TTC After a Loss

Chronic endometritis?

Hi ladies!  I got a call from my RE this afternoon that has left my head spinning.  The results of my endometrial biopsy in December came in and were positive for "significant chronic endometritis" (not endometriosis).  I had no idea what it was until he explained but basically I have this non-symptomatic infection in my endometrium.  He doesn't know how long it's been there but the lab was able to say it wasn't a new onset infection.  He only did a biopsy because he was already doing a SIS and had just read this paper ("Chronic endometritis due to common bacteria is prevalent in women with recurrent miscarriage as confirmed by improved pregnancy outcome after antibiotic treatment").  The plan is to do a course of antibiotics when I get AF (should be sometime in the next couple of days) and that *should* knock out the infection.  I'm curious if anyone else here has any experience or a diagnosis of chronic endometritis?  Has your doctor indicated it has caused fertility issues for you?  This is the first time a test has ever showed anything for me.  Every thing else has always come back normal.  I know it's not a guarantee that this is the cause of our RPL but it's definitely set my head spinning since everything for half a year has been explained as poor egg quality with recommended treatment of IVF/PGD.  Anyway, thanks to all those listening to my ramble! :)
Me: 31     DH: 33
Dx: Me: Recurrent Pregnancy Loss; DH: Low Morphology (2%)
BFP#1: MC 3/1/11 at 6w1d - EDD 10/21/11
BFP#2: 5/3/11 - EDD 1/9/12 - DD Born 1/6/12
image
TTC #2 since 12/13
BFP#3: MC 2/8/14 at 4w5d - EDD 10/13/14
BFP#4: MC 5/6/14 at 4w4d - EDD 1/9/15
BFP#5: MMC discovered 8/4/14 at 9w1d - D&C 8/5/14 - Baby Boy with Trisomy 16 (maternal origin) - EDD 3/8/15
BFP#6: CP 11/6/14 at 4w2d - EDD 7/14/15
IVF #1 with ICSI & PGS: May/June 2015, ER 6/3/15, 17R/17M/15F
IVF #2 with ICSI & PGS: July 2015, ER 7/16/15, 16R/11M/9F
PGS results = 6 normal embryos (4 boys, 2 girls)
FET 9/23/15 = BFFN
Natural FET 11/4/15 = BFP!
Beta 9dp5dt = 92

Re: Chronic endometritis?

  • So many ((hugs)) lady!!!!!
    image
    Hubs & I -29 • Met 5/18/04 • Married 5/8/10
    BFP #1 DS 2/7/11 (Born @ 34 wks via ECS due to Pre-e) TTC #2 since Aug '13
    DX Low AMH (.58) March '14 • FSH-7.5 • E2-35.5 (Nov '14)
    SA- Great numbers • SIS- Clear (Nov '14)
     Cycle 1- Clomid CD3-7 & Trigger-BFP • EDD 1/12/15 
    Ectopic @ 5w6d • Methotrexate Shot 5/18/14
    Cycle 2,3,4- Clomid CD3-7 & Trigger-- BFN
    Cycle 5- Letrozole CD3-7 & Trigger BFFN
    image
    • Everyone Welcom
    TTCAL January Siggy Challenge • Animal Snow Interactions
    image


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  • I don't have any experience and my head would be spinning too! *hugs* for you
    I am not sure how to say this without getting a "solicitation" warning so I guess I just say that I am not longer active on THIS site. 



  • I don't have any experience, but wanted to send hugs your way!
    Together since April 2004.  Married since June 19th, 2010.
     BFP #1: January 31st 2012: CP. 
     BFP #2: June 1st 2012, Due:2/8/13. Avery was born via unplanned c section on 2/13/13. 
     BFP #3: Sept. 25th, 2014. Due: 6/5/15.  MMC on 10/23/14. Confirmed complete molar pregnancy per D&C 10/29/14, 
    HCG officially negative 12/10/14.  Benched until June 2015.
                                                        
    image 

  • I'm sorry to hear this. I have no experience, but sending hugs.xx

    Proudly on the dark side

  • This is what my RE was hoping I had and that's why he put me on 4 weeks of doxy! My doc said it's definitely thought to be a cause of infertility. He was hoping that's where my fluid was from but my biopsy results were negative. I did the antibiotics anyway because many practices will put you on doxy anyway before IVF/FET as a precautionary measure. Obviously I have a bigger issues but the doxy did clear up my acne I've had for years.

