Infertility

Help with ovidrel DESPERATE!!!

edited November 2015 in Infertility
We are doing hybrid Femara + Gonal F + ovidrel + TI + progesterone suppositories. Monday we found out we have 4 mature follies (18 1/2, 18, 17, 15) and our nurse advised me to take my ovidrel shot right away so the other two close to maturing wouldn't grow anymore. I wasn't able to take it until 3pm yesterday, and she advised us to BD today and tomorrow!? I thought O doesn't happen until 36-44 hours after the shot!? Idk what to do!! I mean shouldn't we only BD during that window? The nurses desk is closed today so I need some advice from you ladies!!
Thanks!
Me:23 DH:32
Married 5/14/13
TTC #1 since 5/14
TTC #1 w/ treatments since 5/15
BFN 7/15
BFP 8/15-MMC 9/15

BFP 10/15- Diagnosed BO 12/15
BFP 2/16-EDD 11/18/2016 


Re: Help with ovidrel DESPERATE!!!

  • riveridgionalriveridgional member
    edited November 2015
    Typical O is 36 hours. The instructions you received are the exact instructions we receive everytime. BD the night of the trigger and the night after. If we're up for it, we do the next night too. Even if you O'd 44, those BDs should cover it. If you are worried just BD 3 nights in a row.
    Married to DH 10/6/12
    TTC since 5/14
    Unexplained with (controlled) hypothyroidism and suspected ovulatory dysfunction (but, I do ovulate on my own)
    Clomid 50 mg 3/15 (unmonitored) - BFN
    Clomid 50 mg + metformin 4/15 (unmonitored) - BFN 
    First RE appt. 5/15; Natural cycle 5/15 monitored with 2 mature follicles and Pregnyl Trigger (full dose) + prometrium - BFN
    6/15 HSG - clear tubes & normal uterus; great PCT test results
    TI - 100 mg Clomid + prometrium (AM & PM) + vaginal estrace (AM & PM) 6-7/15 (monitored) --> no additional response and thinned lining - BFN
    TI - Injectables (follistim + Gonal-F, Ganirelix, & 1/2 dose Pregnyl) + prometrium (AM & PM) 9/15 --> 3-7 mature follicles (3 definites and 4+ that could have matured due to trigger) @ O -->BFN + 5 large cysts
    BC for 2 weeks due to cysts
    TI - Injectables (Gonal-F, Ganirelix & full dose Pregnyl) + prometrium (AM & PM) 10/15 --> 1 mature follicle --> BFN 
    TI - Last attempt at injectables (Gonal-F, Ganirelix & 1/2 dose Pregnyl) + crinone (AM only) + vaginal estrace (AM & PM) 11/15 --> 3-4 mature follicles --> BFP!! 11/27/15 @ 13dpo (shockingly, actually waited until then to test)

    Beta #1 @ 16dpo (11/30/15) = 1,075
    Beta #2 @ 19dpo (12/3/15) = 3,150
    One baby: Saw heartbeat @ 5w5d (114 bpm; baby measuring 2.3mm)

