I know many of you (and know all of you stalker-style), but I'll do brief intro just in case...
We've been ttc for just over 2 years now and are seeing an RE at SG. About a year ago we were diagnosed with UI. Since then I've had 2 clomid IUIs, 1 failed IVF cycle (where only 3 eggs were retrieved), 1 IVF cycle converted to an IUI, and 1 IVF cycle flat out cancelled for no response. Some of my stats are really good: CD 3 FSH, AFC of 21. But I have a crappy AMH of .51 at 33 years old. I've never been pregnant and I don't respond to stims worth a shit.
I have a WTF appointment on Monday. I expect to get the DE talk. FWIW, I can get on board with DE. I have witnessed first hand how little genetics matter in the end. But....my insurance will cover 2 more IVFs, but nothing involving donor eggs. While we have major concerns about the financial aspects of DE, my husband is super on board if it means he gets his wife back. I can admit that she has been MIA since our first failed IVF in March of this year.
He has agreed to hear what the RE has to say and has also agreed to get a second opinion. We'll likely get 2nd opinions from Sher and RMANJ. I plan to ask my RE about mini IVF and estrogen priming. Others have suggested that. Our cycles so far have been antagonist and MDL.
I'm sorry you find yourself here!! I barely respond myself.
I cycled at SIRM LV for my first 4 IVFs with my OE's. Out of those first 4 IVFs with max stims I only had two transfers. I think we could have possibly found success had we known about DH's Balanced Translocation and we used donor sperm.
After our failed DE cycle, we attempted estrogen priming and low dose stims. I have seen women over the years find success with this protocol. I was ultimately cancelled because my follicle stopped growing and my E2 fell.
This cycle we are doing estrogen and testosterone priming. Only time will tell if this cycle will be a success. I know that SIRM physicians will not consider this protocol because they believe the testosterone poorly affects egg quality.
Good Luck!! I think SIRM is a great clinic and I think a second opinion is a great idea. Hang in there!!
::: Married June 2003::: TTC #1 since: Aug. 2008 Me: 34, DOR, MTHFR-A1298C (heterozygous), decreased blood flow to uterus, Mild Endo DH: 38, Balanced translocation 5&10, unexplained MFI, normal SA and SCSA Tx History: IUI 1&2= BFN IVF# 1 W/ICSI= BFN IVF# 2: cancelled d/t no response IVF# 3= 1 egg retrieved=immature/not viable IVF# 4= c/p ***CCRM ODWU*** Found DHs BT and Me-decreased blood flow to uterus Recommended DE IVF w/PGD, incorporate electro-acupuncture. Decided to cycle locally ***New RE*** DE IVF# 1(cycle #6) w/pgd, (freeze all): 30R, 23M, 15F, slow/poor embryo development, 4 biopsied, 1 Normal "Norm"; DE IVF w/PGD, incorporate electro-acupuncture. IVF# 6: (OE/DS) cancelled IVF# 7: (OE/DS) 1R, 1M, 1F, arrested day 5 Plan-DE IVF# 2 (cycle #8): DE/DS in May 2015
I am so very sorry. You will be welcomed here with open arms. I hope your consults and WTF give you hope for future cycles. There are other poor responders here who might be able to give you ideas of questions to ask and protocols to research.
I responded more favorably than you, but ended up having the best success with estrogen priming and the addition of HGH. Wishing you the best.
Welcome. I'm a poor responder too so I know your struggles. GL with your 2nd opinions. I'm a S.I.R.M patient. If you have any questions, let me know!
Me & DH (33), 3 Furbabies, TTC since October 2011 Day 3 #’s (Dec 2012) FSH 9, AMH .77, LH 2.4, E2 31, AFC 9
DX: Me-DOR + No Tubes, DH-Fine
Ectopic 2007; lost tube/2nd tube removed Dec 2011
(hydro)
April 2012=IVF#1- EPP Antag+ICSI, 2R,0F (BFN),
Now dx’d with DOR.
June-July 2012=IVF#2- MDL+ICSI&AH,
8R,4M,3F (BFP 9dp3dt) Beta#1 at 11dp3dt=36, Beta#2 at 15dp3dt=156, Beta#3
at 19dp3dt=671, dx'd with SCH, no growth-m/c at 7wks/Lap Dec 2012 to remove small
fibroid.
Feb 2013=IVF#3-MDL, 2/1=baseline, started
10 units mdl, AFC-7, 2/3 start gonal f, self cxld cycle b/c of low
e2.
