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XP:dropping E2 levels in early pregnancy

Leah112Leah112 member
in Pregnant after IF
Hi ladies, I have not posted here in quite some time ( I took a bump break following my loss in June) but wanted to see if anyone had any insight into dropping e2 level in early pregnancy? Last week my e2 level was 900 something and yesterday it was 800. My RE office is having me repeat my E2 level again this week because of the drop. They said that the drop was not "significant" but want to make sure it does not keep dropping. I tried to find more info on this but nothing seems to fit my situation so I decided to post. Any info or experience would be greatly appreciated! TIA!
image TTC#1 Since 10/2011 Dx PCOS 3/2012- started on 1500mg Metformin November 2012 DH diagnosed with varicocele- surgery completed April 2013 1st appointment with RE October 2013-polypectomy to remove uterine polyp October 2013 all necessary testing completed only option is IVF with ICSI due to MFI IVF #1-January 2014 ER- 22 retrieved 18 mature 17 fertilized!!! February 2014 ET one 8aa embie transferred 13 frozen (of the 13 9 were 8aa embies)-BFP! No heartbeat at 22 week anatomy scan-Our sweet angel FET#1- October 2014 transferred two frosties -BFP! 1st beta 271, 2nd beat 6748 5 week ultrasound shows two sacs repeat in 10 days
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Re: XP:dropping E2 levels in early pregnancy

  • blueberries8blueberries8 member
    Every time I've done the antagonist protocol, my E2 seems to crash at the end of the 2ww even when I am pregnant. My RE has never been really concerned about it since there is no clear correlation between E2 and miscarriage as there is with progesterone. Are you taking oral estrogen? Maybe your RE will increase the dose a little? Congrats on your pregnancy, btw :) 
    IUIs #1-3 (1x unmedicated, 2x Clomid) = 2 BFNs, 1 m/c at 7w3d
    IUIs #4-6 (injects) = 3 BFNs
    IVF #1 = BFN
    FET #1 = BFN
    FET #2 = BFN
    IVF #2 = BFP, b/g twins lost at 20w due to partial abruption/PPROM
    IVF #3 = c/p 5w2d
    Long-shot Clomid/Prednisone cycle before next IVF = BFP, our beautiful, healthy girl born 6/26/13!
    ~~
    TTC again March 2014
    FET #3 - May/June 2014     -     all embryos arrested before xfer - back to the drawing board...
    IVF #4 - July/August 2014 
    beta 1 (11dp3dt) 220, beta 2 (13dp3dt) 671, beta 3 (19dp3dt) 10762
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  • Pintobean39Pintobean39 member
    Are you on Estrogen supplements? My e2 was never the same every time they took it and my RE never seemed concerned about it. I actually started decreasing the estrogen I was taking early on. Since I did a FET the medication I took was the only estrogen I was getting.
    Fucking bump!!!!
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  • Leah112Leah112 member
    Yes I am on vaginal estrace(1mg twice per day). The nurse gave me no instructions to increase so I am still on the same dose. She did mention that they only check my E2following a FET but didn't elaborate anymore on it.
    image TTC#1 Since 10/2011 Dx PCOS 3/2012- started on 1500mg Metformin November 2012 DH diagnosed with varicocele- surgery completed April 2013 1st appointment with RE October 2013-polypectomy to remove uterine polyp October 2013 all necessary testing completed only option is IVF with ICSI due to MFI IVF #1-January 2014 ER- 22 retrieved 18 mature 17 fertilized!!! February 2014 ET one 8aa embie transferred 13 frozen (of the 13 9 were 8aa embies)-BFP! No heartbeat at 22 week anatomy scan-Our sweet angel FET#1- October 2014 transferred two frosties -BFP! 1st beta 271, 2nd beat 6748 5 week ultrasound shows two sacs repeat in 10 days
    Report Reply
  • gsanchogsancho member
    I had a big drop when I was about 5w.  They told me that fluctuations weren't unusual, especially if you were on meds.  But I went from about 1400 to 106, which was a huge drop.  They still calmed me by saying it wasn't as crucial as progesterone and hgc, and technically a lot of REs don't even check E2 after the first beta.  They switched up my E2 meds and I was back up to 2000 the next time.  Your drop wasn't very significant, so I think it's fine.  My RE said as long as it's above around 500, they don't worry much.


    Me 33, DH 37 -- TTC since Jan'12 -- Low AMH (0.78) & endo, SA w/ low motility
    IUI's 1-3 = BFN, IVF converted to IUI 4/13 = BFN
    IVF 1.2: 8R 6M 4F -- 2 blastocysts frozen, FET 8/15 = BFP!!
    Beta #s = 445;1,098; 9,545  -- EDD 5/2 -- Team Pink!
    Camila Josephine arrived 4/30 :)
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