    "Great Things are Happening"
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  • Also, no, you shouldn't BF only during that window as O can happen as early as 24 hours after the shot. You want the sperm waiting for the egg. Plus, sperm can live up to 5 days. Each BD is just to get more up there.
    Married to DH 10/6/12
    TTC since 5/14
    Unexplained with (controlled) hypothyroidism and suspected ovulatory dysfunction (but, I do ovulate on my own)
    Clomid 50 mg 3/15 (unmonitored) - BFN
    Clomid 50 mg + metformin 4/15 (unmonitored) - BFN 
    First RE appt. 5/15; Natural cycle 5/15 monitored with 2 mature follicles and Pregnyl Trigger (full dose) + prometrium - BFN
    6/15 HSG - clear tubes & normal uterus; great PCT test results
    TI - 100 mg Clomid + prometrium (AM & PM) + vaginal estrace (AM & PM) 6-7/15 (monitored) --> no additional response and thinned lining - BFN
    TI - Injectables (follistim + Gonal-F, Ganirelix, & 1/2 dose Pregnyl) + prometrium (AM & PM) 9/15 --> 3-7 mature follicles (3 definites and 4+ that could have matured due to trigger) @ O -->BFN + 5 large cysts
    BC for 2 weeks due to cysts
    TI - Injectables (Gonal-F, Ganirelix & full dose Pregnyl) + prometrium (AM & PM) 10/15 --> 1 mature follicle --> BFN 
    TI - Last attempt at injectables (Gonal-F, Ganirelix & 1/2 dose Pregnyl) + crinone (AM only) + vaginal estrace (AM & PM) 11/15 --> 3-4 mature follicles --> BFP!! 11/27/15 @ 13dpo (shockingly, actually waited until then to test)

    Beta #1 @ 16dpo (11/30/15) = 1,075
    Beta #2 @ 19dpo (12/3/15) = 3,150
    One baby: Saw heartbeat @ 5w5d (114 bpm; baby measuring 2.3mm)

    "Great Things are Happening"
  • I did my Ovidrel injection last night (9pm)! I came here wondering the same thing. We bd'd this morning. Hope to again tonight and tomorrow at some point. I'm so afraid to miss it!!
    Me: 33, PCOS with anovulation
    DH: 36, No known issues
    TTC since 11/2014
    1000mg Metformin daily

    Oct-Dec 2015: Letrozole 5mg, Ovidrel, TI = BFN x 2
    Feb-May 2016: Letrozole 5mg, Ovidrel, TI, Prometrium = BFN x 3
    August 2016: Clomid 100mg no response, Letrozole 5mg, Ovidrel, TI, Prometrium = BFN

  • @riveridgional yeah, that's part of my concern though, my instructions were to NOT baby dance the day of trigger. She said not to BD yesterday at all(the day of), only today and tomorrow? So, now I'm a little more confused. Seriously though, thanks for clearing up the sperm waiting for the egg thing. I totally didn't even think about that. I think it would be best to BD tonight then if it's possible it could happen 24 hours after trigger! Thanks!!
    Me:23 DH:32
    Married 5/14/13
    TTC #1 since 5/14
    TTC #1 w/ treatments since 5/15
    BFN 7/15
    BFP 8/15-MMC 9/15

    BFP 10/15- Diagnosed BO 12/15
    BFP 2/16-EDD 11/18/2016 


  • riveridgionalriveridgional member
    edited November 2015
    @alqizwik Sorry, I misread the timing in your post. Hmm...that is interesting. I usually trigger between 8 and 10 am, so maybe that's the difference? I think you should be fine, though. The egg can survive 12-24 hours and I think (similar to what you said) O usually happens around 36-42, so you should also be fine with just BDing today and tomorrow. 36 hours would put you at about 3:00 am tomorrow morning with your 3:00 pm trigger time yesterday.
    Married to DH 10/6/12
    TTC since 5/14
    Unexplained with (controlled) hypothyroidism and suspected ovulatory dysfunction (but, I do ovulate on my own)
    Clomid 50 mg 3/15 (unmonitored) - BFN
    Clomid 50 mg + metformin 4/15 (unmonitored) - BFN 
    First RE appt. 5/15; Natural cycle 5/15 monitored with 2 mature follicles and Pregnyl Trigger (full dose) + prometrium - BFN
    6/15 HSG - clear tubes & normal uterus; great PCT test results
    TI - 100 mg Clomid + prometrium (AM & PM) + vaginal estrace (AM & PM) 6-7/15 (monitored) --> no additional response and thinned lining - BFN
    TI - Injectables (follistim + Gonal-F, Ganirelix, & 1/2 dose Pregnyl) + prometrium (AM & PM) 9/15 --> 3-7 mature follicles (3 definites and 4+ that could have matured due to trigger) @ O -->BFN + 5 large cysts
    BC for 2 weeks due to cysts
    TI - Injectables (Gonal-F, Ganirelix & full dose Pregnyl) + prometrium (AM & PM) 10/15 --> 1 mature follicle --> BFN 
    TI - Last attempt at injectables (Gonal-F, Ganirelix & 1/2 dose Pregnyl) + crinone (AM only) + vaginal estrace (AM & PM) 11/15 --> 3-4 mature follicles --> BFP!! 11/27/15 @ 13dpo (shockingly, actually waited until then to test)

