Trouble TTC

Letrozole ladies, come in...

I'm starting my first dose tomorrow, and I always get nervous about new medications. I did some googling and it doesn't seem like people react too badly to it, but what can I expect? Did you have side effects? 


As a thank you for your time, I offer a shirtless Charlie Hunnam. You're welcome.

image

Me: 27 DH: 35

TTC #1 Since July 2013

Started RE Testing July 2014

2 HSG tests: Right tube is blocked, possible endo.

TSH elevated, started Synthroid 25 mg daily.

October, 2014: Femara 5 mg + TI ---> 3 follies on blocked tube side ---> BFN

November, 2014: Femara + Ovidrel + IUI#1--2 follies (on the good side), 46 mil. motile sperm=BFN

Nov-Dec 2014: Femara + Ovidrel + IUI #2 (1 follie, 76 mil. motile sperm) + Endometrin=BFN

January, 2014: Femara + Ovidrel + IUI #3 (1 follie, 38 mil. motile sperm)=???

New RE appt. scheduled for 1/14.


3T January Siggy Challenge: New Years Resolutions

Mine: Lose the weight I put on from booze and cookies over Christmas.

image


DSculley1824

Re: Letrozole ladies, come in...

  • Thanks @triathlete23! Also, your siggy picture is amazing. I just burst out laughing and then quickly became terrified when I saw where the stem is placed lol.

    Me: 27 DH: 35

    TTC #1 Since July 2013

    Started RE Testing July 2014

    2 HSG tests: Right tube is blocked, possible endo.

    TSH elevated, started Synthroid 25 mg daily.

    October, 2014: Femara 5 mg + TI ---> 3 follies on blocked tube side ---> BFN

    November, 2014: Femara + Ovidrel + IUI#1--2 follies (on the good side), 46 mil. motile sperm=BFN

    Nov-Dec 2014: Femara + Ovidrel + IUI #2 (1 follie, 76 mil. motile sperm) + Endometrin=BFN

    January, 2014: Femara + Ovidrel + IUI #3 (1 follie, 38 mil. motile sperm)=???

    New RE appt. scheduled for 1/14.


    3T January Siggy Challenge: New Years Resolutions

    Mine: Lose the weight I put on from booze and cookies over Christmas.

    image


    [Deleted User]
  • I got moody and mean a few days after the last dose....at least that's what I'm attributing it to ;)
    Me: 26, PCOS, Clear HSG
    DH: 29, Perfectly Normal SA

    Married Since 10/6/2012
    TTC Since 6/2013

    2/2014: Visited OB-GYN, Low Progesterone
    3/2014: 50 mg Clomid, Ovulated, BFN
    4/2014: 50 mg Clomid, Ovulated, BFN
    5/2014: 50 mg Clomid, Ovulated, BFN
    6/2014: 50 mg Clomid, Ovulated, BFN

    7/2014: First RE visit, Diagnosed with PCOS, Started on 5 mg Femara + Ovidrel + TI, 1 22mm Follicle, BFN
    8/2014: 5 mg Femara + Ovidrel + TI, 2 Mature Follicles, BFN
    9/2014: 5 mg Femara + Ovidrel + IUI #1, 3 Mature Follicles, BFN
    10/2014: 5 mg Femara + Ovidrel + IUI #2, 1 Mature Follicle, BFN
    11/2014: 5 mg Femara + 75 mg Follistim + Ovidrel + IUI #3, 3 Mature Follicles, BFN
    12/2014: Starting IVF in January

    1/2015: IVF with ICSI, Currently Stimming

    *****Everyone is Welcome*****

    BandM14mmmKayy
  • Loading the player...
  • Thanks so much for sharing, ladies. @DaydreamSam I'm sorry that you went through the depression, but I'm glad that it didn't last long. If I feel moody I'm sure it will help to remind myself that it's only temporary. 

    @je333206 I've already been moody and mean over IF, so if I can blame it on the meds for a few days I will jump all over that. 
    >:)

    Me: 27 DH: 35

    TTC #1 Since July 2013

    Started RE Testing July 2014

    2 HSG tests: Right tube is blocked, possible endo.

    TSH elevated, started Synthroid 25 mg daily.

