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IVF update

AprilDrew04AprilDrew04 member
in Secondary IF
I tried to update on the weekly check in but not sure if it worked.

So, for those that may have been wondering... my first try at IVF resulted in a cancelled cycle. I had NO response to the meds. One tiny follie.

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DD conceived after 3 years of ttc.
MFI - DH had varicocele repair and took Clomid to get DD b. 02/2010

TTC #2 since 6/2010
10/2012 DH diagnosed with Epilepsy
A few failed IUIs summer 2012 and 2013. 
DH taking clomid and waiting to see if he needs another vericocele repair. 
Hoping for a 2015 baby or babies. 
Wishing, hoping, waiting.


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Re: IVF update

  • AprilDrew04AprilDrew04 member
    Apparently TB does not want me to use the emoticons. :p

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    DD conceived after 3 years of ttc.
    MFI - DH had varicocele repair and took Clomid to get DD b. 02/2010

    TTC #2 since 6/2010
    10/2012 DH diagnosed with Epilepsy
    A few failed IUIs summer 2012 and 2013. 
    DH taking clomid and waiting to see if he needs another vericocele repair. 
    Hoping for a 2015 baby or babies. 
    Wishing, hoping, waiting.


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  • ellebelle2384ellebelle2384 member
    Boo!  I hate this for you. :(  What's the plan going forward?
    Me: 31     DH: 33
    Dx: Me: Recurrent Pregnancy Loss; DH: Low Morphology (2%)
    BFP#1: MC 3/1/11 at 6w1d - EDD 10/21/11
    BFP#2: 5/3/11 - EDD 1/9/12 - DD Born 1/6/12
    image
    TTC #2 since 12/13
    BFP#3: MC 2/8/14 at 4w5d - EDD 10/13/14
    BFP#4: MC 5/6/14 at 4w4d - EDD 1/9/15
    BFP#5: MMC discovered 8/4/14 at 9w1d - D&C 8/5/14 - Baby Boy with Trisomy 16 (maternal origin) - EDD 3/8/15
    BFP#6: CP 11/6/14 at 4w2d - EDD 7/14/15
    IVF #1 with ICSI & PGS: May/June 2015, ER 6/3/15, 17R/17M/15F
    IVF #2 with ICSI & PGS: July 2015, ER 7/16/15, 16R/11M/9F
    PGS results = 6 normal embryos (4 boys, 2 girls)
    FET 9/23/15 = BFFN
    Natural FET 11/4/15 = BFP!
    Beta 9dp5dt = 92

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  • CTinNVCTinNV member
    I'm so sorry, @AprilDrew04. What type of IVF protocol did they use for you? My first cycle was a failure, but not cancelled. (see my sig for more details). I responded better to the Microflare protocol and at least got a couple blasts for testing later after my upcoming third cycle. 

    Is you doctor going to do a cycle review with you?

    Me: 35 DOR - AMH 1.1 FSH 5.6

    DH: 39

    09/01/10 - First pregnancy - my sweet son was born 

    04/25/14 - Miscarriage at 9 weeks - Turner Syndrome 

    08/01/14 - Miscarriage at 8 weeks - Trisomy 9 

    October 2014 - Unsuccessful IUI 

    November 2014 - IUI month skipped due to cyst 

    December 2014 - Unsuccessful IUI 

    January/February 2015 - Failed IVF (standard long protocol) - 7 eggs, 6 mature, 4 fertilized (ICSI), 0 made it to blast, 0 for testing 

    March/April 2015 - Microflare IVF protocol with HGH - 6 eggs, 6 mature, 5 fertilized (ICSI), 2 blasts for biopsy! 

    May/June 2015 - Microflare IVF protocol with HGH - 9 eggs, 6 mature, 5 fertilized (ICSI), 3 blasts for biopsy!

    06/18/15 -  Two healthy embies based on PGS testing by Natera!

    June/July 2015 - FET cycle with estradiol & PIO shots, a Neupogen treatment, and accupuncture

    07/08/2015 - Transferred one lovely embie 

    07/17/2015 - Beta #1 136

    07/20/2015 - Beta #2 529 -- BFP!!!