    Beta #1 @ 16dpo (11/30/15) = 1,075
    Beta #2 @ 19dpo (12/3/15) = 3,150
    One baby: Saw heartbeat @ 5w5d (114 bpm; baby measuring 2.3mm)

    "Great Things are Happening"
  • I asked this question of the nurse at my last RE appointment.  I was told that the reason for the BD the same night as the ovidrel is actually only to clear out your DH's tubes so he has fresh sperm the day of your IUI or TI, etc, and has nothing to do with the woman's cycle.  Sperm count goes down if he ejaculates every day or waits longer than 3 days, but increases after a 48 hour wait.  It's so that you have the highest count and freshest sperm for your IUI or ovulation window!!!
    ***BFP & Child Warning***

    Me: 34, DH: 38 ~ TTC since 2014
    IUI #1-3 (Nov 2015, Feb 2016, May 2016) = BFNs
    IVF ER (July 2016) = 7 PGS normal embryos
    FET #1 (Sept 2016) = BFP! DD born 5/30/17
    FET #2 (April 2019) = BFN
    FET #3 (July 2019) = BFP! DS born 3/27/20
  • I'm supposed to do my Ovidren trigger this Sunday (if all looks good on the ultrasound) at 3pm. The instructions clearly say NOT to BD on the day of the trigger (does anyone know why this is? Does the trigger mess up the sperm or something?). I'm then supposed to have TI the following day, between 10pm and midnight, which is 31-33 hours after the trigger. So I think having TI the day after the trigger is common protocol.
    ME: 36 (PCOS), DH: excellent SA
    NTNP since 11/12, actively trying since 8/14
    m/c @ 7w (4/22/14), m/c @ 6w (11/19/14)
    11/15: Letrozole, Ovidrel, TI = BFP!!!
    Beta #1(14dpo)=349, Beta #2(18dpo)=2,805
    12/17/15: Got to see the heartbeat (105bpm)!
    1/25/16: NT scan = normal (HB=163bpm)
    EDD: 8/10/16 
    8/8/16: Baby boy born @ 12:25am, 8lbs, 20.5 inches
    5/18/17: BFP!!! (11dpo)
    Beta #1(12dpo)=176.4, Beta #2(15dpo)=607.1
  • @jilligan14 - yeah, it definitely has to do with sperm.  If your best chances of getting pregnant are the day after your trigger shot, they won't want you to BD the day before because then your DH's sperm count will actually go down the next day.  It all has to do with when they want your DH's sperm to be top notch (48 hours after the last ejaculation).  In my case, since I'm doing IUI and my IUI is going to be scheduled for 2 days after my ovidrel shot, they want us to BD (or for my DH to masturbate) the same day I take the ovidrel.
    ***BFP & Child Warning***