    I hope this is it for you!!!!!!!!!!!!!!!!!



    imageimageimage
    image
    My FF Chart:
    http://www.fertilityfriend.com/home/490dd7
    TTC #3 since June 2013
    BFP #1 7/21/2013--EDD 3/30/14--D&C 9/24/13
    BFP #2 1/28/14--MC 2/7/14

    IUI #1 5mg Femara + trigger = BFN
    IUI #2 5mg Femara + trigger = BFN
    IUI #3 5mg Femara + trigger = BFN
    IVF #1, Stimmed for 12 days, ER 8/22/14, 9 retrieved, 7M, 7F!!  Freeze all due to fluid in uterus.
    FET end of October 2014 cancelled due to fluid in uterus due to possible c-scar defect
    Surgery scheduled 12/12/14 to fix possible isthmocele
    3/26/15 transferred one 8 cell grade 4 embryo and one 6 cell grade 3 embryo = slow rising betas for 2+ weeks = ectopic MTX shot 4/29/15
    Repeat c-scar surgery June 2015
    2nd and last IVF cycle August 2015, stimmed for 12 days, 2 egg retrieved, both mature and both fertilized.  Transferred both 8-cell embryos on Day 3, beta 9/5/15 = BFFN
    MOVING TO ADOPTION!  


  • I hope that treating the infection is the trick for you!

    4 Losses (2003, 2008, Apr 2012, & Oct 2012)
    All RPL and IF testing with multiple REs = normal

    5 IUIs = BFN

    All AL are welcome
    Image and video hosting by TinyPic

  • I hope the antibiotics help. (Hugs)

    Me: 31 DH: 36
    Dated Since ‘02, Married in ‘06
    BFP#1 05/16/06, EDD01/16/07, MC 06/12/06 at 8 weeks
    BFP #2 08/14/14, EDD 04/22/15, MC 09/17/14 at 9 weeks

    image 

     My Chart

  • Thanks ladies!  I'm glad your docs have heard of this too and looked for it @Pickles4Prez and @Frenchteachermama.  That makes me feel better!  I'll be doing a 7 day course of doxy 2x/day.  I hope it has the side effect of clearing up my acne too! ;)
    Me: 31     DH: 33
    Dx: Me: Recurrent Pregnancy Loss; DH: Low Morphology (2%)
    BFP#1: MC 3/1/11 at 6w1d - EDD 10/21/11
    BFP#2: 5/3/11 - EDD 1/9/12 - DD Born 1/6/12
    image
    TTC #2 since 12/13
    BFP#3: MC 2/8/14 at 4w5d - EDD 10/13/14
    BFP#4: MC 5/6/14 at 4w4d - EDD 1/9/15
    BFP#5: MMC discovered 8/4/14 at 9w1d - D&C 8/5/14 - Baby Boy with Trisomy 16 (maternal origin) - EDD 3/8/15
    BFP#6: CP 11/6/14 at 4w2d - EDD 7/14/15
    IVF #1 with ICSI & PGS: May/June 2015, ER 6/3/15, 17R/17M/15F
    IVF #2 with ICSI & PGS: July 2015, ER 7/16/15, 16R/11M/9F
    PGS results = 6 normal embryos (4 boys, 2 girls)
    FET 9/23/15 = BFFN
    Natural FET 11/4/15 = BFP!
    Beta 9dp5dt = 92

  • I have no advice, or knowledge of this, just ((((HUGS))))
    TTC #3 since 8/2012 image
    DX Endometriosis 2/2002 (lost left tube due to a cyst), PCOS
    6/2010
     BFP - 10/18/2012, EDD - 6/26/2013, Baby Girl lost at 22 weeks (T21), D&E 2/15/2013
    BFP - 4/23/2014, EDD - 1/2/2015 Twin Boys lost at 12 weeks, M/C 6/25/2014