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  • Kelley421Kelley421 member
    :( I'm sorry - fx your doctor can try a protocol that gets a good response.

    Two years, two losses and three IUIs...

    We are having TRIPLETS!

    EDD 1/26/16

     GGB born November 2015!


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  • efhoping2010efhoping2010 member
    I am so sorry  @AprilDrew04, maybe a second opinion and a new protocol too?
    H: 34 dx Azoospermia due to CBAVD from CF  
    ME: 39 IS FINE!!!  DOR and poor AMH/FSH/LH
    IVF/ICSI/PESA #1 Beta 1 373 Beta 2 1783 BOY/GIRL TWINS!! Born April 2010!!
    Natural FET 5/26/12 2 blasts Beta 1 207 Beta 2 513 Beta 3 1377 U/S 6/28 Pregnancy not viable d & c scheduled :( 
    IVF/ICSI/PESA #2 ER 11/15/12 Nothing to transfer :( 
    IVF/ICSI #3 April 2013 MDLF 3dt of 3 embryos, chemical :(  
    IVF #4/ICSI/MESA/CCS/FET EPP April 2015
    ODWU CCRM with Dr. Sch COMPLETE!!!! Put on acai supplement they are studying for DOR and embryo quality.
    DAY 3 Labs Drawn 2/26 put on vitamin D and calcium supplements
    Regroup and Protocol Reveal 3/04 "Bazooka Protocol" EPP with MDLF "Protocol 6 with patches"
    ER/MESA 4/10 ER 9 eggs retrieved MESA success found live swimmers :)
    Fertilization Report 6 eggs mature and ICSI'd 4 eggs fertilized normally
    Day 6 Report to Blast for CCS 4/16: 2 DAY 5 BLASTS BIOPSIED FOR CCS a 4AB and a 3AB!!!!
    CCS Results BOTH BLASTS CCS NORMAL!!!!!!  call on 4/24
    Regroup call to discuss CCS results and FET call on 5/20
    FET prep: CD 1 6/08 CD 3 Start BCP 6/10, HSG 6/12 Lupron Start 10 iu 6/17 End BCP 6/21 CD 1 6/23!!!
    Start vivelle patches 6/25 change e/o/d reduce Lupron to 5iu 6/25 Blood Draw 7/01, 7/08, 7/15, 7/19
    Increase vivelle patches 7/03 2 change e/o/d and 7/05 change e/o/d 3 and 7/07 4 change e/o/d add vaginal estrace 2x a day
    Lining Check/Blood Draw 7/08 and 7/15 End Lupron 7/18  Start PIO 1ml daily 7/18  Blood  Draw 7/19
    Flight to clinic 7/22
    FET 2 CCS BLASTS :):)  7/23 :):) YES YES both thawed and both fully expanded :):)
    7/26 :):) 3dp5dt PM very very faint positive FRER
    7/27: 4dp5dt Neg Digi AM but very very faint positive FRER PM POSITIVE DIGI CLEARBLUE PREGNANT 1-2 :):) 
    7/31:8dp5dt AM POSITIVE DIGI CLEARBLUE PREGNANT 2-3!!!! :):) 
    Beta 1 8/01= 408!!!!!!!!!! at 9dp5dt FET
    Beta 2 8/03 = 1014!!!!!!!!!! at 11dp5dt FET
    8/05/2015 AM POSITIVE DIGI CLEARBLUE PREGNANT 3+!!!! :):) 
    First Ultrasound: 8/20!!!!!! TWINS!!!!!!!!!!!!!!!!!  Genetics says BOTH BOYS!!!!!!!!!
    Second Ultrasound: 9/03!!!!!!!!!!