    Me: 34, DH: 38 ~ TTC since 2014
    IUI #1-3 (Nov 2015, Feb 2016, May 2016) = BFNs
    IVF ER (July 2016) = 7 PGS normal embryos
    FET #1 (Sept 2016) = BFP! DD born 5/30/17
    FET #2 (April 2019) = BFN
    FET #3 (July 2019) = BFP! DS born 3/27/20
  • ^^ This.  Especially if there are known sperm issues, EOD is ideal.  
  • So, it's starting to make more sense. I already knew about the fresh sperm idea. My nurse advised us to BD the day before the trigger for that reason, so they (the sperm) would be at their best for TI, which in my case would be the day after trigger. I'm just a little confused on why some are advised to BD the two days following trigger, and some are being advised to do it the same day. I'm just hoping that the day we skipped wasn't our crucial day. Lol. But I think I've gathered enough info and we will know soon enough if any of our four follies will give us our BFP! :smile: FX for the rest of you ladies! Thanks so much for the info
    Me:23 DH:32
    Married 5/14/13
    TTC #1 since 5/14
    TTC #1 w/ treatments since 5/15
    BFN 7/15
    BFP 8/15-MMC 9/15

    BFP 10/15- Diagnosed BO 12/15
    BFP 2/16-EDD 11/18/2016 


  • And to follow up, I just did some pretty extensive research. The day of trigger is actually a very good day to BD. I don't know why my nurses have always refrained from giving me that info. So, apparently (for anyone who may have the same question I did), two days before and a day before ovulation are the best days to BD. it takes up to 10 hours for the sperm to get through the full process to be in their spot ready for the egg. (Slow swimmers :P). Also, the woman's egg only lives up to 12 hours, compared to the sperm living up to 5 days. It's better for the mature sperm to be waiting for the egg, because freshly ejaculated sperm won't make it to the egg fast enough after you O. Soooo, same day BD as Ovulation is NOT the best for conceiving. The 2 days before are the best!! Hope this helps someone!! :)
    Me:23 DH:32
    Married 5/14/13
    TTC #1 since 5/14
    TTC #1 w/ treatments since 5/15
    BFN 7/15
    BFP 8/15-MMC 9/15

    BFP 10/15- Diagnosed BO 12/15
    BFP 2/16-EDD 11/18/2016 


  • I was told it has to do with sperm regeneration. You'll often here people say "do it all the time!" my doc said every other day is better because it takes the little squirmies time to regenerate. I guess if you time it right, then it's ok...? 

    So technical!!
  • I've been obessively Googling this since Monday so thought I'd throw in my 2 cents. My RE said to BD twice in the 36 hour period following the trigger -- so after my injection at 9pm Monday night, we did Tues. morning & Tues. night. Going to try for this afternoon for good measure. This is my first cycle and already driving me crazy with trying to figure out the timing!
    Me: 33, PCOS with anovulation
    DH: 36, No known issues
    TTC since 11/2014
    1000mg Metformin daily

    Oct-Dec 2015: Letrozole 5mg, Ovidrel, TI = BFN x 2
    Feb-May 2016: Letrozole 5mg, Ovidrel, TI, Prometrium = BFN x 3
    August 2016: Clomid 100mg no response, Letrozole 5mg, Ovidrel, TI, Prometrium = BFN

  • My RE always had me BD the night of trigger and then 36 hours later.  Or we did IUI 36 hours later.  Having those sperm in there waiting is key.  