    October, 2014: Femara 5 mg + TI ---> 3 follies on blocked tube side ---> BFN

    November, 2014: Femara + Ovidrel + IUI#1--2 follies (on the good side), 46 mil. motile sperm=BFN

    Nov-Dec 2014: Femara + Ovidrel + IUI #2 (1 follie, 76 mil. motile sperm) + Endometrin=BFN

    January, 2014: Femara + Ovidrel + IUI #3 (1 follie, 38 mil. motile sperm)=???

    New RE appt. scheduled for 1/14.


    3T January Siggy Challenge: New Years Resolutions

    Mine: Lose the weight I put on from booze and cookies over Christmas.

    image


    [Deleted User]
  • I had hot flashes a few time and a little dizziness, but nothing horrible.  I had no side effects with clomid.
    BandM14
  • Between the letrozole and metformin I get crazy cravings for food :/ other then that in good. Best of luck and I love your pic
    BandM14
  • I was very tired & had hot flashes. I started taking my meds in the evening & it helped a ton as I was asleep for most of the side effects.

    image

    Me: (30) HSG/Bloodwork/Ultrasound: All looks good

    DH: (30): MFI

     IUIs #1-4 = BFN


    IVF #1 December January


    **********************All Welcome**********************

    January 3T Siggy

    image


    BandM14
  • Ditto @kcheese ... I took mine right before bed, and the only thing I noticed was hot flashes/night sweats... But that was it.
    :: Me: 30 ~ DH: 27 ::
       :: TTC since Oct 2013 ~ NTNP since Dec 2010 ::
    :: DX: PCOS Characteristics & MFI ::
    ~May 2014: 1st Consult with RE~
    ~SA #1/#2 (low on all #'s), HSG (found non-threatening uterine fibroid)~
    ~*1500mg Metformin Daily*~
    *June: Medicated Cycle #1: 5mg Letrozole + Trigger + TI + Progesterone = BFN* 
    *July: Medicated Cycle #2: 5mg Letrozole + Trigger + TI + Progesterone = BFN*
     *Aug: Medicated Cycle #3: 5mg Letrozole + Trigger + TI + Progesterone = BFN*
    *Sept: IUI #1: 5mg Letrozole + Follistim + Ovidrel + IUI + Progesterone = BFN*
    Possibly Looking at IVF.. RE Suggested DH See a Urologist Before Moving On With Treatments 
    *Currently on a Break*
    ~*All Welcome*~
     

    image 

     ::: 3T November Siggy Challenge: Animals Being Jerks:::
    BandM14
  • Hey there! Just did my first round last Mon-Fri. The first day I had hot flashes and headaches. After that the physical side effects were minimal, mostly just night sweats. 

    However, like @daydreamsam, I had waves of feeling emotionally upset and weepy. I tried to keep reminding myself "these feelings aren't real, it's just chemicals." If I let myself cry it out for 15 minutes or so, the feelings usually passed.

    Best of luck - hopefully you are like some of these lucky ladies who had zero symptoms!
    BandM14[Deleted User]
  • Thanks so much everyone! Sounds like I can expect to be a little uncomfortable and emotional perhaps, but nothing crazy (if I turn green, or grow an extra ear or something I'll definitely be reporting back to you all).

    Also, based on your advice I'll try starting it at night and see how that goes! Thanks again for taking the time to respond

    Me: 27 DH: 35

    TTC #1 Since July 2013

    Started RE Testing July 2014

    2 HSG tests: Right tube is blocked, possible endo.

    TSH elevated, started Synthroid 25 mg daily.

    October, 2014: Femara 5 mg + TI ---> 3 follies on blocked tube side ---> BFN

    November, 2014: Femara + Ovidrel + IUI#1--2 follies (on the good side), 46 mil. motile sperm=BFN

    Nov-Dec 2014: Femara + Ovidrel + IUI #2 (1 follie, 76 mil. motile sperm) + Endometrin=BFN

    January, 2014: Femara + Ovidrel + IUI #3 (1 follie, 38 mil. motile sperm)=???