     










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  • fuzzbumblefuzzbumble member
    I think you're going to respond much better to the micro flare. I had such a crap response to antagonist too, I wish it would have been cancelled. I just wish you didn't have to wait so long!!!!

    image

    June 19, 2010 - Miracle Baby Girl

    Round 2
    Since March 2013
    BFP April 2013 - Missed M/C July 2013 @ 12w6d
    BFP December 2013 - CP @ 4w3d
    Eight medicated cycles, three IUIs: FAIL
    IVF #1 Antagonist - January 2015: CP/FAIL

    IVF #2 April 2015: Microdose lupron Flare
    ICSI, CCS Freeze all
    6 blasts biopsied/5 normal

    FET #1 June 25, 2015 6AA and 5AA blast transfer
    BFP 3dp5dt!
    Beta 8dp5dt 195.2, 10dp5dt 474.8, 12dp5dt 977, 22dp5dt 25,580
    <3 Twins! Our boy and girl coming end of February!  <3

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  • FrenchteachermamaFrenchteachermama member
    I'm praying that you get a much better response next time!!!!!!



    imageimageimage
    image
    My FF Chart:
    http://www.fertilityfriend.com/home/490dd7
    TTC #3 since June 2013
    BFP #1 7/21/2013--EDD 3/30/14--D&C 9/24/13
    BFP #2 1/28/14--MC 2/7/14
    IUI #1 5mg Femara + trigger = BFN
    IUI #2 5mg Femara + trigger = BFN
    IUI #3 5mg Femara + trigger = BFN
    IVF #1, Stimmed for 12 days, ER 8/22/14, 9 retrieved, 7M, 7F!!  Freeze all due to fluid in uterus.
    FET end of October 2014 cancelled due to fluid in uterus due to possible c-scar defect
    Surgery scheduled 12/12/14 to fix possible isthmocele
    3/26/15 transferred one 8 cell grade 4 embryo and one 6 cell grade 3 embryo = slow rising betas for 2+ weeks = ectopic MTX shot 4/29/15
    Repeat c-scar surgery June 2015
    2nd and last IVF cycle August 2015, stimmed for 12 days, 2 egg retrieved, both mature and both fertilized.  Transferred both 8-cell embryos on Day 3, beta 9/5/15 = BFFN
    MOVING TO ADOPTION!  


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  • Davie813Davie813 member
    Ugh, I'm sorry.  I hope a new protocol does the trick for you!
    *****Signature/Ticker Warning******

    Me: 41, DH: 45
    DD, 6/15/2013
    TTC #2 beginning January 2014
    AMH 1.05; FSH range 7-11

    July 2014: IUI #1.  Follistim + Pregnyl.  2 follicles--BFN
    September 2014: IUI #2.  Follistim + Pregnyl + Ganirelix + Crinone.  4(?) follicles--BFN
    October 2014: IUI #3.  More Follistim + More Ganirelix + Pregnyl + Crinone.  4 follicles--BFP!  Beta #1=10 Beta #2=33 Beta #3=97 Beta #4=158.  M/C 11/1/14
    December 2014: IVF #1.  Microdose Lupron protocol.  9R, 9M, 9F.  3 5-day blasts transferred 12/15. BFFN.
    April 2015: IVF #2.  Microdose Lupron protocol.  16R, 15M, 12F. Transferred 2 5-day blasts 4/12 and froze 4--BFP!  M/C 5/25/15
    August 2015: IVF #3.  14R, 13M, 11F.  Froze 5 blasts for CCS testing.  3 normals.  FET planned for 10/2015.



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  • Jodee37Jodee37 member
    does RE have insight for you? sounds like you were WAY over-suppressed. i want to wring your REs neck for not cancelling you sooner while you were stimming... there comes a point when it's obv its not going well and i think he dropped the ball.  not cool since you are paying OOP for some of this.

    i agree changing the protocol altogether sounds like a good idea.  big hugs lady.  
    Me: 36, DH: 36
    DH's SA = normal
    1 tube only wonder
    AFC 3-5, AMH 0.30

    BFP #1 3/29/11.  EDD 12/4/11... Missed m/c 5/9/11. Cytotec fail. D&C 5/17/11.
    BFP #2   7/5/11.  EDD 3/14/12... Our rainbow Kellen born 3/14/12 via c/s.
    BFP #3 5/30/13.  EDD 2/8/14...  6wk u/s HB 126. 8wk u/s lost HB. D&C 7/12/13.
    BFP #4 2/18/14.  EDD 10/30/14... Ruptured ectopic with L tube removed & D&C 3/7/14.
    BFP #5 7/27/14.  EDD 4/9/15...  m/c @ 5w4d.