    ***Child/pregnancy mentioned***

    When I got pregnant with my DD, we had sex two days prior to ovulation and then I left town for a conference.  We didn't do a trigger that cycle, I just used OPKs.  I was so bummed when my temp went up.  I was shocked to find out I was pregnant.  Two days prior to ovulation worked for us!!
    *** Child & current pregnancy mentioned ***
    Me - 41 (PCOS), Hubby - 43 (healthy)
    7/2013 - Sweet baby girl born (Clomid + TI)
    3/2014 - TTC #2, return to RE 7/2014
    12/2015: IVF #1 transferred two great looking embryos - BFP!
    First ultrasound: TWO beautiful little heartbeats!!
    Harmony: negative; level 2: babies look great and are boy/girl! :) 
  • Okay, so I really don't know what to do now! The instructions say "do NOT have intercourse on the day of the trigger shot" yet some of you are saying I SHOULD have it after the trigger shot? My nurse said to do the trigger, then have TI 31-32 hours after. She said I'll O 36 hours after the shot so the spermies will be waiting for the egg (if I do it 31-32 hours after shot). But what if I O earlier than the 36 hours? I think I might do it the day before trigger and the day after just to cover the bases. Or I can do it after the trigger and the next day. Ugh, I'm going to drive myself crazy with this...
    ME: 36 (PCOS), DH: excellent SA
    NTNP since 11/12, actively trying since 8/14
    m/c @ 7w (4/22/14), m/c @ 6w (11/19/14)
    11/15: Letrozole, Ovidrel, TI = BFP!!!
    Beta #1(14dpo)=349, Beta #2(18dpo)=2,805
    12/17/15: Got to see the heartbeat (105bpm)!
    1/25/16: NT scan = normal (HB=163bpm)
    EDD: 8/10/16 
    8/8/16: Baby boy born @ 12:25am, 8lbs, 20.5 inches
    5/18/17: BFP!!! (11dpo)
    Beta #1(12dpo)=176.4, Beta #2(15dpo)=607.1
  • @jilligan14 - definitely just follow your doctor's orders!!  I'm sure there is a method to all this madness as it depends entirely on each individual treatment plan.  GL!!
    ***BFP & Child Warning***

    Me: 34, DH: 38 ~ TTC since 2014
    IUI #1-3 (Nov 2015, Feb 2016, May 2016) = BFNs
    IVF ER (July 2016) = 7 PGS normal embryos
    FET #1 (Sept 2016) = BFP! DD born 5/30/17
    FET #2 (April 2019) = BFN
    FET #3 (July 2019) = BFP! DS born 3/27/20
  • @jilligan14 I would follow your doctor's orders too. That instruction may be based on your and DH's histories and test results (ie SA and PCT) and/or the prescribed trigger time. If your histories don't suggest any reason and you're curious, you can always ask. Anything to lower the stress in this process, right?

    Generally speaking, BDing everyday is really only an issue if the sperm count is on the lower side to begin with. My RE instructed us to BD every night for 4 nights my first monitored cycle (night before PCT, triggered next day so that night, next night, and night after "if we felt up to it").
    Married to DH 10/6/12
    TTC since 5/14
    Unexplained with (controlled) hypothyroidism and suspected ovulatory dysfunction (but, I do ovulate on my own)
    Clomid 50 mg 3/15 (unmonitored) - BFN
    Clomid 50 mg + metformin 4/15 (unmonitored) - BFN 
    First RE appt. 5/15; Natural cycle 5/15 monitored with 2 mature follicles and Pregnyl Trigger (full dose) + prometrium - BFN
    6/15 HSG - clear tubes & normal uterus; great PCT test results
    TI - 100 mg Clomid + prometrium (AM & PM) + vaginal estrace (AM & PM) 6-7/15 (monitored) --> no additional response and thinned lining - BFN
    TI - Injectables (follistim + Gonal-F, Ganirelix, & 1/2 dose Pregnyl) + prometrium (AM & PM) 9/15 --> 3-7 mature follicles (3 definites and 4+ that could have matured due to trigger) @ O -->BFN + 5 large cysts
    BC for 2 weeks due to cysts
    TI - Injectables (Gonal-F, Ganirelix & full dose Pregnyl) + prometrium (AM & PM) 10/15 --> 1 mature follicle --> BFN 
    TI - Last attempt at injectables (Gonal-F, Ganirelix & 1/2 dose Pregnyl) + crinone (AM only) + vaginal estrace (AM & PM) 11/15 --> 3-4 mature follicles --> BFP!! 11/27/15 @ 13dpo (shockingly, actually waited until then to test)

    Beta #1 @ 16dpo (11/30/15) = 1,075
    Beta #2 @ 19dpo (12/3/15) = 3,150
    One baby: Saw heartbeat @ 5w5d (114 bpm; baby measuring 2.3mm)

    "Great Things are Happening"
  • @jilligan14 So, we've always BD the day before trigger. First reason, it's important to have regenerated sperm like @Caroline351 mentioned. Second, it's good to have sperm waiting for an egg, and it lives up to 5 days.

