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Intro - RPL, PCOS, IVF mentioned - question on chromosomal losses

LilyHarperLilyHarper member
edited October 2014 in TTC After a Loss
Hi Ladies, How are you all doing? I'm a long time lurker, and I think it's finally time I join in, so I hope you'll have me! As always, I'm sorry that we're all here. Most of my information is in my siggy, but basically, I'm 31, have had 3 confirmed mc's. I was diagnosed with PCOS but waited to seek treatment for a while. We left our original RE because we didn't feel they were being aggressive enough, nor taking my losses seriously, since I was seen as "young". The most recent mc was originally confirmed to be a normal karyotype by Natera, but the secondary pathology found it to be a tetraploidy following ICSI (which, uh, shouldn't happen?). Natera confirmed it was possible their test could come back as normal, but be a tetraploidy (with 2 sets from myself, and 2 from my husband) . I love my new RE, but he has no poker face and said no one in the practice had ever seen this before, especially with my previous loss of a triploidy. I know he's going to research the hell out of this and all, but has anyone experienced both a tri and a tetra? I just posted this on IF as well. Thank you ladies! ETA for correct terminology.
Yup.
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Re: Intro - RPL, PCOS, IVF mentioned - question on chromosomal losses

  • jjbmstincojjbmstinco member
    Welcome to the board.  I am sorry for your loss.

    December 4                     image

    Married-1/2012
    TTC-8/2013   BFP-4/18/14  EDD: 12/29/12 MC-5/17/14 @ 7w4d
    BFP #2-11/13/14  EDD: 7/26/14  Beta #1: 11/14/13 (135 progesterone: 19.5)   Beta #2" 11/17/14 (733 ) 
    Hoping for good news!

    Everyone Welcome

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  • rubysirubysi member
    Welcome. I am sorry for your loss.

    image
                ***TTCAL January siggy challenge ***
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  • [Deleted User][Deleted User] member
    Welcome.   I'm so sorry about your loss.
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  • LilyHarperLilyHarper member
    Thanks ladies. @lav17, we did the RPL testing and everything came back normal as well. Don't think I've ever been so frustrated to have tests come back normal! I'm glad to hear your RE is positive. :)
    Yup.
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  • LilyHarperLilyHarper member
    @ktlovess‌ normal karyotypes. I just pm'ed you (I think!)
    Yup.
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  • meredithcarolemeredithcarole member
    So sorry for your losses.
    TTCAL January Siggy Challenge: Animals in the Snow

    image

      
    About Me: 

    AMA 35 :  DH 33
    BFP#1 1/26/14 (EDD: 10/7/14).  MMC 3/10/14 D&C 3/14/14
    RE Consult 11/3/14 - AMH 2.25 "great" . FSH 7.10 . Low Vitamin D
    Myomectomy 12/17/14.  Benched until March.

    image

    My Ovulation Chart
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  • ctk181ctk181 member
    Welcome. I'm so sorry for your losses.
    Married: 4/28/12
    BFP: 7/2/14 ;  1st US 7/21/14 Baby measuring 7w5d, HB of 138;  Discovered MMC 8/18/14 at 11w2d, baby measuring 8w5d, no hb ; 8/19/14 D&C
    image

    TTCAL December siggy challenge - Autocorrect Fails

    image

    | <a href="http://www.fertilityfriend.com" style="font-size:smaller;" >Ovulation Tracker</My Chart

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  • RachaeleighRachaeleigh member
    Sorry for your losses. We haven't ever found a reason for our losses either, very frustrating.
    Welcome

    4 Losses (2003, 2008, Apr 2012, & Oct 2012)
    All RPL and IF testing with multiple REs = normal

    5 IUIs = BFN

    All AL are welcome
    Image and video hosting by TinyPic

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  • FutureMrsWright2012FutureMrsWright2012 member
    No advice, but sorry for your losses.
    TTCAL December Siggy Challenge: Autocorrect Fails
    image


    ***siggy warning*** 

    TTC since 3/2012 
    DH - 34; nml swimmers; Me - 34; sinking AMH (now 0.55), low AFC, nml FSH/LH 
    Clomid + IUI #1 (6/2013) - BFN; #2 (7/2013) - BFFN 
    Bonus info: me - low TNF, low vitamin D, borderline low IGF (all improving) 
    IVF (May/June2014) 5R/5F/2T (ET 6/11) - no frosties. 
    + HPT 8dp5dt. Beta #1 - 71(6/20). Beta #2 381 (6/24) 
    U/S 7/11 (one perfect little bean, HB 150's). EDD 3/1/2015
    Baby boy Lincoln Alexander's HB stopped at 18w and was delivered at 19w (10/3/2014)
    All testing normal/negative including normal chromosomes - no answers... D&C 11/20/2014
    IVF#2 coming in Spring 2015
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  • LilyHarperLilyHarper member
    Thank you everyone. @PetraStonegirl‌ my background certainly isn't bio, but I also couldn't wrap my head around how it was possible (and neither could my RE). The only thing I caught that he thought as a possibility was a meiosis error, but he was clearly just spitballing and immediately said he needed to do more research. I'm just glad because he seems to want to solve it, not kick me out. We never did DNA frag on DH, but I'm sure there's going to be lots of testing we'll be discussing...and I fully realize we might be shelving the 6 frosties we have because they weren't tested. A bit maddening.
    Yup.
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  • MSU_Girl1202MSU_Girl1202 member
    I'm so sorry for your losses. Welcome to the board
    Married 07/2006, TTC since 2010
    08/2011: Clomid 50mg, IUI --> BFN  ,
    10/2011: Clomid 100mg, IUI --> BFN
    04/13: Clomid, IUI BFP --> MC at 6w1d
    05/13: Femara 2.5mg, IUI --> BFN  , 08/13: Femara 2.5mg --> BFN
    03/14: Femara 5mg, IUI --> 1 follicle @ 27d --> BFP! EDD 12/02/14--> blighted ovum, missed MC 6w6d --> D&C
    4/23: D&C...starting over again, with a little part of my heart broken off
    5/31: Femara 7.5mg --> cancelled cycle, no follies
    7/14: Femara 5mg + brevelle + menopur + IUI --> converted to IVF, ER 7/28 --> ET cancelled due to severe OHSS.
    9/20/14:  Frozen Embryo Transfer --> BFP--> EDD 6/6/15 --> MC at 5w3d      
    10/16/14: Frozen Embryo Transfer --> BFN
    2/6/15: Frozen Embryo Transfer --> BFP --> MC at 5w4d
    3/20/16: PGS-tested Frozen Embryo Transfer --> BFP, Living Child born 12/1/15
    6/6/17: Fresh IVF Cycle --> Severe OHSS, 5 PGS-tested embryos frozen
    2/23/18: PGS-tested FET --> BFN
    3/30/18: Cancelled cycle due to lining 4.2mm
    6/21/18: PGS-tested FET --> BFN
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  • LilyHarperLilyHarper member
    @medic7979‌, seriously, no problem. I personally think more info on the chromosomal issues is better, because it seems like with the exception of the "common" ones, there isn't a lot of easily accessible info. And thank you for providing the explanation @ktlovess, between my loss and if background, I know enough to be really dangerous, and forget that (thankfully) other people don't have to know.
    Yup.
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  • [Deleted User][Deleted User] member
    So sorry for your losses. ((hugs)) welcome to the board.
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