April 2013=IVF#3.5-(with new RE)AG/ANT Conv + ICSI. 4/10-4/23
bcp's, 4/20-4/27 lupron, 4/28-ganirelix until end of stimming, 5/2-600 gonal f,
5/4-add 1/2 vial menopur, 5/13-ER (9R,1M,1F), 5/17-ET, 1 beautiful 8 cell
(please be my sticky baby!!!!) 5/28-BFFN.
Oct
2013=IVF#4-LLP+ICSI &AH, 10/14 (6R, 2M, 2F), 10/17-ET, 1 seven cell &
a six cell, BFP at 9dp3dt, 1st beta=56, 2nd beta=52, CP.
Jan
2014=IVF #5-LLP, Cxld after 6 days of stims due to fast
response and lead follicle.
March 2014=IVF
5.5-LLP, Lupron 3/10, BL 3/18, 11 days of stims, Trigger 3/29, ER 3/31. 7R, 2M, 2F. ET 4/3. Txfd one 5 cell & one 9 cell. BFP on hpt from 7dp3dt & on. Praise be to God. Beta #1 at 11dp3dt=106, #2 at 13dp3dt=239. First u/s 4/28, measuring on track & heartbeat seen. 5/5-2nd u/s, measuring on track with strong heartbeat. 5/12- 3rd u/s & released from RE. Grow baby grow, we love you! Baby G&T is a BOY! Born 12/2014 via c/s! 8lbs, 8oz & 21 inches.
DH (32): SA is ok, slightly low morph, normal SCSA Me (32): Slightly low progesterone, hostile CM, carrier for CF, Moderately high NKC, High TNFa, heterozyogous mutated Factor XIII, and +APA
October 2012-May 2014: 4 failed IUIs, 3 failed IVFs, and 1 failed FETw/donor embryos
November 2014: IVF w/ICSI #4 Agonist/Antagonist with EPP and Prednisone, Baby Aspirin, Lovenox, and IVIG for immune issues. Converted to freeze all due to lining issues. 2 blasts frozen on day 6!
January 2015: FET #2 Cancelled due to lining issues
Welcome! Out of curiosity... Have you had a lap to check for endo? I could be way off, but since I have endo I often think others may too. lol I ask because of your good AFC but not as great AMH. In my siggy you'll see my AMH has varied and that's because when there is endo growth it can cause your AMH to be lower. (After a few months on OCP my AMH went up.) Any way, like I said I could be way off.
***signature & ticker warning***
Me: 30 ~ Stage IV Endo ~ AMH .38 ~ AFC 8 AMH .97 as of 4/2012! ~ AMH 1.63 as of 4/2013!?! Him: 29 ~ perfect swimmers Laparotomy w/partial oophorectomy 8/2009 to remove cysts/endo. Stopped BCP 4/2010. Multiple clomid rounds from 11/2010 to 6/2011. ~ All BFN IUI w/clomid 7/2011. IUI w/clomid & injectables 11/2011 & 1/2012. ~ All BFN IVF:EPP 5/2012 ~ (4R, 3M, 2F w/ICSI). Both embryos txfrd. ~ BFN BCP to manage endo from 10/2012 to 12/2012. FET w/donor embryos #1: 10/2013 Cancelled FET w/donor embryos #1.2: 11/2013 ~ ET of 2 beautiful blasts on 11/27. Beta 1: 503(12dp5dt) Beta 2: 1035(14dpt) Beta 3: 3001(16dpt) Beta 4: 8503(19dpt) Twins with an EDD of 8/15/14! Team Purple G&B born 6/30/14 at 33w3d via emergency c/s. If you're wondering about my avatar...it's a fried pickle chip shaped like a fetus!
@DoublePortion I have been suspicious of endo. I have literally always had painful periods, but never a heavy flow. At my last two baselines, I've had cysts on my ovaries despite being on BCPs. My RE isn't big on laps. Thanks for reminding me. I need to ask again based on my most recent news.
TTC#1 since April 2011 IVF#1 July 2012 5R, 3 made it to blast, sET c/p FET#1 Aug 2012 2 blasts transferred BFN IVF#2 Oct 2012 16R/6M/6F/2-8 cell grade 1 transfer Beta 1-237.9, Beta 2-566, Beta 3-8657 US 6w3d shows one baby w/ HB 115 US 7w1d no more heartbeat/ D&C 11/30/12 normal karyotype IVF#3 Mar 2013 6R/4M/4F 1 compacting and 2-8 cell transfer ectopic pg MTX given 3 month break from TTC
IVF#4 Sept 2013--BFN IVF#5-7 Apr 2014, Jun 2014 and Aug 2014 banking embryos for CCS testing. Praying for normals!