    IVF #1    Oct 2014 - antagonist protocol: 9R, 7M, 5F. 3dt of 3 Grade 2 embies. BFN. 
    IVF #2    Jan 2015 cancelled due to dominant follicle.  Converted to IUI #1. BFFN
    IVF #2.1 March 2015 cancelled due to dominant follicle.

    BFP #6  (SUPRISE!) 3/19/15.  EDD 11/30/15...  CP at 4w2d.
    IUI #2:    Clomid + Follistim = 3 follies. BFN.
    IVF #2.2 May 2015 - horrible response to micro lupron flare protocol: 3R, 3M, 3F. 3dt of 2 Grade 3 embies. BFFN. 

    BFP #7 (beyond surprised again!) 4/26/16. EDD 1/5/17. beautiful betas!!!! and then near-fatal hemorrhagic corpus luteum. turns out baby was ectopic after all; another lap 5/6 (@24dpo).

    the universe can fuck off.


     "You are overly paranoid and delusional that every one is out to get you." -lastsliverofhope

    Baby Birthday Ticker Ticker
    all AL welcome. TTC #2 for 43 44 months.
    follow my infertility journey here at timestandsstillblog.com

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  • fuzzbumblefuzzbumble member
    Jodee37 said:

    does RE have insight for you? sounds like you were WAY over-suppressed. i want to wring your REs neck for not cancelling you sooner while you were stimming... there comes a point when it's obv its not going well and i think he dropped the ball.  not cool since you are paying OOP for some of this.


    i agree changing the protocol altogether sounds like a good idea.  big hugs lady.  
    All of this. I'm sure the new protocol will be awesome for you!

    image

    June 19, 2010 - Miracle Baby Girl

    Round 2
    Since March 2013
    BFP April 2013 - Missed M/C July 2013 @ 12w6d
    BFP December 2013 - CP @ 4w3d
    Eight medicated cycles, three IUIs: FAIL
    IVF #1 Antagonist - January 2015: CP/FAIL

    IVF #2 April 2015: Microdose lupron Flare
    ICSI, CCS Freeze all
    6 blasts biopsied/5 normal

    FET #1 June 25, 2015 6AA and 5AA blast transfer
    BFP 3dp5dt!
    Beta 8dp5dt 195.2, 10dp5dt 474.8, 12dp5dt 977, 22dp5dt 25,580
    <3 Twins! Our boy and girl coming end of February!  <3

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  • lilmac2929lilmac2929 member
    Oh I am so sorry.  I hope you get a new protocol and a much better response.  Hugs. 
    DS: Born November 2011
    TTC #2 since April '13
    DH 35, Me: 34
    DX: Unexplained Secondary Infertility, Slight DOR
    Sept 14 - IUI (Clomid + Ovidrel) = BFN
    Oct 14 - IUI (Clomid + Ovidrel + Progesterone) = BFN
    Nov 14- Benched due to cysts Looking for New Doc
    Feb - IUI #3 (Letrozole + Ovridrel)
    March/April - IVF #1 - Antagonist Protocol - Follistim+HGH+Low Dose HCG - 11R/9M/5F - 2 8 cell 3dtransfer - BFN on April 23, 2014


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  • NB817NB817 member
    I am so sorry! I agree with the ladies! Hopefully a new protocol or second opinion will help give you some answers and better results. HUGS!