    My chart here  All ALers welcome!
    Baby Birthday Ticker Ticker
    Lilypie Angel and Memorial tickersLilypie Angel and Memorial tickers
    June 3Missing Our January Snowflake
  • rslh10rslh10 member
    edited January 2015
    Sorry to highjack-- @Pickles4Prez‌ where have you been!?! Come back to us sweet lady! >:D<
    image
    Hubs & I -29 • Met 5/18/04 • Married 5/8/10
    BFP #1 DS 2/7/11 (Born @ 34 wks via ECS due to Pre-e) TTC #2 since Aug '13
    DX Low AMH (.58) March '14 • FSH-7.5 • E2-35.5 (Nov '14)
    SA- Great numbers • SIS- Clear (Nov '14)
     Cycle 1- Clomid CD3-7 & Trigger-BFP • EDD 1/12/15 
    Ectopic @ 5w6d • Methotrexate Shot 5/18/14
    Cycle 2,3,4- Clomid CD3-7 & Trigger-- BFN
    Cycle 5- Letrozole CD3-7 & Trigger BFFN
    image
    • Everyone Welcom
    TTCAL January Siggy Challenge • Animal Snow Interactions
    image


  • Just piling on some more (((hugs)))

    PgAL welcome


    Married 6/11/2011

    Me & Hubby: 34

    TTC journey started 12/2012

    BFP #1 6/5/2013, MC confirmed 6/26/2013 @ 7 wks

    BFP#2 8/25/2013 MC confirmed 10/16/2013 @ 12 wks (D&C 10/18)

    Diagnosis: unexplained RPL, unexplained IF.

    Also have hypothyroidism

    Started TTC again 12/2013

     

    IUI#1:Clomid CD 3-7, Trigger'ed CD 12. IUI CD 14. BFN

    IUI #2:Letrozole CD 3 - 7, Follistim CD 9, Trigger CD 10, IUI CD12. BFN

    Current plan: IVF with PGD. Antagonist - Vivelle Protocal. Stim start 12/1. ER 12/14.

    http://www.fertilityfriend.com/home/502498

    image imageimage

    image


  • No advice, but FX clearing up the infection is helpful! ((Big Hugs))
    image
    I'll be at a new place providing support. 


  • MrsG80inTNMrsG80inTN member
    edited January 2015
    Lots of hugs lady, but hopefully this gives you a good path for the future.

    Me 35 / DH 36
    TTC since 09/2009
    Hashimoto's diagnosis 11/2011 / Endometriosis removal surgery 04/2013
    Other diagnosis: 1 mutation - PAI-1 gene
    BFP#1 9/27/2013  /  EDD 6/4/14  /  MC 10/17/2013
    BFP#2 3/4/14  /  EDD 11/13/14  /  CP
    BFP#3 6/7/14  / EDD 2/16/15  /  CP
    BFP #4 11/7/2014 / EDD 7/17/15  /  CP
    Current  Plan: Waiting to change RE... Appt on 1/16
    RXs: Metformin, Levothyroxin, Baby Aspirin, CoQ10, Vitamin D, Folic Acid, Pre-natal. Progesterone post O.

    imageimage
    ***Jeremiah 29:11 For I know the plans I have for you, says the Lord, plans to prosper you and not to harm you, plans to give you hope and a future.

    All Welcome


  • I don't have any advice, but I hope the antibiotic treatment is successful for you! ((hugs)) and thank you for sharing this info. I have RPL too, and I will be sure to ask my RE about this at my first appointment next week.
    --------------------------------------------------------------------------------------------------------------------
    Me: 31, DH: 30, Married July 2013
    TTC since March 2014
    BFP#1  5.17.14, EDD 1.26.15, MMC (measuring 6w3d at 8w3d), D&C 6.26.14
    BFP#2  9.19.14, EDD 5.29.15, AF on 9.23.14 CP
    BFP#3  12.17.14, EDD 8.25.15, AF on 12.21.14 CP#2

    Current plan: TTC while waiting for RPL results to come back
    Stalk my ute

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