Community› The Bump Message Boards› Infertility
Infertility
New Discussion

Letrozole THEN Clomid?

LizzieJ13LizzieJ13 member
in Infertility
Hi all - anyone move from Letrozole to Clomid? I usually hear of the reverse. I have been happy with (no side effects) and responded fine to Letrozole so far, but my nurse suggested thinking about moving to Clomid. Frankly, I'd be a little nervous from what I hear about Clomid side effects! Thanks for any input.
Me: 33, PCOS with anovulation
DH: 36, No known issues
TTC since 11/2014
1000mg Metformin daily

Oct-Dec 2015: Letrozole 5mg, Ovidrel, TI = BFN x 2
Feb-May 2016: Letrozole 5mg, Ovidrel, TI, Prometrium = BFN x 3
August 2016: Clomid 100mg no response, Letrozole 5mg, Ovidrel, TI, Prometrium = BFN

Report Reply to Post

Re: Letrozole THEN Clomid?

  • halipshalips member
    I've always heard of it done in the reverse as well. At least that's how it was for me. What has your dr said? Are you seeing an RE? 
    *TW* Pregnancy/Loss Mentioned
    Me: 37 /PCOS DH: 37/no issues TTC: 7/13
    Started with RE 12/14; 3 failed rounds of clomid, started letrozole
    IUI #1 & #2- BFN
    IVF #1 - 9/15 Cancelled Day 9
    IVF #2- started stims 10/24  ER- 11/15 6 eggs- 5 fertilized/ 1 frozen
    FET #1 -1 embryo-12/9/15- BFN
    IVF #3- started stims 1/22/16  ER- 2/8 33 eggs(!)- 21 mature, all 21 fertilized - 6 snowflakes!
    FET #2- 2 embryos- April 4th-BFN
    ERA-June 8- results show need 12 addt'l hours of PIO
    FET #3-  2 embryos transferred August 14,2016  BFP! on 8/24! Beta #1-22  Beta #2-83 Beta #3-368 
    Confirmed singleton-Heartbeat on 9/19-160bpm! EDD: May 1, 2017, It's a girl!!
    Pre-term labor/loss-stillborn at 18w. 
    FET #4- 1 embryo-Aug 12th-BFP on 8/23 Beta #1-112 Beta #2-298 Beta #3-1010
    Confirmed Identicals!- Heartbeats seen on 9/8  Miscarriage on 9/18
    FET #5- 1 embryo- 1/12/18-BFN
    Lots of testing and finally determined I have elevated natural killer cells. Will begin prednisone and IVL treatment before next round.
    IVF#4- April 2018 8 eggs, 7 fertilized/3 frozen
    FET #6- 1 embryo- 6/11/18- BFP on 6/21 Beta #1-446, Beta #2-1841 
    Confirmed singleton- 6/29/18 HB-157 EDD: February 22, 2019. It's a Boy!



    BabyFruit Ticker 
    Report Reply
  • mjacks16mjacks16 member
    You should ask your RE for a reason why. I switched from clomid to letrozole because I had a thin lining and some odd side effects on clomid. I did have a better response on the clomid with more mature follicles though. 
    Report Reply
  • Loading the player...
  • CooCoo4UCooCoo4U member
    @LizzieJ13 I'm wondering her reasoning behind that?? I did several rounds of clomid before switching to Femara. Everyone's different hopefully you'll have a great response to it, I didnt
    Report Reply
  • LMart85LMart85 member
    My RE is switching me from letrozole to clomid this next cycle as well...I've taken letrozole the last 5 cycles with okay response...so my RE wants to see how my body responses to clomid....I'm excited...letrozole isn't doing it for me
    Report Reply
  • LizzieJ13LizzieJ13 member
    Thanks everyone. Yes, I am seeing an RE. The nurse asked me if I was interested in switching, since this will be my 4th round of Letrozole. I asked if my response hadn't been good enough and she said no it's been fine. I think they're just trying to switch it up since I'm not doing IUI or IVF so they want to exhaust all options for meds. 

    @LMart85 , what do you mean by an OK response? I've only had 1 follicle each time, maybe they'd like more? My thought is, if an u/s confirms a good-sized follicle and then ovulation is confirmed with a blood test, how would Clomid be different? I am so afraid of mood swings that I think I'm going to stick with Letrozole but I am definitely to interested to hear other experiences.
    Me: 33, PCOS with anovulation
    DH: 36, No known issues
    TTC since 11/2014
    1000mg Metformin daily

    Oct-Dec 2015: Letrozole 5mg, Ovidrel, TI = BFN x 2
    Feb-May 2016: Letrozole 5mg, Ovidrel, TI, Prometrium = BFN x 3
    August 2016: Clomid 100mg no response, Letrozole 5mg, Ovidrel, TI, Prometrium = BFN

    Report Reply
  • LMart85LMart85 member
    When I took letrozole, I only had 1 mature follicle except for 1 month I had 2. My RE would like to see 2 maybe 3 mature follices for a better chance. So if it helps get me pregnant, I'm all for the clomid!
    Report Reply
  • LizzieJ13LizzieJ13 member
    Ah I see. Please update on how the Clomid works for you! I would definitely like to have 2 follicles so maybe it is worth considering.
    Me: 33, PCOS with anovulation
    DH: 36, No known issues
    TTC since 11/2014
    1000mg Metformin daily

    Oct-Dec 2015: Letrozole 5mg, Ovidrel, TI = BFN x 2
    Feb-May 2016: Letrozole 5mg, Ovidrel, TI, Prometrium = BFN x 3
    August 2016: Clomid 100mg no response, Letrozole 5mg, Ovidrel, TI, Prometrium = BFN

    Report Reply
Sign In or Register to comment.
Choose Another Board
Search Boards
"
"