    ME: 35 DH: 39

    Married July 2011

    DD Born 8/12

    TTC #2 since 11/13

    ME: Submucosal Fibroid Surgery Date APRIL 14th 2015 -Left Tube is blocked by Fibroid~Surgeon removed 26 Fibroids from my Ute and Unblocked my Tube

    DH:Azoospermia...Thank God we have 12 vials of frozen swimmers

    July 15-Check to see if Ute is all healed

    IUI #1 8/3/15...BFN

    IUI #2 9/5/15...BFP on 9/17/15

    Beta #1-344

    Beta #2-809

    Beta #3 8,390

    1st u/s 8/8/15 1 bean HB 135 @ 6w5d



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  • 1983Lindsey21983Lindsey2 member
    Bummer!!  I am so sorry that didn't work the first time, but FX that this next protocol will get your ovaries in gear!
    ~~ All Welcome~~
    ME: 32, SER aggregates on eggs, anovulatory
    DH:  33, 2% morphology
    TTC #1 
    2 clomid cycles, 3 hybrid clomid/bravelle IUI's = 4 BFN/1 CP@ 5.5 weeks
    IUI #6 -Follitism IUI cycle converted to IVF and back to IUI-4 mature, 3 maybe mature = BFP!!   DS Born 9/2014
    TTC#2 
    IVF #1 9/15 Antagonist- 19 R 1F (Frozen day 1 @ 2PN stage) Diagnosed with SER aggregates in 13/19 eggs after failed fertilization
    IVF #2 11/15 Antagonist w/ICSI  (Higher stims & Letrosole added last minute on stim day 7)- 39R, 24M (20/24 SER free), 15F (14/15 SER free & all frozen @ 2PN stage) 
    FET#1 Cultured all 16- 2pn embryos to day 5- transferred 1 good hatching blast and 1 early blast on 1/28- None to freeze - beta 2/5

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  • FlamingemuFlamingemu member
    Ditto what all the other ladies said. FX the new protocol works better for you. Sorry this shot was a dud.

    Kid #1 - 09/03/12
    Kid #2 - maybe???
    Diagnosed with Severe Ashermans 
    Hysteroscopy #10 - scar tissue grew back reblocking my right tube
    #11 or IVF with scarring still inside?
    1 lone embryo from September 2016 retreival, dx with Trisomy 16, starting fresh
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  • AprilDrew04AprilDrew04 member
    I already had a talk with the RE. This is the only place that I can do IVF without driving over an hour for appts.

    I was on BCP for just over a month and lupron for for a few weeks before stimming. The RE felt I was over-suppressed. So next time no BCP and a short lupron use before stimming.

    Thanks for your support.

    Image and video hosting by TinyPic 

    DD conceived after 3 years of ttc.
    MFI - DH had varicocele repair and took Clomid to get DD b. 02/2010

    TTC #2 since 6/2010
    10/2012 DH diagnosed with Epilepsy
    A few failed IUIs summer 2012 and 2013. 
    DH taking clomid and waiting to see if he needs another vericocele repair. 
    Hoping for a 2015 baby or babies. 
    Wishing, hoping, waiting.


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  • Davie813Davie813 member
    AprilDrew04 said:I already had a talk with the RE. This is the only place that I can do IVF without driving over an hour for appts.

    I was on BCP for just over a month and lupron for for a few weeks before stimming.     The RE felt I was over-suppressed. So next time no BCP and a short lupron use before stimming.

    Thanks for your support.

    That sounds like a     lot of suppression.  I bet the new protocol will be much better!
    *****Signature/Ticker Warning******

    Me: 41, DH: 45
    DD, 6/15/2013
    TTC #2 beginning January 2014
    AMH 1.05; FSH range 7-11

    July 2014: IUI #1.  Follistim + Pregnyl.  2 follicles--BFN
    September 2014: IUI #2.  Follistim + Pregnyl + Ganirelix + Crinone.  4(?) follicles--BFN
    October 2014: IUI #3.  More Follistim + More Ganirelix + Pregnyl + Crinone.  4 follicles--BFP!  Beta #1=10 Beta #2=33 Beta #3=97 Beta #4=158.  M/C 11/1/14
    December 2014: IVF #1.  Microdose Lupron protocol.  9R, 9M, 9F.  3 5-day blasts transferred 12/15. BFFN.
    April 2015: IVF #2.  Microdose Lupron protocol.  16R, 15M, 12F. Transferred 2 5-day blasts 4/12 and froze 4--BFP!  M/C 5/25/15
    August 2015: IVF #3.  14R, 13M, 11F.  Froze 5 blasts for CCS testing.  3 normals.  FET planned for 10/2015.



