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Estradiol question

iloveflipflopsiloveflipflops member
edited February 2016 in Infertility
Hi to whoever can answer this question.Does taking vaginal estradiol pills  do anything to sperm?
                 

TTC since 2012 

Dx : DOR

IUI #1 (Follistim switched over to Menopur injections) - BFN

Attempted IUI #2 (Menopur injections only cycle) better response on the Menopur then the Follistim combination treatment cycle however my cycle was still canceled due to my eggs not maturing and follicles not growing enough on a high dose of Menopur (Re said I could try a cycle of comid + ovidrel  for an IUI) for my second IUI( praying this works for us)

  Clomid + Ovidrel protocol worked still a BFN as a result

Attempted cycle  Clomid  + Ovidrel protocol for IUI # 3 (Unable to do this cycle due to a cyst)

IUI # 3 Clomid+ Ovidrel protocol - BFP    Beta #1 752  Beta #2  1536    Beta #3 3797

EDD 10/27/14

Our sweet baby boy arrived on 9/2/14 TTC # 2 Conceived without help- June 2015 July 2015- Miscarriage ( blighted ovum)
March 2016 (ectopic pregnancy) :( 

 

 

 

Lilypie Premature Baby tickers
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Re: Estradiol question

  • KilgraveMadeMeDoItKilgraveMadeMeDoIt member
    edited February 2016
    Yes, it does. 

    A bit of a breakdown of the pathway....

    Hypothalamus produces GnRH. GnRH stimulates anterior pituitary to produce FSH and LH (same thing happens in women.)
    FSH stimulates sperm production in Sertoli cells and LH acts on Leydig cells, they produce testosterone
    Increased testosterone suppresses GnRH release, which, as a result, downregulates the rest of the cycle.

    Aromatase is an enzyme that both women and men have. It converts testosterone to oestradiol which can also act on GnRH release (probably; not a well-understood mechanism.) More oestradiol = less LH and FSH. Less oestradiol = more LH and FSH = more stimulation of the gonads. 

    There has been some evaluation of the use of aromatase inhibitors in subfertile men, but I don't think it's been shown to actually help with conception rates even though it did show some ability to increase sperm concentration. 

    (Sorry if that's too detailed. I quite literally have a test on this tomorrow so I'm using your post to review, hah.)
    K.

    Son, K, 9 | Daughter, C, 5 | Daughter, M, expected November 7, 2016
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  • riveridgionalriveridgional member
    edited February 2016
    I think you were wondering more if your use of vaginal estrace can hurt your DH'S sperm for TI. I don't know for certain since I'm not a doctor, but I feel it is highly unlikely since my RE prescribed it for me for use with TI. You don't want to have sex when 30 minutes of use to prevent any estradiol being absorbed by DH and getting into his system. But, it should not affect his sperms' ability to live and get where they need to be. 

    **BFP mentioned * * * 

    I was using it vaginally 2xs a day with timed intercourse when I got my BFP.

    Good luck to you! 
    Married to DH 10/6/12
    TTC since 5/14
    Unexplained with (controlled) hypothyroidism and suspected ovulatory dysfunction (but, I do ovulate on my own)
    Clomid 50 mg 3/15 (unmonitored) - BFN
    Clomid 50 mg + metformin 4/15 (unmonitored) - BFN 
    First RE appt. 5/15; Natural cycle 5/15 monitored with 2 mature follicles and Pregnyl Trigger (full dose) + prometrium - BFN
    6/15 HSG - clear tubes & normal uterus; great PCT test results
    TI - 100 mg Clomid + prometrium (AM & PM) + vaginal estrace (AM & PM) 6-7/15 (monitored) --> no additional response and thinned lining - BFN
    TI - Injectables (follistim + Gonal-F, Ganirelix, & 1/2 dose Pregnyl) + prometrium (AM & PM) 9/15 --> 3-7 mature follicles (3 definites and 4+ that could have matured due to trigger) @ O -->BFN + 5 large cysts
    BC for 2 weeks due to cysts
    TI - Injectables (Gonal-F, Ganirelix & full dose Pregnyl) + prometrium (AM & PM) 10/15 --> 1 mature follicle --> BFN 
    TI - Last attempt at injectables (Gonal-F, Ganirelix & 1/2 dose Pregnyl) + crinone (AM only) + vaginal estrace (AM & PM) 11/15 --> 3-4 mature follicles --> BFP!! 11/27/15 @ 13dpo (shockingly, actually waited until then to test)

    Beta #1 @ 16dpo (11/30/15) = 1,075
    Beta #2 @ 19dpo (12/3/15) = 3,150
    One baby: Saw heartbeat @ 5w5d (114 bpm; baby measuring 2.3mm)

    "Great Things are Happening"
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