPL testing. I'm not sure we will go back to her since she was a brand new practice and doesn't have reports of her IVF success rates yet. I'm going to do research this week while I'm off work. I didn't even think about DOR, but it's definitely a possibility. I just assumed since I was getting pregnant, it had to be okay, but I guess it could be a sign.

    I hate that we are all here. Sending love and thank you for all your support. 





    Age 39, H 38

    Married 8/15

    Pregnancy #1, MMC, D&C November/December 2015
    Pregnancy #2, Dx with Triploidy at 12 weeks, MMC, D&C May 2016
    Pregnancy #3 BFP 10/20/2016- EDD 7/01/2017
    DD was born on June 26, 2017
    Pregnancy #4 CP 4/2018
    Pregnancy #5 BFP 9/13/2018, EDD= 5/27/2019
  • chloe97 said:
    Guys, thank you all for giving me your thoughts, it's so helpful to hear from likeminded people that my thought-process isn't overreactive or getting ahead of ourselves. You guys are all seriously the best!!

    We did meet with an RE the day before we found out we were pregnant and so we still need to undergo the standard RPL testing. I'm not sure we will go back to her since she was a brand new practice and doesn't have reports of her IVF success rates yet. I'm going to do research this week while I'm off work. I didn't even think about DOR, but it's definitely a possibility. I just assumed since I was getting pregnant, it had to be okay, but I guess it could be a sign.

    I hate that we are all here. Sending love and thank you for all your support. 





    Yeah, unfortunately, DOR is one of the first things my OB mentioned as a possible problem, since quality tends to decline along with quantity. I'm really really hoping that's not the problem - for you, me, or any of us!
  • Hello ladies

    I think I am in the same path as most of you.

    ************** t w *********************

    Will be 36 this august, and I get easily pregnant... but cannot stay pregnant for long. (I've had 2 MC: first at 9w but the sac was only 6w and needed D&C / second one at 5w natural MC).  

    I am also thinking about testing as much as I can (afford), and do everything I can to avoid another loss. It is so painful, so horrible and so exhausting... I want to do everything I can to avoid MC.

    I also thought about IVF or any other treatments available for us to have the best chances!! We will have to see if it's affordable though.. but at least I want to have the option.  My OBGYN is reluctant to do more testing or genetic studies as he thinks "we are not at that point" but I have had 2 MC and I don't know if I can take it any more.

    I will be following this post to read your opinions and experience.
    Thanks

    -Y
    Married 06.21.14 / TTC since 11.15 /
    BFP 01.03.2016 / MMC 6w5d D&C 02.2016 // BFP 05.06.16 / natural MC 05.12.16
    Benched 06.2016-08.2016 / TTC again 09.2016! On a diet. Cranky.
    BFP 10.02.2016 / NT scan at 12w looked normal / Anatomy scan at 20w everything ok
    Team blue! / EDD June 11th 2017
    DAVID ROGER was born on May 23rd at 37 weeks.

    Architect, Peruvian living in Chile. I love art, opera and good chocolate.
    Started PhD studies in Architecture on 2017.
    Fur mom of a rescued miniature poodle called Luke Skywalker.


    Lilypie First Birthday tickers
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