    New RE appt. scheduled for 1/14.


    3T January Siggy Challenge: New Years Resolutions

    Mine: Lose the weight I put on from booze and cookies over Christmas.

    image


    [Deleted User]
  • After doing Clomid for 5 months, Letrozole seemed so much nicer. I only had hot flashes and a few headaches here and there. So much easier than the crazy lady I became on Clomid with horrible bloating and being uncomfortable all month.

    Good Luck with your first round!



    Me: 32 DH: 34 Married 7/08 DD Born 8/09 
    TTC#2 Since 2/13 (Secondary IF)
    2/13 thru 2/14 - Year of charting, OPK and TI
    3/14 thru 7/14 - Clomid cycles, DH SA came back good
    8/14 - HSG and more blood work
    9/14 - Letrozole + trigger + IUI#1 = BFN
    10/14 - Letrozole + Bravelle + trigger + IUI#2 = BFP!! EDD 7/27/15
    BandM14
  • The user and all related content has been deleted.
    BandM14
  • Thanks @cwuredhot‌ , @hrushka‌ , and @PeanutRN‌ ! I am starting at 5 mg... Not sure why the Dr decided on that, he never really discussed dosage with me. I already ovulate regularly on my own, so I'm surprised he wouldn't start with the lowest dose, but I also have a potentially blocked tube so maybe he wants to try to get follicles on the good side.

    Thanks again, I feel better hearing all of your feedback :).

    Me: 27 DH: 35

    TTC #1 Since July 2013

    Started RE Testing July 2014

    2 HSG tests: Right tube is blocked, possible endo.

    TSH elevated, started Synthroid 25 mg daily.

    October, 2014: Femara 5 mg + TI ---> 3 follies on blocked tube side ---> BFN

    November, 2014: Femara + Ovidrel + IUI#1--2 follies (on the good side), 46 mil. motile sperm=BFN

    Nov-Dec 2014: Femara + Ovidrel + IUI #2 (1 follie, 76 mil. motile sperm) + Endometrin=BFN

    January, 2014: Femara + Ovidrel + IUI #3 (1 follie, 38 mil. motile sperm)=???

    New RE appt. scheduled for 1/14.


    3T January Siggy Challenge: New Years Resolutions

    Mine: Lose the weight I put on from booze and cookies over Christmas.

    image


  • The user and all related content has been deleted.
    BandM14
  • I had really bad drowsiness, dizziness and headache. Stopped when I started taking them right at bedtime. Other than that I got terrible hot flashes. Nothing I haven't lived to tell about ;-)
    BandM14
  • Last cycle (5mg) I had major headaches. I could hardly deal. This cycle (7.5) I had only a minor headache on 2nd day of meds. Other than that notta it was FABULOUS! After 3 rounds of the clomid crazies it was such a reliefe I had no idea Femara wa!s so much better
    *** Siggy Warning ***
    Me:30 DH:33
    TTC since 10/12 
    HSG- Tubes Clear slight scarring on UTE (unexplained)
    DH SA- Normal
    10/12-6/13 Natural 
    Pcos Dx 7/13 Metformin 500mg x2 daily
    4/14 Provera  10days  then Clomid 50mg CD5-9 (BFN)
    5/14 Provera 10days then Clomid 50mg CD5-9  (BFN)
    6/14 (no provera yay!) Clomid 50mg CD5-9  (BFN)
    7/14 Natural Cycle Moving on to RE appt not til 7/31 (BFN)  
    8/14 Plan of action! Moved up to 1500mg Metformin, Femara 3-7 (Trigger canceled due to not big enough follies and holiday weekend) (BFN)
    9/14 7.5mg Femara CD3-7 +ovidrel  (BFN)
    10/14 5mg Femara(3-7) Follistim 75 (7-9) +Ovidrel +TI (last treatment cycle this year Breaking til after Holidays) (BFP! Beta #1 114, Beta #2 364)
    ~~~~~~~~~~~~ ALL ARE WELCOME! ~~~~~~~~~


    image




    BabyFetus Ticker
    BandM14
  • I had only a few side effects but they also did their job in producing a mature and good looking follicle every time! My joints became painful and tight, I was super moody and headaches all day. Not bad enough to never take them again just a rough few days.