Re: I think I go here now
::: Married June 2003:::
TTC #1 since: Aug. 2008
Me: 34, DOR, MTHFR-A1298C (heterozygous), decreased blood flow to uterus, Mild Endo
DH: 38, Balanced translocation 5&10, unexplained MFI, normal SA and SCSA
Tx History: IUI 1&2= BFN
IVF# 1 W/ICSI= BFN
IVF# 2: cancelled d/t no response
IVF# 3= 1 egg retrieved=immature/not viable
IVF# 4= c/p
***CCRM ODWU***
Found DHs BT and Me-decreased blood flow to uterus
Recommended DE IVF w/PGD, incorporate electro-acupuncture. Decided to cycle locally
***New RE***
DE IVF# 1(cycle #6) w/pgd, (freeze all): 30R, 23M, 15F, slow/poor embryo development, 4 biopsied, 1 Normal "Norm"; DE IVF w/PGD, incorporate electro-acupuncture.
IVF# 6: (OE/DS) cancelled
IVF# 7: (OE/DS) 1R, 1M, 1F, arrested day 5
Plan-DE IVF# 2 (cycle #8): DE/DS in May 2015
http://icanhazbabyz.blogspot.com/
***SAIF Sig****
I am so very sorry. You will be welcomed here with open arms. I hope your consults and WTF give you hope for future cycles. There are other poor responders here who might be able to give you ideas of questions to ask and protocols to research.
I responded more favorably than you, but ended up having the best success with estrogen priming and the addition of HGH. Wishing you the best.
Age: 35 TTC since 2005, MFI & DOR
IVF #1 Sep '11 - canceled poor response
IVF #2 Nov '11 8R/8M/4F 3dt x2 - chemical
IVF #3 April '12 11R/6M/4F 3dt x2 - m/c
FET #1 Aug 2012 3dt x2 - BFN
**new RE**
IVF #4 Jan '13 BFN 11R/6M/6F 5dt x2 - BFN
IVF #5 July '13 16R/10M/10F 5dt x2 + 1 frostie
9dp5dt Beta 1 = 344!! 16dp5dt. Beta 2 = 4822 7wk u/s= 2 heartbeats!
Twin girls! 3/6/14
Me & DH (33), 3 Furbabies, TTC since October 2011
Day 3 #’s (Dec 2012) FSH 9, AMH .77, LH 2.4, E2 31, AFC 9
DX: Me-DOR + No Tubes, DH-Fine
Ectopic 2007; lost tube/2nd tube removed Dec 2011 (hydro)
April 2012=IVF#1- EPP Antag+ICSI, 2R,0F (BFN), Now dx’d with DOR.
June-July 2012=IVF#2- MDL+ICSI&AH, 8R,4M,3F (BFP 9dp3dt) Beta#1 at 11dp3dt=36, Beta#2 at 15dp3dt=156, Beta#3 at 19dp3dt=671, dx'd with SCH, no growth-m/c at 7wks/Lap Dec 2012 to remove small fibroid.
Feb 2013=IVF#3-MDL, 2/1=baseline, started 10 units mdl, AFC-7, 2/3 start gonal f, self cxld cycle b/c of low e2.
April 2013=IVF#3.5-(with new RE)AG/ANT Conv + ICSI. 4/10-4/23 bcp's, 4/20-4/27 lupron, 4/28-ganirelix until end of stimming, 5/2-600 gonal f, 5/4-add 1/2 vial menopur, 5/13-ER (9R,1M,1F), 5/17-ET, 1 beautiful 8 cell (please be my sticky baby!!!!) 5/28-BFFN.
Oct 2013=IVF#4-LLP+ICSI &AH, 10/14 (6R, 2M, 2F), 10/17-ET, 1 seven cell & a six cell, BFP at 9dp3dt, 1st beta=56, 2nd beta=52, CP.
Jan 2014=IVF #5-LLP, Cxld after 6 days of stims due to fast response and lead follicle.
March 2014=IVF 5.5-LLP, Lupron 3/10, BL 3/18, 11 days of stims, Trigger 3/29, ER 3/31. 7R, 2M, 2F. ET 4/3. Txfd one 5 cell & one 9 cell. BFP on hpt from 7dp3dt & on. Praise be to God. Beta #1 at 11dp3dt=106, #2 at 13dp3dt=239. First u/s 4/28, measuring on track & heartbeat seen. 5/5-2nd u/s, measuring on track with strong heartbeat. 5/12- 3rd u/s & released from RE. Grow baby grow, we love you! Baby G&T is a BOY! Born 12/2014 via c/s! 8lbs, 8oz & 21 inches.