    We BD the whole weekend b/c we missed our appointment on Saturday(to check follie size), and were worried we would ovulate on our own. So, we BD 2 days before trigger, and two days after (yesterday and today). I'm really really hoping that we've covered enough days, because it would just be our luck that our crucial day was trigger day :neutral: lol. In all honesty too, we are paying out of pocket, and I don't know how much more our wallets can take. The $500 viles are NOT enough sometimes. This time we had to use two, and our ultrasounds are almost $300 a piece. Ughhh.
    Sorry for the rant, we just really need some good news this month!!
    Thanks ladies for the help!! Seriously :)
    Me:23 DH:32
    Married 5/14/13
    TTC #1 since 5/14
    TTC #1 w/ treatments since 5/15
    BFN 7/15
    BFP 8/15-MMC 9/15

    BFP 10/15- Diagnosed BO 12/15
    BFP 2/16-EDD 11/18/2016 


  • Thanks all for the advice. I think I'll do it day before trigger and day after, as per RE's instructions. I just get so worried when I hear of different plans for different people. DH has good numbers and all when it comes to SA so we could prob do every day but I'll follow the guidelines this time and see if it works.

    @alqizwik I really hope that one of those times worked. It is true that sperm can live up there for awhile so the two days before seems like a good thing. It's such a shame all of this costs so much. fingers crossed that this cycle is your time!!!!
    ME: 36 (PCOS), DH: excellent SA
    NTNP since 11/12, actively trying since 8/14
    m/c @ 7w (4/22/14), m/c @ 6w (11/19/14)
    11/15: Letrozole, Ovidrel, TI = BFP!!!
    Beta #1(14dpo)=349, Beta #2(18dpo)=2,805
    12/17/15: Got to see the heartbeat (105bpm)!
    1/25/16: NT scan = normal (HB=163bpm)
    EDD: 8/10/16 
    8/8/16: Baby boy born @ 12:25am, 8lbs, 20.5 inches
    5/18/17: BFP!!! (11dpo)
    Beta #1(12dpo)=176.4, Beta #2(15dpo)=607.1
  • @jilligan14 thanks :) same to you FX!!
    DH also has good numbers, so maybe that's why we were given different instructions?
    When do you officially start your TWW?
    FX you get your BFP and we look back at our worries and laugh :P
    Me:23 DH:32
    Married 5/14/13
    TTC #1 since 5/14
    TTC #1 w/ treatments since 5/15
    BFN 7/15
    BFP 8/15-MMC 9/15

    BFP 10/15- Diagnosed BO 12/15
    BFP 2/16-EDD 11/18/2016 


  • @alqizwik I go in for ultrasound this Sunday. If it all looks good then I will trigger that afternoon at 3pm and have TI on Monday night. So 2WW wait will begin on Tuesday. I really do hope we get our BFPs and can have a good laugh about all these worries about timing things just right! Good luck!!
    ME: 36 (PCOS), DH: excellent SA
    NTNP since 11/12, actively trying since 8/14
    m/c @ 7w (4/22/14), m/c @ 6w (11/19/14)
    11/15: Letrozole, Ovidrel, TI = BFP!!!
    Beta #1(14dpo)=349, Beta #2(18dpo)=2,805
    12/17/15: Got to see the heartbeat (105bpm)!
    1/25/16: NT scan = normal (HB=163bpm)
    EDD: 8/10/16 
    8/8/16: Baby boy born @ 12:25am, 8lbs, 20.5 inches
    5/18/17: BFP!!! (11dpo)
    Beta #1(12dpo)=176.4, Beta #2(15dpo)=607.1
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