    Good luck!

    Diagnosed PCOS 2013
    7th Round of Fertility treatment (Femara + Ovidrel + IUI) 12/14 = BFP. DS born Sept.15 
    Natural BFP Feb 2017. DD born Oct. 2017
    Natural BFP Aug. 2019, EDD April 2020

    BandM14
  • I just finished my first round of 5mg this past tuesday.  The first couple days on it I was unreasonably full of rage and dizzy/nauseous.  There could be other variables at play but I have no other explanation for why I was so hormonal.  My poor husband... luckily he's a good sport : ) 

    I had extremely heavy bleeding with clots for a couple days.  I usually have very light periods.  I'm wondering if that is related to the femara as well. My first three days of my period were normal and then once I started it, super heavy.  Anyone else have this happen? 

    I go in for my ultrasound tomorrow... hoping everything looks good!  At my baseline scan I was told that my ovaries "don't look like PCOS ovaries" this cycle so I'm hoping we have a good shot.



    image





    BandM14
  • @BandM14 love me some jax teller :)

    I had less side effects on letrozole than I had on clomid, but I also had less of a response I guess you could say.  I would only produce 1-2 mature follicles compared to the 2-4 I was producing on Clomid.  Overall, I liked it a lot better.  
    Me (29), DH (32)
    Aug 2011  - Married
    Jan 2013   - Started TTC
    Jan 2014   - OB started some testing 
                         - HSG - Normal
                         - Ultrasound - Normal
                         - SA - Normal, but tested positive for Ureaplasma
                         - Both of us on antibiotics to treat ureaplasma
                         - Blood work - progesterone: 15.9, TSH: 0.89, FT4: 1.2, Prolactin: 33.4 
    Feb 2014   - Endometrial Biopsy - Normal
    Mar 2014   - Prolactin: 22.9, referred to RE
    Apr 2014   - First RE appointment, put on medication for high prolactin levels 
                      - Clomid (50 mg) 1 follicle, Trigger shot - BFN
                      - Second SA - All Normal, borderline morph (5%) 
    May 2014   - Clomid (100mg) 2 follicles, Trigger shot - BFN
                      - blood work: Estradiol: 32.7, FSH: 5.3, Prolactin: 14.1
    June 2014  - IUI #1, Clomid (150 mg), 3 follicles, Trigger shot - BFN 
    July 2014   - IUI #2, Clomid (150 mg), 4 follicles, Trigger shot - BFN
    Aug 2014   - IUI #3, Femara 2.5, 3 follicles, Trigger shot (first time done by DH!!) - BFN
                      - Hysteroscopy - Normal
    Sept 2014 - IUI #4 Femara 2.5, 1 follicle, possibility of another one, Trigger shot - BFN
                       -Progesterone test 4 DPIUI - 7.8...started crinone.
    Oct 2014 - IUI #5 Follistim 150 3 possibly 4 follicles - Trigger Shot - BFN
    Oct/Nov 2014 - Follistim 150 with TI & Trigger shot - ???

    **October Siggy Challenge**

    I don't even know what he is supposed to be!
    image


    **EVERYONE WELCOME!! :)**

    BandM14
  • I had hot flashes and horrible ovulation pain. I had pain on Clomid but it was even worse for me on letrazol.
    image
    BandM14
  • I'm finishing up my last day of Femara and I only had hot flashes all day with both. I took both clomid and femara at night so I dont know if that changed much. I'm actually having a hot flash right now lol.  Good Luck!
    TTC #1 since 07/2012
    Diagnosed w/ PCOS 11/2010
    Me & DH- 24

    ●Cycle #1-

    1st - Clomid 25mg- Non Responsive
    2nd - Clomid 50mg- Non Responsive
    3rd- Femara 5mg- ???