*******Ticker Warning**********
"God's Delay is not God's Denial"
TTC #1 since August 2011
My Blog
September 2012: Start IF testing
DH (32): SA is ok, slightly low morph, normal SCSA Me (32): Slightly low progesterone, hostile CM, carrier for CF, Moderately high NKC, High TNFa, heterozyogous mutated Factor XIII, and +APA
October 2012-May 2014: 4 failed IUIs, 3 failed IVFs, and 1 failed FETw/donor embryos
November 2014: IVF w/ICSI #4 Agonist/Antagonist with EPP and Prednisone, Baby Aspirin, Lovenox, and IVIG for immune issues. Converted to freeze all due to lining issues. 2 blasts frozen on day 6!
January 2015: FET #2 Cancelled due to lining issues
April 2015: FET #2.1
PAIF/SAIF Welcome!
*******siggy/ticker warning*****
Me(31). DH (31)
DH SA normal count and motility, 1% morphology
Me .72 AMH, Fragile X premutation carrier
IVF #1 (6/12/13) BFN
IVF #2 (8/16/13) BFN
FET 10/4/13 Chemical
IVF #3 MC 5 weeks 5 days
IVF #4 DE 11/7 BFP, edd 7/28/15
All Welcome
***signature & ticker warning***
Me: 30 ~ Stage IV Endo ~ AMH .38 ~ AFC 8
AMH .97 as of 4/2012! ~ AMH 1.63 as of 4/2013!?!
Him: 29 ~ perfect swimmers
Laparotomy w/partial oophorectomy 8/2009 to remove cysts/endo.
Stopped BCP 4/2010.
Multiple clomid rounds from 11/2010 to 6/2011. ~ All BFN
IUI w/clomid 7/2011. IUI w/clomid & injectables 11/2011 & 1/2012. ~ All BFN
IVF:EPP 5/2012 ~ (4R, 3M, 2F w/ICSI). Both embryos txfrd. ~ BFN
BCP to manage endo from 10/2012 to 12/2012.
FET w/donor embryos #1: 10/2013 Cancelled
FET w/donor embryos #1.2: 11/2013 ~ ET of 2 beautiful blasts on 11/27.
Beta 1: 503(12dp5dt) Beta 2: 1035(14dpt) Beta 3: 3001(16dpt) Beta 4: 8503(19dpt)
Twins with an EDD of 8/15/14! Team Purple
G&B born 6/30/14 at 33w3d via emergency c/s.
If you're wondering about my avatar...it's a fried pickle chip shaped like a fetus!
TTC since 08/2012
DX: DOR
While I am no longer trying with OE, I am currently cycling for a FET with SIRM NJ.
I really like the RE (Dr. Peters) and my nurse; the practice runs smoothly and I get very prompt responses from them.
I'm not sure if this helps, but I wanted to let you know my experience so far.
Me (32) DOR, elevated NK Cells/ 2 copies of MTHFR mutation/ MH (35) azoo/high DFI (TTC#1 since 2009)
IVFs#1-4: (4/10-2/12) all BFN
Surprise Bfp (9/11) - c/p
DS IUI#1-2 (9/12, 10/12) - BFN
DS IVF: (11/12) - BFN
DE/DS IVF#1: (10/13) - 2 day 3 embies transferred-BFFN
FET of 2 day 6 blasts: (12/13) - c/p
DE/DS IVF #2: (4/14) - 1 day 5 blast transferred...BFFN...again.
FET 5/14: 1 day 5 hatching blast transferred...another BFFN
Repeat SHG 6/14-normal / Endometrial Receptivity Array biopsy 7/14-Receptive Uterus
New RE, additional testing reveals elevated NK Cells
FET of 1 day 5 blast (RE recommends transferring 1 due to elevated NK cells) with lovenox, steroids & intralipids in October
TTC#1 since April 2011
IVF#1 July 2012 5R, 3 made it to blast, sET c/p
FET#1 Aug 2012 2 blasts transferred BFN
IVF#2 Oct 2012
16R/6M/6F/2-8 cell grade 1 transfer
Beta 1-237.9, Beta 2-566, Beta 3-8657
US 6w3d shows one baby w/ HB 115
US 7w1d no more heartbeat/ D&C 11/30/12 normal karyotype
IVF#3 Mar 2013
6R/4M/4F 1 compacting and 2-8 cell transfer
ectopic pg MTX given 3 month break from TTC
IVF#4 Sept 2013--BFN
http://i61.tinypic.com/34zll06IVF#5-7 Apr 2014, Jun 2014 and Aug 2014 banking embryos for CCS testing. Praying for normals!