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  • MoFreeMoFree member
    I'm very sorry. FX a change in protocol yields better results.
    TTC since 3-08 IVF # 1 Dec 2011 BFP DD born at 31 weeks 6-24-12

    FET #1 Dec 2013 BFN

    FET # 2 Feb 2014 BFN

    No more frosties

    IVF #2. September 2014

    PGD yielded 2 perfect 5d blasts

    SET November 9, 2014
    Nov 23, 2014. Another BFN

    Not sure where to go from here.

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  • 1983Lindsey21983Lindsey2 member
    Hope the new protocol helps!!  I didn't know you could be oversuppressed, but that makes total sense.  I don't know much about protocols for IVF as I am just about to do my first IVF cycle. FX for you next time! 
    ~~ All Welcome~~
    ME: 32, SER aggregates on eggs, anovulatory
    DH:  33, 2% morphology
    TTC #1 
    2 clomid cycles, 3 hybrid clomid/bravelle IUI's = 4 BFN/1 CP@ 5.5 weeks
    IUI #6 -Follitism IUI cycle converted to IVF and back to IUI-4 mature, 3 maybe mature = BFP!!   DS Born 9/2014
    TTC#2 
    IVF #1 9/15 Antagonist- 19 R 1F (Frozen day 1 @ 2PN stage) Diagnosed with SER aggregates in 13/19 eggs after failed fertilization
    IVF #2 11/15 Antagonist w/ICSI  (Higher stims & Letrosole added last minute on stim day 7)- 39R, 24M (20/24 SER free), 15F (14/15 SER free & all frozen @ 2PN stage) 
    FET#1 Cultured all 16- 2pn embryos to day 5- transferred 1 good hatching blast and 1 early blast on 1/28- None to freeze - beta 2/5

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  • STL34STL34 member
    I am sorry you are going through this.  ((HUGS))  I hope the new protocol helps. 

    imageimage


    ~SAIF/PAIF/Everyone Welcome~ 

    Me= 37 and DH = 41 

    Dx: DOR, Endo, APA+ (really high beta 2 glycoprotein antibody and high everything else tested), heterozygous MTHFR mutation, positive for lupus anticoagulant, high FSH, low AMH and both tubes blocked (per HSG on 3/8/11)

    IVF #1 - long lupron (with HGH, intralipids, lovenox and BA); 4 retrieved, 3 fertilized; ET 2 blasts and 1 frozen = BFN

    IVF #2 - a version of antagonist with EPP (with HGH, intralipids, lovenox and BA); 6 retrieved, 4 mature, 3 fertilized, 2 blasts and 1 frozen blast transferred on day 5 = BFN.

    IVF #3 April was postponed to May, May was canceled. June/July was canceled. Had a cyst aspiration and then began IVF #3 in August. ER on 8/22; ET on 8/24 with AH. +HPT on 9/5. Beta #1 (11dpo) = 3; Beta #2 (15dpo) = 29; Beta #3 (17dpo) = 60; Beta #4 (19 dpo) = 118. Heartbeat at 6 weeks 6 days =132.  Lil is here!

    TTC#2:  Trigger + TI = BFN; Clomid + Trigger + IUI = BFN.

    IVF #4:  BCP + MDLF + Lovenox = 7R, 1F = Transferred 1 6-cell embryo on day 3 = BFN

    IVF #5:  MDLF + Lovenox = 4R, 1F = Transferred 1 10-cell compacting embryo on day 3 = BFN

    IVF #6:  (New RE):  Long Antagonist November 2014 (transferred two 8 cell grade 1 embryos and froze one blast) = BFN

    FET#1:  BFN

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