    My Cycle Chart


    October Siggy Challenge
    image


    BandM14
  • I took Letrozole on CD 3,4,5 & 6. I did 2.5mg on the first da7, 5mg day 2, 7.5 mg day 3 and 10 mg day 4.

    I imagined symptoms but nothing was strong enough to make me believe it was anything other than my imagination. It certainly wasn't a big deal. I hope you don't have strong symptoms too -- although sometimes it's nice to have strong symptoms because it feels like you're doing SOMETHING, right? :)

    ***** All Welcome *****
    ***** Siggy Warning *****

    TTC since Dec, 2012. Me: 33; DH: 34

    - Ultrasound to look at "lay of the land": normal
    - Blood work: normal
    - OPKs and ultrasound to confirm ovulation: Yes
    - SA for DH: Normal (a couple numbers on the low side of normal)
    - HSG: Normal
    - Doing several cycles of Letrozole, TI and progesterone
        - Aug cycle of Letrozole, TI and progesterone came back with a BFP-MC at 7 weeks.
    - Benched until Jan
    - Starting Letrozole, TI, Progesteron and HCG Trigger in Feb cycle

     

    BandM14
  • Thanks everyone!! I've taken 3 doses so far, and had some minor hot flashes, and a headache on the second day, but that's been it! I'm thankful that I haven't had any bad side effects, and seriously hoping for a promising u/s on Thursday. Good luck to all of you!!!

    Me: 27 DH: 35

    TTC #1 Since July 2013

    Started RE Testing July 2014

    2 HSG tests: Right tube is blocked, possible endo.

    TSH elevated, started Synthroid 25 mg daily.

    October, 2014: Femara 5 mg + TI ---> 3 follies on blocked tube side ---> BFN

    November, 2014: Femara + Ovidrel + IUI#1--2 follies (on the good side), 46 mil. motile sperm=BFN

    Nov-Dec 2014: Femara + Ovidrel + IUI #2 (1 follie, 76 mil. motile sperm) + Endometrin=BFN

    January, 2014: Femara + Ovidrel + IUI #3 (1 follie, 38 mil. motile sperm)=???

    New RE appt. scheduled for 1/14.


    3T January Siggy Challenge: New Years Resolutions

    Mine: Lose the weight I put on from booze and cookies over Christmas.

    image


    DSculley1824
  • mbrookeRN said:
    I just finished my first round of 5mg this past tuesday.  The first couple days on it I was unreasonably full of rage and dizzy/nauseous.  There could be other variables at play but I have no other explanation for why I was so hormonal.  My poor husband... luckily he's a good sport : ) 

    I had extremely heavy bleeding with clots for a couple days.  I usually have very light periods.  I'm wondering if that is related to the femara as well. My first three days of my period were normal and then once I started it, super heavy.  Anyone else have this happen? 

    I go in for my ultrasound tomorrow... hoping everything looks good!  At my baseline scan I was told that my ovaries "don't look like PCOS ovaries" this cycle so I'm hoping we have a good shot.
    @mbrookeRN Just wanted to let you know that I've also had strange bleeding on the Femara... usually my period is over in 4 days, I'm on CD 6 and still going. I'm thinking it has to be the medication, because it's very unusual for me. Hope your ultrasound went well!

    Me: 27 DH: 35

    TTC #1 Since July 2013

    Started RE Testing July 2014

    2 HSG tests: Right tube is blocked, possible endo.

    TSH elevated, started Synthroid 25 mg daily.

    October, 2014: Femara 5 mg + TI ---> 3 follies on blocked tube side ---> BFN

    November, 2014: Femara + Ovidrel + IUI#1--2 follies (on the good side), 46 mil. motile sperm=BFN

    Nov-Dec 2014: Femara + Ovidrel + IUI #2 (1 follie, 76 mil. motile sperm) + Endometrin=BFN

    January, 2014: Femara + Ovidrel + IUI #3 (1 follie, 38 mil. motile sperm)=???

    New RE appt. scheduled for 1/14.


    3T January Siggy Challenge: New Years Resolutions

    Mine: Lose the weight I put on from booze and cookies over Christmas.

    image


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