I will be going in for my IVF appointment and I am reading up on different protocols for different diagnoses. I have polly cystic ovaries, but not PCOS. I do not have insulin issues, high testosterone, acne or facial hair. I simply do not ovulate due to my pituitary gland no making enough FSH or LH, which gives me poly cystic ovaries. During my past 6 cycles with IUI, overstimming was always a concern of the 2 REs I saw, but I never did, not even close. During my final cycle where I did all follitism I had been on BCPs the month before due to a 50mm cyst from the previous cycle. After I finished the BCPs and the cyst was gone, they started me off at 75iu and I did not respond, then upped me to 100 and still no response, but at 125iu I had a TON of 10mm follicles and they suggested converting to IVF because they thought I had the potential to overstim. We converted to IVF and upped my follitism dose to 225 and I still UNDERstimmed. I only had 4 mature follicles and 3 close behind and my E2 would not get above 600 so we converted back to IUI. I did get my son from this crazy cycle though! We are now trying for #2 just jumping to IVF. I am getting concerned that this is going to be an issue again. I am worried they are going to be super conservative and I will not produce like last time and the cycle will be a bust. I get one shot at this as that is all we can afford. I am getting nervous to make sure it counts! I don't know if I should be pushing for a certain protocol to produce the most follicles? Would my follitism cycle I was on where it was IUI to IVF to IUI be basically an antagonist protocol because I was on BCPs before but not lupron?
My questions are:
1. What protocol did you use?
2. How many follicles did you get?
3. Did you have any frosties?
4. How many cycles did it take you to work? (If you did IVF for a previous child)
5. What was your diagnosis?
Thanks for your help ladies! I am very familiar with IUI and meds, but IVF stuff I am still researching. I want to be as informed as possible going into my appointment so I can make sure I am my own advocate.
~~ All Welcome~~
ME: 32, SER aggregates on eggs, anovulatory
DH: 33, 2% morphology
TTC #1
2 clomid cycles, 3 hybrid clomid/bravelle IUI's = 4 BFN/1 CP@ 5.5 weeks
IUI #6 -Follitism IUI cycle converted to IVF and back to IUI-4 mature, 3 maybe mature = BFP!! DS Born 9/2014
TTC#2
IVF #1 9/15 Antagonist- 19 R 1F (Frozen day 1 @ 2PN stage) Diagnosed with SER aggregates in 13/19 eggs after failed fertilization
IVF #2 11/15 Antagonist w/ICSI (Higher stims & Letrosole added last minute on stim day 7)- 39R, 24M (20/24 SER free), 15F (14/15 SER free & all frozen @ 2PN stage)
FET#1 Cultured all 16- 2pn embryos to day 5- transferred 1 good hatching blast and 1 early blast on 1/28- None to freeze - beta 2/5
Re: IVF Protocol Questions
IVF 1 antagonist
IVF 2 micro lupron flare (for poor responders)
2. How many follicles did you get?
IVF 1 8 (7R 7M 3F, transferred two, CP)
IVF 2 19 (16R 15M 12F, 6 blasts, 5 chromosomally normal)
3. Did you have any frosties?
IVF 1 no
IVF 2 no fresh transfer, see above
4. How many cycles did it take you to work?
No one here will be able to answer this...
5. What was your diagnosis?
Unexplained IF, Recurrent pregnancy loss.
Based on what you said about how you responded, I would request a poor responder protocol. If you aren't responding to injectables, that is classic poor responder
TTC #3 since June 2013
BFP #1 7/21/2013--EDD 3/30/14--D&C 9/24/13
BFP #2 1/28/14--MC 2/7/14
IUI #1 5mg Femara + trigger = BFN
IUI #2 5mg Femara + trigger = BFN
IUI #3 5mg Femara + trigger = BFN
Me: 35 DOR - AMH 1.1 FSH 5.6
DH: 39
09/01/10 - First pregnancy - my sweet son was born
04/25/14 - Miscarriage at 9 weeks - Turner Syndrome
08/01/14 - Miscarriage at 8 weeks - Trisomy 9
October 2014 - Unsuccessful IUI
November 2014 - IUI month skipped due to cyst
December 2014 - Unsuccessful IUI
January/February 2015 - Failed IVF (standard long protocol) - 7 eggs, 6 mature, 4 fertilized (ICSI), 0 made it to blast, 0 for testing
March/April 2015 - Microflare IVF protocol with HGH - 6 eggs, 6 mature, 5 fertilized (ICSI), 2 blasts for biopsy!
May/June 2015 - Microflare IVF protocol with HGH - 9 eggs, 6 mature, 5 fertilized (ICSI), 3 blasts for biopsy!
06/18/15 - Two healthy embies based on PGS testing by Natera!
June/July 2015 - FET cycle with estradiol & PIO shots, a Neupogen treatment, and accupuncture
07/08/2015 - Transferred one lovely embie
07/17/2015 - Beta #1 136
07/20/2015 - Beta #2 529 -- BFP!!!
I have a blog that I kept up after seeing someone else's and wished I could have found more blogs with these details. I documented each day with medicine dosages and appointments and even down to the penny what we spent. We were very lucky to have had follistim donated as that is an expensive drug on my insurance. My blog is www.anotherivfblog.blogspot.com. There are no adds (not trying to make money off of it) as it is just a reference tool for myself and hopefully it will help others!! Check out the pages at the top for my IVFs and I just added our FET that is scheduled for June 4th.
Good luck to you!!!
BFP on Cycle 14--TWINS! Identical twin boys stillborn at 19wks(1/9/10)
3 break cycles; took clomid 50mg, BFP #2 Beta #1 35, Beta #2 338!!! Owen was born 2/11/11!
TTC#2: 4 cycles on clomid: BFNs
BFP #3: Cycle #5 100mg clomid; beta #1 21; beta #2 6=CP
Cycle #6 break cycle TTC no meds=BFN
Cycle #7: 150 clomid+ovidril+IUI=BFN (switched to RE)
Cycle #8: follistem+ovidril+TI=BFN
Cycle #9 Forced break due to cyst
Cycle #10 follistem+ovidril+TI=BFN
Cycle #11 follistem+ovidril+TI=BFN
Cycle#12 Forced break due to cyst, went on BCP; did repeat HSG, Saline U/S
Cycle #13 IVF: Follistim/Menapur ER 11-30 11 eggs, 5 mature, 4 fertilized and 3dt on 12-3; BFN
Cycle #14: IVF#2 lupron/follistim/menopur ER 1-22, 19 eggs, 14 fertilized, 5dt on 1-27, BFP!! beta 1: 63, beta 2: 119; EDD 10-15-13; 1 frozen embie